459 results match your criteria: "Tehran University of Medical Sciences AND Iranian Center of Neurological Research[Affiliation]"

Purpose: Transcranial magnetic stimulation (TMS) has emerged as a promising treatment for various neuropsychiatric conditions, including depression, obsessive-compulsive disorder, and Parkinson's disease. Recent research has focused on evaluating its effectiveness in treating patients with anorexia nervosa (AN). This systematic review and meta-analysis examined the impact of TMS on patients with AN and evaluated any potential adverse effects.

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Stereotactic radiosurgery (SRS) and radiotherapy (SRT) have gained prominence as both adjuvant and primary treatment options for patients with skull base tumors that are either inoperable or present as residual or recurrent lesions post-surgery. The object of the current study is to evaluate the safety and efficacy of robotic-assisted SRS and SRT across various skull base pathologies. The study was conducted under PRISMA guidelines and involved a comprehensive evaluation of databases, including PubMed, Scopus, Embase, Web-of-Science, and the Cochrane Library.

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Antithrombin III deficiency and idiopathic intracranial hypertension: a case report.

J Med Case Rep

January 2025

Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Idiopathic intracranial hypertension (IIH) is a condition where the pressure of the cerebrospinal fluid in the brain increases without a known cause. It typically affects adults but can also occur in adolescents and children, although it is less common. Numerous elements, including coagulopathy, have been documented in previous cases as potential etiological factors of IIH.

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Carpal tunnel syndrome (CTS) is a common peripheral nerve entrapment disorder that is diagnosed using clinical signs and symptoms and confirmed via nerve conduction studies (NCSs). While NCS is a semi-invasive procedure, magnetic resonance imaging (MRI) is a non-invasive diagnostic tool that detects macroscopic nerve abnormalities and evaluates a patient's surgical or medication treatment options. This study assessed magnetic resonance neurography (MRN)'s diagnostic and grading value by comparing it to electrodiagnostic studies in patients with CTS and healthy individuals.

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Stress has been known as a risk factor for the onset and modification of autoimmune disorders such as myasthenia gravis (MG). However, the patients can control their stress and improve their quality of life (QOL) using some factors such as psychological and social support. Psychological capital and social support play a key role in decreasing stress and improving QOL in the patients with MG.

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Mirror aneurysms are rare and pose therapeutic challenges, with both endovascular and microsurgical options available. Single-stage and two-stage procedures are employed, but the optimal strategy remains unclear. This systematic review and meta-analysis evaluate the efficacy and safety of different therapeutic strategies for managing mirror aneurysms.

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Hemifacial spasm (HFS) is an important condition for plastic surgeons to understand, as it significantly affects patients' quality of life and can complicate aesthetic and reconstructive procedures. Magnetic resonance imaging (MRI) has become vital in diagnosing HFS, assessing neurovascular relationships, and planning treatment. Transverse MRI scans often show an upward displacement of the inferior pons at the facial nerve attachment point, signaling neurovascular compression (NVC) in HFS.

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Article Synopsis
  • Ocular ptosis is the drooping of the upper eyelid, and it can result from various causes, including both neurological and non-neurological issues.
  • Commonly seen in the elderly, aponeurotic ptosis arises from age-related changes, while younger individuals may experience drooping from trauma or mechanical factors.
  • Treatment choices vary by cause, with options ranging from medications to surgery, particularly for patients with myasthenia gravis, an autoimmune condition that can lead to significant lid drooping.
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Background: Traumatic brain injury (TBI) is a major cause of global mortality and disability, leading to primary and secondary brain injuries that can result in severe neurological, cognitive, and psychological impairments. Accurate and early prognosis of TBI outcomes is critical, particularly in assessing the risk of neurological decline, intracranial pressure (ICP) changes, and mortality.

Objective: This systematic review aims to evaluate the prognostic value of quantitative pupillometry, particularly the Neurological Pupil Index (NPi), in predicting long-term outcomes in TBI patients.

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Introduction: Memory impairment is a critical challenge in neurodegenerative disorders, particularly in Alzheimer's disease, Parkinson's disease, and age-related cognitive decline. This research explores the molecular mechanisms by which curcumin, a polyphenolic compound derived from Curcuma longa, exerts neuroprotective effects that may ameliorate cognitive deficits associated with these conditions.

Results And Conclusion: Evidence from both preclinical studies and emerging clinical trials indicates that curcumin enhances neuronal signaling and synaptic plasticity, primarily through the modulation of pathways such as NF-κB and PI3K/Akt.

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Article Synopsis
  • * In the study, 689 participants were categorized into three groups based on migraine resistance, with significant differences in the number and type of comorbidities found among them.
  • * The findings suggest that higher comorbidity rates may contribute to the worsening of migraines, potentially making them harder to treat over time.
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Background: Migraine is an important disease due to its impact on global health. Due to association of neck pain with migraine, manual therapy (MT) often used in management. The aim of this study was to evaluate the effects of upper cervical spine MT on specific mechanisms including central sensitization (CS) and brainstem auditory evoked potentials (BAEPs) in subjects with migraine and neck pain.

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In the context of drug-resistant epilepsy, deep brain stimulation (DBS) has received FDA approval. However, there have been reports of potential adverse effects, such as depression and memory impairment associated with DBS.This systematic review and meta-analysis aimed to investigate the impact of DBS on the quality of life (QoL), and seizure frequency of patients who had DRE, and assess its potential adverse events.

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Background: Pyridoxamine 5'-phosphate oxidase deficiency is a rare inborn error of vitamin B metabolism that presents with drug-resistant epileptic seizures. However, the condition is responsive to supplementation with the active vitamin B metabolite pyridoxal 5'-phosphate and, in some cases, pyridoxine.

