22 results match your criteria: "Teaching hospital of the Ruhr-University Bochum[Affiliation]"

Article Synopsis
  • Advancements in molecular engineering have led to the development of CAR T-cell therapy, showing potential for treating various neurological disorders, including brain tumors and autoimmune conditions.
  • Although initial human trials for treating glioblastoma have had limited success, animal studies show promise for other conditions like multiple sclerosis and neuromyelitis optica spectrum disorders.
  • Innovative strategies using modified CAR T cells targeting autoreactive B cells are showing potential for treating autoimmune encephalitis, suggesting a hopeful future for CAR T-cell applications in neurology.
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Objectives: To standardize optic nerve sheath diameter (ONSD) point-of-care ultrasonography (POCUS) and improve its research and clinical utility by developing the ONSD POCUS Quality Criteria Checklist (ONSD POCUS QCC).

Design: Three rounds of modified Delphi consensus process and three rounds of asynchronous discussions.

Setting: Online surveys and anonymous asynchronous discussion.

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Risk factors for multimodal conservative approach failure before bariatric surgery.

BJS Open

January 2024

Department of General and Visceral Surgery, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin and Humboldt-Universitaet zu Berlin, Hindenburgdamm 30,12203 Berlin, Germany.

Background: A multimodal conservative approach (MCA) is internationally recommended prior to bariatric surgery for the majority of patients. This research aimed to identify risk factors for therapy failure within the MCA.

Methods: This study was conducted in a German bariatric obesity centre.

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Background: The treatment of ischemic stroke (IS) has changed considerably in recent years. Particularly the advent of mechanical thrombectomy (MTE) has revolutionized the available treatment options. Most patients in developed countries have access to intravenous thrombolysis (IVT).

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The γ-aminobutyric acid (GABA) is the main inhibitory transmitter in the central nervous system and GABA receptors mediate the inhibitory synaptic transmission. GABA binding to neuronal GABA R leads to a rapid hyperpolarization and a higher excitation threshold due to an increase in membrane Cl permeability. The synaptic GABA R is mostly composed of two α(1-3), two β, and one γ subunit with the most abundant configuration α1β2γ2.

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Sphincter-saving therapy for fistula-in-ano: long-term follow-up after FiLaC.

Tech Coloproctol

February 2021

Department of General and Visceral Surgery, Marien Hospital Witten, Teaching hospital of the Ruhr University Bochum, Marienplatz 2, 58452, Witten, Germany.

Background: The treatment of anal fistula remains a challenge between maintaining continence and radical surgery to prevent recurrence. Fistula-tract Laser Closure (FiLaC) is a sphincter-saving technique using a radial emitting laser fibre to close the fistula tract. The aim of this study was to report long-term outcomes in patients who received FiLaC therapy for transsphincteric and intersphincteric anal fistula between January 2011 and December 2017.

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Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women.

Int J Environ Res Public Health

April 2020

Department of General and Visceral Surgery, Marien Hospital Witten, Teaching hospital of the Ruhr-University Bochum, Marienplatz 2, 58452 Witten, Germany.

This systematic literature review aims to point out sex-specific special features that are important in the bariatric treatment of women suffering from severe obesity. A systematic literature search was carried out according to Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. After the literature selection, the following categories were determined: sexuality and sexual function; contraception; fertility; sex hormones and polycystic ovary syndrome; menopause and osteoporosis; pregnancy and breastfeeding; pelvic floor disorders and urinary incontinence; female-specific cancer; and metabolism, outcome, and quality of life.

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This study aimed to evaluate foetal signal quality obtained using an antenatal foetal ECG system (Monica 24™) and compare it with Doppler ultrasound CTG monitoring (Corometrics® 250 series). Seventy pregnant women (gestational age: between 20 + 0 weeks and 40 + 0 weeks) were examined using the Monica AN24™ system and also underwent Doppler CTG. The signal quality of both methods was compared and correlated with gestational age and pre-pregnancy body mass index (BMI).

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To investigate the functional adaptive process of the fetal autonomic nervous system during hypnosis from the 20th week of gestation till term. Are there changes in the power spectrum analysis of fetal heart rate when the mother is having a clinical hypnosis or control period? Fourty-nine FHR recordings were analysed. Included recordings were from singletons and abdominal fetal ECG-monitored pregnancies.

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Intra- and interobserver variability of intrapartum cardiotocography: a multicenter study comparing the FIGO classification with computer analysis software.

Gynecol Obstet Invest

March 2012

Department of Obstetrics and Gynecology, Marien Hospital Witten, Teaching Hospital of the Ruhr University Bochum, Witten/Herdecke University, Marienplatz 2, Witten, Germany.

