Case Report: Percutaneous Peripheral Nerve Stimulation for the Treatment of Occipital Neuralgia.

Headaches are among the most prevalent medical complaints globally. Occipital neuralgia is a chronic headache disorder characterized by unilateral or bilateral severe pain originating in the neck or skull base and radiating up along the occipital nerve distribution. Effective treatment options for occipital neuralgia can be challenging and some patients may prove to be refractory to conventional medical and interventional therapies.

Prevalence of cannabidiol use and correlates in U.S. adults.

Background: Cannabidiol (CBD) use has been increasing for its putative therapeutic potential for various health conditions. Research using a nationally representative sample is needed to examine characteristics of CBD users.

Methods: Data came from the adult sample (N=47,100) of the 2022 U.

Child Death and Mothers' Subsequent Mental Health in a High-Mortality African Community.

Despite declines in child mortality rates, experiencing a child death remains a common feature of motherhood in many contemporary African populations. Yet, we lack population insights into the consequences of child death for mothers' well-being in the high-mortality regions where it concentrates. Contrasting an extensive psychology literature on the severe and long-lasting consequences of child death for parents in low-mortality settings, a long-standing thesis in multiple social science literature is that the normativity of child death in high-mortality settings can lead to a numbing effect-muting parents' reactions to child loss.

Confirming Subarachnoid Hemorrhage Induction in the Endovascular Puncture Mouse Model.

Background And Purpose: Experimental studies of subarachnoid hemorrhage (SAH) using the endovascular perforation model routinely use either cerebral blood flow (CBF) or intracranial pressure (ICP) monitoring to confirm SAH induction. We designed this study to test the hypothesis that contralateral CBF is a better marker of SAH induction than ipsilateral CBF.

Methods: Sixty-eight adult C57BL/6J mice were subjected to endovascular perforation.

A Qualitative Study of First HIV Test Experiences Among Sexual and Gender Minority Adolescents.

Introduction: This qualitative study examined adolescents' first experiences with HIV testing.

Methods: Data were collected from April 2018 to October 2020 as part of an HIV prevention and sex education intervention; SGM adolescents ( = 175) answered open-ended questions regarding experiences with their first HIV test and advice for other adolescents seeking HIV testing. Data were analyzed through inductive content analysis.

Topical Carboxytherapy for Skin Rejuvenation.

Driven by public demand, new safe and effective approaches for achieving dermal rejuvenation are continuously being developed. Recently, there has been growing interest and advances in carbon dioxide therapy, or carboxytherapy. Based on the Bohr effect, carboxytherapy enhances the release of O from the blood into the surrounding tissues in response to increased blood CO.

Recalcitrant Pediatric Facial Vitiligo Successfully Treated with Roflumilast Cream 0.3% Once Daily.

Vitiligo is an autoimmune disorder that causes melanocyte damage and pigment loss. The clinical presentation of vitiligo consists of patchy areas of lighter skin and results from a loss of functioning melanocytes and may be more visible in darker skin toned patients. Vitiligo affects approximately 2 percent of children and adolescents in the United States, with half of the affected cases undiagnosed.

Incidence and Factors in Delayed Neurological Deficits after Subarachnoid Hemorrhage in Mice.

Background: Delayed cerebral ischemia (DCI) is one of the most feared complications in aneurysmal subarachnoid hemorrhage (SAH). Animal models are crucial to studying the disease mechanisms and potential treatments. DCI in rodents was thought to not exist; herein we examine literature and our experience with DCI in rodents.

Multiscale Measurements of Greenhouse Gas Emissions at U.S. Natural Gas Liquefaction Terminals.

Addressing methane emissions across the liquefied natural gas (LNG) supply chain is key to reducing climate impacts of LNG. Actions to address methane emissions have emphasized the importance of the use of measurement-informed emissions inventories given the systematic underestimation in official greenhouse gas (GHG) emission inventories. Despite significant progress in field measurements of GHG emissions across the natural gas supply chain, no detailed measurements at US liquefaction terminals are publicly available.

Attention and language as mediators of academic outcomes following early psychosocial deprivation.

Children adopted from institutions at older ages are at increased risk of persistent attention problems, lower cognition, and academic difficulties. This study examined cognitive and behavior problems as mediators of the association between early psychosocial deprivation and academic functioning. Participants were 8-17-year-old children adopted from psychosocially-depriving Russian institutions after 14 months of age ( = 34) and before 9 months of age ( = 39).

Improving the Clinical Diagnostic Criteria for Genetically Confirmed Adult-Onset Huntington Disease: Considering Nonmotor Presentations.

Background: Huntington disease (HD) is a genetic neurodegenerative disorder. Given the focus on motor manifestations, nonmotor symptoms are frequently underappreciated in clinical evaluations, despite frequently contributing to primary functional impairment.

Recent Findings: A diagnosis of motor-onset as the definition of manifest symptoms misrepresents the complex nature of HD presentation.

Consensus Recommendations for the Management of Neurosarcoidosis: A Delphi Survey of Experts Across the United States.

Background And Objectives: Neurosarcoidosis poses a diagnostic and management challenge due to its rarity, phenotypic variability, and lack of randomized controlled studies to guide treatment selection. Recommendations for management based on expert opinion are useful in clinical practice and provide a framework for designing prospective studies.

Methods: In this Delphi survey study, specialists with experience in managing patients with neurosarcoidosis were invited to anonymously complete 2 surveys about key elements of evaluation, diagnosis, treatment, monitoring, and long-term management of neurosarcoidosis.

Small Group Learning Communities as a Prototype for Intersectional Black Feminist Praxis in Higher Education.

