Donor hepatitis C status is not associated with an increased risk of acute rejection in kidney transplantation.

Introduction: In renal transplantation, donor hepatitis C virus (HCV) status is crucial to consider when selecting a recipient given the high likelihood of transmission. We analyzed the effect of donor HCV status on post-renal transplant rejection and virologic infectious outcomes using electronic health record data from multiple US health care organizations.

Methods: Using real world data from electronic health records of renal transplant recipients, a propensity score-matched case-control study of one-year renal transplant outcomes was conducted on cohorts of HCV-negative recipients who received an organ from an HCV-positive donor (HCV D+/R-) versus from an HCV-negative donor (HCV D-/R-).

The challenges to detect, quantify, and characterize viral reservoirs in the current antiretroviral era.

A major barrier to cure HIV is the early generation of viral reservoirs in tissues. These viral reservoirs can contain intact or defective proviruses, but both generates low levels of viral proteins contribute to chronic bystander damage even in the ART era. Most viral reservoir detection techniques are limited to blood-based, reactivation, and sequencing assays that lack spatial properties to examine the contribution of the host's microenvironment to latency and cure efforts.

Optimized heparin adsorption using macroporous zeolites: A comprehensive study.

Heparin is a highly valuable active pharmaceutical ingredient, typically derived from porcine intestinal mucosa. Traditionally, various commercial resins have been used as adsorbents for heparin extraction; however, there has been growing interest in exploring more cost-effective adsorbents in recent years to improve heparin recovery. Zeolites, a typical aluminosilicate known for their high surface area, porosity, and thermal stability, were selected for evaluation in this study.

Examining the Proximal Relationship between Religious Coping and Depression among Trauma-Exposed Adults.

Depression is a common consequence of sexual victimization. Although religious coping has been previously studied within the context of sexual victimization, there is a dearth of research examining the potential reciprocal relationships between religious coping and depression among adults with a history of sexual victimization at the daily level. The current study addresses this important gap by leveraging an intensive longitudinal design and data analysis to explore bidirectional daily relations between religious coping and depression symptoms in a community sample of adults with a history of sexual victimization.

Low-Cost Lower Extremity Screening to Predict Shoulder Distraction Force in College Softball Pitchers.

Background: During a windmill softball pitch, the throwing shoulder experiences forces greater than the pitcher's body weight. Various kinematic, kinetic, and performance factors have been related to shoulder forces and torques in softball pitchers, and softball research has examined clinical screening measures such as range of motion, muscular strength, and/or neuromuscular control. However, no studies have explicitly identified low-cost, clinic-friendly screening measures predictive of shoulder distraction forces in softball pitchers.

Gradient Design with Low-tortuosity Overcoming Kinetic Limitations in High-Loading Solid-State Cathodes.

The extensive commercialization of practical solid-state batteries (SSBs) necessitates the development of high-loading solid-state cathodes with fast charging capability. However, electrochemical kinetics are severely delayed in thick cathodes due to tortuous ion transport pathways and slow solid-solid ion diffusion, which limit the achievable capacity of SSBs at high current densities. In this work, we propose a conductivity gradient cathode with low-tortuosity to enable facile ion transport and counterbalance ion concentration gradient, thereby overcoming the kinetic limitations and achieving fast charging capabilities in thick cathodes.

The effect of oral methadone on the QTc interval in cancer pain patients.

Introduction: The QTc prolongation effect of methadone has been extensively studied at higher doses commonly used in opioid dependence maintenance therapy, but evidence remains limited regarding its impact at the lower doses typically prescribed for cancer pain. This study aims to evaluate the effect of oral methadone on QTc intervals in cancer pain patients.

Methods: A retrospective analysis was performed on adult patients initiated on oral methadone therapy for cancer.

Marine heatwaves imperil emblematic reef fishes by altering the energetic landscape of coral reefs.

Marine heatwaves are increasingly common due to human-induced climate change. Under prolonged thermal stress on coral reefs, corals can undergo bleaching, leading to mass coral mortality and large-scale changes in benthic community composition. While coral mortality has clear, negative impacts on the body condition and populations of coral-dependent fish species, the mechanisms that drive these changes remain poorly resolved.

Canopy complexity drives positive effects of tree diversity on productivity in two tree diversity experiments.

Forest canopy complexity (i.e., the three-dimensional structure of the canopy) is often associated with increased species diversity as well as high primary productivity across natural forests.

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium.

Background: Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. We aimed to examine associations of maternal night shift work with cord blood DNA methylation.

Methods: A total of 4487 mother-newborn pairs from 7 studies were included.

Social determinants of occupational injuries among US-based commercial fishermen: a systematic review.

