ATM Expression and Activation in Ataxia Telangiectasia Patients with and without Class Switch Recombination Defects.

Background: Ataxia telangiectasia mutated (ATM) kinase plays a critical role in DNA double-strand break (DSB) repair. Ataxia telangiectasia (A-T) patients exhibit abnormalities in immunoglobulin isotype expression and class switch recombination (CSR). This study investigates the role of residual ATM kinase expression and activity in the severity of A-T disease.

Mediating roles of weight stigma and physical activity avoidance in the associations between severity of gaming disorder and levels of physical activity among young adults.

Background And Aims: There are limited data regarding associations between gaming disorder and physical activity (PA). The present study investigated the direct association between these two variables and assessed the potentially mediating roles of PA avoidance and two types of weight stigma (i.e.

Evaluation of the Effects of Retro-Cavity Preconditioning with or Without Ethylenediaminetetraacetic Acid on Root Surface pH and Dislodgement Resistance of NeoMTA2 and Mineral Trioxide Aggregate Flow Retro-Fills: An Ex Vivo Investigation.

The aim of this study was to investigate the effects of retro-cavity preconditioning with or without 17% ethylenediaminetetraacetic acid (EDTA) solution on root surface pH as well as dislodgement resistance of NeoMTA2 and MTA Flow retro-fills. Forty-eight single-rooted human incisors were selected. After completion of endodontic treatment, root-end resections were performed, and retro-cavities were prepared.

Adult patients with an exacerbation of asthma and a higher risk for pulmonary embolism: a cluster analysis.

Objective: Current literature acknowledges the complexity of exacerbation triggers in patients with asthma. We studied the clinical heterogeneity of patients with asthma exacerbation suspected of having pulmonary embolism using cluster analysis and compared the clusters regarding of the risks for pulmonary embolism.

Methods: In a secondary analysis of a dataset from the University of Florida, USA, individuals who experienced asthma exacerbation between June 2011 and October 2018 were included.

Evaluation of Carboxymethyl Cellulose/Gelatin Hydrogel-Based Dressing Containing Cefdinir for Wound Healing Promotion in Animal Model.

The skin serves as a critical barrier against external pathogens, and its wound healing is a complex biological process that requires careful management to ensure optimal tissue regeneration. Hydrogels, a class of hydrophilic polymers, have emerged as promising materials for wound dressings due to their biocompatibility, biodegradability, and ability to create a moist wound environment conducive to cell proliferation and migration. In this research, a hydrogel dressing containing cefdinir (Cef) was made from a combination of carboxymethyl cellulose (CMC) and gelatin (Gel) by a physical crosslinking method, and their physicochemical, mechanical, and biological properties were investigated.

Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals.

In spite of significant advancements in diagnosis and treatment, cancer remains one of the major threats to human health due to its ability to cause disease with high morbidity and mortality. A multifactorial and multitargeted approach is required towards intervention of the multitude of signaling pathways associated with carcinogenesis inclusive of angiogenesis and metastasis. In this context, plants provide an immense source of phytotherapeutics that show great promise as anticancer drugs.

Tenodesis in Flail Foot: A New Surgical Technique.

Flail foot is a condition characterized by a significant weakness in ankle dorsiflexion, resulting in limited or no active mobility in the ankle. To address this issue, we described a novel approach called tenodesis, which has been developed for ankle joint stabilization. This technique utilizes the patient's tendons to minimize potential complications.

Arthroscopic-Assisted Posterolateral Corner Reconstruction of the Knee: Novel Technique, Classification, Surgical Algorithm, and Midterm Results.

Objectives: This study aimed to introduce a new arthroscopic method for reconstructing the popliteus tendon (PT). This minimally invasive technique is performed through the posterolateral corner (PLC) of the knee, which can reconstruct the posterolateral rotary instability (PLRI) of the knee.

Methods: Thirty-nine patients (8 females, 31 males) with PLC injury and normal knee alignment underwent arthroscopic PT reconstruction.

Slope of the Medial Tibial Plateau and the Incidence of a Medial Meniscal Tear.

Objectives: Previous studies of the association between tibial slope and meniscal tear have led to contradictory results. In this regard, the present study aimed to examine the effect of medial tibial plateau slope on the incidence of isolated medial meniscal tear.

Methods: This study was performed on 75 patients with a posterior horn medial meniscal tear and 150 matched control subjects.

Crocin elicits potent anti-inflammatory and fibrinolytic properties post tendon injury, A new molecule for adhesion therapy.

Background: Post-surgical tendon adhesion formation is a frequent clinical complication with limited treatment options. The aim of this study is to investigate safety and efficacy of orally administration of crocin in attenuating post-operative tendon-sheath adhesion bands in an Achilles tendon rat model.

Methods: Structural, mechanical, histological, and biochemical properties of Achilles tendons were analyzed in the presence and absence of crocin.

Neural reshaping: the plasticity of human brain and artificial intelligence in the learning process.

Unlabelled: This study explores the concept of neural reshaping and the mechanisms through which both human and artificial intelligence adapt and learn.

Objectives: To investigate the parallels and distinctions between human brain plasticity and artificial neural network plasticity, with a focus on their learning processes.

Methods: A comparative analysis was conducted using literature reviews and machine learning experiments, specifically employing a multi-layer perceptron neural network to examine regression and classification problems.

