7,480 results match your criteria: "Texas Dermatology & Laser Surgery Center[Affiliation]"

Integrating priorities at the intersection of cancer and neuroscience.

Cancer Cell

January 2025

Department of Head and Neck Surgery and the Department of Genomic Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA; University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address:

Cancer neuroscience is a rapidly growing multidisciplinary field that conceptualizes tumors as tissues fully integrated into the nervous system. Recognizing the complexity and challenges in this field is of fundamental importance to achieving the goal of translational impact for cancer patients. Our commentary highlights key scientific priorities, optimal training settings, and roadblocks to translating scientific findings to the clinic in this emerging field, aiming to formulate a transformative and cohesive path forward.

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Article Synopsis
  • Poromas are benign skin tumors originating from sweat glands, often appearing as pink or red bumps primarily on hairless areas like palms and soles.
  • A 70-year-old woman had a poroma on her abdomen that showed some histological features similar to another neoplasm, syringocystadenoma papilliferum (SCAP), but lacked certain defining characteristics of SCAP.
  • This case, showing rare SCAP-like features within a poroma, emphasizes the need for careful diagnosis as it may simply reflect a variation of poromas, rather than representing two different tumors.
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, formerly , is a bacterial species characterized by tenacious acne-contributing pathogenic strains. Therefore, bacteriophage therapy has become an attractive treatment route to circumvent issues such as evolved bacterial antibiotic resistance. However, medical and commercial use of phage therapy for has been elusive, necessitating ongoing exploration of phage characteristics that confer bactericidal capacity.

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Article Synopsis
  • The study focuses on establishing Minimal Important Difference (MID) estimates for the FACE-Q Skin Cancer Module, a tool to measure patient outcomes after facial skin cancer surgery.
  • Conducted at four U.S. hospitals from April 2020 to April 2022, 990 patients undergoing Mohs Micrographic Surgery provided data through various scales assessing satisfaction and distress at multiple time points.
  • The findings indicated specific MID estimates for the scales, which are key for improving the understanding and application of patient-reported outcomes in clinical settings.
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Disparities in surgical outcomes often result from subjective decisions dictated by surgical training, experience, and available resources. To improve outcomes, surgeons have adopted advancements in robotics, endoscopy, and intra-operative imaging including fluorescence-guided surgery (FGS), which highlights tumors and anatomy in real-time. However, technical, economic, and logistic challenges hinder widespread adoption of FGS beyond high-resource centers.

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Genome-wide studies define new genetic mechanisms of IgA vasculitis.

medRxiv

October 2024

Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.

Article Synopsis
  • IgA vasculitis (IgAV) is a pediatric disease characterized by skin and systemic symptoms, and researchers conducted comprehensive studies involving genome, transcriptome, and proteome analyses on a large cohort of IgAV patients and controls to better understand the disease mechanisms.* -
  • Significant associations were found with specific genetic risk factors, including two novel non-HLA loci linked to IgA receptor functioning, which may contribute to disease development through altered immune responses.* -
  • Systems biology approaches helped identify key regulatory networks and master regulators in myeloid cells, along with 21 genetic loci that overlap with IgA nephropathy, suggesting shared pathways in these related conditions.*
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Physician-patient racial and cultural concordance is essential to address health care disparities. Yet, limited literature on diversity, equity, and inclusion (DEI) outcomes in graduate medical education (GME) suggests the need for high-yield DEI resources. To describe and identify DEI efforts by US residency program director (PD) associations and areas for collaboration among the GME community.

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Top DEI Topics to Incorporate Into Dermatology Residency Training: An Electronic Delphi Consensus Study.

Cutis

September 2024

Valerie S. Encarnación-Cortés is from the School of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan. Ivan Rodriguez and Drs. Elbuluk and Worswick are from the Department of Dermatology, University of Southern California, Los Angeles. Dr. Rinderknecht is from the School of Medicine, University of San Francisco, California. Dr. Admassu is from the Department of Dermatology, Medical College of Wisconsin, Milwaukee. Drs. Phillips and Pimentel are from the Department of Dermatology, Oregon Health and Science University, Portland. Dr. Castillo-Valladares is from the Department of Dermatology, University of California San Francisco. Dr. Tarbox is from the Department of Dermatology, Texas Tech University, Lubbock. Dr. Peebles is from the Department of Dermatology, Mid-Atlantic Permanente Medical Group, Rockville, Maryland. Dr. Stratman is from the Department of Dermatology, Marshfield Clinic Health System, Wisconsin. Dr. Altman is from the Department of Dermatology, University of New Mexico, Albuquerque. Dr. Parekh is from the Department of Dermatology, Baylor Scott and White Medical Center, Texas. Dr. Daveluy is from the Department of Dermatology, Wayne State University School of Medicine, Detroit. Dr. James is from the Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia. Dr. Kim is from the Department of Dermatology, Baylor College of Medicine, Temple, Texas. Dr. Rosmarin is from the Department of Dermatology, School of Medicine, Indiana University, Indianapolis. Dr. Kakpovbia is from the Department of Dermatology, Grossman School of Medicine, New York University, New York. Dr. Silverberg is from the George Washington University School of Medicine and Health Sciences, Washington, DC. Dr. Bowers is from the Department of Dermatology, Stritch School of Medicine, Loyola University, Chicago. Dr. Vasquez is from the Department of Dermatology, University of Texas Southwestern Medical Center, Dallas. Dr. Ahmed is from the Division of Dermatology, Dell Medical School, University of Texas, Austin.

