Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3.

Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein and nucleic acid biosynthesis, and neurotransmitter production. In humans, thiamine transporters SLC19A2 and SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations in these transporters, which cause thiamine and pyridoxine deficiency, have been implicated in severe neurometabolic diseases.

Effect of salt stress on different tiller positions in rice and the regulatory effect of prohexadione calcium.

Soil salinization has resulted in a significant decrease in crop yields, particularly affecting the production of crops like rice ( L.). Prohexadione calcium (Pro-Ca) can enhance crop resilience against failure by managing plant height.

The role of third component in coumarin-based all-small-molecule ternary organic solar cells with non-fullerene acceptor based on molecular stacking.

The power conversion efficiency (PCE) of ternary all-small-molecule organic solar cells (T-ASM-OSCs) differs significantly from that of the polymer systems (2 %), and the role of third component remains unclear. The electron donor of coumarin derivatives with simple structure and strong and broad light absorption has high PCE for T-ASM-OSCs composed of non-fullerene acceptors (Y6 and DBTBT-IC). Here, we calculated the electronic structure and interfacial properties of the binary C1-CN:Y6 and ternary C1-CN:Y6:DBTBT-IC systems using molecular dynamic (MD) simulations and density functional theory (DFT) to explore the role of the third component (DBTBT-IC).

The impact of gradient variable temperature fermentation on the quality of cigar tobacco leaves.

Introduction: In order to enhance the quality of cigar tobacco leaves (CTLs), a gradient variable temperature fermentation approach was employed.

Methods: The temperature gradient demonstrated a gradual increase from low temperature (35 ± 2°C) to moderate temperature (45 ± 2°C), and then to high temperature (55 ± 2°C). Each temperature gradient underwent a 10-day fermentation process, resulting in a total duration of 30 days.

Explore the toxicological mechanism of 6PPD-Q on human health through a novel perspective: The interaction between lactate dehydrogenase and 6PPD-Q.

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q), an oxidative derivative of tire anti-degradant, has been linked to mortality in coho salmon (Oncorhynchus kisutch) and has exhibited potential human toxicity. Hence, exploring how 6PPD-Q interacts with biomacromolecules like enzymes is indispensable to assess its human toxicity and elucidate its mechanism of action. This investigation aims to explore the impact of 6PPD-Q on lactate dehydrogenase (LDH) through various methods.

Dual-strategy microneedles of bio‑oxygen therapy and artificial enzyme anti-oxidation for psoriasis treatment.

Oxidative stress results from an imbalance between the production of free radicals by oxidants and their removal by antioxidants. Chronic oxidative stress is a key factor in inflammation, characterized by hypoxic microenvironments and elevated levels of reactive oxygen species (ROS). Psoriasis, a common chronic inflammatory skin disorder, profoundly impacts the physical and psychological well-being of affected individuals.

Step Cyclization to Give Part Belt Oxygen-Functionalized Pillar[6,10]arenes.

Part belt oxygen-functionalized pillar[6,10]arenes are synthesized by step cyclization. An oxygen-substituted tetramer and hexamer have been prepared to construct the O3 pillar[6]arene via a hexamer cyclization reaction and the O6 pillar[10]arene through a [4 + 1+4 + 1] cyclization reaction. X-ray crystallographic studies reveal that both macrocycles have a large cavity and indicate that the part belt oxygen-functionalized pillar[6,10]arenes have both similar cyclic structures and certain differences in configuration compared to pillararene.

Changes in and prediction of land carrying capacity in Fujian Province from a dietary nutrition perspective.

Resources and land carrying capacity are vital to the survival and development of human society and form the foundation for ensuring food security. However, evaluating land carrying capacity solely based on grain production is overly simplistic. A comprehensive assessment from the perspective of dietary nutrition is needed to more accurately reflect the actual carrying capacity of land.

Impact of previous cesarean delivery on pregnancy and neonatal outcomes in subsequent in vitro fertilization/intracytoplasmic sperm injection and single frozen-thawed embryo transfer: a historical cohort study with a large sample size.

Purpose: This study aims to explore the impact of a woman's previous cesarean delivery (CD) on pregnancy and neonatal outcomes for subsequent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and single frozen-thawed embryo transfer (FET), compared with vaginal delivery (VD).

