9 results match your criteria: "Tata Memorial Hospital Annex[Affiliation]"
ACS Med Chem Lett
November 2015
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400019, India.
We report design of a series of 2,4-diamino triazines as Mycobacterium tuberculosis (Mtb) dihydrofolate reductase inhibitors. The synthesized compounds were evaluated against Mtb (H37Rv and Dormant stage H37Ra), their cytotoxicity was assessed (HepG2 and A549 cell lines), and selectivity toward Mtb was evaluated by testing against other bacterial strains. Some derivatives showed promising activity along with low cytotoxicity.
View Article and Find Full Text PDFFuture Med Chem
April 2016
Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400019, India.
Background: A series of 2,4-diamino-s-triazines was designed, with potential for activity against Mycobacterium tuberculosis (Mtb) dihydrofolate reductase enzyme, on the basis of virtual screening results and structure-based drug design.
Results: The compounds were evaluated against Mtb (H37Rv) and their cytotoxicity was assessed using VERO cell lines. Of particular note, two compounds were found to have the most promising antituberculosis activity (6b minimum inhibitory concentration: 1.
Nucl Med Rev Cent East Eur
January 2014
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annex, Parel, Mumbai.
Background: To estimate and compare the sacroiliac joint (SIJ) index in skeletal scintigraphy by four different methods of quantification employed in normal subjects of different age groups.
Material And Methods: The whole-body skeletal survey of 100 subjects, who underwent skeletal scintigraphy three hours after injection of 99mTc-Methylene Diphosphonate (MDP), were selected for this analysis. The patients having previous history of low back pain, joint pain or any benign bone joint disorders (e.
Hybridoma (Larchmt)
June 2011
Radiation Medicine Centre, BARC, Tata Memorial Hospital Annex, Parel, Mumbai, India.
Smaller recombinant antibody fragments are at the forefront of in vivo diagnosis and therapy. These units possess better distribution and faster clearance than larger molecules. Among these, single chain antibody fragments (scFv) are emerging as credible alternatives.
View Article and Find Full Text PDFMol Imaging Biol
December 2011
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annex, Parel, Bombay, India.
There have been several endeavors made to investigate the potential role of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography (FDG-PET) (and tracers) and PET-computed tomography imaging in various benign disorders, particularly those related to thoracic structures. These various conditions can be broadly categorized into three groups: (a) infectious diseases (mycobacterial, fungal, bacterial infection), (b) active granulomatous disease such as sarcoidosis, and (c) other non-infectious/inflammatory conditions or proliferative disorders (e.g.
View Article and Find Full Text PDFPET Clin
October 2009
Nuclear Medicine Section, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Semin Nucl Med
March 2009
Radiation Medicine Center (BARC), Tata Memorial Hospital Annex, Mumbai, India.
Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly used to diagnose, characterize, and monitor disease activity in the setting of inflammatory disorders of known and unknown etiology. These disorders include sarcoidosis, atherosclerosis, vasculitis, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and degenerative joint disease. Gallium-67 ((67)Ga) citrate, labeled leukocytes with technetium-99m ((99m)Tc) or indium-111 ((111)In), and (18)F-fluorodeoxyglucose (FDG) represent the most widely used radiopharmaceutical agents.
View Article and Find Full Text PDFToxicol Lett
November 2004
Laboratory Nuclear Medicine Section, Isotope Group, BARC, C/o Tata Memorial Hospital Annex, Jerbai Wadia Road, Parel, Mumbai 400012, India.
Betulinic acid (BA) is known to induce apoptosis in melanoma neuroectodermal and malignant brain cancer cell lines. Present report describes the role of antioxidants on the BA-induced toxicity to human cell line SK-N-MC. Hydrophilic antioxidants viz.
View Article and Find Full Text PDFNucl Med Commun
October 1995
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annex, Parel, Bombay, India.
Human immunoglobulin (HIG) was labelled with 99Tcm using different Sn-ligand (methylene diphosphonate, MDP) in high yields. The effect of Sn:ligand ratios and protein (HIG) on the biodistribution pattern of 99Tcm-HIG in an animal model of turpentine-induced inflammatory lesions was studied. 99Tcm-HIG was excreted predominantly via the renal pathway.
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