Associations Between the Polymorphisms in the Coding Sequence of SLCO1B1 and Blood Lipid Levels Before and After Treatment by Atorvastatin in the Chinese Han Adults with Dyslipidemia.

Purpose: Atorvastatin is commonly used to treat dyslipidemia; however, individual responses vary considerably. This study endeavors to evaluate the relationship between polymorphisms in the coding sequence (CDS) of SLCO1B1 gene and blood lipid levels before and after atorvastatin treatment among the Chinese Han adults with dyslipidemia.

Patients And Methods: A total of 165 Chinese Han adults undergoing atorvastatin therapy were enrolled in this study and followed up quarterly.

Deep source transfer learning for the estimation of internal brain dynamics using scalp EEG.

Electroencephalography (EEG) provides high temporal resolution neural data for brain-computer interfacing via noninvasive electrophysiological recording. Estimating the internal brain activity by means of source imaging techniques can further improve the spatial resolution of EEG and enhance the reliability of neural decoding and brain-computer interaction. In this work, we propose a novel EEG data-driven source imaging scheme for precise and efficient estimation of macroscale spatiotemporal brain dynamics across thalamus and cortical regions with deep learning methods.

Bibliometric and visual analysis of medication therapy management from 2003 to 2023.

Medication therapy management (MTM) includes various clinical pharmacy services that greatly influence society and economy. Despite extensive research in recent years, there is currently a lack of bibliometric analysis on this subject. Articles and reviews on MTM published from 2003 to 2023 were identified and selected from the Web of Science Core Collection.

Prevalence and Correlators of Anxiety and Depression in Premature Coronary Artery Disease.

Purpose: The present study assessed the correlation between anxiety and depression in young and middle-aged Chinese patients with coronary artery disease (CAD).

Patients And Methods: This study included 313 patients diagnosed with premature CAD at the Department of Cardiology between January and July 2023. The Zung Self-Rating Anxiety/Depression Scale (SAS/SDS) was used as a standardized scale to assess mental health symptoms.

Prognostic value of the systemic inflammation response index on 3-year outcomes of elderly patients with acute coronary syndrome after stent implantation.

Background: Few studies have focused on the relationship between the systemic inflammation response index (SIRI) and the prognosis of elderly patients with acute coronary syndrome (ACS).

Objectives: This study aimed to evaluate the predictive value of the SIRI for predicting 3-year outcomes in patients >60 years old after stent implantation and to assess variables associated with SIRI.

Material And Methods: A total of 1,758 patients with ACS who underwent percutaneous coronary intervention (PCI) were enrolled and divided into an older group (n = 960) and a younger group (n = 798) using a cutoff of >60 years.

Establishment of RNA modification regulators index predicting clinical outcomes and immune relevance of kidney cancer patients.

Increasing evidence indicates that RNA modifications are misregulated in human cancers, which might be optimal targets of cancer therapy. However, important RNA regulators in kidney cancer still need further exploration. In this study, we collected regulators representing different types of RNA modification and identified the prognosis-related RNA regulators in kidney cancer patients.

Retraction: The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice.

[This retracts the article DOI: 10.1039/C9RA07262D.].

LncRNA gene polymorphisms and their influence on lung cancer patients in the Chinese Han population.

Lung cancer is primarily classified as NSCLC, which is distinguished by a wide range of genetic variations. This study focused on , a relatively unexplored lncRNA, to explore the impact of its genetic polymorphisms on the susceptibility to NSCLC. We detected expression and its correlation with prognosis and clinical pathological features using bioinformatics analysis.

Association between residential environment quality with mild cognitive impairment among middle and elderly adults in China.

Background: Most studies have focused on the effects of individual environmental risk factors on cognitive function; however, none have evaluated the association between residential environmental quality and cognitive impairment.

Methods: Data from the China Health and Retirement Longitudinal Study (CHARLS) were used to include 12,801 participants in a cross-sectional study and 8781 participants in a cohort study. Residential environmental quality was assessed using indicators such as particulate matter, types of household fuel, water sources, indoor temperature, and building types.

Association between microplastics in human amniotic fluid and pregnancy outcomes: Detection and characterization using Raman spectroscopy and pyrolysis GC/MS.

Microplastic contamination has emerged as a global environmental concern, while the limitation of single-technique identification methods in complex biological matrices calls for multi-analytical approaches for accurate microplastic detection. This study pioneers a dual-method approach, combining Raman spectroscopy and pyrolysis gas chromatography-mass spectrometry (Py-GC/MS), to investigate microplastics in human amniotic fluid. In total, samples from 48 pregnant women were collected and analyzed under stringent quality control measures, then Raman spectroscopy and Py-GC/MS were employed for comprehensive polymer identification and verification.

Correlations of ‑methylguanine DNA methyltransferase () promoter methylation status with magnetic resonance imaging texture features and prognosis of glioblastomas.

O6-methylguanine DNA methyltransferase () promoter methylation is associated with the prognosis of patients with glioblastomas. With the aim of facilitating the discrimination of glioblastoma molecular phenotypes and improving the accuracy of molecular imaging diagnosis, the present retrospective study analyzed the association between promoter methylation and glioblastoma magnetic resonance imaging (MRI) texture features and prognosis. A total of 128 patients with pathologically diagnosed glioblastoma who had undergone preoperative MRI were enrolled.

