Empirical Data-Driven Linear Model of a Swimming Robot Using the Complex Delay-Embedding DMD Technique.

Anguilliform locomotion, an efficient aquatic locomotion mode where the whole body is engaged in fluid-body interaction, contains sophisticated physics. We hypothesized that data-driven modeling techniques may extract models or patterns of the swimmers' dynamics without implicitly measuring the hydrodynamic variables. This work proposes empirical kinematic control and data-driven modeling of a soft swimming robot.

Joint Identification and Sensing for Discrete Memoryless Channels.

In the identification (ID) scheme proposed by Ahlswede and Dueck, the receiver's goal is simply to verify whether a specific message of interest was sent. Unlike Shannon's transmission codes, which aim for message decoding, ID codes for a discrete memoryless channel (DMC) are far more efficient; their size grows doubly exponentially with the blocklength when randomized encoding is used. This indicates that when the receiver's objective does not require decoding, the ID paradigm is significantly more efficient than traditional Shannon transmission in terms of both energy consumption and hardware complexity.

Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels.

Background: HuR/ELAV1, a ubiquitous RNA-binding protein, belongs to the RNA-binding protein family and is crucial for stabilizing and regulating the translation of various mRNA targets, influencing gene expression. Elevated HuR levels are associated with multiple disorders, including cancer and neurodegenerative diseases. Despite the identification of small molecule inhibitors targeting HuR, their detailed characterization remains limited.

Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort.

During the omicron wave of the COVID-19 pandemic and with SARS-CoV-2 vaccines becoming available, seroprevalence rates rose in children and adolescents. This study investigated the impact of both SARS-CoV-2 infections and vaccinations on the incidence of acute and prolonged symptoms in real-world conditions during the transition from the pandemic to the endemic phase. Participants from a pediatric population based seroprevalence study (CorKID study) were followed up at least two and for almost four years by survey of health status features and symptoms suggestive of post-COVID syndrome (PCS).

The Effect of Ga-Ion Irradiation on Sub-Micron-Wavelength Spin Waves in Yttrium-Iron-Garnet Films.

We investigate the effect of focused-ion-beam (FIB) irradiation on spin waves with sub-micron wavelengths in Yttrium-Iron-Garnet (YIG) films. Time-resolved scanning transmission X-ray (TR-STXM) microscopy was used to image the spin waves in irradiated regions and deduce corresponding changes in the magnetic parameters of the film. We find that the changes of Gairradiation can be understood by assuming a few percent change in the effective magnetizationof the film due to a trade-off between changes in anisotropy and effective film thickness.

Repeatome landscapes and cytogenetics of hortensias provide a framework to trace Hydrangea evolution and domestication.

Background And Aims: Ornamental hortensias are bred from a reservoir of over 200 species in the genus Hydrangea s.l. (Hydrangeaceae), and are valued in gardens, households and landscapes across the globe.

Selenium Nucleophilicity and Electrophilicity in the Intra- and Intermolecular SN2 Reactions of Selenenyl Sulfide Probes.

Chalcogenide exchange reactions are an important class of bimolecular nucleophilic substitution reactions (SN2) involving sulfur and selenium species as nucleophile, central atom, and/or leaving group, which are fundamental throughout redox biology and metabolism. While thiol-disulfide exchange reactions have been deeply investigated, those involving selenium are less understood, especially with regards to the polarised selenenyl sulfides RSe-SR' even though the directed reactivity of selenenyl sulfides is biologically crucial for selenoenzymes such as thioredoxin reductase (TrxR) and glutathione peroxidase (GPx). Synthetic methods to create asymmetric selenenyl sulfides with high regiochemical purity only emerged over the last five years; this functional group has already demonstrated powerful applications to cell biology, through probes for molecular imaging (e.

Gold Nanorods Decorated by Conjugated Microporous Polymers for Infrared Responsive Cytostatic Drug Delivery.

Near-infrared (NIR) controlled drug delivery systems have drawn a lot of attention throughout the past few decades due to the deep penetration depth and comparatively minor side effects of the stimulus. In this study, we introduce an innovative approach for gastric cancer treatment by combining photothermal infrared-sensitive gold nanorods (AuNRs) with a conjugated microporous polymer (CMP) to create a drug delivery system tailored for transporting the cytostatic drug 5-fluorouracil (5-FU). CMPs are fully conjugated networks with high internal surface areas that can be precisely tailored to the adsorption and transport of active compounds through the right choice of chemical functionalities.

Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF.

Background: Cardiac myosin binding protein C (cMyC) is an emerging new biomarker of myocardial injury rising earlier and cleared faster than cardiac troponins. It has discriminatory power similar to high-sensitive troponins in diagnosing myocardial infarction in patients presenting with chest pain. It is also associated with outcome in patients with acute heart failure.

Nephronectin Is Required for Vascularization in Zebrafish and Sufficient to Promote Mammalian Vessel-Like Structures in Hydrogels for Tissue Engineering.

Background: Organs and tissues need to be vascularized during development. Similarly, vascularization is required to engineer thick tissues. How vessels are formed during organogenesis is not fully understood, and vascularization of engineered tissues remains a significant challenge.

Combining Ionic Groups with Methallyl Dichloride Coupling delivers New Pathways to Ionic/Non-ionic Hybrid Detergents.

