Diagnostic Power of MicroRNAs in Melanoma: Integrating Machine Learning for Enhanced Accuracy and Pathway Analysis.

This study identifies microRNAs (miRNAs) with significant discriminatory power in distinguishing melanoma from nevus, notably hsa-miR-26a and hsa-miR-211, which have exhibited diagnostic potential with accuracy of 81% and 78% respectively. To enhance diagnostic accuracy, we integrated miRNAs into various machine-learning (ML) models. Incorporating miRNAs with AUC scores above 0.

Expression of cytokeratin 19 in prostatic adenocarcinoma: a systematic review.

Background: Cytokeratins are intracellular proteins known as diagnostic biomarkers or prognostic factors for certain cancers. Cytokeratin 19 (CK-19) expression has been proven to have prognostic value for some cancers, but its relationship with others, such as prostate cancer (PCa), remains unclear. This systematic review article aimed to examine the relationship between CK-19 expression and prostate adenocarcinoma (PAC).

Computer-Aided Detection (CADe) and Segmentation Methods for Breast Cancer Using Magnetic Resonance Imaging (MRI).

Breast cancer continues to be a major health concern, and early detection is vital for enhancing survival rates. Magnetic resonance imaging (MRI) is a key tool due to its substantial sensitivity for invasive breast cancers. Computer-aided detection (CADe) systems enhance the effectiveness of MRI by identifying potential lesions, aiding radiologists in focusing on areas of interest, extracting quantitative features, and integrating with computer-aided diagnosis (CADx) pipelines.

Association between Major Dietary Patterns at Breakfast and Odds of Major Depressive Disorder: A Case-control Study.

Background: No study was conducted to investigate the association between principal component (PCA) derived meal-based dietary patterns and odds of major depressive disorder. We aimed to explore the association between major dietary patterns at breakfast and oddsof major depressive disorder (MDD).

Methods: A total of 200 drug-free patients with MDD and 200 healthy individuals were enrolled in this age- and sex-matched case-control study.

Rare encounter: Osteoid osteoma of the coracoid process base - A case report and in-depth literature review.

Introduction And Importance: Osteoid osteoma (OO) is a common benign bone tumor, mostly affecting young adults. Since it often develops in long bones, OO is rarely considered as a cause of chronic shoulder pain.

Case Presentation: We treated an 8-year-old boy with ongoing shoulder pain that was worse at night but improved with NSAIDs.

Cultural adaptation, validation and standardization of the developmental screening tools ASQ:SE-2 in Iranian children.

The Ages and Stages Questionnaires: Social-Emotional, Second Edition (ASQ) is a parental-report tool designed to assess the social-emotional development of young children. Its adaptation and validation in diverse cultural contexts are vital for its effective application. This study aimed to culturally adapt, validate, and standardize the ASQ for Iranian children.

Neuroimaging Findings of Psychosis in Alzheimer's Disease: A Systematic Review.

Background: Previous studies on neuroimaging findings in Alzheimer's disease (AD) patients with hallucinations and delusions have yielded inconsistent results. We aimed to systematically review neuroimaging findings of delusions and hallucinations in AD patients to describe the most prominent neuroimaging features.

Methods: We performed a comprehensive search in three online databases, including PubMed, Scopus, and Web of Science in June 2023.

Influence of Newborns' Sex on Minor and Trace Element Concentrations in Human Milk During Early Lactation.

This study aimed to investigate the influence of newborns' sex on the concentrations of minor and trace elements in the human milk of lactating mothers during early lactation. The elemental analysis focused on calcium (Ca), potassium (K), sodium (Na), and chlorine (Cl) as minor elements and iodine (I), aluminum (Al), bromine (Br), and rubidium (Rb) as trace elements. Breast milk samples were collected from 75 lactating mothers in Tehran, Iran, during the early feeding stage.

Cardiac magnetic resonance imaging in repaired tetralogy of Fallot: A longitudinal midterm follow-up study.

Background: Biventricular dysfunction is frequent in patients with repaired tetralogy of Fallot, necessitating routine imaging to monitor for worsening conditions and determine whether procedures like pulmonary valve replacement (PVR) are needed. This study aimed to highlight the parameters of cardiac magnetic resonance imaging (CMR) and their association with adverse outcomes in the midterm follow-up of these patients.

Methods: This longitudinal study recruited all patients with a history of tetralogy of Fallot total correction (TFTC) who had two CMR images at a minimum three-month interval at Rajaie Center from 2007 through 2017.

Asymptomatic multifocal avascular necrosis, a commonly overlooked finding in patients with systemic lupus erythematosus.

Background: In patients with Systemic lupus erythematosus (SLE), osteonecrosis of various joints is a debilitating complication associated with the disease and its treatment, in which a considerable proportion of osteonecrosis may be asymptomatic. Recognizing the crucial role of early and timely detection, as well as appropriate management of asymptomatic osteonecrosis, in preventing joint destruction, we conducted a study to evaluate the prevalence of asymptomatic osteonecrosis in SLE patients who have already been diagnosed with symptomatic osteonecrosis. Additionally, we aimed to examine the relationship between proposed risk factors of osteonecrosis and the development of asymptomatic osteonecrosis.

