3,050 results match your criteria: "Tel Aviv Medical Center[Affiliation]"

Anti-amyloid treatments for Alzheimer's disease: A study on physicians' perspectives.

J Alzheimers Dis

December 2024

Cognitive Neurology Unit, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel.

Advances in amyloid targeting therapies (ATT) for Alzheimer's disease have introduced new options, necessitating an understanding of physicians' perspectives as these therapies move from trials to practice. A survey of Israeli specialists found that 84% were familiar with new ATT, but 60% raised doubts about their ability to significantly impact disease progression. Neurologists were more likely to recommend these treatments, but concerns included treatment costs and limited real-world experience.

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Objective: This study investigates persistent physical and neuropsychiatric symptoms in Long COVID, focusing on their severity and assessing risk/resilience factors, including conscientiousness and neuroticism. The study utilizes a mediation model to explore the potential role of psychological distress in mediating its impact on cognitive decline.

Methods: In an online survey, 114 participants diagnosed with Long COVID completed assessments, including the Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) for psychological distress, Subjective Cognitive Decline (SCD) questionnaire for cognitive decline, Pittsburgh Sleep Quality Index (PSQI) for sleep disorders, and Multidimensional Scale of Perceived Social Support (MSPSS) with "BIG-5 inventory" subscales for risk/resilience factors.

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Background: The prevalence and impact of right ventricular dysfunction (RVD) in degenerative mitral regurgitation (DMR) is unknown. We aimed to determine whether RVD assessed by echocardiography in routine clinical practice is independently associated with mortality in patients with DMR.

Methods And Results: We used data from the MIDA-Q (Mitral Regurgitation International DAtabase-Quantitative) registry, which included patients with isolated DMR due to mitral valve prolapse from January 2003 to January 2020 from 5 tertiary centers across North America, Europe, and the Middle East.

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For patients undergoing abdominal surgery, postoperative pulmonary complications (PPCs) are a major source of morbidity and mortality. The use of point-of-care ultrasonography (POCUS), and specifically POCUS of the lungs, has seen many advancements in recent years. We hypothesize that perioperative lung ultrasonography can be used as a predictor for PPCs.

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Purpose: Missense de novo variants in CACNA1G, which encodes the Cav3.1 T-type calcium channel, have been associated with a severe, early-onset form of cerebellar disorder with neurodevelopmental deficits (SCA42ND). We explored a large series of pediatric cases carrying heterozygous variants in CACNA1G to further characterize genotype-phenotype correlations in SCA42ND.

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Introduction: Neovascular age-related macular degeneration is a global public-health concern, associated with a considerable burden to individuals, healthcare systems, and society. The objective of this study was to understand different perspectives on the challenges associated with the clinical management of neovascular age-related macular degeneration, which could elucidate measures to comprehensively improve clinical care and outcomes.

Methods: A survey was carried out of patients with neovascular age-related macular degeneration, their providers, and clinic staff in 77 clinics across 24 countries on six continents, from a diverse range of healthcare systems, settings, and reimbursement models.

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Introduction: In contrast with patients receiving therapy for retinal disease during clinical trials, those treated in routine clinical practice experience various challenges (including administrative, clinic, social, and patient-related factors) that can often result in high patient and clinic burden, and contribute to suboptimal visual outcomes. The objective of this study was to understand the challenges associated with clinical management of diabetic macular edema from the perspectives of patients, healthcare providers, and clinic staff, and identify opportunities to improve eye care for people with diabetes.

Methods: We conducted a survey of patients with diabetic macular edema, providers, and clinic staff in 78 clinics across 24 countries on six continents, representing a diverse range of individuals, healthcare systems, settings, and reimbursement models.

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Introduction: Spinal cord arteriovenous malformations (SCAVM) are rare congenital vascular malformations, characterized by two or more AVMs affecting any of the spinal segments. SCAVM has complex pathophysiology and may be associated with acute, or progressively neurological deficits.

Case Presentation: A 12-year old girl, presented with progressive neurologic deficits secondary to compressive cervical myelopathy due to a cervical metameric SCAVM.

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Purpose: The use of anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CART) therapy for AL amyloidosis (AL) is limited owing to patient frailty. HBI0101 anti-BCMA CART was the first proof of concept for its applicability to AL. This report addresses the AL patient cohort treated to date within the phase Ia/Ib clinical trial (ClinicalTrials.

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Hypersensitivity pneumonitis radiologic features in interstitial lung diseases.

Respir Med

December 2024

Center of Excellence for Interstitial Lung Diseases, Tel Aviv Medical Center, Tel Aviv University, Israel; Institute of Pulmonary Medicine, Tel Aviv Medical Center, Tel Aviv University, Israel. Electronic address:

Article Synopsis
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Objectives: We aimed to study the disease course, outcomes, and predictors of outcome in pediatric-onset anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affecting the kidneys.

