Bat Cutaneous Microbial Assemblage Functional Redundancy Across a Host-Mediated Disturbance.

Understanding the processes and factors that influence the structure of host-associated microbial assemblages has been a major area of research as these assemblages play a role in host defense against pathogens. Previous work has found that bacterial taxa within bat cutaneous microbial assemblages have antifungal capabilities against the emerging fungal pathogen, Pseudogymnoascus destructans. However, our understanding of natural fluctuations in these cutaneous microbial assemblages over time due to shifts in host habitat is lacking.

The mediating role of social support on the link between adverse childhood experiences and adult mental health.

Adverse childhood experiences (ACEs) have been associated with adult mental health, especially anxiety and depression. We aimed to explain these relationships by investigating perceived social support as a mediating factor. In this model, it is proposed that individuals who experience more ACEs will have less perceived social support in adulthood, which in turn will increase reported anxiety and depression symptoms.

Intra-abdominal Hypertension Is a Strong Predictor of Mortality and Poor Clinical Outcome in Severe Acute Pancreatitis.

Background: Acute pancreatitis is one of the leading causes of mortality and morbidity. Most acute pancreatitis scoring systems have no pathophysiologic basis when evaluating severity. Such a limitation led to an interest in measuring intra-abdominal pressure (IAP) as a method to predict outcomes in patients with acute pancreatitis.

Two Blatter Radicals Face-to-Face: A Constrained Diradical Architecture.

Cofacial arrangement of two Blatter radicals enforced by the -naphthalene scaffold represents a new approach to stable diradicals with strong through-space interactions. Two stereoisomers of the naphthalene-diradicals, and , are investigated by XRD, VT-EPR, UV-vis, electrochemical, kinetic, and DFT methods. In solutions, both stereoisomers exist as open-shell singlets with Δ = -3.

Assessing the Relationship Between Self-Rated General Health and Colorectal Cancer Screening Uptake.

Background: Colorectal cancer screening has been shown to be effective in reducing the burden of colorectal cancer. However, the screening rate has been suboptimal, and mortality due to colorectal cancer remains high. With the presence of proactive prevention strategies, low screening rates could still be due to individual factors.

Metals and metalloids pollution levels, partitioning, and sources in the environmental compartments of a small urban catchment in Moscow megacity.

This study examines the contamination levels and sources of 32 metals and metalloids (MMs) in environmental compartments (roadside soil, road dust, and river suspended sediments) of a small urbanized river catchment located in Moscow megacity. MMs partitioning between particle size fractions (PM, PM, and PM) was analyzed by ICP-MS and ICP-AES methods. The pollution level of particle size fractions with MMs decreases in the following series: road dust > suspended sediments > soils.

Racial and Ethnic Representation of the Local Public Health Workforce.

To describe racial and ethnic representativeness of the local health department (LHD) workforce compared with the populations served. In this study, we used a cross-sectional design of the 2021 Public Health Workforce Interests and Needs Survey, 2019 National Association of County and City Health Officials Profile data, and other sources to estimate the racial and ethnic representativeness of LHD workforce. We calculated representativeness as a binary measure of at least representative of the populations served for each race and ethnicity group.

RadOncCalc: A Mobile-Friendly Tool to Enhance Radiation Oncology Practice.

This study introduces RadOncCalc, a mobile and web-based platform designed to consolidate oncology research and guidelines into one accessible tool for radiation oncologists. By providing up-to-date dose constraints and contouring guidelines, RadOncCalc enhances clinical decision-making and patient care quality in radiation oncology.

Guiding Graduate Student Recognition of Implicit Bias Using Interactive Simulation.

Assisting graduate nursing students to recognize implicit bias and racism is imperative when providing health care with culturally diverse groups. The article describes an interactive simulation between graduate students and a standardized patient designed to raise awareness of implicit bias and racism. Students in the Doctor of Nursing Practice and PhD programs participated in interviews with a standardized patient; in team interactions; in content analysis of simulated communications; and in reflection, debriefing, and evaluation sessions.

Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2.

Resistance to androgen receptor (AR)-targeted therapies for prostate cancer (PCa) is characteristic of an aggressive subtype called castration-resistant prostate cancer (CRPC) and is often associated with tumor relapse. Both relapse and poor prognosis in patients with CRPC are associated with increased abundance of the E3 ubiquitin ligase SKP2. Therefore, we investigated the therapeutic potential of combined inhibition of AR and SKP2 for CRPC.

Long-term changes in soil biological activity and other properties of raised beds in Longan orchards.

Introduction: The Longan fruit tree of the Vietnam Mekong Delta is grown in raised beds to improve water drainage during the rainy season and can live as long as 100 years.

Objective: This research explores the extent to which the soil microorganisms as well as soil physical and chemical properties of these raised beds degrade over a period of 60 years under traditional management practices.

Materials And Methods: Raised bed topsoil samples at depths of 0-20 cm were obtained from four different Longan orchards raised bed age groups: group 1) 15-25 years (L1-L5); group 2) 26-37 years (L6-L10); group 3) 38-45 years (L11-L15); and group 4) 46-60 years.

