4,876 results match your criteria: "Tardive Dyskinesia"
Psychiatry Res Neuroimaging
October 2023
Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, China. Electronic address:
Neuronal degeneration and apoptosis may play an important role in the pathogenesis of tardive dyskinesia (TD). Previous studies suggested brain structural and functional abnormalities in patients with TD. We investigated changes in cerebral regional homogeneity (ReHo) in patients with TD using resting-state functional magnetic resonance imaging (rs-fMRI).
View Article and Find Full Text PDFJ Pain Palliat Care Pharmacother
March 2024
Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
J Psychopharmacol
October 2023
Departmentt of Psychiatry, University of Oxford, Oxford, UK.
J Acad Consult Liaison Psychiatry
August 2024
Northwell Health, Long Island Jewish Medical Center, New Hyde Park, NY.
Background: Cholinergic discontinuation symptoms, also known as "cholinergic rebound," from abrupt clozapine discontinuation are characterized by a range of somatic and psychiatric symptoms.
Objective: The objective of this study was to describe the clinical features and management options for clozapine withdrawal-associated cholinergic rebound syndrome (henceforth referred to as CWCRS) and present an illustrative case report.
Methods: Based on a literature search of the databases PubMed, OVID Medline, and Embase as well as reviewing reference lists of relevant past reviews, we carried out a systematic review of case reports on the management of CWCRS from 1946 to 2023.
Biomed Pharmacother
December 2023
Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address:
Haloperidol, one of the representative typical antipsychotics, is on the market for schizophrenia but shows severe adverse effects such as extrapyramidal symptoms (EPS) or cognitive impairments. Oleanolic acid (OA) is known to be effective for tardive dyskinesia which is induced by long-term treatment with L-DOPA. This study aimed to investigate whether OA could ameliorate EPS or cognitive impairment induced by haloperidol.
View Article and Find Full Text PDFJ Int Med Res
October 2023
Department of Mental Health, Tongde Hospital of Zhejiang Province, Mental Health Center of Zhejiang Province, Hangzhou, China.
Background: Long-term use of antipsychotics or other dopamine antagonists can result in the extrapyramidal side effect of tardive dyskinesia (TD).Case presentation: An 18-year-old female patient experienced abnormal speech and behavior and because of an equivocal diagnosis, she was given daily doses of 300 mg of quetiapine and 60 mg of ziprasidone. She had used these medications for 2 years before the appearance of involuntary abnormal movements.
View Article and Find Full Text PDFBrain Behav Immun Health
November 2023
Unit of PharmacoTherapy, -Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713AV, Groningen, the Netherlands.
The term extrapyramidal disorders is most often used for conditions such as Parkinson's disease or Huntington's disease, but also refers to a group of extrapyramidal side effects of antipsychotics (EPS), such as tardive dyskinesia (TD). After a brief description of some clinical features of TD, this article summarizes the relatively scarce results of research on a possible link between mainly cytokine levels and TD. This data was found by systematically searching Pubmed and Embase.
View Article and Find Full Text PDFAsian J Psychiatr
November 2023
Department of Psychiatry, King George's Medical University, Lucknow, U.P. 226003, India.
Cell Rep Med
October 2023
Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address:
Dyskinesia is involuntary movement caused by long-term medication with dopamine-related agents: the dopamine agonist 3,4-dihydroxy-L-phenylalanine (L-DOPA) to treat Parkinson's disease (L-DOPA-induced dyskinesia [LID]) or dopamine antagonists to treat schizophrenia (tardive dyskinesia [TD]). However, it remains unknown why distinct types of medications for distinct neuropsychiatric disorders induce similar involuntary movements. Here, we search for a shared structural footprint using magnetic resonance imaging-based macroscopic screening and super-resolution microscopy-based microscopic identification.
View Article and Find Full Text PDFBrain Res
December 2023
Tianjin Mental Health Institute, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin 300222, China. Electronic address:
Objective: Tardive dyskinesia (TD) is a medically induced movement disorder that occurs as a result of long-term use of antipsychotic medications, commonly seen in patients with schizophrenia (SCZ). The study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of the CNR1 gene, TD and cognitive impairments in a Chinese population with SCZ.
Methods: A total of 216 SCZ patients were recruited.
Cureus
August 2023
Department of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Tardive dyskinesia (TD) is an iatrogenic cause that occurs after prolonged use of antipsychotic and other dopamine-related medications and is described as repetitive, involuntary movement of muscles in the body. This case report focuses on an 80-year-old man who presented with a medical history encompassing dementia, bilateral blindness, glaucoma, hearing loss, hypertension, and hypercholesterolemia. He visited the clinic with a complaint of experiencing visual hallucinations.
View Article and Find Full Text PDFInt Clin Psychopharmacol
November 2023
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
To date, the role of valbenazine (VAL) in a dose-dependent increase in efficacy for tardive dyskinesia (TD) and in the worsening of acceptability and tolerability in a dose-dependent manner remains to be elucidated. Thus, in this systematic review and frequentist network meta-analysis, we compared 16 outcomes of VAL80 mg/d (VAL80) with VAL40 mg/d (VAL40) related to the efficacy, acceptability, tolerability, and safety in the treatment of patients with TD. Using a 95% confidence interval, we calculated the standardized mean difference for continuous variables and the risk ratio for dichotomous variables.
