2,381 results match your criteria: "Tehran University of Medical Science.[Affiliation]"

Article Synopsis
  • - About 20% of transient ischaemic attacks and strokes occur in the posterior circulation, with vertebrobasilar stenosis being a significant cause, linked to a higher risk of recurrent strokes, especially in the early weeks after the event.
  • - A systematic review was conducted on percutaneous transluminal angioplasty and stenting (PTAS) for treating intracranial vertebrobasilar artery stenosis, examining various studies to analyze complications and outcomes.
  • - The review analyzed 31 studies involving 1928 cases, finding an average stenosis rate of about 83%, with notable variations in the reported rates of basilar and vertebral artery stenosis among the included studies.
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Background: Mental illness has been a significant public health challenge in Thailand, where there is a shortage of specialists. Consequently, community nurses (CNs) who are not specialists have been tasked with enhancing mental health outcomes in the primary care system of the country. This study aims to shed light on CNs' lived experiences of caring for psychiatric patients within the primary care units (PCUs).

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Immunomodulatory therapies are beneficial strategies for the improvement of immune system function. Today, due to the increasing prevalence of immune disorders, cancer, and new viral diseases, there is a greater need to introduce immunomodulatory compounds with more efficiency and fewer side effects. Microbial derivatives are fertile and attractive grounds for discovering lots of novel compounds with various medical properties.

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An interesting case series of ticagrelor induced long QTc.

Int J Cardiol Cardiovasc Risk Prev

September 2024

Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

This case series explores three patients who underwent percutaneous coronary intervention (PCI) and experienced prolonged QT intervals under treatment with Ticagrelor. The first case was a female who presented with chest pain and received a Xience stent. The second case involved a male patient who received two Xience stents.

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Introduction: For a long time, molding was one of the most important methods of producing metal, ceramic, and polymer materials. The two essential factors in this method were always cost and time. Technology advancements have made it possible to design in 3D using a computer and additive manufacturing.

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Human T-lymphotropic virus type 1 (HTLV-1) is a RNA virus belonging to Retroviridae family and is associated with the development of various diseases, including adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Aside from HAM/TSP, HTLV-1 has been implicated in the development of several disorders that mimic auto-inflammation. T-cell migration is important topic in the context of HTLV-1 associated diseases progression.

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Article Synopsis
  • Human papillomavirus (HPV) is a common sexually transmitted infection that can lead to various cancers, with this study focusing on its prevalence among women of different ages in Karaj.
  • The research analyzed specimens from 2,109 women, finding that 17% tested positive for HPV, with a majority being low-risk, but a significant number also being high-risk, particularly in younger individuals under 30.
  • The study identified HPV-16 as the most common genotype and emphasizes the importance of targeted health interventions and vaccination for specific age groups to reduce HPV-related risks.
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Background: On December 2019, a novel coronavirus disease (COVID-19) spread worldwide and became a pandemic. Multisystem inflammatory syndrome in children (MIS-C) due to cytokine release syndrome following COVID-19 presents with various manifestations. We hypothesize that one of the rare manifestations is acute abdomen.

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Objective: The aim of this study is to investigate the accuracy of utilizing neural fiber trunk diameter in accurately diagnosing the length of the aganglionic segment in patients definitively diagnosed with Hirschsprung's disease.

Results: In this study, 40 patients (19 males, 21 females; mean age 2.5 ± 2.

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Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that is distinguished for its correlation to myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). As well, HTLV-1 has been documented to have links with other inflammatory diseases, such as uveitis and dermatitis. According to the World Health Organization (WHO), the global distribution of HTLV-1 infection is estimated to extend between 5 and 10 million individuals.

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Background: Patients with -thalassemia major depend on lifelong transfusion, resulting in tissue iron overload. This longitudinal retrospective observational study aims to assess myocardial and liver iron overload using magnetic resonance imaging (MRI) and investigate the lag between myocardial and liver iron unloading in -thalassemia patients undergoing chelation therapy.

Methods: Beta-thalassemia major patients with at least two MRI studies between 2016 and 2020 were enrolled.

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Article Synopsis
  • Glioma is a common type of brain tumor, and a specific mutation can indicate a better chance of recovery.
  • The study used machine learning to analyze data from 22 studies involving over 5,000 patients to see how well it could predict the mutation.
  • Results showed that machine learning is quite accurate in predicting the mutation status, but more work is needed to make it even better for doctors to use in treating patients.
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Effect of silymarin on lipid profile and glycemic control in patients with type 2 diabetes mellitus.

Phytother Res

September 2024

Assistant Professor Medical Science Department, Nutrition Section, Science and Research Branch, Tehran, Iran.

