11,193 results match your criteria: "Texas Tech University Health Sciences Center[Affiliation]"

Aim: To report an analysis of the concept of authentic leadership.

Design: Concept analysis.

Data Sources: Data sources included core databases: CINAHL, PubMed, Embase, ProQuest, APA PsycINFO, ERIC, ABI/Inform and Tomlinson's Nursing Core Collection (2010).

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Special Section on Cannabinoid Signaling in Human Health and Disease-Editorial.

J Pharmacol Exp Ther

October 2024

Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas (J.G.) and Department of Biomedical Sciences, Marshall University, Huntington, West Virginia (D.J.M.)

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Introduction: To update the global burden of inflammatory bowel disease (IBD) using data from the Global Burden of Disease 2021.

Methods: Data from Global Burden of Disease 2021 were analyzed to assess the IBD burden.

Results: In 2021, there were 375,140 new cases and 3.

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Amyloid-Directed Antibodies: Past, Present, and Future.

J Alzheimers Dis

October 2024

Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Background: Alzheimer's disease (AD) is the most common neurodegenerative disorder in patient demographics over 65 years old causing debilitating cognitive impairment. Most commonly, AD is diagnosed clinically as "probable AD", and definitive diagnosis is confirmed through postmortem brain autopsies to detect extracellular amyloid-β (Aβ) plaques and intraneuronal hyperphosphorylated tau tangles. The exact mechanism causing AD is still unknown, but treatments for AD have been actively investigated.

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Deep neck flexor (DNF) muscles contribute to cervical stability and proprioception. Reduced muscle strength and endurance lead to faulty movement patterns, muscle imbalances, and dysfunction. Potentially, the orofacial muscles contribute to cervical strength by providing stability through muscular connections.

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Genome-wide studies define new genetic mechanisms of IgA vasculitis.

medRxiv

October 2024

Department of Medicine, Division of Nephrology, Columbia University, College of Physicians & Surgeons, New York, NY, USA.

Article Synopsis
  • IgA vasculitis (IgAV) is a pediatric disease characterized by skin and systemic symptoms, and researchers conducted comprehensive studies involving genome, transcriptome, and proteome analyses on a large cohort of IgAV patients and controls to better understand the disease mechanisms.* -
  • Significant associations were found with specific genetic risk factors, including two novel non-HLA loci linked to IgA receptor functioning, which may contribute to disease development through altered immune responses.* -
  • Systems biology approaches helped identify key regulatory networks and master regulators in myeloid cells, along with 21 genetic loci that overlap with IgA nephropathy, suggesting shared pathways in these related conditions.*
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Article Synopsis
  • Autoimmune hemolytic anemia (AIHA) is a condition where the body's immune system mistakenly destroys red blood cells due to autoantibodies.
  • AIHA is classified into warm AIHA and cold AIHA based on the temperature at which the autoantibodies are most active, with mixed AIHA being a rare and more severe form exhibiting traits of both.
  • A case study reported mixed AIHA as a manifestation of systemic lupus erythematosus (SLE), and treatment with rituximab and prednisone showed a positive response.
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Effects of Social Determinants of Health on Acute Stroke Care Among Patients With Acute Ischemic Stroke: A Retrospective Cohort Study.

Neurology

November 2024

From the Department of Surgery (C.S.D.), Department of Neurology (C.N.K., D.Q.-O., R.O., W.R.D.C., S.B.), Center of Excellence for Translational Neuroscience and Therapeutics (C.N.K.), and Department of Psychiatry (C.N.K.), School of Medicine, Texas Tech University Health Sciences Center, Lubbock.

Article Synopsis
  • * The study analyzed 139,852 acute ischemic stroke patients in Texas from 2016-2019, revealing that various factors, like age, race, and insurance status, influence the likelihood of receiving critical stroke treatments.
  • * Results showed that older adults, Black and Hispanic patients, and those from rural areas were less likely to receive thrombolysis and thrombectomy, highlighting disparities in acute stroke care associated with SDOH.
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This study analyzed the geographic variation in annual Medicare reimbursement changes for common burn surgery procedures from 2011 to 2022 to clarify trends in reimbursement. The Center for Medicare and Medicaid Services' Physician fee schedule database was analyzed to find state-by-state reimbursement rates for the most common burn surgery procedures. Physician reimbursement was adjusted for inflation utilizing the consumer price index.

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Lisinopril is commonly prescribed to manage conditions such as hypertension and heart failure. Although concerns about fetal toxicity have traditionally limited the use of lisinopril in women of reproductive age, recent American College of Obstetricians and Gynecologists guidelines promote aggressive treatment of hypertension, which may require the use of pharmacologic agents not previously considered in the postpartum period. We aimed to estimate infant exposure to maternal lisinopril through breast milk and report the tolerance of the breastfed infant.

