Rational control of arterial pressure during labor in women with arterial hypertension.

Objectives: Were to identify the advantages and disadvantages of different protocols of antihypertensive therapy in women with arterial hypertension during the process of labour and their effects on the labour progressing and perinatal complications.

Material And Methods: 228 women who had childbirth in 2013-2018 in the Ternopil perinatal centre "Mother and Child" were surveyed. The study included full-term singleton pregnancies in cephalic presentation.

Correction of neurological deficiency in patients with acute ischemic stroke by application of different qualitative composition of infusion solutions.

Objective: Introduction: Infusion therapy is an important component in the treatment of patients with acute ischemic stroke (AIS). The aim: Compare the dynamics of changes neurological deficiency in the application of solutions: 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% in patients with AIS.

Periodontal diseases and atherosclerosis (literature review).

Objective: Introduction: The relationship between periodontal diseases and atherosclerosis is addressed in this article. Both these diseases have an inflammatory basis. Because periodontal disease is a risk factor for developing atherosclerotic vascular disease, diagnosis of the former is important.

DEVELOPMENT OF THE INNER NASAL CAVITY IN ANIMALS IN PHYLO- AND ONTOGENESIS: FUNCTIONAL ANATOMIC SIGNIFICANCE IN THE DEVELOPMENT PERIOD ROZWÓJ WEWNĘTRZNEJ JAMY NOSOWEJ U ZWIERZĄT W FILO- I ONTOGENEZIE: CZYNNOŚCIOWE I ANATOMICZNE ZNACZENIE W OKRESIE ROZWOJOWYM.

Objective: Іntroduction: Main functions of the inner nose in humans are respiration and olfaction. Therefore, human needs a large surface of inhalable and exhalable air contact, warming and moistening. Importance of these organs in animals in phylogenesis before and after the secondary palate development can explain their anatomic and functional designation.

Condition of fagocytosis of experimental animals with periodontitis due to modified reactivity.

Objective: Introduction: Taking into account the patho-immune mechanisms of formation of inflammatory process in periodontium, there is a necessity for in-depth study of the pathogenesis of periodontal diseases from the position of changes in the reactivity of the organism. The aim: Carrying out a comparative estimation of phagocytic activity of leukocytes of animals with inflammation in periodontium with altered reactivity.

Patients And Methods: Materials and methods: Experiments were performed on 30 white rats: Group I - 10 white rats with hypoergic reaction; Group ІІ - 10 white rats with hyperergic reaction; Group III - 10 white rats with normergic reaction - control group.

[CHANGES IN THE INDICATORS OF LIPID PEROXIDAL OXIDATION AND ANTIOXIDANT SYSTEM IN THE SERUM OF THE BLOOD IN ANIMALS WITH EXPERIMENTAL PERIODONTITIS WITH CHANGED REACTIVITY].

The purpose of the experimental study was to study the activity of lipid peroxidation and antioxidant systems in animals of different ages with experimental periodontitis with altered reactivity. Experiments were carried out on 30 non-linear white rats aged 2 months, which were divided into three groups: Group I - 10 animals with a hypoergic reaction, which was modeled by the administration of cyclophosphamide; Group II - 10 animals with hyper-hypergly reaction, which was modeled by administration of pyrogenal; Group III - 10 animals with normal reaction - a control group, which was intramuscularly injected with 1 ml of saline. Blood sampling and killing of animals were performed under thiopental anesthesia 7 days after the start of the experiment.

[PECULIARITIES OF IMMUNE PROFILE IN BLOOD OF RATS IN THE DYNAMICS OF IMMOBILIZATION STRESS ON THE BACKGROUND OF HYPOTHYROIDISM].

The aim of our study was to investigate the peculiarities of changes in the indices of cellular and humoral immunity in the case of immobilization stress, which is implemented against the background of hypothyroidism. It was used 84 white Wistar male rats to study the peculiarities of the stress reaction against hypothyroidism. The study of cellular and humoral immunity was performed on a Beckman Coulter Epics-XL flow cytometer.

[ASSESSMENT OF COMBINED PROPHYLAXIS OF PATHOLOGICAL POSTOPERATIVE FACE SKIN SCARS ACCORDING TO THE VANCOUVER SCALE].

