2 results match your criteria: "Technische Universität (TU)[Affiliation]"
PSD3 downregulation confers protection against fatty liver disease.
Nat Metab
January 2022
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden.
Article Synopsis
- Fatty liver disease (FLD) is increasingly recognized as a significant health concern with unresolved clinical challenges, having both genetic factors and unexplained heritability.
- Research identifies a specific genetic variant (rs71519934) at the PSD3 gene that makes some individuals less susceptible to FLD through a protein change (L186T).
- Reducing PSD3 levels in liver cells lowers fat content, and inhibiting this gene in mice protects against FLD, suggesting that targeting PSD3 could lead to new treatments for humans with FLD.
Jellyfish collagen scaffolds for cartilage tissue engineering.
Acta Biomater
February 2014
University Hospital and Medical Faculty, Technische Universitaät Dresden, Centre for Translational Bone, Joint and Soft Tissue Research, Fetscher Str. 74, D-01307 Dresden, Germany.
Article Synopsis
- Researchers created porous scaffolds from jellyfish collagen aiming to enhance cartilage regeneration, analyzing factors like collagen concentration, salinity, and temperature for optimal fibril formation.* -
- The scaffolds exhibited 98.2% open porosity, demonstrated stability during cyclic compression, and showed elastic characteristics, confirmed through microscopy techniques.* -
- Cytotoxicity tests indicated the material is safe for human mesenchymal stem cells, which displayed increased chondrogenic markers and extracellular matrix components when stimulated.*