Ability and utility of the Physician Well-Being Index to identify distress among Chinese physicians.

Background: Despite the high prevalence of mental stress among physicians, reliable screening tools are scarce. This study aimed to evaluate the capability of the Physician Well-Being Index (PWBI) in identifying distress and adverse consequences among Chinese physicians.

Methods: This cross-sectional online survey recruited 2803 physicians from Southern Mainland China snowball sampling between October and December 2020.

Advancing Metastatic Spine Tumor Research: A Review of AO Spine Knowledge Forum Tumor's Scientific Contributions Derived From the EPOSO Network, 2014-2024.

Study DesignNarrative Review.ObjectivesTo summarize the work of the AO Spine Knowledge Forum Tumor, specifically studies from the Epidemiology, Process and Outcomes in Spine Oncology (EPOSO) study.MethodsA narrative review of all published manuscripts from the EPOSO study was undertaken.

T-cell Engagers in Prostate Cancer.

Owing to the "cold" tumor immune microenvironment of prostate cancer, immune-targeting agents have shown limited efficacy in patients with advanced prostate cancer, highlighting the need for new therapies with novel mechanisms of action. In this context, T-cell engagers (TCEs), which induce T-cell-mediated killing of cancer cells by binding the CD3 receptor on T cells and a specific tumor antigen expressed on malignant cells, represent a promising therapeutic option. Multiple studies have explored the use of TCEs in previously treated patients with metastatic castration-resistant prostate cancer, and several ongoing trials are currently assessing novel TCEs either as single agents or in combinatorial regimens with molecules with a distinct mechanism of action (eg, androgen receptor pathway inhibitors and other immune-targeting agents).

Delayed inflammatory nodule from predominantly low-molecular-weight hyaluronic acid filler secondary to COVID-19 infection.

Delayed inflammatory nodules (DIN) after soft-tissue filler injection may occur after infections, vaccinations, or procedures. We report a DIN from predominantly low-molecular-weight HA (PLMW-HA) filler secondary to COVID-19 infection that was resistant to conservative management, requiring intralesional combination therapy with triamcinolone, 5-fluorouracil, and recombinant human hyaluronidase for resolution.

Best Practices for Imaging of Transcatheter Valve Failure: An Update From the Heart Valve Collaboratory.

This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic valve failure in a practical, imaging directed context for TAVR.

Association Between Cigarette Smoking and Subclinical Markers of Cardiovascular Harm.

Background: Cigarette smoking is a strong risk factor for cardiovascular harm.

Objectives: The study sought to explore the detailed relationships between smoking intensity, pack-years, and time since cessation with inflammation, thrombosis, and subclinical atherosclerosis markers of cardiovascular harm.

Methods: We included 182,364 participants (mean age 58.

Interfacial electromigration for accelerated reactions.

Background: Microdroplets have emerged as effective confined-volume reactors due to their remarkable ability to accelerate chemical reactions compared to bulk systems. Recent research highlights the crucial role of air-liquid interfaces in this acceleration. A microdroplet can be viewed as having two kinetically distinct regions: the interface and the interior.

Handedness and brain asymmetries in nonhuman primates.

A majority of humans are right-handed and exhibit left hemisphere specialization for the comprehension and production of language. To what extent population-level behavioral and brain asymmetries are unique to humans remains a topic of interest across a wide range of scientific disciplines. In this chapter, we present current findings on the expression of population-level behavioral and brain asymmetries in nonhuman primates.

The power of partnership: The Nurse Educator-Student Relationship (NESR) model.

Background: There is a need to examine factors that can positively influence the retention of nursing educators and students as the nursing profession faces a nursing shortage. The nurse educator-student relationship is the most influential in academia and can affect retention. Focusing on the development of the relationship between the educator and the student may provide insight related to the new role required of the student in nursing academia to be successful.

Post-lactation mass recovery and metabolic hormone dynamics in adult female Weddell seals.

Weddell seal (Leptonychotes weddellii) females lose substantial body mass across an intensive, nutritionally restricted lactation period and then must rapidly recover mass during the short Antarctic summer. In this study, we examined endocrine dynamics associated with mass loss across lactation and subsequent realimentation in Weddell seals, comparing patterns between seals that recently gave birth and demographically similar non-reproductive females (skip females) in McMurdo Sound, Antarctica. Postpartum seals near weaning (∼35 days postpartum, n = 64) and skip females (n = 32) were handled during early austral summer (November/December) and rehandled in late summer (January/February).

