40 results match your criteria: "Tehran Medical Sciences University[Affiliation]"
Heliyon
January 2025
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Acute myeloid leukemia is the expansion of leukemic stem cells which might originate from a stem cell or a progenitor which has acquired self-renewal capacity. An aggregation of leukemic blasts in bone marrow, peripheral blood, and extramedullary tissue will result in acute myeloid leukemia. The main difficulty in treating acute myeloid leukemia is multidrug resistance, leading to treatment failure.
View Article and Find Full Text PDFPharmacoecon Open
November 2024
Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main St West, Hamilton, ON, Canada.
BMC Musculoskelet Disord
September 2024
Department of Occupational Health Engineering, School of Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Background: The COVID-19 pandemic has led to the broad acceptance of distance education (DE), with university professors and students conducting the teaching-learning process remotely from their homes. The propose of this study to investigate the prevalence of musculoskeletal disorders (MSDs) before and during the COVID-19 pandemic and identify risk factors associated with DE that may contribute to an increased incidence of these disorders among university professors.
Methods: This cross-sectional analytical study took a comparative approach and involved 310 university professors in Iran.
Pharmacoecon Open
November 2024
Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main St West, Hamilton, ON, Canada.
Introduction: Identifying key differences between manufacturers' submitted analysis and economic reanalysis by the Canadian Agency for Drugs and Technologies in Health (CADTH) is an important step toward understanding reimbursement recommendations. We compared economic values reported in manufacturers' analysis with the CADTH reanalysis and also assessed methodological critiques.
Methods: Two reviewers extracted data from the clinical and economic reports in publicly available CADTH reports from 2018 to 2022.
Curr Med Chem
October 2023
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
Genistein (GEN) is a member of the polyphenol family, known chiefly for its effects on metabolic diseases and gynecological disorders. GEN has anti-cancer properties by inhibiting tumor proliferation, tumor metastasis, invasion, migration, and inducing apoptosis. Ovarian cancer (OC) is ranked 7th among the most common gynecological cancers.
View Article and Find Full Text PDFJ Biomed Mater Res B Appl Biomater
September 2023
Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Wide availability and easy accessibility of acetaminophen oral dosage forms increase the risk of intentional poisoning or unintentional organ toxicity, leading to a wide range of liver failure, nephrotoxicity, and neurotoxicity. In this study, an attempt was made to improve oral bioavailability and reduce the toxicity of acetaminophen using nanosuspension technology. The acetaminophen nanosuspensions (APAP-NSs) were prepared by a nano-precipitation method using polyvinyl alcohol and hydroxypropylmethylcellulose as stabilizers.
View Article and Find Full Text PDFPathol Res Pract
July 2023
Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University, Tehran, Iran.
Short non-coding RNAs called microRNAs (miRNAs) control gene expression by either inhibiting translation or degrading messenger RNA. MiRNAs are crucial for many biological functions, and the deregulation of their expression is strongly linked to the emergence of cancer. A single miRNA controls several gene expressions, allowing it to simultaneously control a number of cellular signaling pathways.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
February 2023
Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.
Background: Coronavirus disease 2019 (COVID-19) is currently one of the world's most critical health issues so far. Given the importance of appropriate treatment in pregnancy and the controversies about Remdesivir effectiveness and complications, the present study aimed to evaluate the impact of Remdesivir on maternal, fetal, and perinatal outcomes in pregnant women with COVID-19 diseases.
Methods: A total of 189 pregnant women with positive polymerase chain reaction (PCR) results for SARS-COV-2, and oxygen saturation [SpO2] of < 95%) were admitted to 12 hospitals affiliated with the Iran University of Medical Sciences from March 1, 2020 to June 7, 2021, namely the first four COVID-19 Picks in Iran.
Curr Med Chem
June 2023
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
Ovarian cancer (OC) is the 3rd common gynecologic cancer. Numerous procedures are involved in the growth of OC, like migration, angiogenesis, proliferation, apoptosis, invasion, and metastasis. Therefore, a better knowledge of the molecular processes complicated in ovarian tumorigenesis can lead to better measures for the prevention and treatment of the disease and its diagnosis.
View Article and Find Full Text PDFMaxillofac Plast Reconstr Surg
March 2022
Department of Dental Anatomy, Tehran Islamic Azad University of Medical Sciences, Dental Branch, Tehran, Iran.
