28 results match your criteria: "Tehran University of Medical Sciences (TUMS) Tehran Iran.[Affiliation]"

Representative clinical images in this study can increase awareness regarding the clinical similarity between this benign adnexal tumor and malignant melanoma and highlight the importance of pathological examination.

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Tumor lysis syndrome (TLS), as an oncologic emergency, may rarely occur in patients with solid organ neoplasms and without previous cancer therapy. Physicians should be highly aware of the possibility of TLS, with special attention in patients having bulky tumors, irrespective of recent treatment with cytotoxic agents for its prompt prevention and treatment.

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The prevalence of hypercalciuria in children is 3%-10% globally and up to 35% in the United States. Hypercalciuria in children has many presentations; it causes different metabolic disorders and can negatively affect a child's growth. It also increases the risk of low bone mineral density and urinary tract infections.

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Key Clinical Message: Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder. This case highlights parkinsonism as a rare initial manifestation of sporadic CJD (sCJD), emphasizing the need for heightened clinical awareness to prevent misdiagnosis. Early and accurate diagnosis of sCJD is crucial for preventing potential iatrogenic transmission and optimizing patient management.

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Background And Aim: Marburg virus (MARV) is a highly virulent virus of animal origin and the cause of a lethal infection (known as Marburg virus disease [MVD]) with a case-fatality ratio ranging from 24% to 90%. While the potential nonzoonotic routes of virus spread are plausible, the risk is not yet fully determined. Here, we described the ways by which MARV spreads within the human population focusing mainly on the potential of sexual transmission.

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Article Synopsis
  • * The condition is characterized by itchy, blistering skin lesions, primarily affecting areas like the axilla and groin, due to IgA autoantibodies disrupting cell adhesion in the skin.
  • * The study presents a case where a 50-year-old male with severe IgA pemphigus had a poor response to Dapsone but was successfully treated with an injection of the TNFa inhibitor, adalimumab.
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  • Bullous pemphigoid (BP) and malignant acanthosis nigricans (AN) were observed in a patient with gastric adenocarcinoma, but they had different behaviors in relation to cancer progression.
  • BP did not show any correlation with the relapse and remission of gastric cancer, while the malignant AN did reflect the paraneoplastic effects of the cancer.
  • The case highlights the unusual coexistence of BP and malignant AN, which has not been documented before in the context of malignancy.
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  • - A 36-year-old male with systemic lupus erythematosus (SLE) presented with acute pericarditis, marking a rare initial symptom of the disease.
  • - He had severe circumferential fibrinous pericarditis and was classified as a high-risk case, prompting extensive investigation.
  • - After 6 weeks of treatment with NSAIDs and corticosteroids, his symptoms resolved completely, highlighting the importance of diagnosing underlying autoimmune conditions in such cases to prevent unnecessary procedures and complications.
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  • A rare case of a slow-growing retro-auricular panfolliculoma in a 70-year-old woman was reported, initially biopsied to rule out basal cell carcinoma.
  • Histopathology confirmed it as a benign follicular tumor with features of all hair follicle segments, demonstrating no signs of malignancy.
  • The tumor was successfully excised and has not recurred, highlighting the benign nature of panfolliculomas and their differentiation from other skin tumors.
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Background And Aims: The COVID-19 pandemic has presented significant challenges to clinical research, necessitating the adoption of innovative and remote methods to conduct studies. This study aimed to investigate these challenges and propose solutions for conducting clinical research during the pandemic.

Methods: A narrative review was conducted (approval ID: IR.

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Background And Aims: Alopecia areata (AA) is a common autoimmune nonscarring hair disorder with strong genetic links. It seems to be associated with several comorbidities affecting the AA treatment plan. On the other hand, the prevalence of comorbidities in different populations can be different based on genetic differences.

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We present a 10-year follow-up and describe our experience in managing a case of neonatal severe primary hyperparathyroidism (NSHPT) for the first time in Iran. Microcephaly, mental retardation, and epilepsy may be long time sequels of NSHPT. The brain MRI findings are compatible with an old hypoxic-ischemic event.

