6,197 results match your criteria: "Tbilisi; I. Beritashvili Center for Experimental Biomedicine[Affiliation]"

Article Synopsis
  • The study assessed left ventricular ultrasound parameters in postmenopausal breast cancer patients undergoing anti-cancer therapy, focusing on cardiac dysfunction.
  • A total of 74 patients were monitored over two years, and 36.5% developed cardiac issues (CTRCD), with no signs of symptomatic heart failure reported.
  • Key findings indicated that global longitudinal strain (GLS) and ejection fraction (EF) declined in patients with CTRCD, while certain measurements remained normal in those without cardiac dysfunction.
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Unlabelled: The relationship between follicle size, oocyte quality, and blastocyst ploidy is not fully established. This question becomes especially important for poor responders and older reproductive age women, where optimal follicle size and oocyte quantity cannot always be achieved during ovarian stimulation. The aim of this study is to determine the relationship between follicle size, oocyte maturation, blastocyst formation, blastocyst ploidy, and pregnancy outcomes in young women undergoing in vitro fertilization (IVF).

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High prevalence of hypertrophic rhinitis makes more topical the problem of search of new, more effective means of treatment this pathology. 37 patients with hypertrophic rhinitis were examined. The clinical examination included the study of complaints and objective visual indicators associated with hypertrophic rhinitis.

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  • Yucca gloriosa leaves have a significant amount of steroid glycosides that undergo transformation from furostanol glycosides to spirostanol glycosides through the enzyme β-glucosidase.
  • There are two forms of β-glucosidase: Form I, which can hydrolyze both natural and synthetic substrates, and Form II, which only acts on synthetic substrates.
  • Form I shows a higher affinity for natural substrates, indicated by a lower Km value, and both enzyme forms operate best at a temperature of 37°C and a pH of 6.3-6.5.
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  • Women with endometriosis exhibit enhanced levels of active vitamin D (1.25OHD) and lower levels of its precursor (25OHD) compared to healthy controls, indicating a potential abnormality in vitamin D metabolism related to the condition.
  • The study aimed to evaluate the impact of laparoscopic treatment on vitamin D metabolite and calcium levels in patients with endometriosis, comparing preoperative and postoperative measurements to those of healthy individuals.
  • Results showed that after surgery, patients had significantly increased 25OHD levels and decreased 1.25OHD and calcium levels, suggesting that endometriosis affects vitamin D metabolism and that surgical intervention can help normalize these levels.
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Article Synopsis
  • - A systematic review and meta-analysis examined the effectiveness of AI algorithms in screening for aortic stenosis (AS), finding that they can accurately diagnose the condition before severe symptoms develop.
  • - The analysis included data from diverse sources (like ECGs and wearable sensors) and assessed various diagnostic metrics, concluding with a sensitivity of 83% and specificity of 81% for the AI algorithms.
  • - Results indicated high diagnostic accuracy (AUC of 0.909), while various factors (geographic region, AS type, data sources, AI methods) contributed to variations in performance, with a noted potential for publication bias affecting the findings.
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The moss bag technique was applied on Kamchatka to assess the effect of Shiveluch volcano on the air quality. Moss bags were exposed in settlements located at different distances from the volcano and affected by ashfall to varying degrees. The inductively coupled plasma optical emission spectrometry was used for the determination of the content of Al, Ba, Co, Cd, Cr, Cu, Fe, Mn, P, Pb, Sr, S, V, and Zn in both exposed and unexposed moss samples.

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Phallus Reconstruction Using the Third Finger Transplant Method: A Case Report.

Cureus

September 2024

Department of Plastic and Reconstructive Surgery, Kuzanov Clinic, Tbilisi, GEO.

There are many methods of phallus reconstruction, often requiring the use of prosthetics and multiple-stage interventions. The unique method discussed in this case report uses a finger complex in order to create a neourethra as well as act in place of the prosthesis, thus offering a one-stage intervention with the restoration of full biomechanical functions of the phallus and no need for revision surgeries. We present a patient, a 52-year-old male, who had previously undergone a subtotal penile resection due to oncological disease.

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Introduction: Alzheimer's disease can cause dementia through brain matter degradation. This study investigates the monoclonal antibody usage for AD treatment, following PRISMA 2020 guidelines, and aims to discern the monoclonal antibody that offers the optimal balance of efficacy and safety for individuals with AD.

Methods: A systematic search was conducted across databases such as PubMed, Cochrane Library, and clinical trial registries for randomized controlled trials.

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Article Synopsis
  • * Out of 100 IDPs tested, 11% were found to have HCV while none tested positive for HIV; approximately half of the participants reported a history of injecting drugs.
  • * IDPs with drug use experience had significantly lower knowledge about HIV compared to non-drug users, indicating a need for improved education and testing resources, while both groups showed similar HCV knowledge.
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Background: Only 10-40% of patients with cancer in low-income and middle-income countries were able to access curative or palliative radiotherapy in 2015. We aimed to assess the current status of diagnostic imaging and radiotherapy services in the Baltic countries, eastern Europe, central Asia, and the Caucasus by collecting and analysing local data.

