Knockdown of miR-182 changes the sensitivity of triple-negative breast cancer cells to cisplatin.

Breast cancer is the most common malignancy that affects women. MicroRNAs (miRNAs) play an essential role in cancer therapy and regulate many biological processes such as cisplatin resistance. The study's objective was to determine whether miR-182 dysregulation was the cause of cisplatin resistance in TNBC cell line MDA-MB-231.

Evaluation of as a Feed Additive in Low-Protein Diets of Broilers.

is a natural antioxidant product that has the ability to improve the performance of poultry. Therefore, the present study aimed to evaluate the effect of using as a feed additive in broiler diets. A total of 252 daily male Ross 308 chicks were randomly assigned to six groups.

Evaluation of medicine use behaviors of adult patients in a rural area: A cross-sectional study from Turkey.

Background/purpose: This study aimed to determine the medicine usage behaviors of patients (>65 years) registered to the family health care center (FHCC) in a rural area.

Methods: This cross-sectional and descriptive study was performed on 224 geriatric patients admitted to the FHCC in Terme town of Samsun between January 2018 and March 2018. The questionnaire consisting of 29 questions about sociodemographic characteristics, knowledge of drugs, and usage habits was applied to the participants by using the face-to-face interview technique.

Effects of the Dietary Blue-Green Algae (Spirulina platensis) Supplementation and Egg Storage Period on Egg Quality Traits, Blastoderm Characteristics and Hatching Results of Mast Geese (Anser anser).

This study aimed to determine the effects of the dietary Spirulina platensis supplementation and egg storage period on egg quality traits, blastoderm characteristics and hatching results of Mast geese. For this purpose, the control group was fed the standard enterprise diet, while the experimental group received the same diet supplemented with 0.5% S.

Anatomy education in transition: examining medical student experiences during the distance education.

Background: Distance education emerged as a potential solution to enhance access, standardize content, and facilitate updates. However, student perceptions varied widely. The COVID-19 pandemic prompted a rapid shift towards distance education in anatomy, presenting challenges and opportunities for medical students globally.

Diagnosis of approximal caries in children with convolutional neural networks based detection algorithms on radiographs: A pilot study.

Objectives: Approximal caries diagnosis in children is difficult, and artificial intelligence-based research in pediatric dentistry is scarce. To create a convolutional neural network (CNN)-based diagnostic system for the prompt and efficient identification of approximal caries in pediatric patients aged 5-12 years.

Materials And Methods: Pediatric patients' digital periapical radiographic images were collected to create a unique dataset.

Can we predict postoperative fever and urinary tract ınfection after retrograde ıntrarenal surgery? Results of a case control matching multicentric RIRSearch study group.

Purpose: Postoperative fever (POF)/urinary tract infection (UTI) is one of the most unpleasant and undesirable conditions for surgeons after retrograde intrarenal surgery (RIRS). RIRS is not recommended for any patient with a positive urine culture to avoid POF and UTI, but some patients may develop postoperative UTI even if the urine culture is sterile. This study investigated the predictive factors of fever and UTIs after RIRS.

Thalamo-insular cortex connections in the rat and human.

The insular cortex (ICx) has a role in large a variety of functions. Thalamus plays an important role in modulating cortical functions. The present study aims to show thalamic-ICx connections using the fluoro-gold (FG) tracing method in rats and diffusion tensoring-based tractography (DTI) in humans.

Implementation of written asthma action plan among asthma patients in Türkiye: a multicenter, cross-sectional, descriptive study.

Background/aim: There is currently no data from Türkiye on whether, following a diagnosis of asthma, patients are given an asthma action plan to implement. There is also no data on whether patients can manage their treatment based on the provided asthma action plans. The present study aimed to determine the use of asthma action plans in Türkiye and the awareness levels of patients about these plans.

Composition, microstructure, rheology, and meltdown behavior of commercial nondairy frozen desserts.

The demand for nondairy and plant-based products has increased, but there is still a need for more information about and improvement in these products, especially when it comes to frozen desserts. Similar to ice cream, which simultaneously is an emulsion, dispersion, and foam, nondairy frozen desserts also have a complex structure. As a starting point, 15 commercial nondairy frozen desserts, marketed as offering an ice cream-like experience, were purchased and evaluated for compositional, physical, structural, rheological, and meltdown properties.

Drug-refractory irritability and related factors in autistic children.

Objectives: Autistic children frequently exhibit irritability, which can manifest as aggression, self-injurious behaviour, and severe tantrums, leading to significant impairments. Two atypical antipsychotics have been licensed by the Food and Drug Administration for the treatment of irritability in autistic children, although a significant percentage of these children do not respond to this treatment. This study aimed to determine the frequency of drug refractory irritability (DRI) and identify the risk factors in a large clinical sample of autistic children.

Simplifying complexity: the novel degradation index for urban stream landscapes-case of Tekirdag.

This study aims to examine the degradation process of urban stream landscapes in Tekirdağ by utilizing a newly developed degradation index (DI) that effectively defines degradation. The DI considers the vital factors that affect urban stream landscapes, making it possible to determine the level of degradation and resulting environmental quality. This index aims to provide valuable insight into the degradation of urban stream landscapes with a minimal amount of independent variables and training samples.

