Cervical cancer stage distribution and survival outcomes in Africa: a systematic review and meta-analysis.

Objective: Cervical cancer is a leading cause of cancer-related deaths among women, with a disproportionate burden in sub-Saharan Africa. Understanding the cervical cancer stage and outcomes is crucial for developing effective interventions and reducing its burden. We aimed to undertake a systematic review and meta-analysis of cervical cancer stage distribution and survival outcomes in Africa.

Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML.

Dysfunction or dysregulation of deubiquitination is closely related to the initiation and development of multiple cancers. Targeted regulation of deubiquitination has been recognized as an important strategy in tumor therapy. However, the mechanism by which drugs regulate deubiquitinase is not clear.

Redox-Detecting Deep Learning for Mechanism Discernment in Cyclic Voltammograms of Multiple Redox Events.

In electrochemical analysis, mechanism assignment is fundamental to understanding the chemistry of a system. The detection and classification of electrochemical mechanisms in cyclic voltammetry set the foundation for subsequent quantitative evaluation and practical application, but are often based on relatively subjective visual analyses. Deep-learning (DL) techniques provide an alternative, automated means that can support experimentalists in mechanism assignment.

Optically Transparent Carbon Electrodes for Single Entity Electrochemistry.

We demonstrate the application and benefit of optically transparent carbon electrodes (OTCEs) for single entity nanoelectrochemistry. OTCEs are prepared by pyrolyzing thin photoresist films on fused quartz coverslips to create conductive, transparent, thin films. Optical, electrical, topographical, and electrochemical properties of OTCEs are characterized to evaluate their suitability for single entity electrochemistry.

What Is the State of the Literature About Refugees Aged 45 and Older from Burma in Third-Country Resettlement Contexts?: A Scoping Review.

Background And Objective: Older adult refugees from Burma face unique challenges in third-country resettlement, yet their experiences are often overlooked in research and policy. This scoping review aims to examine the literature on refugees aged 45 and older from Burma in third-country resettlement contexts, identify factors contributing to successful integration, and elucidate the unique challenges they encounter.

Research Design And Methods: We systematically searched seven databases using Arksey and O'Malley's framework.

Transient Triplet Metallopnictinidenes M-Pn (M = Pd, Pt; Pn = P, As, Sb): Characterization and Dimerization.

Nitrenes (R-N) have been subject to a large body of experimental and theoretical studies. The fundamental reactivity of this important class of transient intermediates has been attributed to their electronic structures, particularly the accessibility of triplet vs singlet states. In contrast, electronic structure trends along the heavier pnictinidene analogues (R-Pn; Pn = P-Bi) are much less systematically explored.

Refractory and Resistant Herpes Simplex Virus Mucocutaneous Infections in Immunocompromised Patients: Literature Review and Proposed Definitions for Use in Clinical Trials.

Herpes simplex virus (HSV) infection is one of the most prevalent viral infections worldwide. In general, host immunity is sufficient to clear viral shedding and recurrences, although it is insufficient to prevent subsequent virologic reactivations. In immunocompromised patients, prolonged and difficult-to-treat HSV infections may develop.

Can social pain be medicated away? A pilot study on everyday discrimination and its exacerbation of opioid misuse risk in people of color with chronic pain.

Despite mounting evidence of a robust relation between discrimination and poor pain outcomes in people of color (POC) with chronic pain, little is known about everyday discrimination's role in increasing the risk of opioid misuse and its potential interactive effects. This study aimed to evaluate the potential moderating effect of everyday discrimination on the relationship between chronic pain severity and the risk of opioid misuse among POC with chronic pain. Everyday discrimination was assessed using the 9-item Everyday Discrimination Scale (EDS), while the risk of opioid misuse was measured with the 14-item Screener and Opioid Assessment for Patients with Pain (SOAPP).

Position-based assessment of head impact frequency, severity, type, and location in high school American football.

Introduction: Research on head impact characteristics, especially position-specific investigations in football, has predominantly focused on collegiate and professional levels, leaving a gap in understanding the risks faced by high school players. Therefore, this study aimed to investigate the effect of three factors-player position, impact location, and impact type-on the frequency, severity, and characteristics of impacts in high school American football. Additionally, we examined whether and how player position influences the distribution of impact locations and types.

Autologous Fat Grafting in Hand Surgery: A Systematic Review.

Background: Autologous fat grafting (AFG) has gained popularity in both cosmetic and reconstructive surgery, including hand surgery, due to its regenerative potential and dual benefits of enhancing aesthetics and function. This systematic review aims to evaluate the efficacy of AFG in treating various hand pathologies.

Methods: A systematic review was conducted following PRISMA guidelines.

Optimizing Point-in-Space Continuous Monitoring System Sensor Placement on Oil and Gas Sites.

We propose a generic, modular framework to optimize the placement of point-in-space continuous monitoring system sensors on oil and gas sites aiming to maximize the methane emission detection efficiency. Our proposed framework substantially expands the problem scale compared to previous related studies and can be adapted for different objectives in sensor placement. This optimization framework is comprised of five steps: (1) simulate emission scenarios using site-specific wind and emission information; (2) set possible sensor locations under consideration of the site layout and any site-specific constraints; (3) simulate methane concentrations for each pair of emission scenario and possible sensor location; (4) determine emissions detection based on the site-specific simulated concentrations; and (5) select the best subset of sensor locations, under a given number of sensors to place, using genetic algorithms combined with Pareto optimization.