View Article and Find Full Text PDFSchizophr Res
June 2024
Department of Psychiatry, University of Southern California, Los Angeles, CA, United States of America. Electronic address:
Nathan S. Kline was a pioneer in psychopharmacology in the United States (US). In 1952, Kline started a research unit at Rockland State Hospital, New York.
View Article and Find Full Text PDFPrim Care Companion CNS Disord
August 2023
Neurocrine Biosciences Inc., San Diego, California.
To evaluate real-world treatment patterns for patients initiating benztropine and to understand treatment approaches in patients with drug-induced movement disorders from a health care provider perspective. A retrospective claims analysis was conducted among patients with evidence of benztropine initiation from January 2017 through March 2020 to assess treatment patterns and patient health care resource utilization. Subsequently, a 30-minute, United States-based online survey fielded from December 2021 to January 2022 was sent to physicians, nurse practitioners, and physician assistants who reported a primary care or psychiatry specialty currently treating drug-induced movement disorders and prescribed benztropine.
View Article and Find Full Text PDFToxicol Appl Pharmacol
October 2023
The Affiliated Kangning Hospital of Wenzhou Medical University, Zhejiang Provincial Clinical Research Center for Mental Disorder, Wenzhou, Zhejiang 325000, China. Electronic address:
Vesicular monoamine transporter 2 (VMAT-2) functions by uptake of cytoplasmic monoamines into vesicles for storage. Valbenazine (VBZ) is a newly FDA-approved oral VMAT-2 inhibitor used for the treatment of movement disorders such as tardive dyskinesia (TD), and Tourette syndrome (TS). Clinical data shows that VBZ is a relatively safe drug with no cardiotoxicity or hepatotoxicity.
View Article and Find Full Text PDFOphthalmology
November 2023
Jules Stein Eye Institute, Los Angeles, California.
Purpose: To review the published literature on the use of levodopa/carbidopa to augment the treatment of amblyopia.
Methods: Literature searches for English language studies were last conducted in October 2022 in the PubMed database with no date restrictions. The combined searches yielded 55 articles, of which 23 were reviewed in full text.
Cureus
July 2023
Internal Medicine, Ascension St. John Hospital, Detroit, USA.
Dysphagia has been associated with antipsychotic drug use. This case report describes the management of dysphagia in a psychiatric patient who presented to the emergency department from a psychiatric facility after choking on a hot dog. The patient was on risperidone 4 mg, initiated a month prior to treat acute psychosis.
View Article and Find Full Text PDFClin Pract
August 2023
Medicine Department, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.
Objective: Previous studies have shown that transcranial direct current stimulation(tDCS) led to an improvement of cognitive function in patients with schizophrenia, but rare study has explored the effect of tDCS on long-term hospitalized chronic schizophrenia with tardive dyskinesia (TD). The present research explored if cognitive function in patients with long-term hospitalized chronic schizophrenia with TD could be improved through tDCS.
Methods: This study is a randomized, double-blind, sham-controlled clinical trial.
Brain Sci
July 2023
Department of Psychiatry, Yuan-Shan Branch of Taipei Veteran General Hospital, Yilan 26604, Taiwan.
With its pathophysiological characteristics strongly similar to patients with tardive dyskinesia (TD), haloperidol (HP)-induced neurotoxicity and orofacial dyskinesia (OD) in animal models have long been used to study human TD. This study aimed to explore the potential protective effects of betaine (BT), a vital biochemical compound present in plants, microorganisms, animals, and various dietary sources. The study focused on investigating the impact of BT on haloperidol (HP)-induced orofacial dyskinesia (OD) in rats, as well as the underlying neuroprotective mechanisms.
View Article and Find Full Text PDFMol Neurobiol
December 2023
Department of Genetics, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India.
Genetic perturbations in dopamine neurotransmission and calcium signaling pathways are implicated in the etiology of schizophrenia. We aimed to test the association of a functional splice variant each in Dopamine β-Hydroxylase (DBH; rs1108580) and Calcium voltage-gated channel subunit alpha1 C (CACNA1C; rs1006737) genes in these pathways with schizophrenia (506 cases, 443 controls); Abnormal Involuntary Movement Scale (AIMS) scores in subjects assessed for tardive dyskinesia (76 TD-positive, 95 TD-negative) and Penn Computerized Neurocognitive Battery (PennCNB) scores (334 cases, 234 controls). The effect of smoking status and SNP genotypes on AIMS scores were assessed using ANOVA; health status and SNP genotypes on three performance functions of PennCNB cognitive domains were assessed by ANCOVA with age and sex as covariates.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
July 2023
Kazan State Medical University, Kazan, Russia.
Tardive dyskinesia (TD) is a delayed, often irreversible iatrogenic movement disorder caused by long-term use of that dopamine receptors blocking drugs. Prevention of TD is paramount, and clinicians should follow best practice recommendations for prescribing antipsychotics, as well as reduction the using of dopamine receptor blocking drugs for non-psychiatric prescriptions. Replacement of antipsychotics with lower affinity for D2 receptors drugs, addition of VMAT2 (tetrabenazine), botulinum therapy, amantadine may be effective.
View Article and Find Full Text PDFCureus
June 2023
Department of Radiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.