This randomized clinical trial was conducted to evaluate the effects of silymarin supplementation on glycemic indices and serum lipid profile in type 2 diabetes mellitus (T2DM) patients. In this open-label randomized clinical trial study, 48 patients with T2DM were eligible to participate for 12 weeks and were divided into two groups randomly: 24 subjects in the intervention (received three 140 mg silymarin capsules daily and diet plan) and 24 in control (received a diet plan). Fasting blood samples and anthropometric data were collected, and glycemic indices and lipid profiles were determined at baseline and at the end of the study.

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Article Synopsis
  • - The study highlights the importance of early diagnosis and treatment of viral keratitis (VK) to improve patient outcomes, focusing on the role of antiviral medications and supportive care.
  • - Researchers analyzed samples from 162 patients suspected of ocular infections and found that 29.6% tested positive for various viruses, with the highest prevalence being varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1).
  • - Multiplex real-time PCR was used for efficient viral diagnosis, revealing that aqueous humor samples were particularly effective for detecting VK, potentially changing how diagnoses are made and reducing unnecessary antibiotic use.
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Background: Large vessel occlusions (LVO) are a common etiology of morbidity and mortality. The current literature lacks a synthesis of the landscape and trends in research.

Objective: We aimed to conduct a bibliometric analysis of the 100 most cited original articles on LVOs to assess the current state of research.

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Cytomegalovirus Infection or Gastric Cancer? A Case Report and Review of the Literature.

Gastroenterol Nurs

August 2024

About the authors:Ahmad Hormati, PhD, is Associate Professor of Gastroenterology, Gastroentrology and Hepatology, Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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Purpose: The Moraxella species is a very uncommon pathogen that leads to microbial keratitis (MK). This study aimed to evaluate the clinical features, predisposing factors, and outcomes of Moraxella keratitis in patients of a tertiary eye hospital.

Methods: This retrospective study was conducted from 2015 to 2022, on patients who were admitted with the diagnosis of Moraxella keratitis confirmed by positive culture in a referral eye hospital.

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Noninfectious Complications in B-Lymphopenic Common Variable Immunodeficiency.

J Investig Allergol Clin Immunol

July 2024

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Science, Tehran, Iran.

Article Synopsis
  • Common variable immunodeficiency (CVID) is a significant disorder characterized by both infectious and noninfectious complications, with 66.4% of patients experiencing noninfectious issues such as enteropathy and autoimmunity.
  • In a study of 387 CVID patients, those with B-cell lymphopenia showed higher rates of certain complications, particularly in the dermatologic, endocrine, and musculoskeletal systems.
  • The study highlights the need for routine monitoring and appropriate treatment strategies, including medication alongside immunoglobulin therapy, to manage complications associated with CVID effectively.
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Background: This study focuses on the phenomenon of demoralization, a common experience among terminally ill patients, especially those diagnosed with cancer. The primary objective is to adapt and validate a practical assessment tool for demoralization, the Demoralization Scale-24 (DS-24), within the context of Iranian society.

Methods: In this cross-sectional study, we employed the DS-24 as the principal instrument, which had been exactly translated and evaluated for its psychometric properties in 160 Persian cancer patients.

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Inactivated herpes simplex virus-1 vaccine formulated in aqueous and alcoholic extracts of propolis boosts cellular and IgG responses.

Iran J Basic Med Sci

January 2024

Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic Center for Education, Culture, and Research (ACECR), Tehran, Iran.

Objectives: In this study, the adjuvant activity of aqueous and alcoholic extracts of propolis was examined on the inactivated herpes simplex virus-1 (HSV-1.

Materials And Methods: BALB/C mice were administered with inactivated (HSV-1; the KOS strain) plus alcoholic and aqueous extracts, followed by assessment of the cellular and humoral immune responses.

Results: Alcoholic and aqueous extracts, as an adjuvant, revealed a significant increase in lymphocyte proliferation and cytotoxic T lymphocyte (CTL) responses versus the HSV-1 group.

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Background: Despite the end of the COVID-19 lockdown and reopening of schools, the long-term effects of quarantine on the weight status, eating habits, and lifestyle of children and adolescents remain unknown. This study aimed to determine the long-term effects of the lockdown on the weight status, eating habits, and lifestyle changes of children and adolescents in Iran.

Method: This descriptive cross-sectional study was conducted from April to May 2022.

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This study aimed to assess the ten-year trend in semen quality among couples referred to the Infertility Center in Kerman between 2008 and 2017. The study included 2952 semen samples from men 18 to 60 years old referred to the infertility center as infertile couples living in Kerman province, Iran, whether they had normal or abnormal semen analysis. A total of 2952 sperm samples were included.

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The health sector is one of the components of development, social welfare and economic growth. The purpose of this study was to develop an economic evaluation model of the environmental and health costs of occupational diseases by hybrid approach. To achieve the study goal, a taxonomy of economic evaluation model of the environmental and health costs of occupational diseases has been developed.

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