Stem cell status and prognostic applications of cuproptosis-associated lncRNAs in acute myeloid leukemia.

Introduction: Acute myeloid leukemia (AML), a highly heterogeneous hematological malignancy, remains a major challenge in adult oncology. Stem cell research has highlighted the crucial role of long noncoding RNA (lncRNA) in regulating cellular differentiation and self-renewal processes, which are pivotal in AML pathogenesis and therapy resistance.

Methods: This study explores the relationship between cuproptosis-related lncRNAs and AML prognosis, providing novel insights into their impact on hematopoietic stem and progenitor cells.

MT-Keyboard: A Bayesian Model-assisted Interval Design to Account for Toxicity Grades and Types for Phase I Trials.

Conventionally, dose finding trials are based on dose-limiting toxicity (DLT) that only captures the most severe toxicities, e.g., treatment related grade 3 or higher toxicity according to the NCI Common Terminology Criteria for Adverse Events.

Understanding the Association Between Neighborhoods and Adolescent Sleep: Evidence from Add Health.

Introduction: Research suggests that perceived neighborhood social environments (PNSE) may contribute to gender and race/ethnicity-based sleep disparities. Our study aimed to examine associations between PNSE factors and adolescents' sleep patterns. As a secondary aim, we examined how gender and race/ethnic groups might moderate these associations.

A faunal inventory of methane seeps on the Pacific margin of Costa Rica.

The methane seeps on the Pacific margin of Costa Rica support extensive animal diversity and offer insights into deep-sea biogeography. During five expeditions between 2009 and 2019, we conducted intensive faunal sampling via 63 submersible dives to 11 localities at depths of 300-3600 m. Based on these expeditions and published literature, we compiled voucher specimens, images, and 274 newly published DNA sequences to present a taxonomic inventory of macrofaunal and megafaunal diversity with a focus on invertebrates.

Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab.

Background & Aims: Atezolizumab/bevacizumab (A/B) is now a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but the optimal second-line regimen is not known. We evaluated real-world treatment patterns and outcomes to investigate factors associated with post-progression survival (PPS).

Methods: In this multicenter, international, retrospective study, we examined clinical characteristics and outcomes of patients with advanced HCC who progressed on first-line A/B.

Achievement of guideline-based lipid goals among very-high-risk patients with atherosclerotic cardiovascular disease and type 2 diabetes: results in 213,380 individuals from the cvMOBIUS2 registry.

Objective: Lowering lipid to reach guideline-indicated goals significantly reduces cardiovascular outcomes in very-high-risk (VHR) patients with atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes (DM2). How well VHR patients currently achieve these goals in community practice is unknown.

Methods: VHR patients with ASCVD and DM2 were identified across 14 US healthcare systems using electronic health records between 1/1/2021-12/31/2022.

Bridging Existing Energy and Chemical Transport Models to Enhance Air Quality Policy Assessment.

Connecting changes in emissions to air quality is critical for evaluating the effects of a specific policy. Here, we introduce a methodology to aid in assessing the air quality impacts of changes in the energy system. A set of widely varying scenarios that describe alternative potential evolutions of the US energy system is constructed using the TIMES energy system model.

Combined Deep Plane Facelift/Necklift and Inspire Hypoglossal Nerve Stimulator Surgery.

A 63 year old female patient presented to our office with two chief complaints, (1) severe OSA with CPAP intolerance and (2) cosmetic face and neck concerns regarding facial rhytids, jowls, and neck laxity. She was evaluated for Inspire candidacy and found to be an appropriate candidate. She underwent a combined Inspire hypoglossal nerve stimulator implant and deep plane facelift and necklift surgery to address her sleep apnea and her cosmetic concerns.

Fluorine-Free Ion-Selective Membrane with Enhanced Mg Transport for Mg-Organic Batteries.

Magnesium batteries offer a safer alternative for next-generation battery technology due to their insusceptibility to dendrite deposition. Selective membranes tailored for magnesium-ion conduction will unlock further technological advancement. Herein, we demonstrate fluorine-free magnesiated sulfonated poly(ether ether ketone) (Mg-SPEEK) selective membranes capable of facilitating magnesium-ion conduction while effectively rejecting soluble organic species.

Linking American Spine Registry (ASR) and Medicare Data:an analysis of 8,755 Lumbar Fusion Cases.

Study Design: Retrospective observational study.

Objective: To evaluate whether the combined American Spine Registry and Medicare (ASR/CMS) data yields substantially different findings versus ASR data alone with regard to key parameters such as risk stratification, complication rates and readmission rates in lumbar surgery investigated through an analysis of 8,755 spondylolisthesis cases.

Summary Of Background Data: Medicare data correlation has been effective for determining revision rates for other procedures such as total hip replacement.

Impact of Ex Vivo Lung Perfusion on Inpatient Cost: A Propensity Score-Matched Analysis of the US Nationwide Healthcare Cost and Utilization Project Database.

Background: The goal of this study was to investigate the association between ex vivo lung perfusion (EVLP) use and inpatient hospitalization cost for lung transplantation in a nationwide sample.

Methods: Lung transplantation patients in 2018-2020 Nationwide Readmissions Database (NRD) were grouped based on use of EVLP. The primary outcome was total inpatient hospitalization cost.