Strategies for combining ionic and non-ionic functional groups are important for altering detergent properties and exploring new chemical spaces within the detergentome. Previous synthesis protocols for ionic/non-ionic hybrid detergents require asymmetric detergent precursors with independently addressable hydroxyl groups that can be decorated with charged groups. However, preparation of ionic/non-ionic headgroups can be tedious in terms of required synthesis steps and resource consumption.

Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention.

Background: Advancing evidence-based, tailored interventions for substance use disorders (SUDs) requires understanding temporal directionality while upholding ecological validity. Previous studies identified loneliness and craving as pivotal factors associated with alcohol consumption, yet the precise directionality of these relationships remains ambiguous.

Objective: This study aims to establish a smartphone-based real-life intervention platform that integrates momentary assessment and intervention into everyday life.

Amino-substituted Azoxybenzenes as Potential Redox-Active Catholyte Materials.

Aryl diazenes, particularly azobenzenes (AB), represent a versatile class of compounds with significant historical and practical relevance, ranging from dyes to molecular machines, solar thermal and electrochemical storage. Their oxygen-substituted counterparts, azoxybenzenes (AOB), share structural similarities but have been less explored, especially in energy storage applications. This study investigates the redox properties of AOB, comparing them to AB, and evaluates their potential as redox-active materials for energy storage systems.

Quantifying Asymmetric Coordination to Correlate Oxygen Reduction Activity in Fe-Based Single-Atom Catalysts.

Precisely manipulating asymmetric coordination configurations and examining electronic effects enable to tuning the intrinsic oxygen reduction reaction (ORR) activity of single-atom catalysts (SACs). However, the shortage of a definite relationship between coordination asymmetry and catalytic activity makes the rational design of SACs ambiguous. Here, we propose a concept of "asymmetry degree" to quantify asymmetric coordination configurations and assess the effectiveness of active moieties in Fe-based SACs.

[Role of ventricular tachycardia ablation in patients with systolic heart failure].

Patients with systolic heart failure (HF) and structural heart disease often suffer from ventricular tachycardias (VTs), which lead to increased morbidity and mortality. Despite advancements in pharmacological therapy and the use of implantable cardioverter-defibrillators, treatment options are limited due to side effects and decreased effectiveness. Catheter ablation (CA) has emerged as a promising therapy for drug-refractory VTs, especially in patients with structural heart disease.

Development and maintenance of consensus recommendations on pediatric outpatient antibiotic therapy in Germany: a framework for rational use.

Unlabelled: In pediatric outpatient care, overuse and misuse of antibiotics is linked to a high risk of adverse events and increased antibiotic resistance. In 2019, building upon the work of the Antibiotic Therapy in Bielefeld (AnTiB) project (founded in 2016), a collaboration among the AnTiB, the German Society for Pediatric Infectious Diseases (DGPI), and the Professional Association of Outpatient Pediatricians and Adolescent Physicians (BVKJ) was established to develop consensus recommendations for antibiotic therapy in pediatric outpatient settings in Germany. This working group became the Antibiotic Stewardship in Outpatient Pediatrics (ABSaP).

Policy options for sustainable access to off-patent antibiotics in Europe.

Securing sustainable access to existing antibiotics optimises agent choice for individual treatments and is crucial to curb antibiotic resistance. Access to antibiotics is often restricted in many countries, due to general market unavailability or episodic shortages. This article outlines key policy options to maintain availability of existing antibiotics and enhance antibiotic supply chain resilience focusing on the perspectives of European Union (EU) and European Economic Area (EEA) institutions and member states.

Genomics yields biological and phenotypic insights into bipolar disorder.

Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.

Regional and institutional trends in assessment for academic promotion.

The assessment of research performance is widely seen as a vital tool in upholding the highest standards of quality, with selection and competition believed to drive progress. Academic institutions need to take critical decisions on hiring and promotion, while facing external pressure by also being subject to research assessment. Here we present an outlook on research assessment for career progression with specific focus on promotion to full professorship, based on 314 policies from 190 academic institutions and 218 policies from 58 government agencies, covering 32 countries in the Global North and 89 countries in the Global South.

Neuromorphic computing at scale.

Neuromorphic computing is a brain-inspired approach to hardware and algorithm design that efficiently realizes artificial neural networks. Neuromorphic designers apply the principles of biointelligence discovered by neuroscientists to design efficient computational systems, often for applications with size, weight and power constraints. With this research field at a critical juncture, it is crucial to chart the course for the development of future large-scale neuromorphic systems.

Understanding the influence of stratification for mine water management: a comparative study.

Managing mine water in the best possible way is of great importance and depends on various factors like environmental protection, regulatory compliance and human health. To understand the complex chemical and hydrodynamic processes within the mine pool, it is critical to establish effective practices and management strategies. This study focuses on the characterisation of hydrodynamic processes affecting flooded underground mines, emphasising the importance of density stratification.

Linking Research Data with Physically Preserved Research Materials in Chemistry.

Results of scientific work in chemistry can usually be obtained in the form of materials and data. A big step towards transparency and reproducibility of the scientific work can be gained if scientists publish their data in research data repositories in a FAIR manner. Nevertheless, in order to make chemistry a sustainable discipline, obtaining FAIR data is insufficient and a comprehensive concept that includes preservation of materials is needed.

[Happiness-A concept for holistic person-centered healthcare in dermatology].

Background: Happiness is a concept in positive psychology. Studies have shown links between happiness, courses of diseases and health. In dermatology the role of happiness has not yet been sufficiently investigated.