Retraction: Hydrogen sulfate ion sensing in aqueous media based on a fused pyrimido benzothiazole derivative.

[This retracts the article DOI: 10.1039/C6RA01980C.].

Application of Principal Component Analysis and DoE-Driven Green Analytical Chemistry Concept to Liquid Chromatographic Method for Estimation of Co-formulated Anti-Hypertensive Drugs.

Background: The fixed-dose combination (FDC) of metoprolol succinate (MTS), cilnidipine (CDN), and telmisartan (TST) is used for the management of hypertension. Numerous reversed phase (RP)-HPLC methods have been reported in the literature for chromatographic analysis of MTS, CDN, and TST. According to the concept of green analytical chemistry (GAC), toxic organic solvents should be avoided or minimized during chromatographic method development for the safety of analysts and the protection of the environment.

Multivariate Analysis and Response Surface Modeling to Green Analytical Chemistry-Based RP-HPLC-PDA Method for Chromatographic Analysis of Vildagliptin and Remogliflozin Etabonate.

Background: The fixed-dose combination (FDC) of vildagliptin (VDG) and remogliflozin etabonate (RGE) is used as antidiabetic medicine. Numerous reverse phase high-pressure liquid chromatographic (RP-HPLC) methods have been reported for the estimation of VDG and RGE using toxic organic solvents such as acetonitrile and methanol. These organic solvents are also hazardous to the environment.

ETECADx: Ensemble Self-Attention Transformer Encoder for Breast Cancer Diagnosis Using Full-Field Digital X-ray Breast Images.

Early detection of breast cancer is an essential procedure to reduce the mortality rate among women. In this paper, a new AI-based computer-aided diagnosis (CAD) framework called ETECADx is proposed by fusing the benefits of both ensemble transfer learning of the convolutional neural networks as well as the self-attention mechanism of vision transformer encoder (ViT). The accurate and precious high-level deep features are generated via the backbone ensemble network, while the transformer encoder is used to diagnose the breast cancer probabilities in two approaches: (i.

Temperature-dependent dielectric relaxation and hydrophobicity of aqueous alanine using time domain reflectometry.

Physical, chemical and microbiological stability of the materials is affected by the rotational and translational mobility of free and hydrated water. The role of water in areas such as protein hydration and enzyme activity, food technology, lyophilization and polymers hydration is, therefore, important and can be well understood in terms of dielectric relaxation spectroscopy. Concentration and temperature-dependent hydrophobicity of amino acid is reflected in their tendencies to appear in appropriate positions in proteins.

2-Pyran-2-one-Functionalized Diketopyrrolopyrrole Dye: Design, Synthesis, and Explosives Sensor.

In this work, a 2-pyran-2-one-functionalized diketopyrrolopyrrole (DPP) (coded as receptor ) was designed, synthesized, and fully characterized by various spectroscopic methods. The physical properties of molecular architecture were studied employing theoretical calculations. Receptor was elegantly scrutinized for the sensing of explosive nitroaromatic compounds (NACs).

Pesticide contamination in agro-ecosystems: toxicity, impacts, and bio-based management strategies.

Continuous rise in application of pesticides in the agro-ecosystems in order to ensure food supply to the ever-growing population is of greater concern to the human health and the environment. Once entered into the agro-ecosystem, the fate and transport of pesticides is determined largely by the nature of pesticides and the soil attributes, in addition to the soil-inhabiting microbes, fauna, and flora. Changes in the soil microbiological actions, soil properties, and enzymatic activities resulting from pesticide applications are the important factors substantially affecting the soil productivity.

A Hybrid Workflow of Residual Convolutional Transformer Encoder for Breast Cancer Classification Using Digital X-ray Mammograms.

Breast cancer, which attacks the glandular epithelium of the breast, is the second most common kind of cancer in women after lung cancer, and it affects a significant number of people worldwide. Based on the advantages of Residual Convolutional Network and the Transformer Encoder with Multiple Layer Perceptron (MLP), this study proposes a novel hybrid deep learning Computer-Aided Diagnosis (CAD) system for breast lesions. While the backbone residual deep learning network is employed to create the deep features, the transformer is utilized to classify breast cancer according to the self-attention mechanism.

MXene-based chemical gas sensors: Recent developments and challenges.

