Cardiovascular Health, Lifestyle Factors, and Social Determinants Among Hispanic or Latino Adults in the United States.

Background: Among Hispanic/Latino subgroups residing in the US, disparities in cardiovascular health status remain largely uncharacterized.

Methods: This national study used the National Health Interview Survey to assess the burden of cardiometabolic risk factors (hypertension, hyperlipidemia, obesity, diabetes) and cardiovascular diseases (history of heart attack, coronary heart disease, angina, stroke) across Hispanic/Latino subgroups (Mexican, Cuban, Puerto Rican, Central/South American), and the extent to which differences are related to lifestyle factors (physical inactivity, smoking, and alcohol consumption) and/or social determinants of health (income, education, food security, and health insurance status).

Results: The weighted study population included 35,549,841 Hispanic/Latino adults (26,008 respondents).

A longitudinal examination into childhood abuse and substance use to PTSD symptoms and deviant peer association: Impact of developmental timing of abuse.

Background: Following child abuse, adolescents often endorse PTSD symptoms and use substances. However, few studies have addressed the longitudinal underlying effects of deviant peer association and revictimization and the developmental impact of PTSD symptoms and substance use.

Objective: To address these limitations, the current study utilized the susceptibility and self-medication hypothesis to examine abuse in childhood ages 0-12 and adolescence ages 12-16 as predictors of substance use in mid-adolescence at age 16 and symptoms of (PTSD) in late adolescence at age 18 mediated by associating with deviant peers and revictimization using a sample of 596 (73.

Safety and efficacy of provocative angiography for localization and treatment of gastrointestinal hemorrhage.

Purpose: Mesenteric angiography and embolization is an effective treatment of gastrointestinal bleeding. In the setting of occult bleeding, provocative maneuvers with intra-arterial vasodilators and thrombolytics can increase the diagnostic yield of angiography. This study aimed to assess the clinical outcomes of provocative angiography and factors that increase the positivity rate for active bleeding at the time of provocation.

Familial chylomicronemia syndrome and treatments to target hepatic APOC3 mRNA.

Familial chylomicronemia syndrome (FCS) is a rare, recessive monogenic disorder characterized by severely elevated plasma triglyceride (TG) levels due to absent or markedly impaired lipoprotein lipase activity, leading to a greatly increased risk of acute pancreatitis. Naturally occurring very low levels of apoC-III are associated with low TG levels; thus, apoC-III is a target for TG lowering, and therapies have been developed to reduce apoC-III. Strategies to inhibit hepatic apoC-III synthesis include antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs).

Encoding 3D information in 2D feature maps for brain CT-Angiography.

We propose learnable 3D pooling (L3P), a CNN module designed to compress 3D information into 2D feature maps using anisotropic convolutions and unidirectional max pooling. Specifically, we used L3P followed by a 2D network to generate predictions from 3D brain CT-Angiography (CTA) in the context of large vessel occlusion (LVO). To further demonstrate its versatility, we extended its application to 3D brain MRI analysis for brain age prediction.

Efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal cancer.

Background: Larotrectinib is the first-in-class, highly selective TRK inhibitor with demonstrated efficacy in various TRK fusion solid tumours. We report the efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal (GI) cancer.

Methods: Patients with TRK fusion GI cancer from NAVIGATE (NCT02576431) were included.

Nature-focused livestreams: Connecting people to nature and to each other.

Engaging with nature has been found to have a range of benefits across the biopsychosocial and spiritual domains of well-being. Nature-focused livestreams (NFLs) offer an alternative to physically engaging with nature and serve as a window to nature as society has become more urbanized and has increasingly moved indoors. In this brief review, we examine the role of NFLs in connecting people with nature and connecting people with each other.

Factors associated with perceived medication safety during transitions of care in patients with cancer: A secondary data analysis of a cross-sectional survey.

Purpose: This study aimed to investigate perceived medication safety in patients with cancer during transitions of care and identify factors associated with their safety perceptions.

Methods: A secondary data analysis was performed on a cross-sectional survey data of from patients with four types of cancer (i.e.

The Seroprevalence and Risk Factors for Spotted Fever Group and Typhus Group Rickettsia Along the Texas-Mexico Border.

Rickettsial pathogens are an endemic and emergent source of disease in Texas, with a historically high rate of transmission along the United States-Mexico border. To better understand the prevalence and risk factors for spotted fever group Rickettsia (SFGR) and typhus group Rickettsia (TGR) along the Texas-Mexico border, we conducted a seroprevalence study of adults residing in Starr County, Texas (N = 616). Plasma samples were screened for IgG reactivity to SFGR and TGR using commercially available ELISA.

Geospatial Analysis of Hymenolepis (Rodentolepis) nana Infection Transmission in Schools among Children in Cusco, Peru.