Through the creation and analysis of Small Group Learning Communities (SGLC) at a predominantly White university in the U.S. South, this study investigated how SGLCs operationalize intersectional Black feminist praxis via dialogue, liberation, and ethic of caring.

A comprehensive survey of complex brain network representation.

Recent years have shown great merits in utilizing neuroimaging data to understand brain structural and functional changes, as well as its relationship to different neurodegenerative diseases and other clinical phenotypes. Brain networks, derived from different neuroimaging modalities, have attracted increasing attention due to their potential to gain system-level insights to characterize brain dynamics and abnormalities in neurological conditions. Traditional methods aim to pre-define multiple topological features of brain networks and relate these features to different clinical measures or demographical variables.

Brevundimonas diminuta Bacteremia in a Case of Adrenal Insufficiency: A Case Report and Literature Review.

is an uncommon Gram-negative bacteria rarely isolated from clinical samples. There are few reports of infections caused by this microorganism, especially in immunocompromised patients. We present a case of a 69-year-old male with a history of adrenal insufficiency who presented with bacteremia.

Pandemic mothering: Mothers' experiences of adaptation and resilience during the COVID-19 pandemic.

Research suggests that the demands of have increased during the COVID-19 pandemic, especially for mothers. Widespread loss of childcare and in-person schooling forced parents to make adjustments to care for their children in new ways, many while working remotely. This qualitative study, guided by Walsh's theory of family resilience, examines mothers' experiences with stress and resilience as they adapted to the COVID-19 pandemic.

Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug.

Nearly without exception, all known cancer chemotherapeutics elicit a resistance response over time. The resulting resistance is correlated with poor clinical outcomes. Here, we report an approach to overcoming resistance through reprogramming oncogene-directed alterations in mitochondrial metabolism before drug activation while simultaneously circumventing drug efflux pumps.

Investigating GLP-1 Injections: Potential Mitochondrial Dysfunction in Non-Diabetic Patients Presenting with Migraines and Hypoglycemia: A Case Report.

Introduction: GLP-1 medications are widely used for weight loss in patients with and without type 2 diabetes. However, limited research exists on their effects in non-diabetic patients, particularly concerning mitochondrial function. This case report investigates the potential of altered mitochondrial dysfunction as a cause of side effects of GLP-1 medications in patients without type 2 diabetes.

Comparison of Diabetes Education Content Experienced by Blind and Nonblind People With Diabetes.

This survey sought to examine disparities in diabetes self-management education and support (DSMES) to illuminate gaps underlying morbidity and mortality disparities experienced by blind people with diabetes and develop a pathway for improved health care delivery and health outcomes. Blind participants were more likely to report getting DSMES on strategies to promote treatment adherence and noncompliance with medical regimen; yet, blind and nonblind participants did not differ on primary care provider visits or amount of time spent in diabetes education. These findings suggest that DSMES content may differ for blind versus nonblind participants.

Discovering novel prognostic biomarkers of hepatocellular carcinoma using eXplainable Artificial Intelligence.

Hepatocellular carcinoma (HCC) remains a global health challenge with high mortality rates, largely due to late diagnosis and suboptimal efficacy of current therapies. With the imperative need for more reliable, non-invasive diagnostic tools and novel therapeutic strategies, this study focuses on the discovery and application of novel genetic biomarkers for HCC using explainable artificial intelligence (XAI). Despite advances in HCC research, current biomarkers like Alpha-fetoprotein (AFP) exhibit limitations in sensitivity and specificity, necessitating a shift towards more precise and reliable markers.

Dietary inclusion of olive cake alone or in combination with in Black goat kids: Implications for performance and health.

Background And Aim: To address the problems associated with the availability and prices of conventional feeds, researchers have started to include alternative feeds to reduce the cost of diets and increase profitability. This study examined the influences of olive cake (OC), either alone or in combination with (SC), in the diet of black kids.

Materials And Methods: Thirty kids were distributed into three treatments: A free OC diet (control [CON]), OC (20% OC), and OCSC (20% OC with 1 g SC head/d).

Chemical EOR Formulation for a Clay-Rich Sandstone Reservoir with Reduced Surfactant Consumption.

Alkali-surfactant-polymer (ASP) flooding can reduce oil-water interfacial tension to ultralow values and mobilize oil in petroleum reservoirs. Surfactant is consumed by adsorption/retention which is significant in clay-rich reservoirs. Alkali can be added to surfactant-polymer formulations to minimize surfactant adsorption.

Wearable, noninvasive, pulsed shortwave (radiofrequency) therapy for postoperative analgesia: A randomized, double-masked, sham-controlled pilot study.

Background: Nonthermal, pulsed shortwave (radiofrequency) therapy (PSWT) is a nonpharmacologic, noninvasive modality that limited evidence suggests provides analgesia. Its potential favorable risk-benefit ratio stems from its lack of side effects and significant medical risks, applicability to any anatomic location, long treatment duration, and ease of application by simply affixing it with tape. Even with a relatively small treatment effect, PSWT might contribute to a multimodal analgesic regimen, similar to acetaminophen.

Comparative Studies on Bulky DNA Damage Binding by Nucleotide Excision Repair Proteins Using Surface Plasmon Resonance, Differential Scanning Fluorometry, and DNase I Footprinting.

Nucleotide excision repair is a crucial cellular mechanism that ensures genomic stability, thereby preventing mutations that can lead to cancer. The human XPC and its yeast ortholog Rad4 protein complexes are central to this process and were the focus of the study. We used surface plasmon resonance and differential scanning fluorimetry to study the binding characteristics of XPC and Rad4 when bound to the bulky cluster di-FAAF-containing 55-mer duplex DNA.