1,391 results match your criteria: "Testicular Choriocarcinoma"
Ann Med Surg (Lond)
December 2024
Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Background: Germ cell tumors (GCTs) are common solid tumors in young men, originating in the testicles or outside the gonads. Choriocarcinoma, a rare and aggressive subtype, primarily affects females but can also occur in males. Treatment options depend on the stage and location of the tumor, with early recognition being crucial for better outcomes.
View Article and Find Full Text PDFWorld Neurosurg
November 2024
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA. Electronic address:
Background: Choriocarcinoma (CC) is a rare and aggressive form of germ cell tumor. There is limited evidence describing clinical outcomes in patients with primary CC and brain metastases (BM). Only a few single case reports have documented the use of stereotactic radiosurgery (SRS) for CC BM.
View Article and Find Full Text PDFHum Pathol
November 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address:
Rev Recent Clin Trials
September 2024
Laboratory of Histology and Embryology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Neoplasma
August 2024
Department of Pathology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Transl Cancer Res
August 2024
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Testicular germ cell tumor (TGCT) is a type of tumor with relatively lower incidence but being more prevalent in young men. The expression of programmed cell death ligand 1 (PD-L1) serves as a potential biomarker for predicting the survival outcomes of other tumors. Some studies discovered higher prevalence of PD-L1 in TGCT patients who achieved favorable treatment outcomes, while other studies showed lower or absent expression of PD-L1 in TGCT with the better prognosis as well.
View Article and Find Full Text PDFFront Oncol
July 2024
Department of General Surgery, General Hospital of Central Theater Command, Wuhan, China.
Testicular choriocarcinoma is a relatively rare malignancy with a highly aggressive nature. Timely diagnosis and treatment can help prolong the survival of patients and even cure them. This case reports a 29-year-old male who presented to the clinic for a month with epigastric pain.
View Article and Find Full Text PDFFront Oncol
July 2024
Department of Radiation Oncology, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, Gansu, China.
Testicular tumors represent a common form of solid tumor in young men, with choriocarcinoma of the testis being a rare, non-granulomatous germ cell tumor. It accounts for less than 0.3% of all testicular germ cell tumors.
View Article and Find Full Text PDFHistopathology
November 2024
Institute of Pathology, University Medical Center, Göttingen, Germany.
Urol Oncol
September 2024
Department of Urology, Loyola University Medical Center, Maywood, IL; Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Purpose: Few studies have quantified differences in histology and implications for survival between male children and adults with germ cell tumors (GCT). We evaluated these differences and associations with cancer-specific survival (CSS) using Surveillance, Epidemiology, and End Results (SEER) cancer registries.
Methods: SEER (1988-2016) was used to identify male patients 0 to 40 years of age diagnosed with seminoma and nonseminomatous GCT (NSGCT).
Cureus
April 2024
Department of Oncology, Kaiser Permanente Northern California, Walnut Creek, USA.
Choriocarcinoma syndrome is a rare form of tumor lysis syndrome that predominantly occurs in patients with metastatic germ cell tumors, particularly those presenting with extensive lung metastases. We report a case of a previously healthy 37-year-old male who presented with a painless left-sided neck lump and nipples with an increased sensitivity to light touch. Workup revealed a significantly elevated beta-human chorionic gonadotropin, a testicular mass, and innumerable pulmonary metastases, suggesting metastatic non-seminomatous germ cell tumor.
View Article and Find Full Text PDFHum Pathol
June 2024
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA; Rogel Cancer Center, Michigan Medicine, Ann Arbor, MI, USA. Electronic address:
Front Med (Lausanne)
March 2024
Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.
Background: Non-gestational choriocarcinoma, also known as primary choriocarcinoma, is extremely rare in men, manifesting with specific signs such as breast feminization, testicular atrophy, and loss of libido. The presentation typically includes elevated serum β-hCG levels, widespread metastatic disease, and a rapid progression of the condition.
Case Report: We present a rare case of a 41-year-old man diagnosed with choriocarcinoma, exhibiting a unique combination of multiple metastases, including lung, brain, bone, and retroperitoneal lymph node metastases, as confirmed by F-FDG PET/CT imaging.
Case Rep Oncol Med
January 2024
GZA Hospitals Antwerp, Department of Endocrinology, Wilrijk, Antwerp, Belgium.
Background: Paraneoplastic secretion of beta-subunit of human chorionic gonadotropin (-HCG) in pulmonary carcinoma is rare. . A 65-year-old man presented with bilateral gynaecomastia with abnormally high levels of -hCG and elevated oestradiol, progesterone, and testosterone levels on April 7, 2023.
View Article and Find Full Text PDFMol Clin Oncol
January 2024
Department of Medical Oncology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C. T.), Chengdu, Sichuan 610041, P.R. China.
Testicular choriocarcinoma (CC) is the rarest subtype of germ cell tumours (GCTs) of the testis, with a high malignant potential and early haematogenous metastasis. Radical surgical resection should be performed primarily for histological diagnosis, while chemotherapy remains the mainstay of therapy for advanced disease. In the present study, the case of a 65-year-old male patient diagnosed with metastatic testicular CC, who did not fully respond to chemotherapy is reported.
View Article and Find Full Text PDFVirchows Arch
July 2024
Institute of Pathology, University Medical Center, Göttingen, Germany.
Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case of high hCG serum levels, the presence of a non-SEM component, i.e.
View Article and Find Full Text PDFPediatr Blood Cancer
February 2024
Department of Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Ann Med Surg (Lond)
November 2023
Department of Urology, King Abdulaziz Medical City.
Introduction: This 10-year registry review aimed to investigate the clinical behaviour and outcomes of mixed germ cell tumours with choriocarcinoma components, a rare and aggressive subtype of testicular cancer, in Saudi Arabia. The study explores the demographic characteristics of affected patients, tumour profiles, and the mortality rate associated with this malignancy.
Methods: Utilizing data from the Saudi Cancer Registry, the authors identified 33 cases of mixed germ cell tumours with choriocarcinoma components among 1001 testicular cancer cases recorded between 2008 and 2017.
Asian J Surg
January 2024
Department of Radiology, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China. Electronic address:
Pathologie (Heidelb)
November 2023
Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37073, Göttingen, Deutschland.
Testicular germ cell tumours (GCT) represent the most common malignant neoplasia in young male adults between the age of 15 and 44. Because of their different biological behaviour it is important to differentiate prepubertal GCTs from postpubertal GCTs. This distinction is made by presence or absence of a germ cell neoplasia in situ.
View Article and Find Full Text PDFIntroduction: Prostatic metastasis from testicular cancer is extremely rare, with only 10 reported cases, all of which were diagnosed as relapse. Herein, we report the case of a patient with concurrent testicular cancer and prostatic metastasis.
Case Presentation: A 57-year-old man presented at our emergency department with urinary retention.
Clin Respir J
October 2023
Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Primary mediastinal choriocarcinoma, also known as non-pregnant choriocarcinoma, is a rare malignancy unrelated to pregnancy, with a higher incidence in males. And primary mediastinal choriocarcinoma is mostly associated with organ and lymph node metastasis, with rapid progression and poor prognosis. Here, we report an extremely rare case of the primary anterior mediastinal choriocarcinoma that occurred in an 18-year-old man with multiple metastases of the lung and brain.
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