Unrecognized Inter-Coronary Communication in a Case of Hypertrophic Cardiomyopathy.

Inter-coronary communication is a rare congenital anomaly, defined as a connection between two patent coronary arteries, and was first described in 1972. We report the case of a 61-year-old Emirati female who presented to the emergency department with chest pain and palpitations, along with a strong family history of cardiac disease. She was initially diagnosed with indolent hypertrophic obstructive cardiomyopathy and accordingly managed; however, the patient remained symptomatic.

A Case Study of Aberrant Aortic Origin of the Right Coronary Artery.

This case report examines a rare cardiovascular abnormality, the Aberrant Aortic Origin of the Right Coronary Artery (AAORCA), in a 75-year-old patient with a history of myocardial infarction, acute renal injury, and cardiogenic shock. Rapid medical intervention, including coronary angioplasty, demonstrated the significance of prompt care. Chronic issues, including tobacco use and left ventricular dysfunction, complicated matters, emphasizing the importance of comprehensive long- term therapy.

Characteristics and Antitumor Activity of Doxorubicin-Loaded Multifunctional Iron Oxide Nanoparticles in MEC1 and RM1 Cell Lines.

The rapid progress in nanotechnology has introduced multifunctional iron oxide nanoparticles as promising agents in cancer treatment. This research focused on the synthesis and assessment of citric-acid-coated, folic-acid-conjugated nanoparticles loaded with doxorubicin, evaluating their therapeutic potential in tumor models. An advanced automated continuous technology line (CTL) utilizing a controlled co-precipitation method was employed to produce highly dispersive, multifunctional nanofluids with a narrow size distribution.

Key concepts and a world-wide look at plant recruitment networks.

Plant-plant interactions are major determinants of the dynamics of terrestrial ecosystems. There is a long tradition in the study of these interactions, their mechanisms and their consequences using experimental, observational and theoretical approaches. Empirical studies overwhelmingly focus at the level of species pairs or small sets of species.

Next Generation Phenotyping and Synthetic Faces in Coffin Siris Syndrome.

Diagnostic wandering and delayed management are major issues in rare diseases. Here, we report a new Next-Generation Phenotyping (NGP) model for diagnosing Coffin Siris syndrome (CSS) on clinical photographs among controls and distinguish the different genotypes. This retrospective and prospective study, conducted from 1998 to 2023, included frontal and lateral pictures of confirmed CSS.

Love as a Commitment Device : Evidence from a Cross-Cultural Study across 90 Countries.

Given the ubiquitous nature of love, numerous theories have been proposed to explain its existence. One such theory refers to love as a commitment device, suggesting that romantic love evolved to foster commitment between partners and enhance their reproductive success. In the present study, we investigated this hypothesis using a large-scale sample of 86,310 individual responses collected across 90 countries.

STUDY OF ORBITAL NEOPLASMS BY MAGNETIC RESONANCE IMAGING PROCEDURE.

The neoplasms of the organ of vision are characterized by significant polymorphism, which is due to the histological diversity of the structures in the eye socket. Almost all types of neoplasms described in humans are found in the orbit. The study aimed to determine the diagnostic value of magnetic resonance imaging in patients with tumors in the eyeball and the eye socket, as well as to determine the superiority of the MRI procedure compared to other instrumental methods of research.

CARVEDILOL IN PATIENTS WITH UNCONTROLLED AND RESISTANT ARTERIAL HYPERTENSION.

Background: The use of beta-blockers in treating resistant hypertension remains poorly understood. While PATHWAY-2 showed a systolic blood pressure benefit with bisoprolol, further research is needed to evaluate other beta-blockers in terms of the effect of systolic blood pressure, assess diastolic blood pressure effects, and guide management in patients intolerant to CCBs as well.

Objectives: Our study aimed to evaluate the efficacy of Carvedilol (non-selective beta-blocker with alpha-1 blocking function) in the management of resistant hypertension, including in patients intolerant to calcium channel blockers.

SMALL BUT MIGHTY: CHARACTERIZATION OF VB_SPY_7, A LYTIC PHAGE TARGETING STREPTOCOCCUS PYOGENES.