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Article Synopsis
  • * A new liquid chromatography-mass spectrometry (LC-MS) method was developed to effectively profile gangliosides, optimizing both the extraction and analysis processes for better accuracy and recovery.
  • * This study found that the ganglioside profiles vary significantly across different cancer cell lines, indicating the potential of the method for identifying specific lipid markers related to cancer types.
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This article offers an up-to-date overview of resources tailored for dermatology residents in the United States preparing for their board certification exams. We have assembled a comprehensive list of exam preparation resources categorized by cost, alongside recommendations from attending and resident physicians regarding the most effective resources for each exam. Although examinations are only one facet of the training involved in becoming a competent dermatologist, these exams help residents focus on learning crucial aspects of medicine.

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Article Synopsis
  • * Although chemotherapy is the standard treatment for cervical cancer in Sub-Saharan Africa, it has not delivered the expected survival rates, especially for patients diagnosed with advanced stages of the disease.
  • * Immune checkpoint inhibitors have shown promise in improving survival for advanced cervical cancer and are included in treatment guidelines in high-income countries, but many African nations face challenges in accessing and utilizing these therapies effectively.
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Background: Artificial intelligence (AI) is increasingly being integrated into various aspects of healthcare, including internal medicine. However, the impact of AI on physicians across different internal medicine specialties remains unclear. This study assesses AI's adoption, utilization, and perceived impact among procedural and non-procedural internal medicine physicians.

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Background: Nanoparticles are increasingly being used in medicine, cosmetics, food, and manufacturing. However, potential toxicity may limit the use of newly engineered nanoparticles. Prior studies have identified particle characteristics that are predictive of toxicity, although the mechanisms responsible for toxicity remain largely unknown.

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Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental Disorders.

Dev Neurosci

October 2024

Department of Psychiatry and Behavioral Sciences, Department of Medicine, Department of Genetics, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, USA.

Introduction: Acute onset of severe psychiatric symptoms or regression may occur in children with premorbid neurodevelopmental disorders, although typically developing children can also be affected. Infections or other stressors are likely triggers. The underlying causes are unclear, but a current hypothesis suggests the convergence of genes that influence neuronal and immunological function.

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Article Synopsis
  • This clinical practice guideline from the ASGE offers evidence-based recommendations for using endoscopy to diagnose and manage pancreatic masses, focusing on needle selection and sample processing.
  • It advises the use of fine-needle biopsy (FNB) needles, particularly 22-gauge over 25-gauge, and recommends fork-tip or Franseen needle types, while suggesting against routine rapid on-site evaluation (ROSE) for initial tissue acquisitions.
  • For managing biliary obstructions and pain in unresectable cases, it recommends self-expandable metal stents (SEMSs) over plastic stents, with covered SEMSs preferred when malignancy is confirmed, and celiac plexus neurolysis (CPN) for abdominal pain.
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Article Synopsis
  • - This study examines how complex cellular structures, specifically Jurkat cells with features like the endoplasmic reticulum and mitochondria, respond to external electric pulses by modeling transmembrane potential and electroporation.
  • - Simulations reveal that electroporation requires a stronger electric field for the endoplasmic reticulum compared to the inner mitochondrial membrane, which is more susceptible to poration, and may be linked to increased intracellular calcium levels.
  • - The research also explores how repeated electric pulses and electrode placement enhance membrane poration, while acknowledging that although more complex models could improve accuracy, basic trends in findings are likely to persist.
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Focused Ultrasound in Cancer Immunotherapy: A Review of Mechanisms and Applications.

Ultrasound Med Biol

January 2025

Department of Mechanical Engineering, Texas Tech University, Lubbock, TX, USA. Electronic address:

Article Synopsis
  • Ultrasound, particularly focused ultrasound (FUS), is recognized not only for its diagnostic capabilities but also for its therapeutic functions in cancer treatment, including tissue ablation.
  • * Cancer immunotherapy, a rising approach that enhances the immune system to combat cancer, is considered one of the four main cancer treatments due to its reduced side effects compared to traditional methods.
  • * The review discusses the emerging field of FUS-induced/assisted cancer immunotherapy, exploring its mechanisms, current applications, and both preclinical and clinical studies to support its development and medical expansion.*
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Serotonin in depression and Alzheimer's disease: Focus on SSRI's beneficial effects.

Ageing Res Rev

November 2024

Nutritional Sciences Department, College Human Sciences,  Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

Depression is a complex and pervasive mental health disorder affecting millions globally. Serotonin, a critical neurotransmitter, plays a central role in the pathophysiology of depression. This review explores serotonin's multifaceted role in depression, focusing on its synthesis, bioavailability, receptor interactions, and the impact of various factors, including diet, stress, and gender differences.

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Immune Implications of Cholesterol-Containing Lipid Nanoparticles.

ACS Nano

October 2024

Department of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, Texas 79601, United States.

Article Synopsis
  • The text discusses lipid nanoparticles (LNPs), primarily composed of liposomes containing cholesterol, which are commonly used in therapeutics.
  • It highlights how these nanoparticles affect drug pharmacokinetics and are easily taken up by macrophages, which can convert cholesterol into oxysterols, linking these compounds to immune modulation and diseases like atherosclerosis.
  • The authors emphasize the need for further research on the metabolism of LNP-associated cholesterol and its immune effects to improve the safety and effectiveness of LNP-based drug delivery systems.
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