Recent Advance of Liposome Nanoparticles for Nucleic Acid Therapy.

Gene therapy, as an emerging therapeutic approach, has shown remarkable advantages in the treatment of some major diseases. With the deepening of genomics research, people have gradually realized that the emergence and development of many diseases are related to genetic abnormalities. Therefore, nucleic acid drugs are gradually becoming a new boon in the treatment of diseases (especially tumors and genetic diseases).

The role of Notch signaling pathway in metabolic bone diseases.

Metabolic bone diseases is the third most common endocrine diseases after diabetes and thyroid diseases. More than 500 million people worldwide suffer from metabolic bone diseases. The generation and development of bone metabolic diseases is a complex process regulated by multiple signaling pathways, among which the Notch signaling pathway is one of the most important pathways.

Increasing connections among temporal invariability, resistance and resilience of alpine grasslands on the Tibetan Plateau.

Ecological stability contains multiple components, such as temporal invariability, resistance and resilience. Understanding the response of stability components to perturbations is beneficial for optimizing the management of biodiversity and ecosystem functioning. Although previous studies have investigated the effects of multiple perturbations on each stability component, few studies simultaneously measure the multiple stability components and their relationships.

Bimetallic MOFs-Derived Hollow Carbon Spheres Assembled by Sheets for Sodium-Ion Batteries.

Metal-organic frameworks (MOFs) have attracted extensive attention as precursors for the preparation of carbon-based materials due to their highly controllable composition, structure, and pore size distribution. However, there are few reports of MOFs using p-phenylenediamine (pPD) as the organic ligand. In this work, we report the preparation of a bimetallic MOF (CoCu-pPD) with pPD as the organic ligand, and its derived hollow carbon spheres (BMHCS).

Vigorous physical activity and self-rated health during adolescence: A cross-sectional survey.

Background: Despite the positive relationship between self-rated health and general physical activity, very little research has touched upon the relationship between self-rated health and vigorous physical activity. Such research will help to promote self-rated health among adolescents by addressing the close relationship between self-rated health and the components of physical activity.

Purpose: In this study, the relationship between self-rated health and vigorous physical activity among Chinese adolescents were analyzed.

Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet ( (L.) P. Beauv.).

A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was performed.

Locating Transition Zone in Phase Space.

Understanding the reaction mechanism is required for better control of chemical reactions and is usually achieved by locating transition states (TSs) along a proper one-dimensional coordinate called reaction coordinate (RC). The identification of RC can be very difficult for high-dimensional realistic systems. A number of methods have been proposed to tackle this problem.

Effects of Endic Anhydride Grafted PPC on the Properties of PHBV Blends.

Poly(β-hydroxybutyrate--β-hydroxyvalerate) (PHBV) was modified with endic anhydride grafted poly(propylene carbonate) (EA-PPC), and then PHBV/EA-PPC composite polymers were prepared by melt blending under the catalysis of stannous octoate (Sn(Oct)). The blends were characterized by an electronic universal testing machine, cantilever impact testing machine, and differential scanning calorimeter (DSC), as well as dynamic mechanical analysis (DMA) and field emission scanning electron microscopy (FESEM). Effects of the amount of Sn(Oct) on the mechanical properties, thermal properties, and morphology of the blends were discussed.

An effective behavior recognition method in the video session using convolutional neural network.

In order to further improve the accuracy of the video-based behavior recognition method, an effective behavior recognition method in the video session using convolutional neural network is proposed. Specifically, by adding the target detection phase before the behavior recognition algorithm, the body region in the video can be accurately extracted to reduce the interference of redundant and unnecessary background noises, and at the same time, the inappropriate images can be replaced, which has reached the role of balance background trade-off, and finally, the neural network can learn the human behavior information with emphasis. By adding fragmentation and stochastic sampling, the long-time time-domain modeling of the whole video session can be established, so that the model can obtain video-level expression ability.

Teaching Analysis for Visual Communication Design with the Perspective of Digital Technology.

The turn of contemporary visual culture has led to the expansion of the connotation and scope of visual communication design (VCD) education, the generation of new artistic concepts and forms, and the great changes in the subject education system. VCD instruction now has an enhanced teaching environment and operational platform because of the rapid advancement of digital technology. Digital technology is expected to break through traditional learning methods in the future and will be more widely integrated into VCD courses.

Synergistic Flame Retardancy of Phosphatized Sesbania Gum/Ammonium Polyphosphate on Polylactic Acid.

Phosphating sesbania gum (DESG) was obtained by modifying sesbania gum (SG) with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and endic anhydride (EA). The structure of DESG was determined using Fourier transform infrared (FTIR) spectroscopy and nuclear magnetic resonance spectroscopy (H-NMR). Flame-retardant polylactic acid (PLA) composites were prepared by melt-blending PLA with DESG, which acted as a carbon source, and ammonium polyphosphate (APP), which acted as an acid source and a gas source.

Transcriptomic and Widely Targeted Metabolomic Approach Identified Diverse Group of Bioactive Compounds, Antiradical Activities, and Their Associated Genes in Six Sugarcane Varieties.

Sugarcane is cultivated mainly for its high sucrose content but it can also produce many metabolites with promising antioxidant potential. However, very few studies have been reported on the biosynthesis of metabolites in sugarcane to date. In this study, we have identified a wide range of amino acids and organic acids in the rind of six sugarcane varieties by the LC-MS/MS method.

EFL Students' L2 Achievement: The Role of Teachers' Organizational Commitment and Loving Pedagogy.

