128,526 results match your criteria: "Tennessee; University of Miami N.N.[Affiliation]"
PLoS Med
January 2025
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Background: Nirmatrelvir with ritonavir (Paxlovid) is indicated for patients with Coronavirus Disease 2019 (COVID-19) who are at risk for progression to severe disease due to the presence of one or more risk factors. Millions of treatment courses have been prescribed in the United States alone. Paxlovid was highly effective at preventing hospitalization and death in clinical trials.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
National Key Laboratory of Agricultural Microbiology and College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China.
The neurotoxin methylmercury (MeHg) is produced mainly from the transformation of inorganic Hg by microorganisms carrying the gene pair. Paddy soils are known to harbor diverse microbial communities exhibiting varying abilities in methylating inorganic Hg, but their distribution and environmental drivers remain unknown at a large spatial scale. Using gene amplicon sequencing, this study examined Hg-methylating communities from major rice-producing paddy soils across a transect of ∼3600 km and an altitude of ∼1300 m in China.
View Article and Find Full Text PDFLearn Health Syst
January 2025
Department of Biomedical Informatics University of Arkansas for Medical Sciences, College of Medicine Little Rock Arkansas USA.
Objective: This project demonstrates the feasibility of connecting medical imaging data and features, SARS-CoV-2 genome variants, with clinical data in the National Clinical Cohort Collaborative (N3C) repository to accelerate integrative research on detection, diagnosis, and treatment of COVID-19-related morbidities. The N3C curated a rich collection of aggregated and de-identified electronic health records (EHR) data of over 18 million patients, including 7.5 million COVID-positive patients, seen at hospitals across the United States.
View Article and Find Full Text PDFOpen Forum Infect Dis
January 2025
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Background: We investigated hospitalized carbapenem-resistant Enterobacterales (CRE) and extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) cases with and without COVID-19, as identified through Emerging Infections Program surveillance in 10 sites from 2020 to 2022.
Methods: We defined a CRE case as the first isolation of , complex, , , , or resistant to any carbapenem. We defined an ESBL-E case as the first isolation of , , or resistant to any third-generation cephalosporin and nonresistant to all carbapenems tested.
Environ Toxicol Chem
January 2025
Molecular Biosciences PhD Program, Middle Tennessee State University, Murfreesboro, TN, United States.
Riparian spiders are used in ecotoxicology as sentinels of bioavailable contaminants that are transferred from aquatic to terrestrial habitats via emergent aquatic insects. Spiders in the family Tetragnathidae are particularly of interest because a high proportion of their diet consists of emergent aquatic insects and their contaminant loads reflect the amount transferred through the food web to riparian predators. The transfer of contaminants can be determined through food web tracers such as stable isotopes and polyunsaturated fatty acids; however, it is unclear how contaminants and tracers vary over the course of a year.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut.
Importance: Opioid use disorder (OUD) impacts millions of people worldwide. Prior studies investigating its underpinning neural mechanisms have not often considered how brain signals evolve over time, so it remains unclear whether brain dynamics are altered in OUD and have subsequent behavioral implications.
Objective: To characterize brain dynamic alterations and their association with cognitive control in individuals with OUD.
PLOS Glob Public Health
January 2025
African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria.
JAMA Ophthalmol
January 2025
Vanderbilt Eye Institute, Department of Ophthalmology & Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
J Med Syst
January 2025
Edward J. Bloustein School of Planning and Public Policy, Rutgers, The State University of New Jersey, 255, Civic Square Building 33 Livingston Ave #400, New Brunswick, NJ, 08901, USA.
Generative Artificial Intelligence (Gen AI) has transformative potential in healthcare to enhance patient care, personalize treatment options, train healthcare professionals, and advance medical research. This paper examines various clinical and non-clinical applications of Gen AI. In clinical settings, Gen AI supports the creation of customized treatment plans, generation of synthetic data, analysis of medical images, nursing workflow management, risk prediction, pandemic preparedness, and population health management.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Advancing New Standards in Reproductive Health, University of California, San Francisco, Oakland.
Importance: Since Dobbs v Jackson Women's Health Organization (Dobbs) removed federal abortion protections, people's views about alternative models of abortion care may have been impacted, yet research on this topic is limited.