The aim of the research was to study the effectiveness of combined prophylaxis of pathological postoperative face skin scars according to the Vancouver scale. The research involved 29 patients, aging 16-48 years old, who underwent maxillofacial surgery by extraoral accesses with wound primary intention healing. The patients were divided into three groups: the control group, which involved the patients, who after the surgery did not undergo any preventive measures to avoid pathological skin scars development, and two study groups.

SUCCESSFUL TREATMENT OF A PROLACTINOMA (CASE REPORT).

Currently, lots of young couples are facing infertility. One of the relatively rare causes of female infertility is prolactinoma - hormonally active pituitary tumor that secretes excessive quantity of prolactin. Excessive prolactin production is leading to anovulation and women infertility.

Morphological and physiological, biological and epidemiological features of acariana of the genus ixodes (latreille, 1795) - human ectoparasites in biogeocenoses of ternopil region.

Objective: Introduction: Ixodine are an integral part of many biotopes, in particular rarefied deciduous and mixed forests, gardens, parks, squares, semi-steppe and steppe areas, etc. Over the past decade, the role of ticks has increased in the transfer of pathogens of many diseases of animals and humans. In particular, these are tick borelliosis, anaplasmosis, erlichiosis, babesiosis, and etc.

Antimicrobial susceptibility of Neisseria gonorrhoeae isolates and treatment of gonorrhoea patients in Ternopil and Dnipropetrovsk regions of Ukraine, 2013-2018.

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health concern globally. However, recent gonococcal AMR data from Eastern Europe are extremely limited and no AMR data for strains spreading in Ukraine have ever been internationally published. We investigated the AMR of N.

A calcium channel blocker nifedipine distorts the effects of nano-zinc oxide on metal metabolism in the marsh frog .

Global decline of amphibian populations causes particular concern about their vulnerability to novel environmental pollutants, including engineering nanomaterials and pharmaceutical products. We evaluated the bioavailability of nanoform of zinc oxide (n-ZnO) in frog and determined whether co-exposure to a common pharmaceutical, a calcium-channel blocker nifedipine (Nfd) can affect this bioavailability. Male frogs were exposed for 14 days to the tap water (Control) and n-ZnO (3.

Metformin Protects the Heart Against Hypertrophic and Apoptotic Remodeling After Myocardial Infarction.

Cardiovascular complications are the most prevalent cause of morbidity and mortality in diabetic patients. Metformin is currently the first-line blood glucose-lowering agent with potential relevance to cardiovascular diseases. However, the underpinning mechanisms of action remain elusive.

Sjögren's syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease.

Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren's syndrome.

AVAILABILITY AND UTILIZATION OF HEALTHCARE RESOURCES IN UKRAINE AND SOME OTHER COUNTRIES.

Aims - to identify features of availability of health staff, facilities and equipment in healthcare, to examine the current state and changes in the number of health facilities and medical staff in health care systems in the countries of the world and in Ukraine. The study uses current global health statistics by WHO and World Bank as well as data on healthcare resources by Center for Medical Statistics of Ukraine for the year 2017. It analyzes and compares availability and use of some healthcare resources in Ukraine and Top 10 countries in the WHO Ranking.

THE SPECIFIC FEATURES OF CELL DEATH OF CIRCULATING NEUTROPHILS IN A SETTING OF EXPERIMENTALLY INDUCED CRUSH SYNDROME.

Although the overall incidence of trauma-induced crush syndrome (CS) is as low as 0.1 per 10,000 of population, which makes it one of the least common traumatic injuries, the hazard of CS lies in the high incidence of hemodynamic and metabolic complications, which call for an early diagnosis of this syndrome. This paper reports the specific features of cell death of neutrophils in rat blood as they changed with time using the model of endogenous toxemia formed in a setting of crush syndrome.

[PECULIARITIES OF STRUCTURAL CHANGES IN RAT LUNGS IN APPLICATION OF DIFFERENT METHODS OF REHYDRATION AFTER GENERAL DEHYDRATION].

