Endothelial cell surface vimentin binding peptide induces angiogenesis under hypoxic/ischemic conditions.

We have previously identified several angiogenic peptides that bind cell surface proteins by screening a phage display peptide library on human umbilical endothelial cells exposed to hypoxic conditions. In this study we describe one of the selected peptides, SP. We found by protein precipitation of endothelial cell lysates that the 12 amino acid SP peptide binds cell surface vimentin.

Psychiatric and autistic comorbidity in fragile X syndrome across ages.

Fragile X syndrome is caused by CGG trinucleotide repeat expansion within the fragile X mental retardation 1 gene, when repeat number exceeds 200. The typical psychiatric profile of fragile X syndrome patients includes cognitive and behavioral deficits, psychiatric comorbidity, and autistic characteristics. Specific psychiatric features have not yet been clarified, specifically in relationship to age and genetic characteristics.

A Hebrew adaptation of the tinnitus handicap inventory.

Objective: To establish a Hebrew version of the English THI.

Design: The English THI (THI-E) was translated into Hebrew by two bilingual investigators, independently. A third investigator then constructed the final Hebrew THI version (THI-H) from the two translations.

"Inside-out" transobturator tension-free vaginal tape for management of occult stress urinary incontinence in women undergoing pelvic organ prolapse repair.

Objectives: To assess the safety and effectiveness of the "inside-out" transobturator tension-free vaginal tape procedure for the management of occult stress urinary incontinence (SUI) in clinically continent women undergoing prolapse repair.

Methods: A total of 117 consecutive continent women (mean age and parity 66.8 ± 9.

Comparison of safety and efficacy of foam-based versus solution-based ciprofloxacin for acute otitis externa.

Objective: To compare and evaluate the efficacy and safety of a foam-based antibiotic formulation in the treatment of acute otitis externa (AOE) with the more conventional solution-based formulation.

Study Design: Phase 2, open-label, randomized controlled trial.

Setting: Multicenter.

Serum biochemical markers for brain damage in children with emphasis on mild head injury.

Despite the high incidence of mild pediatric head injuries, only within the past few years has there been increased interest and research in this area. This interest began when the findings from research done in adult patients showed that the effects of mild closed head injuries could interfere significantly with higher cognitive functioning, which impacted daily activities and employment. Traumatic brain injury (TBI) often involves a combination of mechanical trauma and local hypoxemia, on which serum biomarker concentrations may provide critical therapeutic data to time the brain injury.

Battery ingestion in children.

Introduction: Ingestion of batteries by children became more frequent in recent years, due to the increasing accessibility of electronic toys and devices to children. Due to their electrochemical composition, impacted batteries in the esophagus may cause an extensive damage. Following the removal of a battery, the post-esophagoscopy management is still controversial.

Luc's abscess: the return of an old fellow.

Objective: Mastoiditis, subperiosteal abscess and sigmoid vein thrombosis are the most common suppurative complications of acute otitis media (AOM). Luc's abscess, a subperiosteal temporal collection, is an infrequent complication with a particularly benign course.

Patients: Two children, aged 5 years, presented with AOM complicated by an atypical abscess deep to the temporalis muscle, with no evidence for mastoid or zygomatic arch involvement.

Laryngocele: a rare long-term complication following neck surgery?

Introduction: Laryngocele is an abnormal dilatation of the laryngeal saccule. Suggested etiologies include congenital enlargement of the saccule, weakness of laryngeal tissues, and increased intralaryngeal pressure. Only a few reports have described the late evolution of laryngocele following neck surgery.

Angiogenic peptides improve blood flow and promote capillary growth in a diabetic and ischaemic mouse model.

Objectives: It is a common clinical observation that collateral vessel development is impaired in diabetic patients with ischaemic vascular diseases. Consequently, alternative revascularisation strategies in diabetic patients are needed. This study presents the effect and mechanism of new peptide therapeutic angiogenesis in an ischaemic and diabetic mouse model.