Objective: To examine changes in national support for and personal interest in advance provision (AP) and over-the-counter (OTC) access to medication abortion.
Design, Setting, And Participants: Two nationally representative cross-sectional online surveys were administered to a market research firm's panel members who were assigned female at birth (AFAB) and aged 15 to 49 years from December 2021 to January 2022 (before Dobbs) and June to July 2023 (after Dobbs).
JAMA Ophthalmol
January 2025
Bascom Palmer Eye Institute, Miami, Florida.
Blood Adv
January 2025
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Sickle cell anemia (SCA) is recognized globally, but little is known about affected Hispanic populations. In partnership with Dominican Republic, a Hispanic Caribbean Island with a large SCA population, a TCD screening program provided hydroxyurea to children with conditional velocities. Building local capacity, ten Dominican medical graduates were certified in TCD examinations and trained in hydroxyurea management.
View Article and Find Full Text PDFClin Cancer Res
January 2025
University of Colorado Cancer Center, Aurora, Colorado, United States.
Background: Investigator-initiated trials (IITs) may address important biological and clinical questions that may not be prioritized by pharmaceutical sponsors. However, little is known about the process by which IIT proposals are evaluated and activated.
Methods: We performed a retrospective study of IIT concepts submitted through the Academic Thoracic Oncology Medical Investigators Consortium (ATOMIC), which comprises 13 institutions in the U.
Obstet Gynecol
January 2025
Departments of Obstetrics and Gynecology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin; University of Pittsburgh Medical Center, Magee-Women's Hospital, and the Children's Hospital of Pittsburgh, Pittsburgh, and the Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; the Department of Neurosurgery, Duke University Medical Center, Duke Children's Hospital, Durham, North Carolina; the University of Michigan, Ann Arbor, Michigan; the Department of Surgery (and Maternal Fetal Care Center), Boston Children's Hospital, Boston, Massachusetts; Children's Minnesota, St. Paul and Minneapolis, Minnesota; the Johns Hopkins Center for Fetal Therapy, Baltimore, Maryland; Vanderbilt University Medical Center, Nashville, Tennessee; Wexner Medical Center, The Ohio State University, Columbus, Ohio; Stanford University School of Medicine, Stanford, and UC Davis Fetal Care and Treatment Center, Sacramento, California; St. Louis University, St. Louis, Missouri; University of Rochester Medical Center, Rochester, New York; and UTHealth Houston Fetal Center, University of Texas McGovern Medical School at Houston, Houston, Texas.
Objective: To assess the association between mode of delivery and 2-year motor function in children with prenatal diagnosis of myelomeningocele.
Methods: A multisite retrospective cohort study of children with myelomeningocele across 14 NAFTNet (North American Fetal Therapy Network) centers born between 2007 and 2020 who had a physical examination available at 2 years of life. Exclusion criteria were in utero myelomeningocele repair, postnatal myelomeningocele diagnosis, missing data on fetal presentation at delivery, and contraindications to labor.
JMIR Cancer
January 2025
Center for Biomedical Informatics, Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, 50 N. Dunlap St, Memphis, TN, 38103, United States, 1 9012875836.
Background: Breast cancer screening plays a pivotal role in early detection and subsequent effective management of the disease, impacting patient outcomes and survival rates.
Objective: This study aims to assess breast cancer screening rates nationwide in the United States and investigate the impact of social determinants of health on these screening rates.
Methods: Data on mammography screening at the census tract level for 2018 and 2020 were collected from the Behavioral Risk Factor Surveillance System.
J Natl Compr Canc Netw
January 2025
National Comprehensive Cancer Network.
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma and affects an estimated 1,500 people annually in the United States. DFSP frequently exhibits extensive local infiltration. Initial treatment is through surgical excision, and care should be taken to ensure that negative margins are achieved to minimize recurrence.
View Article and Find Full Text PDFJ Natl Compr Canc Netw
January 2025
National Comprehensive Cancer Network.
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide criteria for selecting individuals for screening and offer recommendations for evaluating and managing lung nodules detected during initial and subsequent annual screening. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for Lung Cancer Screening.
View Article and Find Full Text PDFWorld J Pediatr Congenit Heart Surg
January 2025
Heart Institute, Le Bonheur Children's Hospital, Memphis, TN, USA.