Methods: This was a retrospective cohort study that included a total of 5817 patients who desired to transfer a single vitrified-thawed blastocyst from the same oocyte retrieval cycle as their last live birth between January 2011 and January 2021 at a single reproductive medicine center. Patients with a single previous CD were classified in the CD group, while those with a single VD were assigned to the VD group.

Advancing diurnal analysis of vegetation responses to drought events in the Yangtze River Basin using next-generation satellite data.

Extreme climate events, particularly droughts, pose significant threats to vegetation, severely impacting ecosystem functionality and resilience. However, the limited temporal resolution of current satellite data hinders accurate monitoring of vegetation's diurnal responses to these events. To address this challenge, we leveraged the advanced satellite ECOSTRESS, combining its high-resolution evapotranspiration (ET) data with a LightGBM model to generate the hourly continuous ECOSTRESS-based ET (HC-ET) for the middle and lower reaches of the Yangtze River Basin (YRB) from 2015 to 2022.

Association between exposure to urinary metal and all-cause and cardiovascular mortality in US adults.

Background: Further evidence is required regarding the influence of metal mixture exposure on mortality. Therefore, we employed diverse statistical models to evaluate the associations between eight urinary metals and the risks of all-cause and cardiovascular mortality.

Methods: We measured the levels of 8 metals in the urine of adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018.

3D-Printed Hydrogel Scaffolds Loaded with Flavanone@ZIF-8 Nanoparticles for Promoting Bacteria-Infected Wound Healing.

Bacterial-infected skin wounds caused by trauma remain a significant challenge in modern medicine. Clinically, there is a growing demand for wound dressings with exceptional antibacterial activity and robust regenerative properties. To address the need, this study proposes a novel multifunctional dressing designed to combine efficient gas exchange, effective microbial barriers, and precise drug delivery capabilities, thereby promoting cell proliferation and accelerating wound healing.

[Relationship between Benggang erosion and landscape pattern in the southern red soil zone based on path analysis].

Benggang (collapsing hill) erosion is one of the most serious ecological problems in the south of China. Understanding the relationship between Benggang erosion and landscape pattern is conducive to the study of Benggang occurrence and development from the perspective of landscape ecology, with great significance for Benggang prevention and ecological protection. We classified the Lanxi River Basin in Anxi County, Fujian Province into 32 small watersheds.

Isolation, identification, and evaluation of lactic acid bacteria with probiotic potential from traditional fermented sour meat.

Sour meat is a popular traditional fermented product and is a rich source of novel strains with probiotic potential. In this study, we aimed to assess the probiotic potential of lactic acid bacteria (LAB) strains isolated from fermented sour meat. Firstly, the microbial diversity of sour meat from four different areas in China was analyzed.

The effects of different doses of compound enzyme preparations on the production performance, meat quality and rumen microorganisms of yak were studied by metagenomics and transcriptomics.

Yak () is a large ruminant endemic to the Tibetan plateau. The addition of enzyme complexes to feed can significantly improve their growth performance. Therefore, studying the effects of ruminant compound enzyme preparations dosage on yak rumen microorganisms and production performance is crucial to promoting the development of the yak industry.

Association between anthropometric indices and hypertension: identifying optimal cutoff points for U.S. adults across different populations.

Objective: This study compares the relationships between five anthropometric indices, a body shape index (ABSI), body roundness index (BRI), waist circumference (WC), body mass index (BMI) and waist-to-height ratio (WHtR), and hypertension, assessing their predictive capacities. The aim is to determine the specific numerical changes in hypertension incidence, systolic blood pressure (SBP) and diastolic blood pressure (DBP) for each increase in standard deviation of these indices, and to identify the optimal predictive indicators for different populations, including the calculation of cutoff values.

Methods: This study used data from the NHANES datasets spanning 2007 to 2018.

Intelligent Gesture Recognition Gloves for Real-Time Monitoring in Wireless Human-Computer Interaction.

Flexible sensors mimic the sensing ability of human skin, and have unique flexibility and adaptability, allowing users to interact with intelligent systems in a more natural and intimate way. To overcome the issues of low sensitivity and limited operating range of flexible strain sensors, this study presents a highly innovative preparation method to develop a conductive elastomeric sensor with a cracked thin film by combining polydimethylsiloxane (PDMS) with multiwalled carbon nanotubes (MCNT). This novel design significantly increases both the sensitivity and operating range of the sensor (strain range 0-50%; the maximum tensile sensitivity of this sensor reaches 4.

Propionate-functionalized chitosan hydrogel nanoparticles for effective oral delivery of insulin.

