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Cytokine gene polymorphisms in common variable immunodeficiency.
Int Arch Allergy Immunol
September 2009
Immunology, Asthma and Allergy Research Institute, Children's Medical Center Hospital, Tehran University of Medical Sciences 62 Qarib St, Keshavarz Blvd., PO Box: 14185-863, Tehran 14194, Iran.
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and an increased susceptibility to recurrent infections, autoimmunity and cancers. There are some conflicting results regarding the cytokine profile of CVID patients. While cytokine production could be associated with gene polymorphism, genetic profiles of a number of cytokines were analyzed in this study.
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