Iron metabolism in rheumatic diseases.

Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), and gout, this balanced iron regulation is impaired.

Research on transition metals for the multicomponent synthesis of benzo-fused γ-lactams.

Benzo-fused γ-lactams are fundamental in medicinal chemistry, acting as essential elements for various therapeutic agents due to their structural adaptability and capability to enhance biological activity. In their synthesis, transition metals play a pivotal role as catalysts, offering more efficient alternatives to traditional methods by facilitating C-N bond formation through mechanisms like intramolecular coupling. Recent advances have especially spotlighted transition-metal-catalyzed C-H amination reactions for directly converting C(sp)-H to C(sp)-N bonds, streamlining the creation of these compounds.

Developing an Emergency Medical Services Resilience Assessment Tool in Climate Change: A Study Protocol.

Background: Climate change poses significant threats to the health and safety of communities worldwide. Extreme weather events can disrupt critical infrastructure and overwhelm emergency medical services (EMS) systems. As the frequency and intensity of these climate-related disasters continue to increase, it is essential that EMS organizations develop robust strategies to enhance their resilience.

Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Analysis.

Background: The present study is a systematic review and meta-analysis aiming to investigate the effects of alcohol consumption on male sex hormones in humans.

Methods: We conducted searches on PubMed, Scopus, Science Direct, and Google Scholar from June 2020 to June 2022. We included observational studies (cohorts, case-controls, and cross-sectional studies) comparing FSH, LH, or testosterone levels in alcohol consumers versus non-consumers.

Evaluation of Emerging Antimicrobials Resistance in Nosocomial Infections Caused by : The Comparison Results of Observed Cases and Compartmental Model.

In recent years, the global rise of antibiotic-resistant () has become a significant threat to public health. This study aimed to identify and track outbreaks of antibiotic resistance, specifically among the antibiotics used to treat nosocomial infections. This hospital-based study utilized data from a nosocomial infection surveillance system to investigate reported cases of antibiotic resistance.

Evaluating the Role of KRAS and NRAS 3' Untranslated Region Polymorphisms in Susceptibility and Clinical Features of Laryngeal Squamous Cell Carcinoma.

Laryngeal squamous cell cancer (LSCC) is one of the most common head and neck cancers in which genetic factors play an important role in its occurrence. This study investigated the association of and gene polymorphisms with the risk of LSCC. polymorphisms including rs712, rs61764370, rs8720, and rs9266, as well as NRAS rs14804, were compared in the patient group (n=120) and the control group (n=100).

Neuroenhancement by repetitive transcranial magnetic stimulation (rTMS) on DLPFC in healthy adults.

The term "neuroenhancement" describes the enhancement of cognitive function associated with deficiencies resulting from a specific condition. Nevertheless, there is currently no agreed-upon definition for the term "neuroenhancement", and its meaning can change based on the specific research being discussed. As humans, our continual pursuit of expanding our capabilities, encompassing both cognitive and motor skills, has led us to explore various tools.

The association between the amount of fetal fraction in cell-free DNA testing and adverse pregnancy outcomes: A cohort study.

Background: Noninvasive perinatal testing is a new method of screening for aneuploidy called cell-free DNA (cfDNA). Fetal fraction (FF) plays a crucial role in assessing the reliability of aneuploidy detection through noninvasive perinatal testing.

Objective: We aimed to investigate the association between the amount of FF in cfDNA testing and adverse pregnancy outcomes.

Improving reproductive outcomes in frozen embryo transfer over fresh embryo transfer in women with endometrioma: A historical cohort study.

Background: Endometrioma, a common manifestation of endometriosis, often indicates the severity of the disease. In vitro fertilization and embryo transfer (ET) are key therapeutic strategies for infertility associated with endometriosis. However, the optimal type of ET (frozen or fresh) and its impact on pregnancy success rates remain debated, with limited studies available.

Evaluation of utilization of amplified blastocoel fluid DNA gel electrophoresis band intensity as an additional minimally invasive approach in embryo selection: A cross-sectional study.

Background: Embryo selection for transfer is critical in assisted reproduction. The presence of DNA in the blastocoel cavity of human blastocysts is assumed to be a consequence of common preimplantation chromosomal abnormalities.

Objective: This study examined the relationship between the amount of blastocoel fluid (BF) DNA and the band intensity of amplified BF-DNA in gel electrophoresis, considering the influence of ploidy status.

Outcomes of antibiotic therapy and transvaginal ultrasound-guided efficacy of transvaginal ultrasound-guided drainage in treating tubo-ovarian abscesses: Three case reports.

Background: To introduce minimally invasive methods for the successful treatment of tubo-ovarian abscesses (TOAs), an antibiotic regimen was considered the first line of treatment. However, in some cases, this approach fails, and another intervention (laparotomy or minimally guidance drainage) is required.

Case Presentations: 3 women with a history of long-time infertility, all of them were candidates for in vitro fertilization referred to the obstetrics and gynecology department with similar manifestations.

Vimentin as a contributing factor in SARS-CoV-2-induced orchitis on postmortem testicular autopsy of COVID-19 cases: A case-control study.

Background: Coronavirus disease 2019 (COVID-19) was identified in China in late December 2019 and led to a pandemic that resulted in millions of confirmed cases and deaths. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), uses distinct receptors and co-receptors to enter host cells. Vimentin has emerged as a potential co-receptor for SARS-CoV-2 due to the high level of vimentin expression in testis tissue.