Changing trends of peritonsillar abscess.

Objective: This retrospective, cohort study aims to assess the changing characteristics of peritonsillar abscess (PTA).

Method: Data were obtained from PTA patient records admitted to a secondary hospital over a 10-year period.

Results: A total of 427 patients, aged 31.

Major upper extremity replantations.

The usual mechanism of a major amputation creates a mutilating injury. Although survival rate is high, the functional results are guarded [1, 2]. The aim of this study is to review our experience with major upper extremity replantations performed between the years 1987-2007 with respect to the type of amputation as proposed by Chuang et al.

Laryngeal cancer in acquired immunodeficiency syndrome.

With improved survival, more AIDS patients, especially heavy smokers and alcohol abusers, may be confronted with laryngeal squamous cell carcinoma. Since curative treatment may require aggressive combined therapy, these patients, often suffering from immunosupression and poor general condition, present unique therapeutic challenges. The objective of the study was to describe treatment dilemmas.

Revisiting benign paroxysmal positional vertigo pathophysiology.

Benign paroxysmal positional vertigo is the most common peripheral cause of vertigo. Although its pathophysiologic mechanisms remain unclear, different locations have been attributed throughout the last century, from the days of Bárány. Disease was initially located by Dix and Hallpike in the utricle, but later, Schuknecht's works elicited the cupulolithiasis and canalolithiasis theories, localizing the pathology to the semicircular canal system and mainly to the posterior one.

Pain reduction using transcranial electrostimulation: a double blind "active placebo" controlled trial.

Objective: To examine the efficacy of transcranial electrical stimulation a non-invasive method of reducing pain.

Design: A randomized, double-blind, placebo-controlled trial.

Subjects: A total of 119 patients with chronic pain.

Nasopharyngeal cysts.

Introduction: Nasopharyngeal cysts are uncommon, and are mostly asymptomatic. However, these lesions are infrequently found during routine endoscopies and imaging studies. In even more rare cases, they may be the source for unexplained sinonasal symptoms, such as CSF rhinorrhea, visual disturbances and nasal obstruction.

Foreign bodies in pleura and chest wall.

Background: In contrast to other locations, foreign bodies in pleura and chest wall have been rarely reported and there is no consensus with regard to treatment.

Methods: Between 1971 and 2001, 22 patients with foreign bodies in pleura or chest wall were admitted to our department. Their charts were reviewed for preoperative diagnosis, history, kind and location of the foreign bodies, length of retention, management of patients, and complications.

Acute myocardial infarction associated with pregnancy.

Acute myocardial infarction (AMI) during pregnancy or the early post-partum period is rare but has been shown to be associated with poor maternal as well as fetal outcome. Major changes in both diagnosis and treatment of AMI in the nonpregnant patient have lead to improved outcome which may also affect pregnant patients. The purpose of this paper is to review available information related to the pathophysiology and clinical profile and provide recommendations for the diagnosis and management of AMI occuring during pregnancy and the early post-partum period.

Does the portal of entry determine our view? Interfaces between dyadic and three-way assessment of a clinical family transitioning to parenthood.

The purpose of this interface was to explore the influences of dyadic and three-way observation on clinical assessment of young families. Three independent clinicians observed a clinically referred family using semistructured play paradigms, each with only a limited view of the family. One had only the data on dyadic interactions, the second only had data on the family triad, and the third observed both the dyads and the triad.

Integration of a palliative and terminal care center into a comprehensive pediatric oncology department.

Background: The sharp division between curative cancer therapy and palliative care results in the late introduction of palliative care and a high incidence of suffering in children with cancer. We established a Palliative Care Unit (PCU) that is fully integrated with the Pediatric Hematology Oncology Department (PHOD). We wished to explore the impact of such integrative model on patterns of hospitalizations and exposure to palliative care of pediatric oncology patients.