Black posterior vitreous detachment: A 10-year historical cohort of pigmented uveal tumors.

Objective: Pigmentary posterior vitreous detachment (PVD), referred to as "black PVD," is a rare entity describing PVD along with pigment dispersion in the vitreous. There are a few case reports describing pigmentary PVD, yet the association between pigmentary PVD and uveal and optic disc tumors was not described before. The aim of this study was to report the clinical features of patients with pigmentary PVD associated with these tumors.

Digital light processing printing of non-modified protein-only compositions.

This study explores the utilization of digital light processing (DLP) printing to fabricate complex structures using native gelatin as the sole structural component for applications in biological implants. Unlike approaches relying on synthetic materials or chemically modified biopolymers, this research harnesses the inherent properties of gelatin to create biocompatible structures. The printing process is based on a crosslinking mechanism using a di-tyrosine formation initiated by visible light irradiation.

The proteomic response of to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance.

The polyene antimycotic amphotericin B (AmB) and its liposomal formulation AmBisome belong to the treatment options of invasive aspergillosis caused by . Increasing resistance to AmB in clinical isolates of species is a growing concern, but mechanisms of AmB resistance remain unclear. In this study, we conducted a proteomic analysis of exposed to sublethal concentrations of AmB and AmBisome.

Hyperreflective retinal foci are associated with retinal degeneration after optic neuritis in neuromyelitis optica spectrum disorders and multiple sclerosis.

Background: Hyperreflective retinal foci (HRF) visualized by optical coherence tomography (OCT) potentially represent clusters of microglia. We compared HRF frequencies and their association with retinal neurodegeneration between people with clinically isolated syndrome (pwCIS), multiple sclerosis (pwMS), aquaporin 4-IgG positive neuromyelitis optica spectrum disorder (pwNMOSD), and healthy controls (HC)-as well as between eyes with (ONeyes) and without a history of optic neuritis (ONeyes).

Methods: Cross-sectional data of pwCIS, pwMS, and pwNMOSD with previous ON and HC were acquired at Charité-Universitätsmedizin Berlin.

Efficacy and safety of ibuprofen and naproxen in the treatment of oligoarticular juvenile idiopathic arthritis: bi-national cohort study.

Objectives: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Nonsteroidal anti-inflammatory drugs (NSAIDs) and intra-articular corticosteroid injections are first-line therapy for oligoarticular JIA. NSAIDs Adverse events (AEs) include gastrointestinal ulcers/bleeding and impaired renal function.

Incremental benefit of high dose compared to standard dose influenza vaccine in reducing hospitalizations.

Evidence regarding the high-dose (HD) vaccine's relative vaccine effectiveness (rVE) and absolute benefit in reducing influenza-related hospitalizations compared to the standard-dose (SD) vaccine is warranted. We estimated the adjusted rVE and the number needed to vaccinate (NNV) of the HD vaccine compared to the SD vaccine among Clalit Health Services members aged ≥65 years. Among 418,603 and 393,125 members vaccinated in the 2022-2023 and 2023-2024 influenza seasons, the adjusted rVE was 27% (95% CI: -12% to 61%) for 2022-2023 and 7% (95% CI: -36% to 42%) for 2023-2024, with NNV to prevent one hospitalization event being 2262 (95% CI: 1004 to ∞) and 7662 (95% CI: 1293 to ∞), respectively.

Does Teething Disrupt Infant Sleep? A Longitudinal Auto-Videosomnography Study.

Objective: To examine prospectively the relationship between teething and infant sleep using objective sleep measurements.

Study Design: Over a 4-week period, 849 infants aged 3-18 months (mean = 8.4 ± 1.

How we see the world: Inflexible interpretation updating as a predictor and moderator of PTSD symptoms in high-risk occupations.

Objective: The way we interpret information shapes our perception of reality. Predictive processing frameworks propose that the ability to update interpretations based on disconfirming information is key to recovery from potentially traumatic events (PTEs). However, direct evidence for this assumption is scarce and comes from studies using paradigms with low ecological validity.

Reducing self-stigma among survivors of childhood maltreatment: Randomized controlled trial of a brief video intervention.

Objective: Survivors of childhood maltreatment (CM) often experience self-stigma, the internalization of negative attitudes such as shame, self-blame, and a reluctance to disclose their experiences. These self-perceptions pose a significant barrier to treatment-seeking and may exacerbate psychiatric distress. Prior research indicates that social contact-based interventions are effective in reducing stigma, but no study to date has examined their impact on self-stigma and increasing openness to treatment-seeking among CM survivors.

Odronextamab monotherapy in R/R DLBCL after progression with CAR T-cell therapy: Primary analysis of the ELM-1 study.

Patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) progressing after chimeric antigen receptor T-cell therapy (CAR T) have dismal outcomes. The prespecified post-CAR T expansion cohort of the ELM-1 study investigated the efficacy and safety of odronextamab, a CD20×CD3 bispecific antibody, in patients with disease progression after CAR T. Sixty patients received IV odronextamab weekly for 4 cycles followed by maintenance until progression.

Thymidine Phosphodiester Chemiluminescent Probe for Sensitive and Selective Detection of Ectonucleotide Pyrophosphatase 1.