Article Synopsis
  • Dermatology residency education currently lacks sufficient training on diversity, equity, and inclusion (DEI), which may negatively impact care for diverse populations.
  • A study aimed to identify key DEI topics to integrate into residency programs, gathering input from experts and participants through anonymous surveys.
  • Sixty-one DEI topics were proposed by dermatology experts, and the study utilized a modified electronic Delphi method to reach a consensus on which topics should be prioritized in curricula.
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Moving Beyond Traditional Methods for Treatment of Acne Keloidalis Nuchae.

Cutis

September 2024

Clinical Assistant Professor (Adjunct), Department of Urban Health and Population Science, Center for Urban Bioethics, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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Article Synopsis
  • - Localized scleroderma (LS) is an autoimmune disease that causes skin inflammation and fibrosis, leading to symptoms like hardening and discoloration of the skin, which can result in disability.
  • - This study utilized single-cell RNA sequencing (scRNA-seq) to analyze skin cells from 27 LS patients and 17 healthy controls, focusing primarily on endothelial cells due to their known role in a related condition, systemic sclerosis (SSc).
  • - The analysis identified eight subclusters of endothelial cells, with certain pathways upregulated in LS, suggesting these cells may contribute to disease progression and associated skin abnormalities.
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: Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are non-melanoma skin cancers (NMSCs) and the most prevalent cancers in the United States. Image-guided superficial radiotherapy (IGSRT) is a relatively new treatment option that uses high-resolution dermal ultrasound integrated with superficial radiotherapy to improve tumor visualization. IGSRT is a clinically equivalent non-surgical alternative to Mohs micrographic surgery at 2 years of follow-up in early-stage NMSC, but larger cohort studies with longer follow-up periods that allow for analysis of patient outcomes by demographic and disease characteristics are needed.

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Article Synopsis
  • * Mild-to-moderate AD is typically treated with topical anti-inflammatory medications and basic skin care, while moderate-to-severe cases often need systemic therapy, including off-label immunosuppressants, which carry safety concerns.
  • * New targeted biologics and small molecules are emerging as more effective and safer treatment options for AD, leading to the development of standardized recommendations for treating pediatric patients with moderate-to-severe cases.
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Article Synopsis
  • This study examines how various social determinants of health (SDH), not just socioeconomic factors, impact the management of head-neck melanomas (HNM) in the U.S. using the Social Vulnerability Index (SVI).
  • It analyzed data from over 374,000 adults diagnosed with HNM from 1975 to 2017, revealing that higher social vulnerability is linked to reduced surgical options, increased likelihood of radiation treatment, and more advanced disease at diagnosis.
  • Key findings indicate that household composition, socioeconomic status, and minority-language status significantly influence disparities in HNM management, despite limitations like unknown causes of death and reliance on county-level SVI calculations.
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Recommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype.

J Am Acad Dermatol

February 2025

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

Article Synopsis
  • Extramammary Paget's disease (EMPD) can be linked to underlying internal adenocarcinomas, with varying associations based on the EMPD subtype.
  • A systematic literature review identified that perianal EMPD has a higher rate (25%) of associated adenocarcinomas compared to penoscrotal and vulvar types (6% each).
  • The proposed screening algorithms suggest specific tests based on EMPD subtype, emphasizing thorough screening for high-risk perianal cases and more cost-effective approaches for lower-risk penoscrotal and vulvar cases.
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This article offers an up-to-date overview of resources tailored for dermatology residents in the United States preparing for their board certification exams. We have assembled a comprehensive list of exam preparation resources categorized by cost, alongside recommendations from attending and resident physicians regarding the most effective resources for each exam. Although examinations are only one facet of the training involved in becoming a competent dermatologist, these exams help residents focus on learning crucial aspects of medicine.

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Article Synopsis
  • The case study discusses a 64-year-old woman who suffered from spongiotic dermatitis in the vaginal area, which was initially misdiagnosed as various genital infections.* -
  • Despite negative STD tests and multiple ineffective treatments, a biopsy ultimately confirmed the diagnosis of spongiotic dermatitis, showcasing its similarity to other conditions that complicate diagnosis.* -
  • This case highlights the crucial role of biopsy in accurately diagnosing spongiotic dermatitis and emphasizes the need for more research to better understand its prognosis and clinical features.*
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Article Synopsis
  • - The study investigates the impact of vitiligo on mental health in African American pediatric patients, highlighting a higher prevalence of psychiatric issues like depression and anxiety compared to peers without the condition.
  • - Among 327 affected children, those with vitiligo had significantly higher rates of various mental health disorders and a notable percentage did not receive treatment for suicidal thoughts.
  • - The findings suggest that understanding the psychological effects of vitiligo in this demographic could lead to improved quality of life and dermatological outcomes for affected children.
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