Risky Remedy: Rasburicase-Induced Methemoglobinemia in Tumor Lysis Syndrome Complicated by G6PD Deficiency.

Tumor lysis syndrome (TLS) is a critical oncologic emergency characterized by metabolic disturbances resulting from rapid cancer cell lysis. Rasburicase, a recombinant urate oxidase, is the primary treatment for hyperuricemia in TLS but poses a risk for methemoglobinemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. We present the case of a 59-year-old male with diffuse large B-cell lymphoma (DLBCL) who developed spontaneous TLS.

Functional annotation of regulatory elements in rainbow trout uncovers roles of the epigenome in genetic selection and genome evolution.

Rainbow trout (RBT) has gained widespread attention as a biological model across various fields and has been rapidly adopted for aquaculture and recreational purposes on 6 continents. Despite significant efforts to develop genome sequences for RBT, the functional genomic basis of RBT's environmental, phenotypic, and evolutionary variations still requires epigenome reference annotations. This study has produced a comprehensive catalog and epigenome annotation tracks of RBT, detecting gene regulatory elements, including chromatin histone modifications, chromatin accessibility, and DNA methylation.

Health Disparities in Hospice-Home Health Transitions in Hispanic Older Adults With Co-occurring Dementia and Cardiovascular Disease.

Purpose: In the US, nearly one-third of skilled home health (HH) patients and nearly one-half of hospice patients live with Alzheimer's disease and related dementias (ADRD). Hispanic older adults are more likely to live with ADRD than white non-Hispanic older adults. Persons with ADRD, compared to their counterparts without ADRD, have a prolonged trajectory of decline and experience multiple care transitions between health care settings, bringing risks for poor outcomes.

The Influence of Winning and Losing Gambling Experience on Mood State and Alcohol Cravings.

Previous work has explored the bi-directional relation between alcohol consumption and gambling behavior within gambling contexts, highlighting the role of salient factors such as mood. The present experiment sought to further explore how mood state and the urge to consume alcohol vary as a function of the experience of winning or losing while gambling. In this experiment, 76 individuals who reported past year gambling and past month alcohol use were randomly assigned to one of four conditions - neutral gambling, winning gambling, losing gambling, or movie watching.

Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study.

Background: A key driver that leads to age-associated decline and chronic disease is mitochondrial dysfunction. Our previous work revealed strong community interest in the concept of mitochondrial fitness, which led to the development of a video-based science communication intervention to prompt behavior change in adults aged 50 years and older.

Objective: This study aimed to conduct formative and summative evaluations of MitoFit, an instructional, biologically based communication intervention aimed at improving physical activity in older adults aged 50 years and older.

Density functional theory for fractional charge: Locality, size consistency, and exchange-correlation.

We show that the exact universal density functional of integer electronic charge leads to an extension to fractional charge in an asymptotic sense when it is applied to a system made of asymptotically separated densities. The extended functional is asymptotically local and is said to be i-local. The concept of i-locality is also applicable to nuclear external potentials, and a natural association exists between the localities of a density and a set of nuclei.

Expanding options to recruit, grow, and retain the public health workforce.

The public health workforce continues to atrophy due to mass and early retirement, under-funding, slow hiring processes, lack of advancement opportunities, and shifting policies. Organizational research into workforce sustainability is crucial for ensuring a robust, diverse staff capable of delivering essential public health services. We examined career ladders, a potential solution to workforce challenges, through interviews with 10 health departments (HDs) across seven states.

Comparative metagenomics of microbial communities and resistome in southern farming systems: implications for antimicrobial stewardship and public health.

Agricultural practices significantly influence microbial diversity and the distribution of virulence and antimicrobial resistance (AMR) genes, with implications for ecosystem health and food safety. This study used metagenomic sequencing to analyze 60 samples (30 per state) including water, soil, and manure (10 each) from Alabama (a mix of cattle and poultry sources) and Tennessee (primarily from cattle). The results highlighted a rich microbial diversity, predominantly comprising Bacteria (67%) and Viruses (33%), with a total of over 1,950 microbial species identified.

First Report of Crown and Root Rot on Eastern Redbud () Caused by in Tennessee.

Eastern redbuds () are the important trees in Tennessee nurseries, known for their vibrant spring blooms, and heart-shaped foliage (Kidwell-Slak and Pooler 2018). In May 2023, container-grown eastern redbuds exhibited crown and root rot symptoms. Disease incidence was 50% of 100 plants and severity was 40% for the affected root area.

First Report of Causing Root Rot on in Tennessee and the United States.

Swamp white oak () is a North American species of medium-sized trees in the beech family. One-year-old swamp white oak seedlings grown in field conditions in a commercial nursery in Warren County, Tennessee exhibited severe root rot in July 2024. Dark brown lesions were observed in the affected roots (Fig.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Language Justice as Health Equity in Palliative Care: A Scoping Review.

Context: Communication is the foundation of optimal healthcare provision. Linguistic diversity is a reality in palliative care settings.

Objectives: To identify the state of the literature on language interpreting in palliative care and to examine inclusion of stakeholders in dissemination products.