P(═O)R-Directed Asymmetric Catalytic C-H Olefination Leading to C-N Axially Chiral Targets.

A novel P(═O)R-directed asymmetric catalytic olefination has been developed, enabling efficient access to carbon-nitrogen axially chiral products with excellent yields (up to 92%) and enantioselectivity (up to 99% enantiomeric excess). The synergistic coordination of phosphine oxide functionality and l-pGlu-OH with the Pd metal center, serving as an efficient directing group and chiral ligand, was key to the success of this C-H functionalization system. The reaction demonstrated a broad substrate scope, yielding 33 distinct C-N axial products.

The Impact of Emotional Intelligence Among a Multigenerational Workforce: EQ Appraisal in a Multigenerational Workforce.

Emotionally intelligent leaders make conscious efforts to evaluate employee satisfaction, retention, engagement, conflict resolution, quality patient care, and overall facility performance. Variances among generations like communication styles, technology preferences, promotability attitudes, and work ethic can affect day-to-day team behaviors. Highlighting the importance of daily interactions, the purpose and aim of this project are to determine whether the implementation of emotional intelligence (EQ) training will improve communication in a multigenerational workforce.

The contributions of knowledge and trust involving the use of child car seats among Indigenous Peoples in Canada.

Objective: The purpose of the current study was to examine the effects of child vehicle restraint-related knowledge and trust in information on car seat use among Indigenous Peoples in Canada.

Methods: An in-person survey was administered to participants who identified as Indigenous (i.e.

Relaxation of Photoexcited Electron-Hole Pairs at Si(111) Surfaces with Adsorbed Ag Monolayered Clusters of Increasing Size.

The efficiency of silicon solar cells is affected by the light absorption and recombination losses of photoexcited charge carries. One possible way to improve the efficiency is through the deposition of transition metal nanoparticles on Si surfaces. Here, we first carry out density functional theory (DFT) calculations to obtain electronic structures for Ag ( = 1-7) monolayered clusters adsorbed on Si(111)/H surfaces.

Postpartum Depression Screening Practices in the Neonatal Intensive Care Unit: Opportunities for Improvement.

Purpose: The purpose of this scoping review is to provide an overview of postpartum depression (PPD) screening practices for mothers with infants in the neonatal intensive care unit (NICU), identify gaps in PPD screening, and provide potential solutions for improved screening.

Background: The American Academy of Pediatrics (AAP) recommends routine screening for PPD at the first, second, 4th, and 6th months of well-child visits. However, mothers of premature or critically ill infants in the NICU often miss this screening.

CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.

Importance: Bioenergetic failure has been proposed as a driver of amyotrophic lateral sclerosis (ALS). CNM-Au8 is a suspension of gold nanocrystals that catalyzes the conversion of nicotinamide adenine dinucleotide hydride into NAD+, resulting in an increase of cellular adenosine triphosphate production.

Objective: To determine the effects of CNM-Au8 on ALS disease progression.

Characterizing the genetic diversity and population structure of Plasmodium knowlesi in Aceh Province, Indonesia.

As in other parts of Southeast Asia, efforts to achieve or sustain malaria elimination in Indonesia have been threatened by the emergence of human infection with the primate species P. knowlesi. To understand the transmission dynamics of this species, investigation of P.

GZ17-6.02 interacts with carboplatin and etoposide to kill neuroblastoma cells.

The biology of GZ17-6.02 alone and more so in combination with either of the standard-of-care agents etoposide or carboplatin killed MYCN overexpressing neuroblastoma (NB) cells is unknown. The methods involved in this study are in-cell immunoblotting, trypan blue exclusion, plasmid and siRNA transfection, assessment of autophagy using a plasmid expressing LC3-GFP-RFP.

Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.

Importance: Amyotrophic lateral sclerosis (ALS) is a fatal disease. The sigma-1 (σ1) receptor emerged as a target for intervention.

Objective: To determine the effects of pridopidine, a σ1-receptor agonist, in ALS.

Verdiperstat in Amyotrophic Lateral Sclerosis: Results From the Randomized HEALEY ALS Platform Trial.

Importance: Myeloperoxidase is one of the most abundant peroxidase enzymes in activated myeloid cells. Myeloperoxidase inhibitors may have a clinical benefit in amyotrophic lateral sclerosis (ALS) by slowing neurodegeneration via reduced neuroinflammation and oxidative stress.

Objective: To determine the safety, tolerability, and efficacy of verdiperstat, a selective myeloperoxidase inhibitor, in ALS.

A prospective multicenter validation of RETREAT for post-transplantation hepatocellular carcinoma recurrence prediction.

Background: The RETREAT score is a simple risk stratification tool for post-liver transplantation (LT) hepatocellular carcinoma (HCC) recurrence that has been validated in retrospective cohort studies. A prospective, multicenter study is needed to further demonstrate accuracy especially given evolving clinical demographics and HCC transplant practice.

