3 results match your criteria: "Tangdu Hospital of the Fourth Military Medical University (Air Force Medical University).[Affiliation]"
Comparison of the efficacy and safety of the adalimumab biosimilar TQ-Z2301 and adalimumab for the treatment of Chinese patients with active ankylosing spondylitis: a multi-center, randomized, double-blind, phase III clinical trial.
Clin Rheumatol
October 2022
Department of Rheumatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- The study aimed to evaluate the clinical equivalence of TQ-Z2301, a biosimilar to adalimumab, for treating active ankylosing spondylitis in Chinese patients.
- Conducted across 19 centers in China, the trial involved 380 participants who received either TQ-Z2301 or adalimumab for 24 weeks, assessing response rates and various health outcomes.
- Results showed that TQ-Z2301 had an ASAS20 response rate of 86.7%, which met the equivalence criteria compared to 80.7% for adalimumab, with similar safety and immunogenicity profiles in both groups.
Uncovering a Distinct Gene Signature in Endothelial Cells Associated With Contrast Enhancement in Glioblastoma.
Front Oncol
June 2021
Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, China.
Purpose: Glioblastoma (GBM) is the most aggressive and lethal type of brain tumors. Magnetic resonance imaging (MRI) has been commonly used for GBM diagnosis. Contrast enhancement (CE) on T1-weighted sequences are presented in nearly all GBM as a result of high vascular permeability in glioblastomas.
View Article and Find Full Text PDFEffects of Ghrelin on the Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocyte MH7A Cells.
Biol Pharm Bull
February 2019
Department of Rheumatology and Immunology, Tangdu Hospital of the Fourth Military Medical University (Air Force Medical University).
Ghrelin is a circulating peptide hormone, which involved in promoting feeding and regulating energy metabolism in human and rodents. Abnormal synovial hyperplasia is the most important pathologic hallmark of rheumatoid arthritis (RA), which is characterised by tumor-like expansion. Existing studies indicated that there may exist some relation between the decreased ghrelin and the abnormally proliferating synovial cells in RA.
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