2,431 results match your criteria: "Tepecik Research and Training Hospital; İzmir-Turkey. kilicaslanbaris@yahoo.com.[Affiliation]"

Introduction: Mucormycosis is an acute onset, invasive, fungal infection, characterized by organ involvement, and caused by Mucor, Rhizopus, or Absidia. Our aim was to present a case of mucormycotic infection and emphasize its importance in a diabetic immunosuppressed patient with acute myeloid leukemia (AML).

Case Presentation: A 68-year-old hypertensive and diabetic male patient with a diagnosis of AML developed respiratory failure and exhibited diffuse bilateral consolidation in high-resolution computed tomography (HRCT).

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Objective: Respiratory syncytial virus (RSV) is the primary etiology of lower respiratory tract infection in children. The fluctuating incidence of RSV, particularly in light of the COVID-19 pandemic, has shifted the spotlight onto preventive strategies. Our study aims to investigate both the risk factors and clinical symptoms of RSV.

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Virtual anatomical atlas of the deep brain nuclei.

Neurosurg Rev

November 2024

Department of Neurosurgery, Yeditepe University, School of Medicine Kosuyolu Hospital, Kosuyolu Street, Kadıkoy, İstanbul, 34718, Türkiye.

This study aims to improve understanding of the anatomy of the deep brain nuclei relevant to deep brain stimulation as well as stereotactic lesioning procedures, including radio frequency, high-focused ultrasound, and radiosurgery. We created interactive, three-dimensional virtual models from cadaveric dissections and radiological segmentation. We used five brain specimens (ten hemispheres) obtained from routine autopsies, prepared according to Klingler's method.

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  • Cervical fixation is frequently used to treat various spinal conditions and the study aimed to investigate risks related to high-riding vertebral arteries (HRVA), narrow C2 pedicles (NC2P), and ponticulus posticus (PP) that can occur during screw placement.
  • The study analyzed 382 C2 vertebrae using CT angiography to measure specific parameters and found that 9.6% of patients had HRVA and 13% had NC2P, with notable differences in prevalence between males and females.
  • The findings stressed the importance of understanding the presence of HRVA, NC2P, and PP to improve safety during cervical fixation procedures, with digital models aiding in planning the screw trajectory and minimizing the risk of
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  • Glycemic variability (GV) is a common issue in critically ill patients, and this study explored its impact on 28-day mortality through a multicenter analysis involving 578 patients across five ICUs in Turkey.
  • The study tracked several glycemic parameters within the first 24 hours, finding significant differences in CV (coefficient of variation), SD (standard deviation), and MGD (maximal-minimal glucose difference) between survivors and non-survivors, with higher levels linked to increased mortality risk.
  • Results indicated that CV is an independent risk factor for mortality, with a strong correlation with MGD, suggesting that monitoring these glycemic metrics could be critical for predicting patient outcomes in intensive care settings.
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Background: Despite global efforts, HIV/AIDS remains a significant public health challenge, with Türkiye witnessing a consistent rise in annual diagnoses. Patient satisfaction with antiretroviral therapy (ART) is crucial for treatment adherence and effectiveness. This study examines treatment satisfaction levels among people living with HIV (PLWH) in Türkiye and identifies associated factors.

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(1) Background: Metastatic L-type sarcomas (liposarcoma and leiomyosarcoma) are rare and have a poor prognosis. Trabectedin is an effective agent that can be used after anthracyclines. This study was designed to evaluate the real-life effectiveness and safety of trabectedin.

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  • Spinal muscular atrophy (SMA) is a genetic disorder leading to muscle weakness and atrophy, with high rates of morbidity and mortality despite recent treatments.
  • * The study reviewed 16 SMA type 1 patients, noting complications like gastrointestinal issues, respiratory distress, and infections, with a 50% mortality rate during the follow-up period.
  • * Findings suggest higher survival rates are linked to more nusinersen treatments and better overall health scores, indicating a need for a multidisciplinary approach to patient management.
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Purpose: To assess the impact of the The Controlling Nutritional Status (CONUT) score, an indicator of nutritional status, on the survival and prognosis after radical cystectomy.

Materials And Methods: The medical records of patients who underwent consecutive radical cystectomy operations with the diagnosis of muscle-invasive bladder cancer at our clinic were retrospectively examined. The patients were separated into two groups based on the cut-off CONUT score which was derived using the receiver operating characteristic (ROC) curve.

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Background: The aim was to investigate which of two different b values (b 500 s/mm² and b 800 s/mm²) are more effective in the differentiation of benign-malignant nodules using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI).

Materials And Methods: Patients presenting with a preoperative diagnosis of nodular goiter or multinodular goiter were included in this study. These patients underwent neck MRI examinations, and their cases were analyzed retrospectively.

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Background: The retina is affected by Parkinson's disease (PD).

Purpose: We aimed to assess the anatomical and vascular deterioration of the retina in PD.

Methods: Sixty-six patients with PD and 66 healthy volunteers were evaluated in this study.

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Objective: To investigate serum, placental levels of active-matrix metalloproteinase-8 (aMMP-8), myeloperoxidase (MPO) in preterm-birth with/without pre-eclampsia and term counterparts in relation with clinical periodontal parameters.

Methods: Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full-term (FT), pre-term (PT) or pre-term complicated by pre-eclampsia (PTPE) deliveries.