Hymenolepis nana is an emergent parasitosis, and the role of schools in infection transmission is unclear. Data from a cross-sectional study evaluating children for H. nana infection in schools in three districts of Anta province in Peru were analyzed.

Development of Coup de Sabre in an HIV-Positive Patient: A Case Study from Lilongwe, Malawi.

Coup de Sabre is a subset of localized linear scleroderma disease influenced by autoimmune, vascular, and genetic factors. The disease often follows an active, relapsing, and remitting course causing the development of permanent sequelae, such as tissue atrophy, pigment alterations, and bony deformities. Treatment strategies have ranged from surgical to injectable and medical management approaches with varying success.

Exploratory Co-Design on Electronic Health Record Nursing Summaries: Case Study.

Background: Although electronic health record nursing summaries aim to provide a concise overview of patient data, they often fall short of meeting nurses' information needs, leading to underutilization. This gap arises from a lack of involvement of nurses in the design of health information technologies.

Objective: The purpose of this exploratory co-design case study was to solicit insights from nurses regarding nursing summary design considerations, including key information types and the preferred design prototype.

Unraveling Solvent and Substituent Effects in the Photodynamics of Light-Dependent Microtubule Inhibitors for Cancer Phototherapy.

In photopharmacology, molecular photoswitches enable light-controlled drug activities, offering precision in targeting biomolecular functions while minimizing side effects. Photostatins (PSTs) are photoswitchable analogs of combretastatin A-4 (CA4), designed to inhibit tubulin polymerization for cancer treatment. However, the influence of substituents and molecular environments on their photochemistry remains unclear.

P(═O)R-Directed Asymmetric Catalytic C-H Olefination Leading to C-N Axially Chiral Targets.

A novel P(═O)R-directed asymmetric catalytic olefination has been developed, enabling efficient access to carbon-nitrogen axially chiral products with excellent yields (up to 92%) and enantioselectivity (up to 99% enantiomeric excess). The synergistic coordination of phosphine oxide functionality and l-pGlu-OH with the Pd metal center, serving as an efficient directing group and chiral ligand, was key to the success of this C-H functionalization system. The reaction demonstrated a broad substrate scope, yielding 33 distinct C-N axial products.

The Impact of Emotional Intelligence Among a Multigenerational Workforce: EQ Appraisal in a Multigenerational Workforce.

Emotionally intelligent leaders make conscious efforts to evaluate employee satisfaction, retention, engagement, conflict resolution, quality patient care, and overall facility performance. Variances among generations like communication styles, technology preferences, promotability attitudes, and work ethic can affect day-to-day team behaviors. Highlighting the importance of daily interactions, the purpose and aim of this project are to determine whether the implementation of emotional intelligence (EQ) training will improve communication in a multigenerational workforce.

The contributions of knowledge and trust involving the use of child car seats among Indigenous Peoples in Canada.

Objective: The purpose of the current study was to examine the effects of child vehicle restraint-related knowledge and trust in information on car seat use among Indigenous Peoples in Canada.

Methods: An in-person survey was administered to participants who identified as Indigenous (i.e.

Relaxation of Photoexcited Electron-Hole Pairs at Si(111) Surfaces with Adsorbed Ag Monolayered Clusters of Increasing Size.

The efficiency of silicon solar cells is affected by the light absorption and recombination losses of photoexcited charge carries. One possible way to improve the efficiency is through the deposition of transition metal nanoparticles on Si surfaces. Here, we first carry out density functional theory (DFT) calculations to obtain electronic structures for Ag ( = 1-7) monolayered clusters adsorbed on Si(111)/H surfaces.

Postpartum Depression Screening Practices in the Neonatal Intensive Care Unit: Opportunities for Improvement.

Purpose: The purpose of this scoping review is to provide an overview of postpartum depression (PPD) screening practices for mothers with infants in the neonatal intensive care unit (NICU), identify gaps in PPD screening, and provide potential solutions for improved screening.

Background: The American Academy of Pediatrics (AAP) recommends routine screening for PPD at the first, second, 4th, and 6th months of well-child visits. However, mothers of premature or critically ill infants in the NICU often miss this screening.

CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.

Importance: Bioenergetic failure has been proposed as a driver of amyotrophic lateral sclerosis (ALS). CNM-Au8 is a suspension of gold nanocrystals that catalyzes the conversion of nicotinamide adenine dinucleotide hydride into NAD+, resulting in an increase of cellular adenosine triphosphate production.

Objective: To determine the effects of CNM-Au8 on ALS disease progression.

Characterizing the genetic diversity and population structure of Plasmodium knowlesi in Aceh Province, Indonesia.

As in other parts of Southeast Asia, efforts to achieve or sustain malaria elimination in Indonesia have been threatened by the emergence of human infection with the primate species P. knowlesi. To understand the transmission dynamics of this species, investigation of P.