Background: Impella 5.5 ventricular assist device (VAD) insertion is typically done via the axillary artery or directly through the aorta; however, an axillary artery must be ≥6 mm in diameter, which excludes many pediatric patients who do not meet this criterion. The innominate artery is a larger vessel that can better accommodate the Impella VAD in pediatric patients.
View Article and Find Full Text PDFAm J Physiol Renal Physiol
January 2025
Department of Medicine, Boston Medical Center and Department of Medicine, Boston University. Chobanian & Avedisian School of Medicine.
Transcriptomic analysis of microdissected human glomeruli has suggested novel molecular signatures associated with MN by revealing several genes differentially upregulated in MN compared to other glomerular diseases. We focused on a novel protein, Family with sequence similarity 114 member A1 (FAM114A1) that was identified as the top classifier gene in the dataset. To determine the localization of FAM114A1 within glomeruli, we performed immunofluorescence (IF) staining on normal human kidney specimens.
View Article and Find Full Text PDFInt J Surg Pathol
January 2025
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN, USA.
squamous cell carcinoma is a recently recognized entity characterized by a non-viral-related non-keratinizing squamous cell carcinoma with chromosomal rearrangement between on 6p22.3 and on Xq28. This neoplasm is associated with an aggressive clinical behavior, particularly regarding local recurrences and distant metastases even with its deceptively bland histomorphology.
View Article and Find Full Text PDFJ Comp Eff Res
January 2025
Value & Implementation Outcomes Research, Oncology, Merck & Co., Inc., Rahway, NJ, USA.
This ambispective observational study assessed the impact of Noona, an electronic patient-reported outcomes (ePRO) platform, for patients with non-small cell lung cancer (NSCLC) treated in a community oncology setting. Adults with advanced NSCLC, ECOG performance status of 0-2, who received first-line (1L) pembrolizumab (monotherapy or with chemotherapy) were eligible. Those initiating pembrolizumab from 1 July 2017 to 30 June 2019, identified retrospectively (historical cohort), were compared with those initiating pembrolizumab from 1 October 2019 to 30 September 2021 who were prospectively offered Noona (standard of care [SoC] cohort).
View Article and Find Full Text PDFAm J Public Health
January 2025
Sarah M. Leder, Shane Lamba, Chava Sonnier, and Kenneth T. Jones are with the Veterans Health Administration (VHA) Office of Health Equity, Washington, DC. A. Alex McConnell, Alexis R. Matza, Wyatt E. Meriwether, Jillian C. Shipherd, and Michael R. Kauth are with the VHA Lesbian, Gay, Bisexual, Transgender, and Queer+ (LGBTQ+) Health Program, Washington, DC. George R. Brown is with the East Tennessee State University, Department of Psychiatry, Johnson City, TN.
To distinguish differences in physical and mental health between transgender and gender-diverse (TGD) veterans identified via diagnostic codes, self-identification, and their combination. We used sociodemographic characteristics and physical and mental health diagnoses for TGD veterans receiving care in Veterans Health Administration (VHA). Among the cohort of 12 745 TGD veterans, 69.
View Article and Find Full Text PDFPlant Dis
January 2025
Tennessee State University, Otis Floyd Nursery Research Center, 472 Cadillac Lane, McMinnville, Tennessee, United States, 37110;
Tulip poplar () is a member of the Magnolia family, is a large, fast-growing, long-lived, deciduous tree native to eastern North America. One-year-old tulip poplar seedlings grown under field conditions in a commercial nursery in Warren County, Tennessee, exhibited severe root rot in May 2024. Dark brown to black lesions were observed on the affected roots.
View Article and Find Full Text PDFJ Med Chem
January 2025
Boehringer Ingelheim RCV GmbH & Co. KG, A-1121 Vienna, Austria.
The Son of Sevenless (SOS) protein family includes two highly homologous proteins, SOS1 and SOS2, that act as guanine nucleotide exchange factors (GEFs) for RAS proteins. They catalyze the GDP-to-GTP exchange, resulting in an increase of the active GTP-bound form of RAS. Despite highly similar structures and expression patterns, SOS1 is generally accepted as the dominant RAS GEF for downstream signaling in pathological states.
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