In Silico and In Vitro Verification of the Effects of Chemotherapeutic Doxorubicin and 5-Fluorouracil in Combination With Curcumin and Vitamin C on MCF-7 Cells.

Breast cancer ranks among the most prevalent cancers. Enhancing the effectiveness of chemotherapy and patient survival is the objective of many studies. In the literature, no study has investigated the combined effect of vitamin c and curcumin with chemotherapy drugs on cell viability in the MCF-7 cell line, nor the mechanism of inflammation induced by cancer drugs, both in vitro and in silico.

Which is a Better Predictor for the Safety and Efficacy of Retrograde Intrarenal Surgery; Stone Size or Volume? A Study of RIRsearch Study Group.

To compare the predictive effects of stone size and volume on the efficacy and safety of retrograde intrarenal surgery (RIRS) and to determine the cutoff values of stone volume for prediction of RIRS efficacy and safety. Patients who underwent RIRS between 2017 and 2021 in six referral centers were retrospectively included in the study. The database of the RIRsearch group, which was formed prospectively, was used for this retrospective analysis.

Does COVID-19 reduce anti-Mullerian hormone levels in women of reproductive age in late periods of infection?

Objective: The question of whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection influences ovarian function and oocyte quality has arisen as angiotensin converting enzyme-2 receptors, which facilitates viral infection, are found on reproductive system tissues, including the vagina, placenta, uterus, and ovaries. The primary objective of this prospective study was to evaluate the impact of SARS-CoV-2, on ovarian function, with a focus on anti-Mullerian hormone (AMH) and acute phase reactant levels in patients well after recovery from coronavirus disease-2019 (COVID-19).

Material And Methods: This prospective cohort study was conducted in the department of obstetrics and gynecology at a single center between October 2020 and June 2021.

A revision of Anadolua (Orthoptera: Tettigoniidae: Tettigoniinae) based on morphological and bioacoustic characters: Newly confirmed data suggesting a new synonym and two new species.

In the present paper, a number of twelve populations of genus Anadolua have been studied by focusing on their morphological and bioacoustic characters. Both bioacoustics and morphological CDF analyses (especially in males) indicate the existence of two new species (A. bergeri sp.

Chocolate microstructure: A comprehensive review.

Chocolate is a food with complex microstructure properties. In this study, chocolate surface and internal microstructures are discussed considering final product quality and stability. In addition, the effects of the solids and continuous phase components and the interactions between them, and also process effects on the microstructure were reviewed.

Investigation of Electromagnetic Wave Propagation in Photonic-like Welded Materials Using the Finite Element Method.

In this study, two identical and two dissimilar materials are conjoined by applying the friction welding method to yield various rods. This investigation's primary focus entails examining the repercussions associated with the heat-affected zone (HAZ) arising from elevated temperatures at the welding interfaces on the propagation of electromagnetic (EM) waves within the resultant structures. The study incorporates the photonic crystal approach in conjunction with Maxwell's equations, and the subsequent solution of the latter is executed using the finite element method.

Morphometric analysis and tortuosity typing of the large intestine segments on computed tomography colonography with artificial intelligence.

Background: Morphological properties such as length and tortuosity of the large intestine segments play important roles, especially in interventional procedures like colonoscopy.

Objective: Using computed tomography (CT) colonoscopy images, this study aimed to examine the morphological features of the colon's anatomical sections and investigate the relationship of these sections with each other or with age groups. The shapes of the transverse colon were analyzed using artificial intelligence.

The effects of structured coordinative exercise protocol on physical fitness, motor competence and inhibitory control in preschool children.

The aim of the study was to evaluate the effects of a structured coordinative exercise intervention based on motor skill elements on physical fitness (PF), motor competence (MC) and inhibitory control (IC) in preschool children. A total of 41 kindergarten children (27 boys and 17 girls) aged between 5 and 6 years participated and were divided into exercise (EG; n = 18) and control (CG; n = 23) groups. The exercise group participated in a structured coordinative exercise programme focusing on locomotor and balance skills such as side-stepping, galloping, jumping and running for 30 min, 2 days a week for 8 weeks.

Evaluation of Mortality Statistics in Turkey from 2017 to 2022: An Analysis of the Impact of COVID-19.

Background: Examining death statistics at regular intervals is highly useful for assessing public health. This study aimed to analyze cause-specific mortality statistics, to ascertain their distribution over the years, and to offer remedial solutions to enhance public health outcomes.

Methods: In this retrospective descriptive study, an analysis was conducted on data sourced from the "Death and Cause of Death Statistics" provided by the Turkish Statistical Institute between 2017 and 2022.

The Impact of Human-Animal Interaction on Animal Welfare and Owners' Job Performance: A Study on Cats, Dogs and Birds.

Human-Animal Interaction (HAI) has been significant since ancient times, initially with animals, especially dogs, assisting in hunting and food gathering. Over time, this relationship evolved into domestication, companionship, and therapeutic roles in society. In urban areas, pet ownership is widespread, driven by companionship, therapeutic benefits, and social status.