Aim: To validate and compare the RETREAT score to other post-LT HCC recurrence risk scores in a contemporary, prospective cohort of patients.

Acute pulmonary embolism treatment in lung transplant recipients: mechanical thrombectomy and catheter directed thrombolysis.

Purpose: Acute pulmonary embolism (PE) presents a significant challenge in lung transplant recipients (LTR), even with prophylactic anticoagulation. Due to the heightened risk of complications in this population, the optimal treatment approach for acute PE remains uncertain. This retrospective case series aims to elucidate the outcomes of percutaneous mechanical thrombectomy with the Inari device (MT) and catheter-directed thrombolysis (CDT) in managing acute PE in lung transplant patients.

MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance.

MicroRNAs (miRNAs) are a class of small non-coding RNAs which are associated with post-transcriptional regulation of gene expression. Dysfunction or aberrant expression of miRNAs is predominant in various malignancies including lung cancer. Lung cancer is one of the commonest causes of cancer-related death worldwide, with a five-year survival of only 10-20%.

Accounting for unmet needs resulting from cancer-related cognitive impairment.

Purpose: Cancer-related cognitive impairment (CRCI) causes a wide range of unmet needs for cancer survivors. It is unknown which clinical, demographic, cognitive, and psychological factors underpin and account for these various unmet needs. This study aimed to (a) identify factors associated with CRCI-related unmet needs, and (b) establish the most pertinent factors that account for CRCI-related unmet needs.

Neuromodulation of Fear and Anxiety Circuits.

Anxiety is a complex and heterogeneous condition consisting of multiple component processes and neural underpinnings. Recent neural accounts for anxiety have expanded beyond the canonical anxiety and fear circuitry centered on the amygdala to a distributed network. A burgeoning form of clinical intervention with remarkable potential to directly engage the neural substrates of anxiety is non-invasive brain stimulation (NIBS), which is especially notable for the ability to modulate macro- and meso-scopic circuits and networks.

Serum Metabolomic Markers of Dietary Potassium and Risk of Chronic Kidney Disease.

Background: Discovering metabolomic markers of dietary potassium may help improve dietary assessment of potassium and trace the impact of dietary potassium on chronic kidney disease (CKD) development.

Methods: We included adults from the Atherosclerosis Risk in Communities (ARIC) study without CKD at visit 1 (N = 3,812). Cross-sectional associations between dietary potassium and serum metabolites were assessed using multivariable linear regression models.

Tumor-specific surface marker-independent targeting of tumors through nanotechnology and bioorthogonal glycochemistry.

Biological targeting is crucial for effective cancer treatment with reduced toxicity but is limited by the availability of tumor surface markers. To overcome this, we developed a nanoparticle-based, Tumor-specific suRfACE maRker-independent (TRACER) targeting approach. Utilizing the unique biodistribution properties of nanoparticles, we encapsulated Ac4ManNAz to selectively label tumors with azide reactive groups.

Vascular architecture-on-chip: engineering complex blood vessels for reproducing physiological and heterogeneous hemodynamics and endothelial function.

Human circulation exhibits significant diversity and heterogeneity of blood vessel shapes. The complex architecture of these vessels may be physiological or pathological resulting in unique hemodynamics and endothelial cell phenotypes that may determine the regulation and alteration of cell signaling pathways and vascular function. While human microphysiological systems of blood vessels (vessel-chips) have mimicked several aspects of vascular pathophysiology, engineering of these tools is still limited to the fabrication of homogeneous tubular structures, especially when living endothelial cell culture is also included.

Bowel Disorder Incidence and Rectal Spacer Use in Patients With Prostate Cancer Undergoing Radiotherapy.

Importance: The polyethylene glycol-based hydrogel spacer (PHS) system temporarily separates the rectum from the prostate in patients undergoing radiotherapy (RT) for prostate cancer (PCa).

Objective: To compare incidence of bowel disorders and related procedures in patients receiving RT with and without PHS.

Design, Setting, And Participants: This retrospective cohort study used 4 datasets: Medicare 5% Standard Analytic Files, Medicare 100% Standard Analytic Files, Merative MarketScan Commercial Database, and Premier Healthcare Database.

Screening for Food Insecurity: US Preventive Services Task Force Recommendation Statement.

Importance: According to survey data, 12.8% of households experienced food insecurity in 2022, with 7.7% of households experiencing low food security and 5.

Long-Term Functional Outcomes of Free Flaps Versus Locoregional Flaps in Soft Tissue Reconstruction for Oral Cavity Cancer: A Systematic Review.

Background: The choice between free flaps and locoregional flaps for soft tissue reconstruction in oral cavity cancer patients is critical for determining long-term functional and oncological outcomes. This systematic review evaluates the efficacy of these reconstructive techniques, focusing on survival, recurrence, quality of life (QoL), and functional parameters such as speech, swallowing, and the need for gastrostomy or tracheostomy.

Methods: A systematic review adhering to PRISMA guidelines was conducted using PubMed, Scopus, Cochrane, and EBSCO databases.