The long-running Covid-19 pandemic has forced researchers across the globe to develop novel sensors and sensor materials for detecting minute quantities of biogenic viruses with high accuracy in a short period. In this context, MXene galleries comprising carbon/nitride two-dimensional nanolayered materials have emerged as excellent host materials in chemical gas sensors owing to their multiple advantages, including high surface area, high electrical conductivity, good thermal/chemical conductivity and chemical stability, composition diversity, and layer-spacing tunability; furthermore, they are popular in clinical, medical, food production, and chemical industries. This review summarizes recent advances in the synthesis, structure, and gas-sensing properties of MXene materials.

Menthol Inhibits Growth by Affecting the Membrane Integrity Followed by Apoptosis.

Inclusion of in the list of pathogens with potential drug resistance threat in recent years has compelled scientists to explore novel and potent antifungal agents. In this study, we have evaluated anti- potential of menthol against different growth forms and synergistic potential with fluconazole. Menthol inhibited planktonic growth of all the isolates completely at ≤3.

Direct Arylation: A Greener Synthesis of Anthraquinone-Naphthalene diimide-Based Small Chromophores for Applications in Organic Thin Film Transistors.

In this paper, we report the design and synthesis of three naphthalene diimide- (NDI) and anthraquinone- (AQ) based organic chromophores derived from direct arylation reactions; NDI-AQ, AQ-NDI-AQ and NDI-AQ-NDI. Compared to classic cross-coupling reactions, this method reduced the number of synthetic and purification steps. The chemical structures, photophysical and electrochemical properties of these molecules were characterized using UV-vis spectroscopy, fluorescence emission spectroscopy and cyclic voltammetry (CV).

Proteomic profile of Candida albicans biofilm.

Candida albicans biofilms are characterized by structural and cellular heterogeneity that confers antifungal resistance and immune evasion. Despite this, biofilm formation remains poorly understood. In this study, we used proteomic analysis to understand biofilm formation in C.

Effect of Pd-Sensitization on Poisonous Chlorine Gas Detection Ability of TiO: Green Synthesis and Low-Temperature Operation.

Ganoderma lucidum mushroom-mediated green synthesis of nanocrystalline titanium dioxide (TiO) is explored via a low-temperature (≤70 °C) wet chemical method. The role of Ganoderma lucidum mushroom extract in the reaction is to release the ganoderic acid molecules that tend to bind to the Ti metal ions to form a titanium-ganoderic acid intermediate complex for obtaining TiO nanocrystallites (NCs), which is quite novel, considering the recent advances in fabricated gas sensing materials. The X-ray powder diffraction, field emission scanning electron microscopy, Raman spectroscopy, and Brunauer-Emmett-Teller measurements etc.

Assessment of antibacterial and anti-biofilm effects of zinc ferrite nanoparticles against Klebsiella pneumoniae.

In response to the emergence of drug resistance and limited therapeutic options, researchers are in action to look for more effective and sustainable antimicrobial practices. Over few years, novel nanoparticles are proving to be potent and promising for effectively dealing with ever- evolving microbial pathogens and diseases. In the present investigation, antibacterial and anti-biofilm efficiencies of zinc ferrite nanoparticles (ZnFeO NPs) are explored against opportunistic pathogens Klebsiella pneumoniae (K.

Appraisal of groundwater from lithological diversity of the western coastal part, Maharashtra, India: An integrated hydrogeochemical, geospatial and statistical approaches.

The present study attempts to decipher the seasonal variations in hydro-geochemistry of groundwater in the Terekhol River Basin, western coastal region, Maharashtra, India. A total of 65 groundwater samples of post-monsoon (POMS) and pre-monsoon (PRMS) seasons were collected and analyzed for major ion composition using standard analytical procedures of APHA. Piper and Gibbs plots is used to elucidate the controlling factors which altering the groundwater composition.

Chloroxylon swietenia (Roxb.) DC induces cell death and apoptosis by down-regulating the NF-κB pathway in MCF-7 breast cancer cells: In vitro and in vivo investigations.

Background: Natural products with targeted bioactivity have gained major attention in the field of cancer research owing to emerging anti-cancer drug resistance and off target toxicities. Chloroxylon swietenia (Roxb.) DC is recognized as a folklore medicinal plant and has numerous therapeutic benefits in the folklore medicine system, however the anti-cancer potential of this plant and its mechanism of action is poorly understood.

Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV retinitis.

Valganciclovir HCl (VGH) is the widely used drug for the treatment of cytomegalovirus (CMV) retinitis infection with an induction dose of 900 mg per oral (p.o.) twice a day and a maintenance dose of 900 mg (p.

Integrated approach for the evaluation of groundwater quality through hydro geochemistry and human health risk from Shivganga river basin, Pune, Maharashtra, India.

The present study is focused on seasonal variation in groundwater quality, hydrochemistry, and associated human health risk in the Shivganga river basin, Western Maharashtra, India, to promote sustainable development of groundwater resources of this semi-arid region. The qualitative geochemical analysis, contamination levels, and human health risk assessment (HHRA) of groundwater are integral steps in groundwater management in the Deccan Plateau basalt flow region of India. Representative groundwater samples (n = 68) collected from the Shivganga River basin area of Pune district, Maharashtra, during pre-monsoon (PRM) and post-monsoon (POM) seasons in 2015 were analyzed for major cations and anions.

Aggregation-Induced Emission-Based Material for Selective and Sensitive Recognition of Cyanide Anions in Solution and Biological Assays.

Cyanide is one of the highly poisonous pollutants to our environment and toxic to human health. It is important to develop the widely applicable methods for their recognition to secure safe uses for people coming into contact and handling cyanide and their derivatives. In this regard, the aggregation-induced emission materials possess high potential for the development of simple, fast, and convenient methods for cyanide detection through either "turn-off" or "turn-on".

Dielectric relaxation and molecular interactions study of saccharides in aqueous solutions.

Time domain reflectometry (TDR) technique has been extensively used to study dielectric relaxation and solution properties of carbohydrates. Using TDR techninque, complex permittivity spectra of monosaccharides (d-fructose and d-xylose) and disaccharides (d-maltose monohydrates) were obtained in the frequency range of 10 MHz-50 GHz at various concentrations and temperatures. The static dielectric constant (ε), dielectric constant at high frequency (ε), relaxation time (τ) and relaxation time distribution parameter (β) extracted from the complex permittivity spectra using least squares fit method.

Physicochemical behavioral changes in consort with nitrogen metabolism of cyanobacterium Anabaena PCC 7120 under arsenite regimes.

The present study was undertaken to investigate the arsenite (As III)-induced changes in the diazotrophic cyanobacterium Anabaena PCC 7120. It was observed that the growth of cyanobacterial decreased with increase in As (III) concentration. The cells exposed to As (III) showed morphological variation (deformity) due to the formation of deeper constrictions in vegetative cells.

Coconut-Water-Mediated Carbonaceous Electrode: A Promising Eco-Friendly Material for Bifunctional Water Splitting Application.

The organic and eco-friendly materials are extended to prevail over the worldwide energy crisis where bio-inspired carbonaceous electrode materials are being prepared from biogenic items and wastes. Here, coconut water is sprayed over three-dimensional (3D) nickel foam for obtaining a carbonaceous electrode material, i.e.

Synthesis and evaluation of N-(4-(substituted)-3-(trifluoromethyl) phenyl) isobutyramides and their N-ethyl analogous as anticancer, anti-angiogenic & antioxidant agents: In vitro and in silico analysis.

N-(4-(substituted)-3-(trifluoromethyl) phenyl) isobutyramides and their N-ethyl analogues (flutamides) are versatile scaffolds with a wide spectrum of biological activities. A series of new N-(4-(substituted)-3-(trifluoromethyl) phenyl) isobutyramides (8a-t) and their N-ethyl analogous (9a-t) were synthesized and characterized. The inhibitory potential of the synthesized compounds on the viability of three human cancer cell lines HEP3BPN 11 (liver), MDA-MB 453 (breast), and HL 60 (leukemia) were assessed.

High Stability and Long Cycle Life of Rechargeable Sodium-Ion Battery Using Manganese Oxide Cathode: A Combined Density Functional Theory (DFT) and Experimental Study.

Sodium-ion batteries (SIBs) can develop cost-effective and safe energy storage technology for substantial energy storage demands. In this work, we have developed manganese oxide (α-MnO) nanorods for SIB applications. The crystal structure, which is crucial for high-performance energy storage, is examined systematically for the metal oxide cathode.