3 results match your criteria: "Technical University of Munich and Helmholtz Munich[Affiliation]"
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis.
Sci Immunol
December 2024
Department of Immunobiology, Université de Lausanne, Epalinges, Switzerland.
The molecular mechanisms by which worm parasites evade host immunity are incompletely understood. In a mouse model of intestinal helminth infection using (), we show that helminthic glutamate dehydrogenase (heGDH) drives parasite chronicity by suppressing macrophage-mediated host defense. Combining RNA-seq, ChIP-seq, and targeted lipidomics, we identify prostaglandin E (PGE) as a major immune regulatory mechanism of heGDH.
View Article and Find Full Text PDFEvaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis.
Virol J
June 2024
Institute of Virology, School of Medicine, Technical University of Munich and Helmholtz Munich, Schneckenburgerstr. 8, 81675, Munich, Germany.
Background: Infection with the Epstein-Barr virus (EBV) elicits a complex T-cell response against a broad range of viral proteins. Hence, identifying potential differences in the cellular immune response of patients with different EBV-associated diseases or different courses of the same disorder requires interrogation of a maximum number of EBV antigens. Here, we tested three novel EBV-derived antigen formulations for their ability to reactivate virus-specific T cells ex vivo in patients with EBV-associated infectious mononucleosis (IM).
View Article and Find Full Text PDFHepatitis B Virus Neutralization with DNA Origami Nanoshells.
ACS Appl Mater Interfaces
May 2024
Department of Biosciences, School of Natural Sciences and Munich Institute of Biomedical Engineering, Technical University of Munich, Boltzmannstraße 11, 85748 Garching, Germany.
Article Synopsis
- Researchers developed DNA origami nanoshells that trap and neutralize hepatitis B virus (HBV) in cell cultures.
- The nanoshells, modified with synthetic monoclonal antibodies, enhance neutralization potency by roughly 100 times compared to free antibodies due to their physical barrier and multivalent binding effects.
- The study suggests that using these DNA shells holds promise for creating effective antiviral treatments from components that are ineffective alone.