Objective: To evaluate and compare the computer analyzing software system with subjective interpretation using the FIGO classification of intrapartum cardiotocograms.

Methods: Twenty-four obstetricians and 19 midwives from 3 hospitals [19 junior (≤3 years) and 24 senior (>3 years) experience] participated in this study. Forty-three doctors and midwives interpreted intrapartum cardiotocographic (CTG) readings from 12 parturients without knowing the clinical outcome.

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Comparison of non-invasive fetal electrocardiogram to Doppler cardiotocogram during the 1st stage of labor.

J Perinat Med

March 2010

Department of Obstetrics and Gynecology, Faculty of Medicine, Marien-Hospital Witten, University Witten/Herdecke, Teaching hospital of the Ruhr-University Bochum, Witten, Germany.

Objective: We compared a non-invasive fetal electrocardiogram (fECG) to Doppler cardiotocogram (CTG) during the 1(st) stage of labor.

Study Design: This was a prospective observational study of non-invasive fECG using five abdominal electrodes and one Doppler ultrasound probe in 27 patients. Data were analyzed for reliability, clinical and statistical equivalence.

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Introduction: Epiploic appendagitis is a rare cause of focal abdominal pain which, depending on its localisation, can mimic a variety of abdominal diseases. We describe a patient with an inflamed necrotic appendix epiploicum with immediate contact to a non-inflamed appendix vermiformis mimicking acute appendicitis. Considering the rare localization, this is the first report of this kind in the literature.

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Introduction: In-flight medical and surgical emergencies (IMEs) onboard commercial aircrafts occur quite commonly. However, little epidemiological research exists concerning these incidents.

Methods: Thirty-two European airlines were asked to provide anonymous data on medical flight reports of IMEs for the years 2002 to 2007.

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Cutaneous lesions of the external ear.

Head Face Med

February 2008

Department of General and Visceral Surgery, Augusta Kranken Anstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany.

Skin diseases on the external aspect of the ear are seen in a variety of medical disciplines. Dermatologists, othorhinolaryngologists, general practitioners, general and plastic surgeons are regularly consulted regarding cutaneous lesions on the ear. This article will focus on those diseases wherefore surgery or laser therapy is considered as a possible treatment option or which are potentially subject to surgical evaluation.

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Skin cancer on the nose is commonly treated with surgical excision resulting in defects that require closure. The surgeon is faced with many reconstructive options. The paramedian forehead flap is one commonly used technique.

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Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS). We report on a 42-year-old male patient with a ten year history of metastatic medullary thyroid carcinoma suffering from paraneoplastic Cushing's Syndrome caused by ectopic hypersecretion of ACTH and a simultaneous Cortisol producing adrenal metastasis.

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Background: Epiploic appendagitis (EA) is a rare cause of focal abdominal pain in otherwise healthy patients with mild or absent secondary signs of abdominal pathology. It can mimick diverticulitis or appendicitis on clinical exam. The diagnosis of EA is very infrequent, due in part to low or absent awareness among general surgeons.

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Keloids are defined as dermal fibrotic lesions which are considered an aberration of the wound healing process. Their etiology and pathogenesis are poorly understood. Different treatment modalities are described in the literature depending on the morphology and size of the keloid.

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Synopsis of otoplasty.

Facial Plast Surg

November 2004

Department of Otorhinolaryngology, Head and Neck Surgery, Prosper Hospital, Academic Teaching Hospital of the Ruhr University Bochum, 45659 Recklinghausen, Germany.

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Correction of the lobule.

Facial Plast Surg

November 2004

Department of Otorhinolaryngology, Head and Neck Surgery, Prosper Hospital, Academic Teaching Hospital of the Ruhr University Bochum, 45659 Recklinghausen, Germany.

Many techniques have been described for the correction of protruding ears. Most of them concentrate on correcting the form and position of auricular cartilage. The lobule is a soft tissue structure.

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The modified converse technique in combination with cavum rotation.

Facial Plast Surg

November 2004

Department of Otorhinolaryngology, Head and Neck Surgery, Prosper Hospital, Academic Teaching Hospital of the Ruhr University Bochum, 45659 Recklinghausen, Germany.

We report our experiences in 210 patients with protruding ears who underwent a surgical correction of their deformity using a modified "Converse technique." The technique combines a posterior incomplete cartilage incision with permanent cartilage sutures and a cavum rotation if necessary. The described technique provides a good anterior width and normal relief, with shaped anthelix and crus superior, can be achieved.

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