The coordination chemistry and anticancer activity of organo-ruthenium(II), -iridium(III) and -rhodium(III) complexes with sulfonyl-substituted thiourea ligands.

Some half-sandwich compounds with a variety of ligands and metal centres have shown promising anticancer activity. Herein we report a series of reactions between the sulfonylthiourea ligands -TolSONHC(S)NHPh, EtSONHC(S)NHPh and CHSONHC(S)NHPh and [(η--cymene)RuCl], [(η-arene)RuCl(PR)] (arene = benzene or -cymene), [Cp*MCl(PR)] or [Cp*RhCl] (M = Ir(III), Rh(III)), Cp* = η-pentamethylcyclopentadienyl, PR = triphenylphosphine (PPh), tris(2-cyanoethyl)phosphine (tcep) and 1,3,5-triaza-7-phosphaadamantane (pta) and their corresponding piano stool complexes. Single crystal X-ray diffraction structure determinations indicated that the resulting linkage isomer of the complex, , (coordination S,N placing the sulfonyl group near the coordination sphere) or (coordination S,N, placing the sulfonyl group away from the coordination sphere), is directly related to the steric bulk around the metal centre.

Sustainable Land Use Strengthens Microbial and Herbivore Controls in Soil Food Webs in Current and Future Climates.

Climate change and land-use intensification are threatening soil communities and ecosystem functions. Understanding the combined effects of climate change and land use is crucial for predicting future impacts on soil biodiversity and ecosystem functioning in agroecosystems. Here, we used a field experiment to quantify the combined effects of climate change (warming and altered precipitation patterns) and land use (agricultural type and management intensity) on soil food webs across nematodes, micro-, and macroarthropods.

The contributions of motor skill proficiency to cognitive and social development in early childhood.

With limited evidence from intervention studies, causal relationships between motor competence and cognitive and social development have yet to be clearly established. In this research, we investigated whether a targeted training programme to improve fundamental movement skills (i.e.

People experience similar intrusions about past and future autobiographical negative experiences.

We know much about people's problematic reactions-such as distressing intrusions-to negative, stressful, or traumatic events. But emerging evidence suggests people react similarly to negative and potentially-traumatic events. Given similar processes underlie remembering the past and imagining the future more generally, we wondered how similar involuntary memories, or intrusions, are for experienced vs.

Equity of access to pathological diagnosis and bronchoscopy for lung cancer in Aotearoa New Zealand.

Background: Māori are less likely to survive their lung cancer once diagnosed, but it remains unclear whether this is partially driven by poorer access to best-practice diagnostic services.

Methods: We examined all lung cancer registrations in Aotearoa New Zealand between 2007-2019 (n=27,869) linked to national administrative health datasets and further stratified by ethnicity, tumour type and stage of disease. Using descriptive and regression analyses, we compared ethnic groups in terms of the basis of diagnosis (e.

Understanding the impact of environmental, social, and governance incidents on food producing corporations.

This study investigates the intricate relationship between Environmental, Social, and Governance-related reputational disasters and the financial performance of prominent, food-producing agricultural corporations. Results reveal a significant differential response pattern between large and small firms after ESG-related events. Large entities initially exhibit resilience with no immediate negative returns, while smaller entities face substantial, significant, and persistent stock market depreciation.

Investigation of 44-methylgambierone reactivity with periodate: Structural reassignment, solvent instability and formation of a furanoid analogue.

Gambierones are sulfated polyethers produced by benthic dinoflagellates in the genera Gambierdiscus, Coolia and Fukuyoa. While relative toxicity data for gambierones suggests they are low compared with ciguatoxin analogues, gambierones have been suggested for use as marker compounds for environmental monitoring programs for the presence of Gambierdiscus in marine waters. The published structure of gambierone and analogues of it, including 44-methylgambierone (44-MeGAM), have been reported to possess 1,2- and 4,5-cis diols, while only the 1,2- diol unit has been shown to undergo periodate oxidation.

Stakeholder perceptions of physical literacy: results from a national consultation in England.

Background: There is a lack of evidence of stakeholder perspective and understanding of physical literacy among relevant stakeholders from England. As part of research commissioned by Sport England to develop a physical literacy consensus statement for England, this study presents findings from the first national consultation with stakeholders in England.

Methods: One hundred and ninety-three individual stakeholders (50.

Psychological distress in Aotearoa New Zealand adults with type 1 diabetes.

