Highly Chemoselective Zn -Catalyzed Hydrosilylation of Alkynes.

Hydrosilylation of C=C double and C≡C triple bonds is one of the most widely used processes in organosilicon chemistry, mostly catalyzed by Pt-based complexes. Herein, the synthesis of a dicationic Zn -based complex with a tripodal tris(2-pyridylmethyl)amine (TPA) ligand is reported which was found to be a highly chemoselective catalyst for hydrosilylation reactions of alkynes. Mechanistic studies revealed that unlike typical Zn-catalyzed hydrosilylation reactions where the key step is the activation of the Si-H bond, this system catalyzes the hydrosilylation reaction through the activation of C≡C triple bonds, which presumably is the reason for its high chemoselectivity.

Dual Reactivity of a Geometrically Constrained Phosphenium Cation.

A geometrically constrained phosphenium cation in bis(pyrrolyl)pyridine based NNN pincer type ligand (1 ) was synthesized, isolated and its preliminary reactivity was studied with small molecules. 1 reacts with MeOH and Et NH, activating the O-H and N-H bonds via a P-center/ligand assisted path. The reaction of 1 with one equiv.

Geometrically constrained square pyramidal phosphoranide.

Geometrical constriction of main group elements leading to a change in the reactivity of these main group centers has recently become an important tool in main group chemistry. A lot of focus on using this modern method is dedicated to group 15 elements and especially to phosphorus. In this work, we present the synthesis, isolation and preliminary reactivity study of the geometrically constrained, square pyramidal (SP) phosphoranide anion (1).

Thermodynamic uncertainty relations for many-body systems with fast jump rates and large occupancies.

A universal large N theory of nonequilibrium fluctuations emerges in the limit of fast jump rates and large occupancies. We use this theory to derive a set of coarse-grained thermodynamic uncertainty relations-one of them being an activity bound. Importantly, the activity serves as a tighter bound for the entropy production in 1D systems.

Clostridium difficile infection in hospitalized patients with inflammatory bowel disease: Prevalence, risk factors, and prognosis.

To evaluate the frequency, possible risk factors, and outcome of Clostridium difficile infection (CDI) in inflammatory bowel disease (IBD) patients.There has been an upsurge of CDI in patients with IBD who has been associated with increased morbidity and mortality. Various risk factors have been found to predispose IBD patients to CDI.

Risk of Colectomy in Patients With Pediatric-onset Ulcerative Colitis.

Objectives: Data describing the incidence and risk factors for colectomy in pediatric ulcerative colitis (UC) is inconsistent. Our aim was to describe the colectomy rate and to identify risk factors associated with colectomy in a large cohort of children with UC with long-term follow-up.

Materials And Methods: We performed a retrospective chart review of pediatric UC cases that were diagnosed at Schneider Children's Medical Center of Israel between 1981 and 2013.

Clinical Implications for Children Born With Congenital Cytomegalovirus Infection Following a Negative Amniocentesis.

Background: Recently, congenital cytomegalovirus (cCMV) infection was reported irrespective of a negative amniotic fluid prenatal analysis for cytomegalovirus (CMV). The question of whether this phenomenon represents low sensitivity of the test or late development of fetal infection (after amniocentesis) was discussed, but not answered. However, if late transmission is the rule, then infants born with cCMV after negative amniocentesis would be expected to carry better prognosis than those who tested positive.

Efficacy of rasagiline in patients with the parkinsonian variant of multiple system atrophy: a randomised, placebo-controlled trial.

Background: Multiple system atrophy is a complex neurodegenerative disorder for which no effective treatment exists. We aimed to assess the effect of rasagiline on symptoms and progression of the parkinsonian variant of multiple system atrophy.

Methods: We did this randomised, double-blind, placebo-controlled trial between Dec 15, 2009, and Oct 20, 2011, at 40 academic sites specialised in the care of patients with multiple systemic atrophy across 12 countries.

Persistence of Klebsiella pneumoniae ST258 as the predominant clone of carbapenemase-producing Enterobacteriaceae in post-acute-care hospitals in Israel, 2008-13.

Objectives: To study the molecular characteristics of carbapenemase-producing Enterobacteriaceae (CPE) in post-acute-care hospitals (PACHs) in Israel and to analyse the temporal changes between 2008 and 2013.

Methods: CPE isolates were obtained during two cross-sectional, point prevalence national surveys of PACHs in Israel performed in 2008 and 2013. Surveillance cultures were collected by streaking rectal swabs onto selective media.

[A forgotten eponym: the Mackiewicz sign].

In 1913, Dr. Jacob Mackiewicz, a Polish-Jewish neurologist, described a clinical sign (a maneuver) which indicates a femoral nerve injury or L4 root injury. He called it the "cruralis phenomenon", but in the German and Slavic literature, the sign is named after him: "the patient lies prone, the examiner lifts the thigh in one hand, with the other hand, bends the patient's knee slowly; this maneuver causes severe pain in the anterior part of the thigh and over the groin".

[Inhibition of lectin induced peripheral blood lymphocyte proliferation by colorectal cancer extract: a preliminary report of three cases].

Background: Tumor infiltrating lymphocytes (TIL) in colorectal cancer are a manifestation of local, cell mediated immune response to the malignant tumor. Tumor progression is due to impairment of the host ability to control tumor growth. Several studies suggested possible causes for such impairment, however, the precise factor(s) underlying such malfunction is uncertain.

The effect of hyperthermia (42.5 degrees C) on zymosan-induced synovitis of the knee.

Though heat has been used for many years for the treatment of painful joints such therapy rarely increases the intra-articular temperature significantly. This pilot study investigated the effect of intra-articular hyperthermia induced by microwaves from a combined heating/cooling instrument on zymosan-induced synovitis in the rabbit. There was histological evidence not only of a reduction in the intensity of the inflammatory response but also in its type with the absence of giant cell formation.