New routes for spermine biosynthesis.

The polyamine spermine is a flexible linear teraamine found in bacteria and eukaryotes, and in all known cases is synthesized from triamine spermidine by addition of an aminopropyl group acquired from decarboxylated S-adenosylmethionine (dcAdoMet). We have now identified in bacteria a second biosynthetic route for spermine based on the formation of carboxyspermine from spermidine, dependent on aspartate β-semialdehyde (ASA). This route also produces thermospermine from spermidine via carboxythermospermine.

Anatomo-functional organization of insular networks:From sensory integration to behavioral control.

Classically, the insula is considered an associative multisensory cortex where emotional awareness emerges through the integration of interoceptive and exteroceptive information, along with autonomic regulation. However, since early intracortical microstimulation (ICMS) studies, the insular cortex has also been conceived as a mosaic of anatomo-functional sectors processing various types of sensory information to generate specific overt behaviors. Based on this, the insula has been subdivided into distinct functional fields: an anterior field associated with oroalimentary behaviors, a middle field involved dorsally in hand movements and ventrally in emotional reactions, and a posterior field engaged in axial and proximal movements.

Evidence and Recommendation for Infantile Krabbe Disease Newborn Screening.

Krabbe disease (KD), which affects 0.3-2.6 per 100 000 live births, is an autosomal recessive lysosomal disorder caused by variants in the GALC gene that reduce galactosylceramidase (GALC) activity, leading to psychosine accumulation, cerebral white matter degeneration, and peripheral neuropathy.

Unraveling the mystery of citrate transporters in Alzheimer's disease: An updated review.

A key molecule in cellular metabolism, citrate is essential for lipid biosynthesis, energy production, and epigenetic control. The etiology of Alzheimer's disease (AD), a progressive neurodegenerative illness marked by memory loss and cognitive decline, may be linked to dysregulated citrate transport, according to recent research. Citrate transporters, which help citrate flow both inside and outside of cells, are becoming more and more recognized as possible participants in the molecular processes underlying AD.

Pre-Clinical Model of Dysregulated FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis.

The bi-functional enzyme FicD catalyzes AMPylation and deAMPylation of the endoplasmic reticulum chaperone BiP to modulate ER homeostasis and the unfolded protein response (UPR). Human hFicD with an arginine-to-serine mutation disrupts FicD deAMPylation activity resulting in severe neonatal diabetes. We generated the mFicD mutation in mice to create a pre-clinical murine model for neonatal diabetes.

Association of COMT genetic polymorphism with neuromodulation treatment response in women with fecal or urinary incontinence.

Background: Prior studies have failed to demonstrate clinical or statistical difference in fecal incontinence (FI) symptom improvement with neuromodulation by percutaneous tibial nerve stimulation (PTNS) vs sham. The results of these studies may be indicative of a placebo or sham effect and led us to investigate possible genetic biomarkers of placebo response among women with FI.

Objective: To evaluate the relationship between response to PTNS or sham and genetic polymorphisms associated with placebo response in women with FI.

Pediatric Central Nervous System Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pediatric Central Nervous System Cancers provide multidisciplinary diagnostic workup, staging, and treatment recommendations for diffuse high-grade gliomas and medulloblastomas in children and adolescents. This article summarizes the studies and panel discussion that serve as the rationale for comprehensive care recommendations included in the NCCN Guidelines for Pediatric Central Nervous System Cancers.

NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 2.2025.

The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations for the evaluation, diagnosis, and comprehensive care of patients with MDS based on a review of recent clinical evidence that has led to important advances in treatment or has yielded new information on biologic factors that may have prognostic significance in MDS. The multidisciplinary panel of MDS experts is convened at least on an annual basis. During the annual meeting, the panel evaluates new and emerging data to inform their recommendations.

Ovarian expression of functional MTTP and apoB for VLDL assembly and secretion in chickens.

In mammals, tissues other than liver and intestine are known to possess functional MTTP (microsomal triglyceride transfer protein) and apoB (apolipoprotein B) capable of VLDL (very low-density lipoprotein) assembly. Birds are oviparous and possess unique capabilities in lipid biology to accommodate yolk formation through massive deposition of hepatically assembled yolk-targeted VLDLy into ovarian follicles. Following identifications of MTTP and ApoB expression within chicken ovarian stroma, granulosa, theca, and epithelial cells of various classes of follicles, we sought to define the functionality of ovarian MTTP and ApoB in VLDL assembly.