The psychological burden of type 1 diabetes (T1D) can negatively impact health outcomes. This study evaluates the prevalence of low mood (WHO-5), disordered eating (DEPS-R), diabetes distress (PAID) and fear of hypoglycaemia (HFS-II), in a sample of 250 New Zealand adults (8.4% Māori/91.

Ferrocenyl β-Diketonate Compounds: Extended Ring Systems for Improved Anticancer Activity.

A library of ferrocenyl β-diketonate compounds with varying degrees of aromatic functionality have been synthesized and fully characterized. This includes cyclic voltammetry and the analysis of four new structures by single crystal X-ray diffraction. The compounds cytotoxic potential has been determined by MTT screening against pancreatic carcinoma (MIA PaCa-2), ovarian adenocarcinoma (A2780), breast adenocarcinomas (MDA-MB-231 and MCF-7) and normal epithelial retinal (ARPE-19).

Climate change profiles of New Zealanders over time: a one-year latent transition analysis of climate change beliefs and concern.

Scientific evidence unequivocally shows that human activities cause climate change, but some people still deny it. Using New Zealand Attitudes and Values Study data from 2018 and 2019 ( = 34,733), we examined segmentation profiles regarding beliefs and concern about climate change ('Climate change is real', 'Climate change is caused by humans', 'I am deeply concerned about climate change'), the probabilities of transitioning to and from profiles over time, and the characteristics of individuals in each profile. Five profiles were identified with varying levels of climate change beliefs and concern.

Unexpected Delayed Incursion of Highly Pathogenic Avian Influenza H5N1 (Clade 2.3.4.4b) Into the Antarctic Region.

The current highly pathogenic avian influenza H5N1 panzootic is having substantial impacts on wild birds and marine mammals. Following major and widespread outbreaks in South America, an incursion to Antarctica occurred late in the austral summer of 2023/2024 and was confined to the region of the Antarctic Peninsula. To infer potential underlying processes, we compiled H5N1 surveillance data from Antarctica and sub-Antarctic Islands prior to the first confirmed cases.

Investigating the existence of an osmotic barrier between xylem fibres and vessels in sugar maple (Acer saccharum) using microCT.

Sugar maples (Acer saccharum Marshall) develop elevated stem pressures in springtime through the compression and expansion of gas bubbles present within xylem fibres. The stability of this gas within the fibres is hypothesised to be due to the elevated sugar concentration of maple sap and the presence of an osmotic barrier between fibres and vessels. Without this osmotic barrier gas bubbles are predicted to dissolve rapidly.

A Multimodal Bracelet to Acquire Muscular Activity and Gyroscopic Data to Study Sensor Fusion for Intent Detection.

Researchers have attempted to control robotic hands and prostheses through biosignals but could not match the human hand. Surface electromyography records electrical muscle activity using non-invasive electrodes and has been the primary method in most studies. While surface electromyography-based hand motion decoding shows promise, it has not yet met the requirements for reliable use.

Evaluating the Effectiveness of Indigenous Health Curricula: Validation and Application of the NOSM CAST Instrument.

Objectives: In recent years, Indigenous health curricula have been integrated into medical education in response to international calls to improve Indigenous health care. Instruments to evaluate Indigenous health education are urgently needed. We set out to validate a tool to measure self-reported medical student preparedness to provide culturally safe care to Indigenous Peoples.

Predicting Physical Violence Against Corrections Officers Across Three Levels of Severity Using Individual and Environmental Characteristics.

Working in prisons can be a challenging job, managing a population of incarcerated people while keeping oneself, one's colleagues, and the people themselves safe. Some corrections officers may expect violence in the workplace, yet being a victim of violence is no trivial experience. In prison, violent incidents are categorized according to the severity of the violence perpetrated.

Large language models (LLMs) and the institutionalization of misinformation.

Large language models (LLMs), such as ChatGPT, flood the Internet with true and false information, crafted and delivered with techniques that psychological science suggests will encourage people to think that information is true. What's more, as people feed this misinformation back into the Internet, emerging LLMs will adopt it and feed it back in other models. Such a scenario means we could lose access to information that helps us tell what is real from unreal - to do 'reality monitoring.

Communicating health information to children: is a child-rights-based approach being adopted by nurses? An integrative review.

Background: Childhood is a time when health behaviours are established and the foundations for health literacy are cemented. In Aotearoa New Zealand nurses are responsible for communicating health messages to children at key stages in children's lives.

Objectives/aims: This review explores the ways in which nurses communicate health messages to children and adolescents in Aotearoa New Zealand.