Optimizing droplet coalescence dynamics in microchannels: A comprehensive study using response surface methodology and machine learning algorithms.

Droplet coalescence in microchannels is a complex phenomenon influenced by various parameters such as droplet size, velocity, liquid surface tension, and droplet-droplet spacing. In this study, we thoroughly investigate the impact of these control parameters on droplet coalescence dynamics within a sudden expansion microchannel using two distinct numerical methods. Initially, we employ the boundary element method to solve the Brinkman integral equation, providing detailed insights into the underlying physics of droplet coalescence.

A systematic review and meta-analysis of the effectiveness of perineural dextrose injection in peripheral compression neuropathies of the upper limbs.

Background: Entrapment neuropathies, marked by nerve compression at various anatomical sites, can be effectively managed using conservative approaches like injections. Dextrose 5 % water injection has emerged as a potential therapy by reducing inflammation and promoting tissue regeneration. We aimed to evaluate dextrose injection's efficacy in treating entrapment neuropathies in upper extremities.

New horizons in the treatment of psoriasis: Modulation of gut microbiome.

The last decennia have witnessed spectacular advances in our knowledge about the influence of the gut microbiome on the development of a wide swathe of diseases that extend beyond the digestive tract, including skin diseases like psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. The novel concept of the gut-skin axis delves into how skin diseases and the microbiome interact through inflammatory mediators, metabolites, and the intestinal barrier. Elucidating the effects of the gut microbiome on skin health could provide new opportunities for developing innovative treatments for dermatological diseases.

Antimicrobials profiling, biofilm formation, and clonal lineage of methicillin-resistant isolated from cockroaches.

Cockroaches are widely recognized as vectors for transmitting pathogenic microorganisms in hospital and community environments due to their movement between contaminated and human-occupied spaces. (. ), particularly methicillin-resistant (MRSA), is a primary global health concern because of its capacity to cause a wide range of infections and its resistance to many antibiotics.

Computational epitope-based vaccine design with bioinformatics approach; a review.

The significance of vaccine development has gained heightened importance in light of the pandemic. In such critical circumstances, global citizens anticipate researchers in this field to swiftly identify a vaccine candidate to combat the pandemic's root cause. It is widely recognized that the vaccine design process is traditionally both time-consuming and costly.

Podoplanin expression in various types of oral dysplasia and oral squamous cell carcinoma.

Objective: This study was aimed at investigating the roles of podoplanin (PDPN) as a marker associated with malignant development, progression, and poor prognosis in oral leukoplakia and various forms of oral squamous cell carcinoma (OSCC), particularly in relation to the extent of invasion.

Methods: Immunohistochemical analysis of PDPN was conducted on 77 histologically confirmed, formalin-fixed, paraffin-embedded samples representing various degrees of OSCC invasion and dysplasia grades.

Results: The samples were analyzed with Fisher's exact test and the Kruskal-Wallis test.

Vitamin D receptor (VDR) gene polymorphisms and risk for polycystic ovary syndrome and infertility: An updated systematic review and meta-analysis.

Background: Vitamin D receptor (VDR) gene polymorphisms have been implicated in polycystic ovary syndrome (PCOS). Despite VDR gene polymorphisms importance and their risk for PCOS, they have not been extensively studied. The main objective was to evaluate the associations between VDR gene polymorphisms and risk for PCOS.

FOXR2 in cancer development: emerging player and therapeutic opportunities.

Cancer, a leading cause of global mortality, remains a significant challenge to increasing life expectancy worldwide. Forkhead Box R2 (FOXR2), identified as an oncogene within the FOX gene family, plays a crucial role in developing various endoderm-derived organs. Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases.

Experts' Views on Factors Influencing Resource Allocation for Infectious Disease Emergencies Based on Humanitarian Principles: A Qualitative Study.

Introduction: Infectious diseases can result in global emergencies and a shortage of resources, leading to ethical and humanitarian challenges. This study aimed to identify the factors that affect the allocation of health resources based on humanitarian principles during infectious disease emergencies.

Methods: This study was conducted using a qualitative approach known as content analysis, and 23 specialists and experts with practical experience and theoretical knowledge in this area were carefully selected to participate in the study.

Effect of one-week New Zealand blackcurrant extract on rowing performance and cognitive function in National team male rowers.

This research investigated the impact of New Zealand blackcurrant (NZBC) on 2000-meter rowing ergometer performance and cognitive abilities. Nine trained male rowers from Iran's national team participated in a double-blind, placebo-controlled crossover study, undergoing three sessions with NZBC (600 mg∙day-1), placebo (PL), and control (CL) treatments over seven days, followed by a 14-day washout period. Participants completed a 2000-meter ergometer test provided self-reported ratings of perceived exertion (RPE) and completed a cognitive function assessment five minutes following the rowing exercise.

Content Analysis of Food and Beverage Advertisements on TV, Radio, and Billboards in Iran.

Food advertising may influence food preferences and consumption. Due to these advertisements' role in health, the present study has updated the data available on television and radio food advertisements in Iran until 2020. Meanwhile, food advertisements on billboards have been analyzed for the first time.

Psychometric Properties of the Persian Version of PID5BF + M in Iranian Drug Users.

Background: This study aimed to adapt and evaluate the psychometric properties of the PID5BF + M as a brief measure for assessing DSM-5 and ICD-11 personality disorder traits in Iranian drug users. The sample consisted of 380 participants, including both clinical (28.68%) and nonclinical (71.