The emergence of antibiotic-resistant pathogens necessitates alternative therapies for treating microbial infections, especially in the oral cavity and upper respiratory tract. Our team has developed Phage Pastilles, a controlled-release formulation containing bacteriophages that target common pathogens, including Streptococcus pyogenes, Streptococcus salivarius, Staphylococcus aureus, Enterococcus faecalis, and E. coli.

INTEGRATED MANAGEMENT OF OVARIAN ENDOMETRIOMAS: PRE- AND POST-SURGICAL USE OF DIENOGEST.

Aim: to evaluate the efficacy of an integrated management approach for ovarian endometriomas using Dienogest administered both before and after laparoscopic cyst enucleation in women with infertility.

Materials And Methods: The prospective, comparative clinical trial included 44 patients aged 18-35 years with ovarian endometriomas and infertility. Patients were randomly divided into two groups: the study group (20 participants) received Dienogest for six months before and after laparoscopic cyst enucleation, while the control group (24 participants) underwent laparoscopic cyst enucleation without additional hormonal treatment.

BINOCULAR INTERACTION IN AMBLYOPIA.

The review presents new ideas about developmental mechanisms of amblyopia, which are currently discussed in literature. Objective evidence has accumulated that amblyopia affects both monocular and binocular functions in visual processing. Given the increasing evidence of fundamental and clinical research, it is most likely that binocular dysfunction is primary, and monocular reduction is visual acuity is secondary to this disease.

CORRELATION BETWEEN EJECTION FRACTION AND CORONARY SINUS BLOOD FLOW DURING OFF-PUMP CORONARY ARTERY BYPASS GRAFTING SURGERY.

Introduction: Many studies have shown that coronary artery bypass grafting (CABG) increases the survival rate of patients, but the effect of bypass grafting on cardiac function is still a matter of debate.

Objective: The objective of our study was to determine: a. To what extent can the change in coronary sinus flow be used as an intraoperative criterion for the assessment of adequate revascularization.

STUDY OF ORAL HEALTH AND SUPPORTIVE STRUCTURES FOR PROSTHETIC RESTORATIONS IN METHADONE MAINTENANCE THERAPY BENEFICIARIES AND DRUG USERS.

Introduction: Methadone Maintenance Therapy (MMT) is commonly used to treat opioid addiction but can cause significant oral health issues, including poor oral hygiene, dental caries, periodontal disease, and bone resorption. These issues can negatively impact on overall quality of life, leading to both aesthetic and functional concerns.

Aim Of The Study: This research compares the oral health of individuals in methadone maintenance treatment (MMT) with those starting MMT.

PHAGE-BACTERIA INTERACTIONS UNDER METAL STRESS: A STUDY OF THE NOVEL STENOTROPHOMONAS MALTOPHILIA PHAGE VB_STM18.

Stenotrophomonas maltophilia is a highly adaptable gram-negative bacteria, demonstrating resilience in metal-contaminated environment, which makes it a key subject for understanding microbial survival under heavy metal stress. This study investigates the effects of cadmium ions (Cd²⁺) on the growth dynamics, cadmium uptake, and bacteriophage vB_Stm18-host interactions, with implications for environmental microbiology and applied biotechnology. Growth analysis revealed that S.

PERCUTANEOUS OCCLUSION OF MAJOR AORTOPULMONARY COLLATERALS IN TRANSPOSITION OF THE GREAT ARTERIES USING AMPLATZER PICCOLO OCCLUDERS: CASE REPORT.

Collateral vascular arteries from the descending aorta to the pulmonary arteries are uncommon after arterial switch operation. We describe a case of transposition of the great arteries (TGA) with significant aortopulmonary collateral vessels causing management difficulties after an arterial switch operation. Preoperatively, the presence of collaterals exacerbated aortic diastolic runoff and led to myocardial ischemia.

NEVI IN CHILDREN: CLINICO-DERMOSCOPIC CONCEPTS ASSOCIATED WITH LOCATION.

Unlabelled: Nevi developed in children are one of the topical issues of pediatric dermatology. The constant change in size and shape often worries parents, and unnecessary removal of the nevi is planned. The development of accompanying scars and sometimes recurring nevi presents a new problem for parents and dermatologists.