Background: Commercial fishing is a multibillion-dollar industry that supports job growth, small- to large- businesses, and port and city revenue. The commercial fishing industry continues to be one of the most dangerous in the US, with a fatality rate nearly 40 times higher than the national average. Dangers of the fishing industry are multi-faceted and include hazardous working conditions, strenuous labor, long work hours, and harsh weather.

Blockade of AR improved brain perfusion and cognitive function in a mouse model of Alzheimer's disease.

Alzheimer's disease (AD) is a neurodegenerative disorder that affects more than 6.2 million Americans aged 65 and older, particularly women. Along with AD's main hallmarks (formation of β-amyloid plaques and tau neurofibrillary tangles), there are vascular alterations that occurs in AD pathology.

Neuromorphic computing at scale.

Neuromorphic computing is a brain-inspired approach to hardware and algorithm design that efficiently realizes artificial neural networks. Neuromorphic designers apply the principles of biointelligence discovered by neuroscientists to design efficient computational systems, often for applications with size, weight and power constraints. With this research field at a critical juncture, it is crucial to chart the course for the development of future large-scale neuromorphic systems.

Antibiotic susceptibility testing using minimum inhibitory concentration (MIC) assays.

Antimicrobial resistance is due to genetic changes that allow bacteria to evade antibiotic treatment. Antimicrobial susceptibility testing is critical for the detection of antibiotic-resistant strains, the selection of effective therapeutic strategies against bacterial infections, and the evaluation of the efficacy of novel antimicrobials. Among the variety of clinical microbiology methods used for antibiotic susceptibility testing, minimum inhibitory concentration (MIC) assays have become the gold standard in clinical practice.

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection.

Background: Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are complex and challenging due to their intricate pathophysiology and limited treatment options.

Methods: This review systematically sourced articles related to neurodegenerative diseases, neurodegeneration, quercetin, and clinical studies from primary medical databases, including Scopus, PubMed, and Web of Science.

Results: Recent studies have included quercetin to impact the cellular and molecular pathways involved in neurodegeneration.

Recent and future trends in osteopathic orthopedic surgery residency match rates following the transition to a single accreditation system.

Context: Medical education in the United States has undergone significant changes, specifically within the osteopathic community. In 2020, a merger occurred between the American Osteopathic Association (AOA) and the Accreditation Council for Graduate Medical Education (ACGME), forming a single accreditation system (SAS) for graduate medical education and residency placement, with the purpose to create consistency within graduate medical education and to provide equal opportunities for applicants pursuing all specialties in medicine. However, osteopathic medical students, especially students applying to competitive residencies including orthopedic surgery, have faced challenges, raising concerns about future implications within this field.

Locating Polyubiquitin Receptors on the 19S Regulatory Proteasome of by Cross-Linking Mass Spectrometry.

The effectiveness of state-of-the-art cross-linking strategies and mass spectrometry (MS) detection was explored in an important biological context, namely, the ubiquitin-proteasome system, which is responsible for most of the regulated protein degradation in eukaryotic cells. The locations of possible binding sites on the 19S proteasome regulatory particle for Lys linked polyubiquitin chains were examined using cross-linking strategies and MS based detection by comparing two types of cross-linkers: a (bis)-sulfosuccinimidyl suberate (BS) and diethyl suberothioimidate (DEST). The well-established BS-based strategy produced 328 cross-linked peptides; however, no ubiquitin-19S cross-links were observed.

Cardiovascular and locomotor effects of binary mixtures of common 'bath salts' constituents: Studies with methylone, methylenedioxypyrovalerone and caffeine in rats.

Background And Purpose: The use of 'bath salts' drug preparations has been associated with high rates of toxicity and death. Preparations often contain mixtures of drugs, including multiple synthetic cathinones or synthetic cathinones and caffeine. Little is known about the interactions of 'bath salts' constituents and adverse effects often reported by users.

Role of lamins in cellular physiology and cancer.

Lamins, which are crucial type V intermediate filament proteins found in the nuclear lamina, are essential for maintaining the stability and function of the nucleus in higher vertebrates. They are classified into A- and B-types, and their distinct expression patterns contribute to cellular survival, development, and functionality. Lamins emerged during the transition from open to closed mitosis, with their complexity increasing alongside organism evolution.

The Current and Future Burden of Long COVID in the United States (U.S.).

Background: Long COVID, which affects an estimated 44.69-48.04 million people in the U.

The Role of the Parametric Thyroid Feedback Quantile Index in Cardiovascular Risk Evaluation Among Euthyroid Koreans.

Context: Thyroid hormones play a crucial role in metabolic regulation and maintaining cardiovascular homeostasis. The Parametric Thyroid Feedback Quantile-based Index (PTFQI) assesses central thyroid hormone sensitivity by standardizing the inverse relationship between free thyroxine (T4) and thyroid-stimulating hormone (TSH).

Objective: To investigate the relationship between PTFQI and cardiovascular risk in the euthyroid Korean population.