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  • Macrosomia, or excessive fetal growth, is commonly seen in infants of mothers with diabetes, but it can also occur in non-diabetic women, leading to various complications.
  • A study analyzed 8,956 non-diabetic pregnant women to explore the link between second-trimester lipid profiles and macrosomia, excluding those with pre-existing conditions that could affect lipid levels.
  • Results showed that higher triglycerides, total cholesterol, and LDL cholesterol were associated with macrosomia, while low HDL cholesterol was linked negatively; only triglycerides remained significantly associated after further analysis.
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  • * Researchers collected 1,346 nasopharyngeal swab samples, isolating 879 high-quality genomes for analysis, focusing on clades, lineages, age-related associations, and mutations over a 10-month period.
  • * Specific variants like B.1.1.7 (Alpha) and B.1.617.2 (Delta) were identified, along with unique mutations linked to the later Omicron variant, emphasizing the need for ongoing genetic monitoring to improve COVID-19 prevention strategies.
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Objective: The primary aim of this study is to elucidate the spiritual needs encountered by family members who intricately engage in the progression of illness within the palliative care framework, thus assuming the paramount responsibility of caregiving.

Methods: This study was approved by the Institutional Review Board and Ethics Committee of the University of Health Sciences İzmir Tepecik Training and Research Hospital (17/01/2022-2022/01-16). The research was designed as a prospective study.

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Surgical management of delayed mucosal cyst after rhinoplasty: a case report.

J Surg Case Rep

November 2024

Department of ENT-Head and Neck, Health Sciences University Bozyaka Research and Training Hospital, Bahar, Saim Çıkrıkçı Cd. No:59, Çiğli 35170, Turkey.

Mucosal cysts are rare late complications of rhinoplasty, appearing anywhere from weeks to years post-surgery. The cyst's location can cause both cosmetic and functional issues. Definitive treatment requires complete surgical excision of the cyst and its capsule to prevent recurrence.

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Background: Human papillomavirus (HPV), the most common pathogen causing sexually transmitted diseases worldwide, is also an oncogenic virus. Due to the inadequacy of serologic tests in the diagnosis of HPV, NAATs (nucleic acid amplification tests), such as PCR (polymerase chain reaction), represent the gold standard today. Endocervical brush sampling in women has been successfully used for HPV genotyping for many years.

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Role of CT-based body composition parameters in the course of COVID-19.

Turk J Med Sci

October 2024

Department of Radiology, Tepecik Training and Research Hospital, Health Sciences University, İzmir, Turkiye.

Background/aim: A significant correlation is observed between the course of coronavirus disease 2019 (COVID-19) and body composition parameters including visceral fat quantification, muscle mass, and hepatic attenuation. The aim of the study was to investigate the correlation between the extent of lung involvement and various computed tomography (CT) parameters, as well as laboratory findings in COVID-19 patients.

Materials And Methods: A retrospective analysis was conducted on 72 adult patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection who underwent two consecutive thorax CT scans at least 2 weeks apart.

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Background And Objectives: Bipolar electrocautery systems in neurosurgical procedures may induce thermal damage to adjacent tissues, especially neural tissues. Therefore, it is crucial to control thermal spread from the tips of bipolar forceps into adjacent tissues. The goal of this study was to compare the thermal damage induced in unintended adjacent tissues during coagulation with 6 different bipolar forceps.

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Introduction: Menopausal symptoms in women are influenced by personality traits as well as physical and psychological characteristics. The effects of coronavirus disease 2019 (COVID-19) phobia on personality traits and menopausal symptoms in premenopausal and postmenopausal women were examined in this study.

Material And Methods: The study was conducted in a cross-sectional and descriptive design with 410 women.

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Assessment of Genetic Variants Linked to Susceptibility to Mechanical Prosthetic Valve Thrombosis.

Am J Cardiol

January 2025

Department of Cardiology, Koşuyolu Kartal Heart Training and Research Hospital, Istanbul, Türkiye; Division of Health Sciences, Ardahan University, Ardahan, Türkiye.

Prosthetic valve thrombosis (PVT) is a critical and life-threatening condition driven by multifactorial etiologies, including genetic predispositions. The study was designed as a single-center retrospective manner. Echocardiographic features and genetic test including factor II/prothrombin (G20210A), factor V Leiden (G1691A), factor V R2 (A4070G), apolipoprotein (Apo) B-100 (G10708A), ApoE (C112R), ApoE (R158C), methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, factor XIII G103T (V34L), β-fibrinogen (455G>A), PAI-1 4G/5G, and HPA-1 GPIIIa (T196C) genotyping variations were assessed.

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  • * Data from the international dataset revealed that the highest number of disasters occurred between 2001 and 2010, with transportation accidents being the most prevalent type.
  • * Asia experienced the majority of these disasters, accounting for 45.6%, followed by Africa at 26.1%, while road accidents were identified as the leading cause within the transport accident category.
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Supplemental oxygen alters the pentose phosphate pathway in the developing mouse brain through SIRT signaling.

Neurochem Int

November 2024

Izmir Biomedicine and Genome Center, Balcova, 35330, Izmir, Turkey; İzmir International Biomedicine and Genome Institute, Dokuz Eylül University, Izmir, Turkey.

Oxygen support plays a critical role in the management of preterm infants in neonatal intensive care units. On the other hand, the possible effects of oxygen supplementation on cellular functions, specifically glucose metabolism, have been less understood. PURPOSE: of the study is to investigate whether supplemental oxygen alters glucose metabolism and pentose phosphate pathway (PPP) activity in the brain tissue and its relevance with silent information regulator proteins (SIRT) pathway.

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  • The study investigates the prognostic factors for C3 glomerulopathy (C3G), focusing on the total chronicity score (TCS) derived from a new histological index (C3G-HI).
  • 74 patients from 20 medical centers were analyzed to determine factors affecting kidney health outcomes, with a particular emphasis on hemoglobin levels and their correlation with patient survival and kidney function.
  • Results indicated that low hemoglobin levels were linked to worse outcomes in C3G patients, and a TCS of 4 or higher correlated with significantly lower kidney survival rates over three years.
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