EFFECTIVENESS OF COMBINED SURGICAL AND HORMONAL THERAPY IN TREATMENT OF ENDOMETRIOMAS.

Introduction: Endometrial cyst, or endometrioma, is a specific form of endometriosis that often reveals with severe symptoms and requires ongoing treatment. High rate of recurrence after surgical intervention presents a significant challenge in the management of this disease.

Aim Of The Study: Aim of the study was to determine the effectiveness of combined therapy (surgical and hormonal) of endometrioma in terms of development of recurrences, the rate of pregnancy and change in pain intensity.

EVALUATING ORAL AND MAXILLOFACIAL HEALTH CHALLENGES IN INTRAVENOUS DRUG USERS: A CROSS-SECTIONAL STUDY OF DRUG REPLACEMENT THERAPY PARTICIPANTS AND NON-PARTICIPANTS.

Introduction: Intravenous drug use has a significant impact on oral and maxillofacial health, often resulting in complications like tooth loss and osteomyelitis. This study investigates the differences in oral health between drug users enrolled in replacement therapy and those not yet participating, with the goal of assessing the impact of structured treatment programs.

Aim: to evaluate and compare the prevalence of oral and maxillofacial complications among drug users involved in replacement therapy and those newly registering for treatment.

Efficacy of Flow Diverters in Managing Multiple Aneurysms: A Clinical Case Report.

Brain aneurysms, also known as cerebral aneurysms, are the growths of the parent artery. Based on their shape, aneurysms can be categorized as saccular or non-saccular. Several factors have been linked to multiple brain aneurysms but the most prevalent is arterial hypertension.

High-Output Mechanical Circulatory Support in Left Main Interventions: The Magenta Elevate High-Risk PCI First-in-Human Study.

Background: The Magenta Elevate is a 9-F, self-expanding, catheter-mounted pump delivered sheathed through a commercially available 10-F femoral introducer over the wire to the left ventricle (LV), providing temporary hemodynamic support up to an equivalent of normal cardiac output.

Objectives: The authors sought to assess the feasibility and outcomes of Elevate-supported high-risk percutaneous coronary intervention (HR-PCI) in a first-in-human study and study the hemodynamic impact of high-output support during prolonged interventional left main coronary artery (LM) occlusions.

Methods: In this study, 14 patients underwent Elevate-supported HR-PCI, with 8 patients undergoing 20 prolonged (39 ± 16 seconds) balloon occlusions of an unprotected LM.

Insights into diagnostic difficulties in spinal muscular atrophy: a Case Report series.

Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder caused by mutations in , with disease severity influenced by the number of copies. Although SMA is one of the most common autosomal recessive disorders, molecular diagnosis still presents challenges. We present a case series illustrating the variable clinical presentations and diagnostic complexities of spinal muscular atrophy (SMA).

Doxycycline post-exposure prophylaxis for preventing bacterial sexually transmitted infections (STIs): Are clinical providers supportive?

Background: Bacterial sexually transmitted infections (STIs) continue to increase in the United States. Despite evidence of the effectiveness of doxycycline post-exposure prophylaxis (Doxy-PEP) to prevent STIs, little is known about providers' attitudes and willingness to implement Doxy-PEP.

Methods: An online questionnaire was sent to 575 clinical providers in New York State in September 2022.

Design and rationale of the eLym™ System for Decompensation of Excess Lymphatic Fluid via the Thoracic Duct in Acute Heart Failure (DELTA-HF).

Aims: The interstitial space is the major compartment in which the excess fluid is located, forming peripheral congestion in acute decompensated heart failure (ADHF). The lymphatic system is responsible for the constant drainage of the compartment. In ADHF, the inefficiency of this system causes extravascular fluid accumulation, underscoring the crucial role of lymphatic system failure in ADHF's pathophysiology.

Quality of registration of antenatal, intrapartum, and newborn information in the Georgian birth registry.

Background: The Georgian Birth Registry (GBR) is a comprehensive digital birth registry covering 99.8% of births nationwide. By law, registration in the GBR is mandatory, with data primarily transferred from medical records (MRs) by designated personnel at medical facilities.