ZBTB48 is a priming factor regulating B-cell-specific CIITA expression.

The class-II transactivator (CIITA) is the master regulator of MHC class-II gene expression and hence the adaptive immune response. Three cell type-specific promoters (pI, pIII, and pIV) are involved in the regulation of CIITA expression, which can be induced by IFN-γ in non-immune cells. While key regulatory elements have been identified within these promoters, our understanding of the transcription factors regulating CIITA expression is incomplete.

GHRH in diabetes and metabolism.

Despite over a century of insulin therapy and recent advances in glucose monitoring, diabetes and its complications remain a significant burden. Current medications are not durable, with symptoms often returning after treatment ends, and responses vary between patients. Additionally, the effectiveness of many medications diminishes over time, highlighting the need for alternative approaches.

One-year ecological momentary assessment of alcohol use, mood, and stress among individuals with alcohol use disorder during SARS-CoV-2 pandemics: a gender-specific reflection.

Alcohol consumption (AC) is a leading risk factor for death, morbidity, and disability worldwide. Gender-specific differences in AC and its moderators, which may serve as markers for preventing severe alcohol use disorders (AUD), showed inconsistent results. Additionally, the impact of COVID-19-related lockdowns on these differences remains unclear.

Phenolic content and antioxidant activity of Croatian and German honey.

Since honey has a therapeutic role in the treatment of many diseases, we investigated the content of phenolic compounds and the antioxidant activity in acacia ( L.), chestnut ( Mill.) and lime-tree ( spp.

Unpredictable Aortic Behavior in Identifying Risk Factors for Reintervention: A Prospective Cohort Study.

Background:  Although advancements in the management of thoracic aortic disease have led to a reduction in acute mortality, individuals requiring postoperative reintervention experience substantially worse long-term clinical outcomes and increased mortality. We aimed to identify the risk factors for postoperative reintervention in this high-risk population.

Patients And Methods:  This prospective observational cohort study included patients who survived endovascular or open surgical treatment for thoracic aortic disease between January 2009 and June 2020.

Comprehensive multicentre retrospective analysis for predicting isocitrate dehydrogenase-mutant lower-grade gliomas.

Objective: To differentiate glioma grading and determine isocitrate dehydrogenase (IDH) mutation status, which are crucial for prognosis assessment and treatment planning in glioma patients.

Methods: This retrospective study included patients diagnosed with adult diffuse glioma from 1 January, 2018 to 31 July, 2023 in two independent institutions. It documented and analysed clinical and radiographic features.

Increased risk of fracture among patients with iron overload: a population-based matched cohort study.

Introduction: Iron overloading disorders are associated with decreased bone mineral density. However, evidence on fracture risk is scarce. Therefore, we evaluated the risk of fracture associated with iron overload disorders, compared to matched controls.

Formation of Chlorinated Carbohydrate Degradation Products and Amino Acids during Heating of Sucralose in Model Systems and Food.

Sucralose is an artificial sweetener whose stability during the thermal treatment of food is controversially discussed. In the present work, sucralose was subjected to different kinds of heat treatment either as such, in the presence of protein, or as an ingredient of food. Compared with sucrose, sucralose showed remarkable instability and discoloration after heating at 85-90 °C for 1 h.

Metal-Phthalocyanine-Based Two-Dimensional Conjugated Metal-Organic Frameworks for Electrochemical Glycerol Oxidation Reaction.

Electrochemical glycerol oxidation reaction (GOR) is a promising candidate to couple with cathodic reaction, like hydrogen evolution reaction, to produce high-value product with less energy consumption. Two dimensional conjugated metal-organic frameworks (2D c-MOFs), comprising square-planar metal-coordination motifs (e.g.

Alanine mutation of the targeting subunit of the myosin phosphatase, MYPT1 at threonine 696 reduces cGMP responsiveness of mouse femoral arteries.

The femoral artery (FA) is the largest vessel in the hindlimb circulation and its proper tone regulation ensures adequate blood supply to muscle tissue. We investigated whether an alanine mutation of the targeting subunit of myosin-light-chain-phosphatase (MLCP), MYPT1, at threonine 696 (MYPT1-T696A/+), decisive for enzyme acivity, affects the responsiveness of young and old FAs (y-FAs and o-FAs) to activation of nitric-oxide/soluble-guanylate-cyclase/protein-kinase-G cascade (NO/sGC/PKG). Contractile responses of the vessels were measured by wire myography.

[ePROs in the routine care of a major oncology center: Results and experiences].

Background: To what extent and under what conditions electronically captured patient-reported outcomes (ePROs) can be used in routine medical care and contribute to improved patient care is a widely discussed question. In the field of oncology, few studies in Germany have focused this topic that go beyond the scope of time-limited studies.

Method: First, we present the centrally coordinated collection of ePROs in the routine care of a comprehensive cancer center of the German Cancer Aid in its development, and then describe its qualitative dimension.

A social information processing perspective on social connectedness.

Social connectedness (SC) is one of the most important predictors for physical and mental health. Consequently, SC is addressed in an increasing number of studies, providing evidence for the multidimensionality of the construct, and revealing several factors that contribute to individual differences in SC. However, a unified model that can address SC subcomponents is yet missing.

Noncollinear Magnetic Structures in the Chiral Antiperovskite β-FeSeO.

We present the magnetic properties of the chiral, polar, and possibly magnetoelectric antiperovskite β-FeSeO as derived from magnetization and specific-heat measurements as well as from powder neutron diffraction and Mössbauer experiments. Our macroscopic data unambiguously reveal two magnetic phase transitions at ≈ 103 K and ≈ 78 K, while Rietveld analysis of neutron powder diffraction data reveals a noncollinear antiferromagnetic structure featuring magnetic moments in the - plane of the trigonal structure and a ferromagnetic moment along . The latter is allowed by symmetry between and , weakly visible in the magnetization data yet unresolvable microscopically.

Surface superconductivity in the topological Weyl semimetal t-PtBi.

Topological superconductivity is a promising concept for generating fault-tolerant qubits. Early experimental studies looked at hybrid systems and doped intrinsic topological or superconducting materials at very low temperatures. However, higher critical temperatures are indispensable for technological exploitation.

Rationale and study protocol of a regional health panel in Saxony, Germany (GEPASA).

Background: The citizens' perspectives on health care are central to the assessment of the health care situation and to regional development. In Germany, however, strategic goals for health care delivery are planned based on population statistics and partly on regional morbidity. Saxony is a German federal state with high average age and low density of physicians which makes the population perspective on quality of health care especially intersting.

Exploring the dynamics of ultrasound training in medical education: current trends, debates, and approaches to didactics and hands-on learning.

Introduction: Medical education, especially in ultrasound training, is undergoing significant changes. This study examines practical issues in ultrasound medical education, emphasizing state-of-the-art teaching methods, their effectiveness, and implementation challenges.

Methods: The study analyzed advancements in ultrasound education, including randomized controlled trials comparing peer-to-peer teaching with traditional faculty-led instruction.

[EyeMatics-Multicenter data evaluation of real-world data with interoperable medical informatics].

The evaluation of real-world data (RWD) enables insights to be gained from a wide range of patient data collected in routine clinical practice. In addition, multicenter analyses represent a broad and representative patient population and have the potential to capture the actual treatment situation. As a basis for this, the definition of datasets and an infrastructure for data exchange is necessary.