Introduction: There is no study on the effectiveness of hyaluronic acid (HA) placement either with or without absorbable collagen sponge (ACS) in reducing or preventing bisphosphonate-related osteonecrosis of the jaws (BRONJ). This preliminary animal study examined the efficacy of this clinically important treatment.
Methods: For simulating BRONJ, zoledronic acid was administered to 40 rats for 5 weeks.
Eur J Med Res
February 2022
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.
The global COVID-19 pandemic has affected the world's population by causing changes in behavior, such as social distancing, masking, restricting people's movement, and evaluating existing medication as potential therapies. Many pre-existing medications such as tocilizumab, ivermectin, colchicine, interferon, and steroids have been evaluated for being repurposed to use for the treatment of COVID-19. None of these agents have been effective except for steroids and, to a lesser degree, tocilizumab.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
February 2022
Nutrition and Food Sciences Research Center, Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical University (IAUTMU), Tehran, Iran.
Initial evidence on the endocrine-disrupting effects of genetically modified (GM) food motivated us to evaluate the reproductive toxicity of GM and non-GM plant-derived edible oils in female Wistar rats. Sunflower (non-GM), maize (GM), and canola (GM) oils as popular resource dietary oils were purchased from the local market. After tracking the target sequence of CaMV 35S and Nos terminator in all selected batch numbers of edible oils by real-time PCR, oil samples were daily gavaged to 10 weeks Wistar rats for 28 days.
View Article and Find Full Text PDFNucleosides Nucleotides Nucleic Acids
July 2024
Medical Genomics Research Center, Islamic Azad Tehran Medical Sciences University, Tehran, Iran.
Type 2 diabetes mellitus (T2DM) is a multifactorial polygenic disease. Potassium inwardly-rectifying channel, subfamily J, member 11 ( gene mutations can result in susceptibility of T2DM. The aim of this study is to investigate the relationship between risk of T2DM and its complications (retinopathy & renal) and polymorphisms rs5210 and rs5215 of the gene in a group of Iranian population.
View Article and Find Full Text PDFUltrasonography
July 2021
Department of Radiology, Tehran Medical Sciences University, Imaging Center of Imam Khomeini Hospital, Tehran, Iran.
Purpose: This study investigated the accuracy of models reconstructed from ultrasound image processing by comparing the radial displacement waveforms of a subject-specific artery model and evaluated stress changes in the proximal shoulder, throat, and distal shoulder of the plaques depending on the degree of carotid artery stenosis.
Methods: Three groups of subjects (healthy and with less than 50% or more carotid stenosis) were evaluated with ultrasonography. Two-dimensional transverse imaging of the common carotid artery was performed to reconstruct the geometry.
Obstet Gynecol Sci
May 2021
Department of Gynecology and Obstetrics, Faculty of Medicine, Islamic Azad University, Tehran Medical Sciences University, Tehran, Iran.
Objective: Hormonal and inflammatory mechanisms are involved in the pathogenesis of polycystic ovarian syndrome (PCOS), which is a prevalent metabolic disorder among women of reproductive age. We aimed to evaluate the comparative efficiency of short-term oral administration of Korean red ginseng extract (KRGE) and the standard treatment on PCOS by focusing on the histopathological parameters and serum levels of luteinizing hormone (LH), folliclestimulating hormone (FSH), testosterone, and nuclear factor kappa B (NF-κB).
Methods: A PCOS rat model was established by oral gavage of letrozole (1 mg/kg) for 21 days.
Environ Sci Pollut Res Int
June 2021
Nutrition and Food Sciences Research Center, Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University (IAUTMU), Tehran, Iran.
Arsenic is ranked in the top ten environmental toxicants but its impact on type 2 diabetes mellitus (T2DM) and its association with other human health effects is contradictory. We aimed in this study to compare the urinary arsenic concentration (u As) in older age adults (> 40 years) and their T2DM subgroup in an age and gender-matched case control study to find the association of u As with, diet, oxidative stress, smoking, anthropometric factors, and lifestyle in our study participants. Face-to-face interviews based on structured questionnaires were conducted on 200 female and male volunteers (100 cases and 100 control).
View Article and Find Full Text PDFCell Mol Biol Lett
April 2020
4Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Mollasadra St, Tehran, Iran.
Purpose: Ectodermal dysplasias are characterized by developmental abnormalities in ectodermal structures. Hypohidrotic ectodermal dysplasias (HED) are the most common subtype. They are most commonly inherited via X-linked recessive routes.
