5,351 results match your criteria: "Technical University Munich[Affiliation]"
J Neurol
December 2024
APHM, Hôpital de la Timone, CEMEREM, Marseille, France.
Objective: In this multicentric study, we were interested in the vision-related quality of life and its association with visual impairment in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in comparison to multiple sclerosis (MS) and healthy controls.
Methods: We analysed extracted data from the German NEMOS registry including National Eye Institute Visual Function Questionnaire (NEI-VFQ) scores, high and low contrast visual acuity (HCVA, LCVA), visually evoked potentials (VEP) and the scores for the expanded disability status scale (EDSS) and other neurological tests which assessed their disease-related impairment. The mean follow-up time of our patients was 1.
ACS Nano
December 2024
Dipartimento di Fisica, Sapienza Università di Roma, P. le Aldo Moro 5, 00185 Rome, Italy.
One of the frontiers of nanotechnology is advancing beyond the periodic self-assembly of materials. Icosahedral quasicrystals, aperiodic in all directions, represent one of the most challenging targets that has yet to be experimentally realized at the colloidal scale. Previous attempts have required meticulous human-designed building blocks and often resulted in interactions beyond the current experimental capabilities.
View Article and Find Full Text PDFEur J Cancer
November 2024
University of Perugia, Unit of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
This guideline was developed in close collaboration with multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF) and the European Organization for Research and Treatment of Cancer (EORTC). Recommendations for the diagnosis and treatment of melanoma were developed on the basis of systematic literature research and consensus conferences. Cutaneous melanoma (CM) is the most dangerous form of skin tumor and accounts for 90 % of skin cancer mortality.
View Article and Find Full Text PDFBehav Res Ther
December 2024
Department of Clinical Psychology and Psychotherapy, Friedrich-Alexander-Universität Erlangen Nürnberg, Nägelsbachstraße 25a, 91052, Erlangen, Germany. Electronic address:
This study was aimed to evaluate whether the efficacy of invoking anti-depressive self-statements to cope with depressed mood can be enhanced for depressed individuals by systematically guiding them to amplify the expression of conviction in their voice. Accordingly, we recruited N = 144 participants (48 clinically depressed individuals, 48 sub-clinically depressed individuals, and 48 non-depressed individuals). Participants were randomly assigned to an experimental or control condition.
View Article and Find Full Text PDFSpine J
December 2024
Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich.
Background Context: Primary spondylodiscitis occurs through the hematogenous spread of a pathogen entering the body via a point of entry. The infection's origin often remains unclear. During dental procedures or through minor traumas, oral bacteria can enter the bloodstream and disseminate throughout the body.
View Article and Find Full Text PDFEur J Cancer
December 2024
Department of Medical Oncology, Institut régional du Cancer de Montpellier (ICM), Montpellier, France; Société Française de Médecine Prédictive et Personnalisée (SFMPP), Montpellier, France; Center for Ecological and Evolutionary Cancer Research (CREEC), Montpellier University, Montpellier, France. Electronic address:
Background: Poly (ADP ribose) polymerase inhibitors (PARPis) are a treatment option for patients with advanced high-grade serous or endometrioid ovarian carcinoma (OC). Recent guidelines have clarified how homologous recombination deficiency (HRD) may influence treatment decision-making in this setting. As a result, numerous companion diagnostic assays (CDx) have been developed to identify HRD.
View Article and Find Full Text PDFPlant Commun
December 2024
Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address:
Machine learning and deep learning have been employed in genomic selection (GS) to expedite the identification of superior genotypes and accelerate breeding cycles. However, a significant challenge for current data-driven deep learning models in GS is their low robustness and interpretability. To address this challenge, we developed Cropformer, a deep learning framework for predicting crop phenotypes and exploring downstream tasks.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department of Sports Orthopaedics, Technical University Munich, Ismaningerstr. 22, 81675 Munich, Germany.
: Lateral extraarticular tenodesis (LET) has been advocated in revision anterior cruciate ligament reconstruction (ACLR) to improve knee stability and furthermore, decrease failure rates. The aim of this study was to compare clinical outcomes, knee laxity, and failure rates after revision ACLR with LET (ACLR + LET) versus without LET. It was hypothesized that ACLR + LET improves clinical outcomes and reduces the failure rate.
View Article and Find Full Text PDFCommun Med (Lond)
December 2024
Institute of Computational Biology, Helmholtz Munich, 85764, Neuherberg, Germany.
Background: Distal sensorimotor polyneuropathy (DSPN) is a common neurological disorder in elderly adults and people with obesity, prediabetes and diabetes and is associated with high morbidity and premature mortality. DSPN is a multifactorial disease and not fully understood yet.
Methods: Here, we developed the Interpretable Multimodal Machine Learning (IMML) framework for predicting DSPN prevalence and incidence based on sparse multimodal data.
Arch Orthop Trauma Surg
December 2024
Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center, Munich (MUM), University Hospital, LMU Munich, Munich, Germany.
Introduction: There is a clear roadmap for the treatment of primary insertional Achilles tendinopathy (IAT), but data on the outcome of revision surgery is missing. The current study aimed to analyze the outcome following revision surgery for surgically failed IAT.