Association of anthropometric parameters with intelligence quotient in early school-aged children: a cross-sectional study in Iran.

Background: While the link between body growth indices in the first three years of life and neurodevelopment is well established, the relationship between these indicators and intelligence levels in later stages is not well understood. This study aimed to investigate the association between various anthropometric indices and Intelligence Quotient in early school-aged children.

Methods: This cross-sectional study recruited healthy students aged 7 to 8 years from four primary schools in Tehran, Iran.

Computationally efficient collimator-detector response compensation in high energy SPECT using 1D convolutions and rotations.

. Modeling of the collimator-detector response (CDR) in single photon emission computed tomography (SPECT) reconstruction enables improved resolution and accuracy, and is thus important for quantitative imaging applications such as dosimetry. The implementation of CDR modeling, however, can become a computational bottleneck when there are substantial components of septal penetration and scatter in the acquired data, since a direct convolution-based approach requires large 2D kernels.

Effects of anti-inflammatory dietary supplements on pelvic pain in females with endometriosis: A GRADE-assessed systematic review and meta-analysis of RCTs.

Background: Endometriosis, the most perplexing gynecologic condition, impairs the quality of life because it is usually accompanied by persistent severe acyclic pelvic pain and infertility as its two main symptoms. The majority economic burden of endometriosis is due to infertility and pelvic pain. Therefore, alleviating pelvic pain in patients with endometriosis is a necessity.

Effects of L-carnitine supplementation on lipid profile in adult patients under hemodialysis: a systematic review and meta-analysis of RCTs.

Background: Chronic kidney disease (CKD) affects 10% of the global population and leads to end-stage renal disease (ESRD). Hemodialysis is a common treatment for ESRD, but patients often have low carnitine levels, leading to dyslipidemia, a risk factor for cardiovascular disease and the leading cause of mortality. This study aimed to assess the effects of L-carnitine on lipid profiles in adult hemodialysis patients.

Development of silk fibroin/collagen film containing GI-20 peptide-loaded PLGA nanoparticles against corneal herpes simplex virus-1.

Herpes simplex virus-1 (HSV-1) is the primary cause of infectious blindness. Despite impressive therapeutic outcomes of conventional treatments, HSV-1 drug resistance can be easily developed. Thus, more constructive strategies should be implemented.

Psychometric properties of Farsi version of Demoralization Scale-II (DS-II) in Iranian cancer patients.

Objectives: Demoralization, a prevalent form of psychological distress, significantly impacts patient care, particularly in terminally ill individuals, notably those diagnosed with cancer. This study aimed to assess psychometric properties of Farsi version of Demoralization Scale-II (DS-II) in Iranian cancer patients.

Methods: This study was descriptive-analytical cross-sectional research.

Allele frequency of genetic variations related to the gene-drug pair in a group of Iranian population.

Objectives: The efficacy and safety of drug treatments vary widely due to genetic variations. Pharmacogenomics investigates the impact of genetic variations on patient drug response. This research investigates the frequency of genetic variations in the Iranian population, comparing them with global data to provide insights into the pharmacogenomic approach in the Iranian population.

Contribution of bone turnover markers (BTMs) and vitamin D to bone health in Iranian elderly women.

Purpose: While only a few postmenopausal women exhibit biochemical signs of hypovitaminosis D, it has been shown that vitamin D insufficiency has detrimental effects on the overall skeleton mineralization, bone turnover rate, and may be a significant risk factor for osteoporosis and fracture. We evaluated the concurrent effect of Vitamin D levels and biochemical markers of bone turnover on bone health of postmenopausal women.

Methods: The present study was conducted within the framework of the Bushehr Elderly Health (BEH) program, a population-based prospective cohort study being conducted in Bushehr, a southern province of Iran.

Cost-effectiveness analysis of anticoagulation options for non-valvular atrial fibrillation in Iran.

Background: Atrial fibrillation (AF) imposes a substantial economic and clinical burden, particularly in developing countries like Iran. This study aimed to evaluate the cost-effectiveness of anticoagulation options for non-valvular atrial fibrillation (NVAF) in Iran.

Methods: We conducted a cost-effectiveness analysis comparing warfarin, apixaban, dabigatran 110 mg, dabigatran 150 mg, and rivaroxaban for NVAF patients from the Iranian payer's perspective.

Association between the dietary inflammatory index and risk of lung cancer: a multi-centered case-control study.

Purpose: Dietary factors might contribute to the risk of lung cancer by increasing the concentration of inflammatory markers. The literature-derived Dietary Inflammatory Index (DII) has been established to evaluate the inflammatory potential of diet correlated with inflammatory markers. The association between DII scores and the risk of lung cancer has been conflicting.