ENPP-1 is a transmembrane enzyme involved in nucleotide metabolism, and its overexpression is associated with various cancers, making it a potential therapeutic target and biomarker for early tumor diagnosis. Current detection methods for ENPP-1 utilize a colorimetric probe, , which has significant limitations in sensitivity. Here, we present probe , the first nucleic acid-based chemiluminescent probe designed for rapid and highly sensitive detection of ENPP-1 activity.

Long-read structural and epigenetic profiling of a kidney tumor-matched sample with nanopore sequencing and optical genome mapping.

Carcinogenesis often involves significant alterations in the cancer genome, marked by large structural variants (SVs) and copy number variations (CNVs) that are difficult to capture with short-read sequencing. Traditionally, cytogenetic techniques are applied to detect such aberrations, but they are limited in resolution and do not cover features smaller than several hundred kilobases. Optical genome mapping (OGM) and nanopore sequencing [Oxford Nanopore Technologies (ONT)] bridge this resolution gap and offer enhanced performance for cytogenetic applications.

Machine learning-based prediction of disease progression in primary progressive multiple sclerosis.

Primary progressive multiple sclerosis (PPMS) affects 10-15% of multiple sclerosis patients and presents significant variability in the rate of disability progression. Identifying key biological features and patients at higher risk for fast progression is crucial to develop and optimize treatment strategies. Peripheral blood cell transcriptome has the potential to provide valuable information to predict patients' outcomes.

A retrospective cohort study examining the outcomes of patients who present for fertility care and exceed a set body mass index threshold for treatment.

Objective: To evaluate the characteristics of patients who exceeded the body mass index (BMI) threshold for fertility treatment at their initial visit and identify those for whom treatment would be constrained.

Design: Retrospective cohort study.

Setting: Academic medical center.

Heart transplant survival and the use of donors with intracranial bleeding: United Network for Organ Sharing Registry propensity-score matched analysis.

Objective: The transplantation of hearts from donors who experienced intracranial bleeding (ICB) has been associated with inferior long-term survival in both single-center analyses and, more recently, with the United Network for Ogan Sharing Registry. The purpose of this study was to further explore this relationship through propensity score matching in recipients receiving donor hearts from ICB and non-ICB donors in a large national registry.

Methods: We performed a retrospective cohort analysis of the United Network for Organ Sharing Registry Organ Procurement and Transplantation Network between 2006 and 2018 for adult candidates wait-listed for isolated heart transplantation.

Pseudomorphic Transformation in Nanostructured Thiophene-Based Materials.

This study reveals the capability of nanostructured organic materials to undergo pseudomorphic transformations, a ubiquitous phenomenon occurring in the mineral kingdom that involves the replacement of a mineral phase with a new one while retaining the original shape and volume. Specifically, it is demonstrated that the postoxidation process induced by HOF·CHCN on preformed thiophene-based 1D nanostructures preserves their macro/microscopic morphology while remarkably altering their electro-optical properties by forming a new oxygenated phase. Experimental evidence proves that this transformation proceeds via an interface-coupled dissolution-precipitation mechanism, leading to the growth of a porous oxidized shell that varies in thickness with exposure time, enveloping the pristine smooth core.

Coping, meaning in life, and quality of life during ongoing conflict: insights from Israeli populations.

Background: Conducted in May 2024, this study examines the well-being of Israeli evacuees and non-evacuees from conflict zones. We assess health-related quality of life (HRQoL), meaning in life (MIL), coping strategies, psychological symptoms, and self-mastery. Aims include exploring effects of trauma and socio-demographics on HRQoL and MIL, analyzing mediating roles of psychological symptoms and coping, and evaluating if evacuation status moderates these relationships during ongoing conflict.

Safety and efficacy of immune checkpoint inhibitors in patients with pre-treatment reduced left ventricular function.

Aims: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment outcomes. However, the response varies across different populations, and their use may lead to life-threatening cardiovascular (CV) events. While pre-treatment reduced left ventricular ejection fraction (LVEF) is considered a marker for high-risk cardiotoxicity and a contraindication for anthracycline and HER2-targeted therapies, there is limited evidence on the safety and efficacy of ICIs therapy in patients presenting with pre-treatment reduced LVEF.

Modeling and the Use of Surrogate Endpoints: Is This a Valid Approach?

Background: Development of novel colorectal cancer (CRC) screening tests is a dynamic field. Decision analytic modeling based on inputs derived from rigorous prospective studies informs CRC screening guidelines. Exploratory modeling may have a place in early phases of test development.

Impact of thermal exposure on deciduous teeth: A comparative analysis with permanent teeth.

Children are particularly vulnerable to fatalities from fire incidents, and the crucial role of dentition in the identification processes is well known. Despite this, research on burned deciduous teeth is lacking, often assuming similarities with burned permanent teeth, disregarding their morphological and chemical distinctions. This goal of this study was to investigate the effect of burning on deciduous teeth, focusing on post-burning tooth color assessment.

Talquetamab plus Teclistamab in Relapsed or Refractory Multiple Myeloma.

Background: Talquetamab (anti-G protein-coupled receptor family C group 5 member D) and teclistamab (anti-B-cell maturation antigen) are bispecific antibodies that activate T cells by targeting CD3 and that have been approved for the treatment of triple-class-exposed relapsed or refractory multiple myeloma.

Methods: We conducted a phase 1b-2 study of talquetamab plus teclistamab in patients with relapsed or refractory multiple myeloma. In phase 1, we investigated five dose levels in a dose-escalation study.