Material And Methods: Included were patients with IAT revision surgery at a single reference center (01/2010-10/2016) and a follow-up of at least 12 months.
Front Neurol
November 2024
Department of Neurosurgery, Medical Center, University Hospital Freiburg, Freiburg im Breisgau, Germany.
Background: Post-dural puncture headache (PDPH) is still mostly regarded a minor complication after lumbar puncture. In the International Classification of Headache Disorders (ICHD)-3 headaches lasting longer than 14 days or persisting after epidural blood patch (EBP) are not even considered. We illustrate that there may be many patients with persisting headaches and a large disease burden.
View Article and Find Full Text PDFIntroduction: This study evaluates the clinical value of a deep learning-based artificial intelligence (AI) system that performs rapid brain volumetry with automatic lobe segmentation and age- and sex-adjusted percentile comparisons.
Methods: Fifty-five patients-17 with Alzheimer's disease (AD), 18 with frontotemporal dementia (FTD), and 20 healthy controls-underwent cranial magnetic resonance imaging scans. Two board-certified neuroradiologists (BCNR), two board-certified radiologists (BCR), and three radiology residents (RR) assessed the scans twice: first without AI support and then with AI assistance.
Nature
December 2024
CatalYm, Munich, Germany.
Cancer immunotherapies with antibodies blocking immune checkpoint molecules are clinically active across multiple cancer entities and have markedly improved cancer treatment. Yet, response rates are still limited, and tumour progression commonly occurs. Soluble and cell-bound factors in the tumour microenvironment negatively affect cancer immunity.
View Article and Find Full Text PDFPoult Sci
November 2024
Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China. Electronic address:
Parental living environment significantly impacts on offspring, yet related studies are lacking in livestock and poultry production. The present study found that lipopolysaccharide (LPS, Escherichia coli, 0.2 mg/kg) stimulation in F0 hens led to growth retardation and a decrease in egg-laying rate in the unchallenged F1 hens.
View Article and Find Full Text PDFNat Methods
December 2024
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Dissecting human neurobiology at high resolution and with mechanistic precision requires a major leap in scalability, given the need for experimental designs that include multiple individuals and, prospectively, population cohorts. To lay the foundation for this, we have developed and benchmarked complementary strategies to multiplex brain organoids by pooling cells from different pluripotent stem cell (PSC) lines either during organoid generation (mosaic models) or before single-cell RNA sequencing (scRNA-seq) library preparation (downstream multiplexing). We have also developed a new computational method, SCanSNP, and a consensus call to deconvolve cell identities, overcoming current criticalities in doublets and low-quality cell identification.
View Article and Find Full Text PDFNat Rev Immunol
December 2024
Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette/Belvaux, Luxembourg.
Clin Res Cardiol
December 2024
Klinik Und Poliklinik Für Innere Medizin I, University Hospital Rechts Der Isar, School of Medicine and Health, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Background: Aortic stenosis (AS) induces cardiac remodeling upon chronic left ventricular (LV) pressure overload. Here, we analyzed the clinical outcome of patients undergoing transcatheter aortic valve replacement (TAVR) for symptomatic AS with regard to varying LV hypertrophy patterns. Moreover, we investigated the genetic influence on development of different hypertrophy patterns, measured by polygenic risk scores (PRS).
View Article and Find Full Text PDFLancet Diabetes Endocrinol
December 2024
Institute of Diabetes Research, Helmholtz Munich, German Research Center for Environmental Health, 80939 Munich, Germany; Technical University Munich, School of Medicine and Health, Forschergruppe Diabetes at Klinikum rechts der Isar, Munich, Germany. Electronic address:
Eur J Cancer
January 2025
Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; Fleur Hiege Center for Skin Cancer Research, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address:
Background: Cancer immunotherapy has revolutionized melanoma treatment, but the high number of non-responders still emphasizes the need for improvement of therapy. One potential avenue for enhancing anti-tumor treatment is through the modulation of coagulation and platelet activity. Both have been found to play an important role in the tumor microenvironment, tumor growth and metastasis.
View Article and Find Full Text PDFChemosphere
December 2024
Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, School of Medicine and Health, Technical University Munich, Munich, Germany.
Environmental mercury (Hg) follows a biogeochemical cycle resulting in a variety of Hg species. Therefore, human exposure to the three Hg species inorganic Hg via crops and air, methyl Hg through fish consumption and ethyl Hg due to the use as antiseptic agent in medical applications is a rising concern. Especially pregnant women and their developing fetus present a vulnerable population.
View Article and Find Full Text PDFLancet Oncol
December 2024
Comprehensive Cancer Center Munich of the Technical University Munich and the Ludwig Maximiliaan University, Munich, Germany; Princess Máxima Center and University Medical Center Utrecht, Utrecht, Netherlands.
Arterioscler Thromb Vasc Biol
December 2024
Institute of Molecular Vascular Medicine, Klinikum rechts der Isar, Technical University Munich, Germany (L.M., F.F.).
EMBO J
December 2024
Division of Genetics and Cell Biology. Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Via Olgettina 58, Milan, IT, Italy.
J Med Internet Res
December 2024
Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.