Case Presentation: In this case report, a 10-year-old Iranian male of Fars ethnicity came to a regional hospital in Tehran, Iran with a chief complaint of tic-like movement.

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Acetyl-11-keto-β-boswellic acid is one of the main active components of Boswellia sp. resin with the most potent anti-inflammatory activity. In recent years, herbal therapy has received considerable attention for the treatments of inflammatory and demyelinating diseases such as Multiple sclerosis (MS).

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Article Synopsis
  • Bladder cancer is a major public health issue in Iran, with a study analyzing data from 2006 to 2015 revealing a modest rise in incidence rates, particularly among older populations.
  • The study identified 51,379 cases, predominantly in males (81.97%), with urothelial cell carcinoma being the most common subtype, while squamous cell carcinoma showed a decline in incidence.
  • Findings highlight a significant male predominance (approximately 4.5:1 ratio) and suggest further investigation is needed to understand the rising trends and associated risk factors for bladder cancer.
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  • - Multiple sclerosis is a serious condition, and the study compared the efficacy and safety of a biosimilar drug called Xacrel to the original drug, Ocrevus, in patients with Relapsing Multiple Sclerosis (RMS) over 96 weeks.
  • - The main goal was to see if both drugs had similar effects on reducing annual relapse rates (ARR) at 48 weeks, while also assessing other factors like disability progression, MRI results, and safety.
  • - Results showed that Xacrel was equivalent to Ocrevus in reducing ARR, with no significant differences in efficacy or safety observed during the trial, confirming Xacrel as a viable alternative to Ocrevus.
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CSF and blood levels of Neurofilaments, T-Tau, P-Tau, and Abeta-42 in amyotrophic lateral sclerosis: a systematic review and meta-analysis.

J Transl Med

October 2024

Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Recent literature suggests that markers of neuroaxonal damage, such as neurofilaments and tau protein, might serve as potential biomarkers for ALS. We conducted this systematic review and meta-analysis study to compare cerebrospinal fluid (CSF) and blood levels of total tau (t-tau), phosphorylated tau (p-tau), amyloid beta peptide 42 (Abeta-42), and neurofilaments in ALS patients and controls. A systematic search of Cochrane Library, PubMed, Embase, and ISI Web of Science was conducted on March 18, 2022, and updated on January 26, 2023.

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Article Synopsis
  • Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young people, and there are few cases reported of demyelinating events after COVID-19 vaccination.
  • In a study, 8 out of 338 newly diagnosed MS patients experienced their first symptoms within 6 weeks post-Sinopharm vaccine, with an average onset of 2 weeks.
  • All patients were found to have demyelinating lesions on MRI and were treated with medications like intravenous steroids and Rituximab; however, more comprehensive studies are necessary to better understand the relationship between the vaccine and MS onset.
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  • Isaacs' syndrome is a rare condition that causes persistent muscle activity, leading to symptoms like twitching, stiffness, and cramps, and is associated with peripheral nerve hyperexcitability.
  • A study involving 12 patients examined their clinical signs, diagnostic tests, antibody presence (like LGI1 and CASPR2), and the search for related cancers, which ultimately returned inconclusive results.
  • The patients responded well to treatments like carbamazepine or gabapentin, along with immunotherapies, resulting in full recovery within 3-6 months.
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  • COVID-19 has been linked to an increase in mucormycosis and subsequently septic cavernous sinus thrombosis, prompting a study on the effects of anticoagulation (AC) in patients with COVID-related complications.
  • In this retrospective study involving 29 patients, researchers compared health outcomes, including mortality and neurological sequelae, between those who received AC and those who did not.
  • The findings indicated no significant differences in recovery or mortality rates between AC receivers and non-receivers, but due to the small sample size, the results remain inconclusive regarding the effectiveness of AC in this context.*
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  • * In a study of seven NB cases, signs of increased intracranial pressure were prominent, including symptoms like blurred vision and nerve palsy, while MRI scans revealed various brain abnormalities.
  • * All patients tested negative for Brucella in blood and CSF serology, but the diagnosis was confirmed using molecular techniques like PCR, highlighting the need for these advanced methods in suspected cases of NB.
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Who Are the Stakeholders in Promoting Mental Health?

Med J Islam Repub Iran

June 2024

Research Center for Addiction & Risky Behaviors, Department of Psychiatry, Iran University of Medical Sciences, Tehran, Iran.

Background: It is now confirmed that mental health promotion policies need innovations beyond the scope of the health sector. In this study, an attempt was made to identify the most effective stakeholders of the public sector in the field of mental health promotion in Iran to help the policy-makers and to encourage inter-sectoral collaboration and further involvement of these effective sectors in mental health promotion plans.

Methods: This was a mixed-methods study.

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Article Synopsis
  • Pediatric migraines negatively affect kids' daily lives and school performance, making it essential to find effective treatments for prevention.
  • A network meta-analysis was conducted to compare the efficacy and safety of different oral medications for stopping migraine episodes in children.
  • The study aimed to analyze data from various clinical trials to determine how well these treatments work and identify any potential side effects.
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  • The prodrome phase of a migraine attack occurs 24-48 hours before the headache and involves symptoms that can be mistaken for triggers.
  • This review analyzes existing studies to clarify the distinction between prodromal symptoms and migraine triggers, using clinical and neurophysiological data.
  • Understanding the interaction between brain activity during the prodromal phase and potential triggers is essential for improving migraine management and exploring their underlying mechanisms.
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