Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate)-based microspheres as a sustained platform for Huperzine A delivery for alzheimer's disease therapy.

Huperzine A (HupA) is used in Alzheimer's disease (AD) therapy for its effective inhibition of acetylcholinesterase (AChE) and enhancement of cholinergic neuronal function. However, direct oral administration and injection of HupA cause side effects like nausea, anorexia, and rapid metabolism. Using a tripolymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate (PBVHx), from the polyhydroxyalkanoate (PHA) family synthesized via synthetic biology, we present a novel AD therapy strategy with peritoneally administered PBVHx microspheres loaded with HupA (HupA-PBVHxMs).

The impact of a positive discipline group intervention on parenting self-efficacy among mothers of young children.

Introduction: Instilling healthy behaviors in early childhood is crucial as they can have lifelong impacts. However, many Chinese mothers lack effective parenting strategies, resulting in low self-efficacy. Positive Discipline, a non-punitive and non-indulgent approach, can help enhance maternal parenting self-efficacy and promote healthy lifestyle behaviors in children.

Bouncing back from life's perturbations: Formalizing psychological resilience from a complex systems perspective.

Experiencing stressful or traumatic events can lead to a range of responses, from mild disruptions to severe and persistent mental health issues. Understanding the various trajectories of response to adversity is crucial for developing effective interventions and support systems. Researchers have identified four commonly observed response trajectories to adversity, from which the resilient is the most common one.

Prospective associations between heterogeneous sleep profiles and depressive symptoms in adolescents: The mediating role of coping styles.

Introduction: Extant literature has linked sleep disturbance to depressive symptoms. However, the coexistence of naturally occurring sleep profiles among adolescents and the prospective associations between sleep profiles and depressive symptoms remain poorly understood. This study aims to uncover sleep patterns in Chinese adolescents based on a comprehensive set of sleep features (e.

Interface-assisted synthesized covalent organic framework film for efficient extraction of microcystins in aquatic organisms.

Covalent organic framework (COF) film-based solid-phase extraction (F-SPE) has garnered great attention in sample pretreatment. However, harsh synthesis conditions of COF films have severely hindered their potential applications. In this study, a kind of COF (TPB-DMTP) films were fabricated via a liquid-liquid interfacial synthesis method at a mild condition.

Exploring Working Memory in Context Sensitivity.

Context sensitivity refers to the ability to identify cues regarding the nature of stressor situations. This skill is a necessary precursor to successful emotion regulation and may involve detecting the presence or absence of stressor cues. Previous research has suggested that context sensitivity relies in part on working memory (WM), one component of cognitive control or executive functioning.

Fadeout and persistence of intervention impacts on social-emotional and cognitive skills in children and adolescents: A meta-analytic review of randomized controlled trials.

Researchers and policymakers aspire for educational interventions to change children's long-run developmental trajectories. However, intervention impacts on cognitive and achievement measures commonly fade over time. Less is known, although much is theorized, about social-emotional skill persistence.

Measuring Socioeconomic and Stress Disparities in Infant Declarative Memory Using the Visual Paired Comparison Task.

Research suggests that socioeconomic circumstances and stress predict memory skills in adults and older children, yet few studies have addressed this question in infancy. The current study used the visual-paired comparison paradigm to examine whether socioeconomic circumstances, maternal perceived stress, and/or maternal physiological stress, all measured prenatally, predict memory performance among 6-month-old infants. We found no significant associations between infant memory and any measure of socioeconomic circumstance or stress.

Storage deterioration and detection of egg multi-scale structure: A review.

This review summarized the processes and mechanisms of deterioration in different components of eggs during storage. The mechanisms linked to reduced glycosylation, structural decay, and ovomucin degradation during egg-white thinning were elucidated, along with the weakening of lysozyme-ovomucin interactions. The degradation and S-conformation transformation of ovalbumin were studied, and the potential application of solubility-viscosity theory in egg-white thinning was discussed.

Food Avoidance beyond the Gluten-Free Diet and the Association with Quality of Life and Eating Attitudes and Behaviors in Adults with Celiac Disease.

Background: The only treatment for Celiac Disease (CeD), which affects about 1% of the population, is a gluten-free diet (GFD). Studies have indicated an association between the GFD, a diminished quality of life (QOL), and maladaptive eating patterns. This study aims to explore food avoidance behaviors in adults with CeD.

Anti-Inflammatory Activity of Labdane and Norlabdane Diterpenoids from Leonurus sibiricus Related to Modulation of MAPKs Signaling Pathway.