Methods: This Access to Radiotherapy (ART) comprehensive analysis used data from 12 countries: the three Baltic countries (Estonia, Latvia, and Lithuania), two countries in eastern Europe (Moldova and Ukraine), four countries in central Asia (Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan), and three countries in the Caucasus (Armenia, Azerbaijan, and Georgia), referred to here as the ART countries.

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Isolation and characterization of Yersinia phage fMtkYen3-01.

Arch Virol

October 2024

Department of Biological and Environmental Science and Nanoscience Center, University of Jyväskylä, Jyväskylä, Finland.

Yersinia enterocolitica causes yersiniosis, the third most common gastrointestinal infection in humans throughout Europe. The emergence of multidrug resistance and the lack of effective new antibiotics have drawn attention to phage therapy as a treatment option. Here, we report the complete genome sequence of phage fMtkYen3-01, which infects Y.

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Oral diseases are among the most common non-communicable diseases around the globe and become a public health challenge that considerably impact general health and well-being in all ages across the lifespan. Oral health is an integral part of general health, where poor oral health and other lifestyle-related chronic diseases have a common risk factor background. The underlying causes of oral health inequalities are often complex and related to country-specific historical, economic, cultural, social, or political factors.

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Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

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A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

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Article Synopsis
  • The study investigates the associated production of Higgs and W bosons, focusing on how the relative signs of the Higgs couplings to W and Z bosons impact the process.
  • Two specific searches were conducted using large amounts of collision data from the LHC to analyze different coupling scenarios: one for opposite-sign couplings and another for same-sign (standard model-like) couplings.
  • The results significantly exclude the opposite-sign coupling hypothesis and set a strict upper limit on the production rate of this process compared to standard model predictions.
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Bistable Perception Discriminates Between Depressive Patients, Controls, Schizophrenia Patients, and Their Siblings.

Schizophr Bull

October 2024

Biophysics Department, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, NL-6525, The Netherlands.

Background And Hypothesis: Individuals with schizophrenia have less priors than controls, meaning they rely less upon their prior experiences to interpret the current stimuli. These differences in priors are expected to show as higher alternation rates in bistable perception tasks like the Structure-from-Motion (SfM) paradigm. In this paradigm, continuously moving dots in two dimensions are perceived subjectively as traveling along a three-dimensional sphere, which results in a direction of motion (left or right) that shifts approximately every few seconds.

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Background And Aim: In 2018, the country of Georgia legalized cannabis for recreational use and decriminalized limited possession. This study aimed to assess whether cannabis use increased among young adults (ages 18-29 years) in Georgia after national policy changes and to evaluate whether perceived access became easier after legalization and current risk factors of young adult cannabis use.

Methods: We used data from the Georgian nationally representative survey administered in 2015 (n = 1308) and 2022 (n = 758), before and after decriminalization.

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Takotsubo syndrome (TTS) still remains as an enigmatic phenomenon. In particular, long-term challenges (including clinical recurrence and persistent symptoms) and specific entities in the setting of TTS have been the evolving areas of interest. On the other hand, a significant gap still exists regarding the proper risk-stratification of this phenomenon in the short and long terms.

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In the recent years, there has been a burgeoning interest in Takotsubo syndrome (TTS), which is renowned as a specific form of reversible myocardial dysfunction. Despite the extensive literature available on TTS, clinicians still face several practical challenges associated with the diagnosis and management of this phenomenon. This potentially results in the underdiagnosis and improper management of TTS in clinical practice.

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Exposure to healthcare procedures might be a source of hepatitis C virus (HCV) transmission in Georgia, one of the few countries currently on track to eliminate hepatitis C. While there has been a history of iatrogenic transmission of HCV, the risk of HCV transmission related to endoscopic procedures has not been previously assessed in Georgia. The goal of this study was to assess HCV seroconversion among individuals undergoing endoscopic procedures to estimate the relative role and incidence of HCV infection attributable to endoscopic procedures.

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Plaque-like cutaneous mucinosis associated with pain: A case report.

SAGE Open Med Case Rep

October 2024

Petre Shotadze Tbilisi Medical Academy, Tbilisi, Georgia.

Plaque-like cutaneous mucinosis (PCM) is a rare atypical subtype of Lichen myxedematosus, characterized by hyperpigmented plaques typically found on the midline trunk. We report the case of a 26-year-old woman with a 1-year history of painful, pruritic, hyperpigmented plaques over her spine. Physical examination revealed soft plaques in the midline of the back, and histopathology showed dermal mucin deposition, consistent with PCM.

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Article Synopsis
  • * Out of 1,032 participants, 3.3% died during treatment and 8.7% after, with a median death time of 21 months post-TB treatment, particularly within the first 3 years.
  • * Those with HIV co-infection had a significantly higher risk of post-TB mortality (almost four times higher) compared to those without HIV, highlighting the need for better care for TB patients with comorbidities.
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