1 results match your criteria: "Teach School of Zhejiang Chinese Medical University[Affiliation]"
Metabolome-wide Mendelian randomization assessing the causal relationship between blood metabolites and primary ovarian insufficiency.
Clin Nutr ESPEN
November 2024
Department of the Reproductive Endocrinology Division, Hangzhou Women's Hospital, Teach School of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310000, China. Electronic address:
Article Synopsis
- Primary ovarian insufficiency (POI) is a major cause of female infertility, with rising incidence rates, prompting research into associated metabolites through Mendelian randomization (MR) methods.
- The analysis identified 27 metabolites from a pool of 278 potentially linked to POI, highlighting significant ones like dodecanedioate and indolepropionate, and carried out various sensitivity analyses to strengthen findings.
- The study combines genetic data and metabolomic profiles, revealing six crucial metabolic pathways that could help illuminate the biological mechanisms underpinning POI.