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Uncontrolled diabetes can lead to diabetic nephropathy (DN). The aim of the study was to investigate the relationship between different dietary micronutrient patterns and risk of DN in women. This was a case-control study.

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Key Clinical Message: Aluminum phosphide poisoning may cause rare visual impairment. In a case, a 31-year-old female, visual loss was linked to shock-induced hypoperfusion, causing oxygen lack and cerebral atrophy, emphasizing the need for identifying atypical symptoms.

Abstract: This case report describes the multidisciplinary evaluation of a 31-year-old female patient who suffered from visual impairment as a result of aluminum phosphide (AlP) poisoning.

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Article Synopsis
  • - The text discusses a unique case of granular parakeratosis, which is a skin condition characterized by keratinization issues, in a 27-year-old female.
  • - The patient exhibited brown discoloration plaques and red (erythematous) areas on the back of her hands that lasted for 8 months.
  • - The development of these skin lesions is likely linked to factors such as frequent washing, the use of detergents, and skin maceration.
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This study reports a patient developing TEN after the first dose of (BBIBP-CorV). He developed numerous purpuric and dusky patches with flaccid bullae and areas of epidermal detachment covered more than 30% of the body area within 6 days. After treatment with dexamethasone and cyclosporin, he recovered within 14 days.

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Despite its widespread usage as a chemotherapy drug in cancer treatment, doxorubicin (DOX) has limitations such as short in vivo circulation time, low solubility, and poor permeability. In this regard, a pH-responsive chitosan (CS)- montmorillonite (MMT)- nitrogen-doped carbon quantum dots (NCQDs) nanocomposite was first developed, loaded with DOX, and then incorporated into a double emulsion to further develop the sustained release. The incorporated NCQDs into the CS-MMT hydrogel exhibited enhanced loading and entrapment efficiencies.

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Mediterranean diet is a healthy eating pattern associated with various health advantages. Different scoring methods of adherence to this diet have been used to investigate the association between the Mediterranean diet and muscle outcomes. The present study aimed to investigate the association of the Mediterranean Dietary Quality Index (Med-DQI) with handgrip strength (HS) and muscle endurance (ME).

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Sarcoidosis with multiple organ involvement and uncommon symptoms: A case report.

Clin Case Rep

August 2022

Clinical Research and Development Center Shahid Beheshti Hospital, Qom University of Medical Sciences, Shahid Beheshti Boulevard Qom Iran.

Sarcoidosis is a complicated inflammatory disease characterized by the formation of non-caseating epithelioid granulomas in many organs. Herein, we reported a sarcoidosis case with multiple organ involvements and our diagnostic criteria and treatment plan.

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A 60-year-old woman presented with non-itchy shiny translucent papules on her right breast surface. She had a history of quadrantectomy and chemoradiotherapy due to medullary breast carcinoma 20 years ago. Cutaneous lymphangioma occurred secondary to surgery and radiotherapy 8 years ago.

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Background: Alopecia areata (AA) is a nonscarring hair loss with autoimmune pathophysiology, which is associated with psychiatric disorders including anxiety and depression. Sleep disorders are commonly seen with anxiety and depression. Here we evaluate the sleep quality of AA patients.

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Poor sleep quality can lead to increased obesity. Low carbohydrate diet (LCD) is considered as an approach for sleep quality and obesity improvement. The aim of this investigation is to evaluate the relationship between LCD and sleep quality with the mediatory effect of inflammatory markers including transforming growth factor-β (TGF-β), high-sensitivity C-reactive protein (hs-CRP), total antioxidant capacity: In our cross-sectional study, 304 obese women aged from 19 to 50 years were enrolled.

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Background: The association of plant-based diets and biomarkers of bone, insulin, and inflammation is still unclear.

Objectives: We investigated the associations between biomarkers of bone, insulin, and inflammation and three plant-based diet indices: an overall plant-based diet index (PDI); a healthy plant-based diet index (hPDI); and an unhealthy plant-based diet index (uPDI).

Methods: We included 178 elderly subjects who referred to health centers in Tehran.

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