Application of CRISPR/Cas9 technology in the modeling of Gaucher disorder.

Gaucher disease (GD) is a metabolic disorder caused by mutations in the , located on 1q22. This gene encodes glucocerebrosidase (glucosylceramidase) enzyme. GD has a wide range of clinical manifestations from a perinatally lethal type to an asymptomatic form.

Effects and Mechanisms of Silibinin on Influenza A/H1N1 Pathogenesis in a Mouse Model.

Silymarin is a polyphenolic flavonoid extracted from milk thistle. It has potent immunomodulatory effects and can inhibit the replication of influenza A virus (IAV). The present study aimed to determine the inflammatory and anti-inflammatory cytokine secretion patterns in mice before and after silibinin treatment.

Design and evaluation of screening and self-care (mobile) application for oral and dental problems and emergencies.

Introdution: Although oral and dental diseases may occur in unexpected or even emergency conditions, but some of the diagnosis and treatments can be algorithmically done following some guidelines. The development and implementation of a system that provides users with a record of history and a proposal of required actions can be not only efficiently practical, but also virtually simple.

Materials And Method: A system made up of web and mobile apps is proposed and evaluated for screening and self-care of oral and dental problems and for providing advice on dental emergencies and therapeutic measures.

Nurses' viewpoint of sustaining work despite musculoskeletal pain: A qualitative study.

Background: The nursing profession consistently has the highest rates of musculoskeletal disorders (MSDs) among occupations due to physical and psychological pressures, leading to an increased number of sickness absences, early retirement, staff shortage, poor health conditions, and need for medical care. Absence among healthcare workers puts the quality of patient care at risk, and increase colleagues' workload and employer staffing expenses. This study aimed to investigate the viewpoints of Iranian nurses about sustaining work despite musculoskeletal pain.

Effect of acupressure on childbirth outcomes in nulliparous women: A randomized clinical trial.

Background: Non-pharmaceutical method is one of the conventional methods of reducing labor pain. Acupressure is suggested as an effective method for reducing labor pain with favorable effects on the outcome of childbirth. Different acupressure methods are suggested for this purpose; the most effective one has to be investigated.

Talent identification and succession planning strategies for the appointment of nursing unit managers: A systematic review.

Talent acquisition and succession planning are critical to the appointment of nursing managers to ensure high-quality leadership and improved outcomes in healthcare organizations. This review was carried out with the aim of systematically reviewing the literature on talent identification and succession methods for the appointment of nursing unit managers in the Islamic Republic of Iran (IRI). In this study, a comprehensive literature search was conducted using electronic databases, including PubMed, Cochrane Library, PsycINFO, Scopus, Web of Science, and Google Scholar, to identify relevant studies published between 2010 and 2023.

An analysis of causal relationships among the factors affecting the academic performance of students at the Alborz University of Medical Sciences.

Background: University graduates are leaders, great human resources, and responsible for the economic and social development of every country. The present study aimed at evaluating the mediating role of self-efficacy in the relationship between stress and effort-reward imbalance (E.R.

Using the mind map method in medical education, its advantages and challenges: A systematic review.

Mind mapping stands as a contemporary approach to education, introducing an innovative means of teaching and learning. In current times, this technique is embraced due to its ability to enhance the learning and retention process. This investigation explored the imperative nature of adopting novel educational methodologies such as mind mapping, while also examining its benefits and constraints.

Explaining the perception of students and professors regarding the clinical education challenges and strategies of the operation room.

Background: Clinical education is an essential part of medical science education in the operating room, and considering its high importance, it is necessary to identify challenges in this regard. The study aims to explain the perception of students and professors regarding the challenges and strategies for improving education in the operating room. The context of this study was the Khomein School of Medical Sciences.

Barriers and facilitators of community-based nursing development: A scoping review.

In the last few decades, chronic diseases have spread and new and emerging health and social issues have affected people's health. COVID-19 and other emerging and re-emerging diseases are creating new challenges for societies that affect how healthcare is managed. It is through the development of community-based nursing that some of these problems can be solved.

Molecular Detection of in Ticks Isolated from Domestic Animals in Slaughterhouses and Farms, Shahr-E-Rey, Tehran, Iran.

Background: causes Q fever, a zoonotic and vector-borne disease. Ticks serve as vectors for this bacterium. This study aimed to determine the prevalence of infection in ticks in Shahr-e-Rey County, Tehran Province.

Modeling the Distribution of Dominant Hard Ticks in Southeastern Coastal Areas of the Caspian Sea.

Background: Ticks are hematophagous arthropods that have direct and indirect effects on hosts, including the transmission of pathogens. An environmental suitability study of some vector species of hard ticks was conducted using the MaxEnt model in the south-eastern region of the Caspian Sea in Iran.

Methods: The ticks were collected monthly (2014-2015) at 45 study sites covering different areas in terms of topography.

Development and Optimization of a Nanoparticle-Based Imidacloprid Insecticide for Effective Control of .

Background: The German cockroach () is a pest with a global distribution that has adapted to live in human environments. threatens human health by producing asthma-inducing allergens, carrying pathogenic/antibiotic-resistant microbes, and contributing to unhealthy indoor environments. Effective application of insecticides can play an important role in cockroach control programs.