Since student L2 achievement is the primary objective of all language education contexts, a huge number of inquiries have explored the role of students' personal characteristics in promoting their L2 achievement. A plethora of studies have also assessed the impact of teachers' personal and professional qualities on students' L2 achievement. Yet, the effects of teachers' organizational commitment and loving pedagogy have largely been neglected.

Intelligent Correction Method of Shooting Action Based on Computer Vision.

Aiming at the problem that the students' long-term use of nonstandard shooting action leads to poor basketball teaching effect, an intelligent correction method of shooting action based on computer vision is proposed. Combined with the principle of computer vision, the image acquisition model of basketball shooting action is constructed. The edge contour and adaptive feature segmentation of basketball images are detected, and abnormal shooting movements are recognized.

Recent advances in yeast genome evolution with stress tolerance for green biological manufacturing.

Green biological manufacturing is a revolutionary industrial model utilizing yeast as a significant microbial cell factory to produce biofuels and other biochemicals. However, biotransformation efficiency is often limited owing to several stress factors resulting from environmental changes or metabolic imbalance, leading to the slow growth of cells, compromised yield, and enhanced energy consumption. These factors make biological manufacturing competitively less economical.

Transcriptome analysis and characterization of genes associated to leaf tannin content in foxtail millet [Setaria italica (L.) P. Beauv.].

Background: Chinese chestnut is an economically important tree species whose yield and quality are seriously affected by red spider attack. Tannins is one of the most important class secondary metabolites in plants, and is closely associated with plant defense mechanisms against insect and herbivory. In our previous studies, it was revealed that several low-tannin foxtail millet varieties growing under the Chinese chestnut trees could attract red spiders to feed on their leaves and protect the chestnut trees from the infestation of red spiders, meanwhile, the growth and yield of foxtail millet plants themselves were not greatly affected.

Exploring the Independent Learning of Music Students in Higher Teacher Training Colleges in a Pluralistic Network Environment.

As the main base for training teachers, normal colleges and universities can not only reserve a large number of talents for the construction of teachers but also help to improve the professional quality and teaching ability of teachers. Carrying out research on music education in normal colleges and universities can further meet the diversified needs of the current society for music talents and promote the improvement of art cultivation and cultural level of music students in normal colleges and universities. This paper discusses the preparation work of higher normal music colleges under the new curriculum standards from four aspects: "experience learning, independent learning, cooperative learning, and inquiry learning.

Sports Feedback System Based on Video Digital Processing.

The current sports feedback system has high application value and is widely used in physical education courses, but it has problems such as large feedback error, long response time, and incomplete data, leading to poor effect of sports feedback system. In order to improve the effectiveness of sports feedback system, a sports feedback system based on video digital processing is designed. By constructing the overall architecture of video digital sports feedback system, the positioning module, interface module, power supply circuit module, sampling module, input module, signal extraction module, and video digital processing module are designed.

A Secure Private Cloud Storage Platform for English Education Resources Based on IoT Technology.

The contemporary ubiquitous "cloud" network knowledge and information resources, as well as ecological pedagogy theory, have enlarged teaching research's perspective, widened teaching research's innovation area, and created practical options for English classroom reform. Cloud education relies on the Internet of Things, cloud computing, and big data to have a huge impact on the English learning process. The key to the integration of English education resources is the storage of huge amount of English teaching data.

Morphological and Molecular Analyses of the Interaction between and .

Powdery mildew disease caused by is the most widespread disease in global cut-rose production, as well as a major disease in garden and pot roses. In this study, the powdery mildew resistance of different wild rose varieties was evaluated. Rose varieties with high resistance and high sensitivity were used for cytological observation and transcriptome and expression profile analyses to study changes at the morphological and molecular levels during the interaction between and .

Hierarchical attention network for multivariate time series long-term forecasting.

Multivariate time series long-term forecasting has always been the subject of research in various fields such as economics, finance, and traffic. In recent years, attention-based recurrent neural networks (RNNs) have received attention due to their ability of reducing error accumulation. However, the existing attention-based RNNs fail to eliminate the negative influence of irrelevant factors on prediction, and ignore the conflict between exogenous factors and target factor.

Text Feature Extraction for Public English Vocabulary Based on Wavelet Transform.

Text interpretation of public English vocabulary is a critical task in the subject of natural language processing, which uses technology to allow humans and computers to communicate effectively using natural language. Text feature extraction is one of the most fundamental and crucial elements in allowing computers to effectively grasp and read text. This paper proposes a text feature extraction method based on wavelet analysis that performs fast discrete wavelet transform and inverse discrete wavelet transform on the feature vectors under the traditional TF-IDF vector space model to address the problem of low feature differentiation of high-dimensional data in text feature extraction.

The Association of Sports Participation With Depressive Symptoms and Anxiety Disorder in Adolescents.

Aim: An increasing body of evidence has evidenced that physical activity is negatively associated with depression and anxiety in adolescents, although the associations between various modalities of PA with depression and anxiety have yet to be effectively explored. This study aimed to investigate the associations between sports participation and depression and anxiety among a sample of Chinese adolescents.

Methods: 2,374 adolescents from eight schools were invited to participate in this survey, of whom 1,714 adolescents from grades 7, 8, 10 and 11 were included for final analysis.

Assessment of Effect of Perceived Social Support on School Readiness, Mental Wellbeing, and Self-Esteem: Mediating Role of Psychological Resilience.

Objective of this study is to investigate the impact of perceived social support on the self-esteem, mental wellbeing, and school readiness of left-behind (LB) children. It further aims at understanding the mediating role of psychological resilience between the relationships of perceived social support and self-esteem, mental wellbeing, and school readiness. For this purpose, population frame of the LB children between the ages of 8-12 years in Mainland China was taken.