Dehydration of the organism leads to the disturbances in homeostasis and structural changes in the lungs. Inadequate rehydration can also lead to the undesirable consequences. Experiments were carried out on rats, which modeled general dehydration and its correction: with metered potable water consumption, with water consumption without restrictions and correction by using a physiological solution.

CORRECTION OF ANDROGEN DEFICIENCY IN MEN WITH HYPOTHYROIDISM.

The percentage of men with low and subnormal blood testosterone levels (less than 12 nmol/l) is increasing with age. The injection form of testosterone undecanoate (TU) represents the first long-acting injectable testosterone medication with a satisfactory safety profile, which is administered 4 times a year, does not lead to supraphysiological increases in testosterone blood levels, with the achievement of its stable levels. The aim is to investigate the effectiveness of therapy with testosterone undecanoate in patients with hypothyroidism and androgen deficiency.

Basic clinical and pathogenetic aspects of developing the complications during multiple pregnancies.

Objective: Introduction: In order to evaluate the value of the Placenta Growth Factor (PlGF) in the developing the gestational complications during multiple pregnancies, a study of this indicator in serum of 320 pregnant women with multiple pregnancies in the first trimester, as well as 40 pregnant women with single pregnancy, constituted a control group. The aim: of the study is to investigate the effect of the placental growth factors on gestational process during multiple pregnancies.

Patients And Methods: Materials and methods: A prospective study of maternity pregnancy in 320 females with multiple pregnancies was conducted, which comprised the main group of the subjects and 40 healthy women with unipolar pregnancy.

Medical and social issues of cardiovascular diseases and their solution based on the experimental study of myocardial fibrosis.

Objective: Introduction: The prevalence and incidence of cardiovascular diseases have been attracting considerable attention in recent decades. This is partly due to the fact that myocardial fibrosis is the major consequence of the most nosological units of cardiovascular diseases. We believe that early pathogenic therapy of myocardial fibrosis should be taken into consideration as a solution to this issue.

[State of bone in children living in different conditions of environment].

Objective: Introduction: Environmental pollution, deficiency of fluorine and iodine significantly affect the state of dental health of children and the structural and functional status of the bone system. The aim: Therefore, the task of our study was to establish a connection between the structural and functional state of bone tissue and dental ankles with anthropogenic and geochemical factors in the environment.

Patients And Methods: Materials and methods: In order to achieve the goal of the study, we examined 496 children aged 6-15 years living in areas with different ecological loads.

Long-Term Efficacy and Safety of Biosimilar CT-P10 Versus Innovator Rituximab in Rheumatoid Arthritis: 48-Week Results from a Randomized Phase III Trial.

Objective: The aim of this study was to investigate long-term clinical outcomes of extended treatment with CT-P10, a rituximab biosimilar, compared with rituximab reference products sourced from the USA and the EU (US-RTX and EU-RTX) in rheumatoid arthritis (RA) for up to 48 weeks.

Methods: In this multinational, randomized, double-blind trial, adults with active RA received up to two courses of CT-P10, US-RTX, or EU-RTX alongside methotrexate. Efficacy endpoints included Disease Activity Score 28-joint count (DAS28) and American College of Rheumatology (ACR) response rates.

AWARENESS OF PRIMARY IMMUNODEFICIENCY DISEASES AMONG MEDICAL STUDENTS.

Primary immunodeficiency diseases (PID) are a group of more than 300 rare, chronic disorders in which a part of the body's immune system is missing or functions improperly. The issue of early diagnosis, timely and effective treatment, prevention of complications and improved prognosis remains extremely relevant. The aim of this study was to assess the awareness of graduating medical university students about the signs of primary immunodeficiency in children and adults.

[THE STRUCTURE OF THE ILEUM AFTER THE RESECTION OF LIVER PARENCHYMA].

The ileum was morphologically examined in 45 sexually mature white male rats, which were divided into 3 groups: I group included 15 intact animals, II - 15 rats, in which 31.5% of the liver parenchyma was removed, III - 15 animals after resection 58,1% of liver parenchyma. Euthanasia of rats was performed by bloodletting under the conditions of thiopental anesthesia 1 month after the beginning of the experiment.