Hemodynamic evaluation of endovascular techniques of stenting and coiling for the treatment of internal carotid artery aneurysm: a computational study.

The selection optimum endovascular method for the treatment of different cerebral aneurysms has been the main challenge for surgeons. In the present article, the computational technique is used for the hemodynamic evaluation of two main endovascular techniques of stent and coiling for the reduction of the hemorrhage risk of ICA aneurysms. Comprehensive analyses of the blood flow are performed to detect potential regions with high risk at critical stages of the cardiac cycle.

One or two? Comparison of the cardiorenal effects between combination therapy and monotherapy with SGLT2i or GLP1RA.

Objective: This study aimed to evaluate the cardiorenal effect of combining sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) when compared with monotherapy of either agent in patients with type 2 diabetes (T2D).

Methods: PubMed, Web of Science, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrial.gov were systematically searched from inception to June 2024.

Synergistic effects of anlotinib and DDP on breast cancer: targeting the VEGF/JAK2/STAT3 axis.

Background: Anlotinib, a highly selective inhibitor of VEGFR2, has demonstrated significant anti-tumor effects in various cancers. However, its potential synergistic effects with DDP (cisplatin) in breast cancer (BRCA) remain to be fully elucidated. This study aims to discover the therapeutic efficacy of anlotinib on BRCA, specifically the synergistic effects with DDP, and to elucidate the underlying molecular mechanisms.

Analysis of MDA, SOD, TAOC, MNCV, SNCV, and TSS scores in patients with diabetes peripheral neuropathy.

To explore the impact of score in patients with diabetes peripheral neuropathy (DPN) treated with traditional Chinese medicine package (TCMP) plus red light therapy and lipoic acid on malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), total antioxidant capacity (TAOC), motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV), and Toronto Clinical Scoring System (TSS). A total of 108 patients with DPN hospitalized in the hospital were chosen and divided into groups with the random number table. In the control group (CG) 54 patients were treated with conventional lipoic acid, and 54 patients in the experimental group (EG) accepted TCMP plus red light on the basis of the CG.

Analysis of risk factors for carotid artery plaque in asymptomatic adults.

Objective: This study aimed to investigate the risk factors affecting the presence of carotid plaque in asymptomatic adults.

Methods: Asymptomatic adults (age > 40 years, no symptoms of cardiovascular and cerebrovascular diseases) undergoing routine health examinations from physical examination department were included in this study. Carotid plaque was measured by Resona 7OB and Resona 8EXP color Doppler ultrasound and L9-3U and L4-5WU probes.

Heterogeneity of tumor microenvironment cell groups in inflammatory and adenomatous polyposis coli mutant colorectal cancer based on single cell sequencing.

Background: The prognosis of colorectal cancer (CRC) is known to vary across different etiologies. Inflammatory bowel disease (IBD) is often identified as a factor contributing to poorer outcomes. However, the mechanisms that link IBD to a worse CRC prognosis remain to be elucidated.

Impact of Chondroitin Sulfate Proteoglycan 4 Pseudogene 12 Genetic Variants on Colorectal Cancer Risk: A Case-Control Study.

This study aims to investigate the correlation between the chondroitin sulfate proteoglycan 4 pseudogene 12 () polymorphism and the risk of colorectal cancer (CRC). This case-control study involved 850 patients with CRC and 850 health controls. The genotypes of (rs2880765, rs6496932, and rs8040855) were determined by the TaqMan-MGB probe method.

Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.

This study aims to investigate whether butylphthalide can inhibit ferroptosis and ameliorate cerebral ischaemia-reperfusion (I/R) injury in rats by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) / heme oxygenase-1 (HO-1) signalling pathway, known for its antioxidative and cytoprotective properties. Middle cerebral artery occlusion reperfusion (MCAO/R) rat models were established. Male rats were randomly divided into five groups: a sham-operated group (sham), MCAO/R group, MCAO/R ​+ ​ML385 (Nrf2-specific inhibitor) group, MCAO/R ​+ ​NBP (butylphthalide) group and MCAO/R ​+ ​ML385 ​+ ​NBP group.

The weight reduction mediated by anti-obesity medication and the cardiovascular outcome.

The association between anti-obesity medications (AOMs) as well as their weight-loss effects and cardiovascular outcomes need to be comprehensively investigated. We searched PubMed, Embase, the Cochrane Center Register of Controlled Trials for Studies, and Clinicaltrial.gov website from the inception to April 2024 and included 129 randomized controlled trials (RCTs) of AOMs.

Fingolimod alleviates type 2 diabetes associated cognitive decline by regulating autophagy and neuronal apoptosis via AMPK/mTOR pathway.

This study aimed to reveal the role of fingolimod (FTY720) in mice with type 2 diabetes-associated cognitive decline and explore its potential neuroprotective mechanism. Mice were divided into five groups: normal control, normal control + FTY720 (1.0 mg/kg/day), type 2 diabetes mellitus, type 2 diabetes mellitus + low-dose FTY720 (0.