View Article and Find Full Text PDFUltrasonography
April 2017
Department of Radiology, Imaging Center of Imam Khomaini Hospital, Tehran Medical Sciences University, Tehran, Iran.
Purpose: The aim of this study was to introduce and implement a noninvasive method to derive the carotid artery pressure waveform directly by processing diagnostic sonograms of the carotid artery.
Methods: Ultrasound image sequences of 20 healthy male subjects (age, 36±9 years) were recorded during three cardiac cycles. The internal diameter and blood velocity waveforms were extracted from consecutive sonograms over the cardiac cycles by using custom analysis programs written in MATLAB.
Indian J Hematol Blood Transfus
March 2015
Health Research Institute, Research Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
This study investigates PCR analysis of immunoglobulin heavy chain (IgH) and T cell receptor (TCR) gene rearrangements on paraffin-embedded tissue sections and bone marrow aspirates of patients suspected to have lymphoproliferative disorders but with inconclusive diagnosis in histopathological examination. 130 samples of patients with inconclusive immunohistochemistry results were evaluated for clonal rearrangement of IgH and TCR genes. Based on histopathology examination, the patients were divided into three groups: the first group without any definite diagnosis of lymphoproliferative disorders (60 cases, 46.
View Article and Find Full Text PDFTrauma Mon
December 2013
Department of Surgery, Firouzgar Medical Center, Tehran Medical Sciences University, Tehran, IR Iran.
Curr HIV Res
June 2013
Department of Radiopharmacy, Tehran Medical Sciences University, Iran.
Due to the fact that a definite treatment for AIDS disease has not been discovered so far, antiretroviral drugs are relatively significant in controlling the disease. In this study, Lamivudine- which is an old and effective anti-AIDS drug- was connected to PEGylated chitosan nanoparticle in order to produce a new and greater version of Lamivudine. First, physicochemical studies such as HNMR, FTIR spectroscopy and CHN analysis were performed to ensure the proper synthesis.
View Article and Find Full Text PDFMed Ultrason
June 2012
Shariaty Hospital, Tehran Medical Sciences University, Tehran, Iran.
Objectives: The aim of this study is to determine whether Doppler indices predict intra-ventricular hemorrhage and perinatal mortality in fetal growth restricted pregnancies (FGR).
Material And Methods: In this cohort study, 43 FGR fetuses underwent multi-vessel Doppler ultrasounds weekly or twice weekly after admission. Blood gases of the umbilical cord were analyzed immediately after delivery.
Talanta
June 2005
Department of Food Science and Nutrition, Faculty of Pharmacy, Tehran Medical Sciences University, Tehran 14174, Iran.
Partial least squares modeling and gas-chromatographic fatty-acid fingerprints are reported as a method for the simultaneous determination of cottonseed, olive, soybean and sunflower edible oil mixtures. In this work, two sets of three- and four-component combinations of oils were prepared, hydrolyzed and the obtained free fatty acids analyzed by gas chromatography (GC) without any further derivatization. The normalized percentages of the myristic (14:0), palmitic (16:0), palmitoleic (16:1), stearic (18:0), oleic (18:1), linoleic (18:2) and linolenic (18:3) acids were chromatographically measured in samples and used for constructing calibration matrix.
View Article and Find Full Text PDFJ Oral Maxillofac Surg
March 2008
Department of Oral and Maxillofacial Surgery, Tehran Medical Sciences University, Tehran, Iran.
Purpose: To identify intraoperative complications, neurosensory disturbance (NSD), and horizontal relapse after surgical correction of mandibular prognathism using bilateral intraoral verticosagittal ramus osteotomy (IVSRO).
Patients And Methods: Between 1995 and 2005, 237 Iranian patients underwent IVSRO to achieve mandibular setback. Their operation reports, cephalometric radiographs (2 weeks preoperatively and 12 months postoperatively), and neurosensory questionnaires were assessed to identify intraoperative complications, NSD of the inferior alveolar nerve (IAN), and horizontal relapse.
J Clin Pediatr Dent
March 2008
Orthodontic department, Dental school and Dental research center, Tehran medical sciences university, Tehran, Iran.
Unlabelled: The aim of this investigation was to examine the accuracy of Moyers probability tables and the Tanaka and Johnston prediction equations in predicting the size of unerupted canines and premolars of the maxillary and mandibular quadrants in an Iranian population and to derive a standard formula for it.
Methods: Out of a sample of 280 subjects, 50 (25 males and 25 females) were selected by specific inclusion criteria. An electronic digital caliper was used to read the nearest 0.