Oral delivery of macromolecular drugs is often hampered by the harsh gastrointestinal environment, which makes the drugs have poor bioavailability. Insulin, the most used drug for diabetes, also faces the same challenge for oral administration. Hence, we decorated microbial metabolite propionate on chitosan (CS) to fabricate insulin-loaded propionate-modified CS hydrogel nanoparticles (IN-CS/PA HNPs).

Epitaxy Orientation and Kinetics Diagnosis for Zinc Electrodeposition.

An accurate assessment of the electrodeposition mechanism is essential for evaluating the electrochemical stability and reversibility of the metal anodes. Multiple strategies aimed at uniform Zn deposition have been extensively reported, yet it is challenging to clarify the Zn crystal growth regularity and activity due to the obscured physicochemical properties of as-deposited Zn. Herein, we present a protocol for elucidating the controlled epitaxial growth process of Zn crystals and quantifying their surface electrochemical activity using scanning electrochemical microscopy.

Exploring the effect and mechanism of action of Jinlida granules (JLD) in the treatment of diabetes-associated cognitive impairment based on network pharmacology with experimental validation.

Objectives: To explore the effect and the probable mechanisms of JLD in the treatment of type 2 diabetes mellitus (T2DM) - associated cognitive impairment (TDACI).

Methods: The effect of JLD in combating TDACI was assessed in T2DM model mice by conducting Morris water maze (MWM) behaviour testing. Active components and their putative targets, as well as TDACI-related targets, were collected from public databases.

Pharmacological Effects of a Ginseng-Containing Chinese Medicine Formula in Treating Hepatocellular Carcinoma Based on Comprehensive Bioinformatics and Experimental Validation.

Ginseng-containing Shentao Ruangan granules (STR) have been a well-known Chinese medicine prescription for the treatment of hepatocellular carcinoma (HCC) in China for decades. This study aimed to establish an experimental framework to decipher the underlying mechanism of STR in the treatment of HCC. Microarray analysis, network pharmacology, RNA-sequencing (RNA-seq), bioinformatics analysis, and and experiments were used as integrated approaches to uncover the effects and mechanisms of action of STR.

[Characteristics, Health Risks, and Source Analysis of Heavy Metal Pollution in Surface Soil in Shanxian County].

Soil heavy metal （HM） pollution is a prominent global environmental problem. Understanding the risk characteristics and quantitative analysis of potential sources of soil HM pollution is of great significance for accurate prevention and control, scientific management, and safe utilization of soil resources. In the surface soil of Shanxian County, the contents of eight HMs, such as As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn, were collected and identified in 330 surface soil samples.

[Carbon Emission Analysis and Carbon Reduction Strategy of Small and Medium-scale Municipal Wastewater Treatment Plants in Cities and Towns].

The carbon emissions of three typical processes （AAO, MSBR, and oxidation ditch） were systematically analyzed from the perspective of the whole wastewater treatment process based on the annual data of eleven urban small and medium-scale WWTPs in the year 2022, and the effects of different influent characteristics （TP, TN, BOD, COD, influent volume, and COD/TN） on the carbon emissions were studied by using the partial least squares structural equation modeling （PLS-SEM） method. The results showed that indirect carbon emissions dominated the total carbon emissions of small and medium-scale WWTPs （69.5%）, and carbon emissions from electricity consumption were the largest source （43.

A glucan from the stems of Acanthopanax senticosus: Structure and anticolorectal cancer activity.

ASPN-1, a novel glucan with a molecular weight of 33.31 kDa, was purified from Acanthopanax senticosus stems, characterized in structure, and evaluated for antitumor potential. The analysis of the structure of ASPN-1 revealed that it consisted of a backbone constructed from →4)-α-D-Glcp-(1 → glucosyls, branched at the O-3 position by an α-D-Glcp-(1 → residue and at the O-6 positions with α-D-Glcp-(1 → 6)-α-D-Glcp-(1 → and/or α-D-Glcp-(1 → residues.

Advance in the application of metabolomics technology in poultry.

Metabolomics is a science that takes small molecular metabolites in organisms as the research object and determines the dynamic changes of metabolites at the overall level through a variety of modern analytical techniques. At present, metabolomics technology has been widely used in biological significance interpretation, food safety and quality, breeding, disease diagnosis, functional compound identification, and other fields. Its application in poultry science has also become the focus of widespread attention.