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Dynamic Causal Modeling of Hippocampal Links within the Human Default Mode Network: Lateralization and Computational Stability of Effective Connections.

Front Hum Neurosci

October 2016

National Research Centre "Kurchatov Institute"Moscow, Russia; NBICS-Faculty, Moscow Institute of Physics and TechnologyMoscow, Russia; Faculty of Psychology, M.V. Lomonosov Moscow State UniversityMoscow, Russia; Center for Cognitive Programs and Technologies, Russian State University for the HumanitiesMoscow, Russia; Applied Cognitive Research, Department of Psychology, Technische Universitaet DresdenDresden, Germany.

The purpose of this paper was to study causal relationships between left and right hippocampal regions (LHIP and RHIP, respectively) within the default mode network (DMN) as represented by its key structures: the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and the inferior parietal cortex of left (LIPC) and right (RIPC) hemispheres. Furthermore, we were interested in testing the stability of the connectivity patterns when adding or deleting regions of interest. The functional magnetic resonance imaging (fMRI) data from a group of 30 healthy right-handed subjects in the resting state were collected and a connectivity analysis was performed.

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