Methods: Patients eligible for this study had a diagnosis of granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), or ANCA positive pauci-immune glomerulonephritis, were ≤ 18 years at diagnosis, had renal disease defined by biopsy or dialysis dependence, and had clinical data at diagnosis and either 12- or 24-months. Ambispective data from the ARChiVE/PedVas Registry was used.

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Introduction: It has been reported that approximately 80-90% of apical prolapse repair is through reconstructive or obliterative vaginal surgery. Although several procedures have been described, to date there is a lack of consensus on the best surgical procedure. The aim of this study was to perform a thorough review of the current literature on the efficacy and safety of the iliococcygeus fixation technique for the treatment of vaginal vault prolapse.

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The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson's Disease.

Int J Mol Sci

November 2024

Movement Disorders Center, Neurological Institute, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.

Parkinson's disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted the need for a multi-target DMT approach in PD that recognizes the various risk factors and their intricate interplay in contributing to PD-related neurodegeneration. Widespread risk factors, such as emotional stress and metabolic factors, have increasingly become focal points of exploration.

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Response to commentary re parental regret following decision for sons to undergo elective post-neonatal circumcision.

J Pediatr Urol

November 2024

Department of Pediatric Urology, Dana-Dwek Children's Hospital, Tel-Aviv Medical Center, Tel-Aviv, Israel; School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

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Parkinson's Disease is a progressive neurodegenerative disorder afflicting almost 12 million people. Increased understanding of its complex and heterogenous disease pathology, etiology and symptom manifestations has resulted in the need to design, capture and interrogate substantial clinical datasets. Herein we advocate how advances in the deployment of artificial intelligence models for Federated Data Analysis and Federated Learning can help spearhead coordinated and sustainable approaches to address this grand challenge.

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Patient Perspectives on Upper-Limb Daily Function in Parkinson's Disease.

Mov Disord Clin Pract

November 2024

Occupational Therapy Department, Faculty of Social Welfare & Health Sciences, University of Haifa, Haifa, Israel.

Background: Dexterity impairments are common among people with Parkinson's disease (PWP), yet little is understood about the effect of upper-limb (UL) dysfunction on daily activity performance.

Objectives: The aims were to (1) map the dexterity activities most affected and meaningful to PWP; (2) explore the associations between perceived dexterity function and disease severity, cognitive and motor UL impairments, dexterity ability, self-reported activities of daily living (ADL) function, and quality of life (QOL); (3) investigate variables explaining perceived dexterity function; and (4) examine the differences in perceived dexterity function based on dominance affectedness.

Methods: A total of 43 PWP (mean age = 70.

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West Nile virus encephalitis: Clinical characteristics and a comparison to other infectious encephalitides.

J Neurol Sci

December 2024

Department of Neurology, Tel Aviv Medical Center, Tel Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Encephalitis Center, Tel Aviv Medical Center, Tel Aviv, Israel.

Article Synopsis
  • The study aimed to compare the functional outcomes of adults with acute infectious encephalitis, focusing on West Nile virus encephalitis (WNVE) compared to other types such as VZV and HSV1.
  • A total of 105 patients were analyzed, revealing that WNVE and VZV patients were generally older and had worse clinical outcomes at discharge compared to HSV1 patients.
  • Notably, WNVE exhibited a pronounced inflammatory response, and the findings suggest a prevalence of WNVE and VZV over HSV1, highlighting the need for further research on West Nile virus infections.
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Innovative 3-Dimensional Imaging in Preoperative Evaluation for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer-A Pilot Study.

J Obstet Gynaecol Can

November 2024

Department of Gynecologic Oncology, Lis Hospital for Women, Tel Aviv Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: The efficacy of secondary cytoreductive surgery (SCS) in recurrent ovarian cancer remains controversial, necessitating meticulous preoperative planning. While three-dimensional (3D) imaging has transformed surgical approaches in various disciplines, its application in gynaecologic oncology is nascent. This study introduces a novel investigation employing preoperative 3D modelling in SCS preparation.

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The impact of body mass index on the risk of postoperative complications following myomectomy.

Am J Obstet Gynecol

November 2024

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA.

Article Synopsis
  • * This research aimed to investigate the link between BMI and short-term postoperative complications following myomectomy, analyzing data from the American College of Surgeons database from 2012 to 2020 and excluding vaginal myomectomy cases.
  • * The study found that 11.4% of the 27,387 patients experienced complications, with rates varying by BMI category, where patients with obesity class 1 had fewer major complications, while those in obesity class 2 and 3 had more complications compared to
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