Temple Volumization: A Review of Anatomy and Optimal Injection Techniques.

Background: Cosmetically unappealing temporal volume loss can develop as a result of facial aging.

Objective:  To present an evidenced-based approach towards safe and effective temple filling.

Methods: We review the underlying anatomy of the temple and optimal anatomy-driven injection techniques associated with temple volumization.

Safety of Non-vitamin K Antagonist Oral Anticoagulants on Outcomes After Transcatheter Aortic Valve Replacement: An Updated Meta-Analysis.

The existing evidence on the use of non-vitamin K oral anticoagulants (NOACs) after transcatheter aortic valve replacement (TAVR) surgery is inconclusive and contradictory. Likewise, major society guidelines remain ambivalent about NOAC use around the time of TAVR. The objective of our meta-analysis was to assess the efficacy of NOACs in comparison to vitamin K antagonists (VKAs) in lowering complications following TAVR.

Efficacy of Intraosseous Versus Intravenous Drug Administration in Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis.

This meta-analysis compared the efficacy of intraosseous (IO) versus intravenous (IV) drug administration in out-of-hospital cardiac arrest (OHCA). We systematically searched Embase, Web of Science, PubMed, and Cochrane Library through September 20, 2024, for relevant studies. The primary outcome was favorable neurological outcome, with secondary outcomes, including survival to hospital discharge and return of spontaneous circulation (ROSC).

Community-Acquired Methicillin-Resistant Staphylococcus aureus Pneumonia.

Community-acquired pneumonia secondary to methicillin-resistant Staphylococcus aureus (MRSA) is a rare occurrence that is known to occur in young adults with no recent hospitalization. It is known to present with hemoptysis and is usually associated with concomitant influenza infection and is classically diagnosed by sputum culture or broncheoalvolar lavage. Routine treatment of community-acquired pneumonia does not suffice in the event of MRSA growth, and, if left untreated, can develop into serious medical complications of sepsis, multiloculated fluid collections, and multiorgan failure.

Wernicke Encephalopathy Presenting With Hearing Loss and Vision Loss in a Nonalcoholic Patient.

Wernicke encephalopathy is an acute neuropsychiatry syndrome resulting from thiamine deficiency associated with significant morbidity and mortality. We reported a case of a 25-year-old woman with a history of abdomen pain, nausea, vomiting, weight loss, and sore throat who presented with acute neurological symptoms, including binocular diplopia, hearing loss, vision loss, and difficulty ambulating. Examination revealed bilateral vision loss with perception only to light, ophthalmoplegia, hearing loss, gait ataxia, and areflexia.

A Case of a Rheumatoid Arthritis Patient on Newly Initiated Tumor Necrosis Factor Inhibitor Treatment Developing Granulomatosis With Polyangiitis Vasculitis: A Conundrum About Disease Overlap or Drug-Induced Vasculitis.

Granulomatosis with polyangiitis (GPA) is a necrotizing vasculitides subset of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAVs) that involves small-sized arteries affecting multisystemic organs. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammatory polyarthritis involving the small joints. GPA and RA can have overlapping clinical presentations, including vasculitis, ocular inflammation, interstitial lung disease, and arthritis, but existing evidence indicates they are distinct conditions.

Trajectories of depressive symptoms in a population-based cohort of Black and White women from late reproductive age through the menopause transition: a 30-year analysis.

Objective: The aim of this study was to examine how depressive symptoms change in midlife and across the menopause transition.

Methods: We conducted a secondary analysis of data from a prospective population-based cohort, the Coronary Artery Risk Development in Young Adults study. We included women (n = 2,160) with ≥3 responses to the Center for Epidemiologic Studies Depression Scale (CES-D) beginning at examination year 5, at approximately 30 years of age, and again at years 10, 15, 20, 25, 30, and 35 (ages 35 through 60 years).

The AD3 locus of synaptotagmin-1 C2 domains modulates domain stability.

Synaptotagmin-1 (syt1) functions as the Ca-dependent sensor that triggers the rapid and synchronous release of neurotransmitters from neurotransmitter-containing vesicles during neuronal exocytosis. The syt1 protein has two homologous tandem C2 domains that interact with phospholipids in a Ca-dependent manner. Despite the crucial role of syt1 in exocytosis, the precise interactions between Ca, syt1, and phospholipids are not fully understood.

Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis.

Despite evidence linking the gut microbiome to neuropathic pain (NP), it is not known if altering gut microbiota can alleviate NP via the microbiome-gut-brain axis. This study examined if healthy gut microbiota of sham male rats (Sham+V) and dysbiotic gut microbiota of NP rats (spinal nerve ligation: NP, SNL+V) can be disrupted and restored, respectively, via fecal microbiota transplant (FMT) from the opposite group [Sham+(SNL-FMT) and SNL+(Sham-FMT), respectively]. All groups received FMT daily for two weeks, followed by three weeks without FMT.

Surgical Capacity Assessment and Leverage in the Palestinian Land (SCALPEL-I) Study: The First Nationwide Plastic Surgery Capacity Evaluation in Palestine.

Background: Access to surgical care in low-to-middle-income countries (LMICs), especially in war-torn areas such as the occupied Palestinian territory (oPt), is a global health priority. The plastic surgical capacity in the oPt has not been evaluated. This study provides the first systematic evaluation of plastic surgical capacity in the oPt.

Psychology of nerve injury, repair, and recovery: a systematic review.

Background: Peripheral nerve injuries (PNIs) are associated with significant physical and psychological challenges, impacting both functional recovery and quality of life. Despite the physical focus of traditional treatments, psychological factors play a crucial role in the outcomes of PNI repair and recovery.

Objectives: This systematic review aims to evaluate the impact of psychological and social factors on the repair and recovery of peripheral nerve injuries.

Treatment of patients with aneurysmal subarachnoid hemorrhage and multiple aneurysms: Concurrent versus delayed treatment.

Objective: 8-30 % of patients who present with aneurysmal subarachnoid hemorrhage (aSAH) have multiple intracranial aneurysms (MIA). Although prompt treatment to secure ruptured aneurysms (RA) is standard of care, there is no clear consensus regarding whether incidental unruptured aneurysms (UA) should be treated during the same procedural time as the RA. This study aims to examine the effect of treatment of UA during the same procedural time as treatment for the RA (concurrent treatment) versus delaying the treatment of an UA after discharging the patient (delayed treatment).

A review on gut microbiota and miRNA crosstalk: implications for Alzheimer's disease.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and progressive neuronal damage. Recent research has highlighted the significant roles of the gut microbiota and microRNAs (miRNAs) in the pathogenesis of AD. This review explores the intricate interaction between gut microbiota and miRNAs, emphasizing their combined impact on Alzheimer's progression.

Dyspnea, dysfunctional breathing disorders, and the Bayesian brain hypothesis.

Clinicians frequently evaluate patients who present with dyspnea. This term describes uncomfortable breathing during physical activity, and the intensity or degree of dyspnea can vary in an individual depending on circumstances and between individuals. In some cases, the level of dyspnea appears out of proportion to other information relevant to the cardiorespiratory system, and this situation has been described as dysfunctional breathing.