, a widely cultivated herbaceous plant in Asian countries, exhibits diverse medicinal applications. Recent studies emphasize its pharmacological properties and efficacy in promoting bone health. In addition to the known compounds and their pharmacological activities, in this study, we isolated and elucidated two new labdane-type diterpenoids, (3,5,6,10)-3,6-dihydroxy-15-ethoxy-7-oxolabden-8(9),13(14)-dien-15,16-olide (1: ) and (4,5,10)-18-hydroxy-14,15-bisnorlabda-8-en-7,13-dione (2: ), a new natural phenolic compound, and a known compound from using advanced spectroscopic techniques, including circular dichroism spectroscopy, high-resolution mass spectrometry, and 1- and 2-dimensional NMR.

Access to energy and women's human capital in sub-Saharan Africa.

This study examines the link between access to energy and women's human capital by focusing on women's life expectancy and school enrollment. To evaluate this relationship, we take a supranational perspective by using data from a panel of 34 sub-Saharan African countries over a 21-year period from 2000 to 2020. To do so, the ordinary least squares estimation technique applied to a fixed effects specification was adopted.

Respiratory-Swallow Coordination and Its Relationship With Pharyngeal Residue, Penetration, and Aspiration in People With Parkinson's Disease.

Purpose: Respiratory-swallow coordination (RSC) frequently changes in people with Parkinson's disease (PwPD). Little is known about how these changes relate to impairments in swallowing safety (penetration and aspiration) and efficiency (pharyngeal residue). Therefore, the aims of this study were to assess the relationships between RSC, pharyngeal residue, penetration, and aspiration in PwPD.

Depressive and Anxiety Symptoms Were More Common for Transgender Individuals Whose Gender-Affirming Surgeries Were Cancelled or Delayed Due to COVID-19: A Global Cross-Sectional Study.

Gender-affirming surgeries, which have well-established mental health benefits, were cancelled and delayed for transgender people worldwide during the COVID-19 crisis. Of 253 scheduled gender-affirming surgeries among transgender adults across 35 countries in late 2020, 27% (=69) reported that the COVID-19 crisis limited their access to gender-affirming surgery (i.e.

Hollow microporous organic network fiber membrane for efficient extraction of okadaic acid from marine organisms.

Membrane-based micro-solid phase extraction (M-μSPE) has garnered great attention in sample pretreatment, suffering an inherent contradiction between permeability and adsorption capacity. In this study, a pure microporous organic network (TEB-DIB-MON) fiber membrane was prepared by combining electrostatic spinning technology, Sonogashira-Hagihara reaction and template sacrifice method. The prepared TEB-DIB-MON membrane exhibited a large specific surface area with a hollow and porous structure, thereby providing excellent solvent permeability and high adsorption capacity for okadaic acid (OA, an algal toxin).

Needs and Preferences for Remote-Delivered Mindfulness-Based Cognitive Therapy in Patients After Acute Coronary Syndrome: A Qualitative Study.

Background: Following acute coronary syndrome (ACS), up to 40% of patients report elevated depressive symptoms which is associated with a two-fold increase in mortality risk due to behavioral and biological mechanisms. Mindfulness-Based Cognitive Therapy (MBCT) delivered via synchronous group videoconferencing could help reduce depressive symptoms.

Objective: To guide MBCT adaptation for ACS patients for a future clinical trial, this qualitative study aimed to explore ACS patients' (1) symptoms after ACS, (2) needs for behavioral health treatment, (3) perspectives on mindfulness intervention and group videoconference delivery, and (4) willingness to self-collect dried blood spots in a research study.

Top-down attention shifts behavioral and neural event boundaries in narratives with overlapping event scripts.

Understanding and remembering the complex experiences of everyday life relies critically on prior schematic knowledge about how events in our world unfold over time. How does the brain construct event representations from a library of schematic scripts, and how does activating a specific script impact the way that events are segmented in time? We developed a novel set of 16 audio narratives, each of which combines one of four location-relevant event scripts (restaurant, airport, grocery store, and lecture hall) with one of four socially relevant event scripts (breakup, proposal, business deal, and meet cute), and presented them to participants in an fMRI study and a separate online study. Responses in the angular gyrus, parahippocampal gyrus, and subregions of the medial prefrontal cortex (mPFC) were driven by scripts related to both location and social information, showing that these regions can track schematic sequences from multiple domains.

Course-Skill Atlas: A national longitudinal dataset of skills taught in U.S. higher education curricula.

Higher education plays a critical role in driving an innovative economy by equipping students with knowledge and skills demanded by the workforce. While researchers and practitioners have developed data systems to track detailed occupational skills, such as those established by the U.S.