2,920 results match your criteria: "Tampere University Hospital and Tampere University Medical School; Tampere-Finland. ari.mennander@hotmail.com.[Affiliation]"
Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19.
iScience
October 2024
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes.
View Article and Find Full Text PDFDietary Inflammatory Index and Head and Neck Cancer: A Multicenter Case-Control Study in Iran.
J Res Health Sci
August 2024
Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: The inflammatory potential of diet may affect carcinogenesis. This study aimed to determine the association between dietary inflammatory index (DII) and the risk of head and neck cancer (HNC), as well as the interaction between DII and cigarette smoking in HNC development within the Iranian population. This is a case-control study.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
- In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
- There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
Preferences for albumin use in adult intensive care unit patients with shock: An international survey.
Acta Anaesthesiol Scand
October 2024
Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Introduction: Use of albumin is suggested for some patients with shock, but preferences for its use may vary among intensive care unit (ICU) physicians.
Methods: We conducted an international online survey of ICU physicians with 20 questions about their use of albumin and their opinion towards a randomised trial among adults with shock comparing the use versus no use of albumin.
Results: A total of 1248 respondents participated, with a mean response rate of 37%, ranging from 18% to 75% across 21 countries.
Non-technical skills for neurosurgeons: An international survey.
Brain Spine
August 2024
Department of Neurosurgery, Fondazione I.R.C.C.S. Istituto Neurologico "C. Besta", Milano, Italy.
Article Synopsis
- Neurosurgery requires not only technical skills but also non-technical skills (NTSs) to achieve mastery, highlighting the importance of both in surgical practice.
- An international survey of 372 neurosurgeons indicates that qualities like attention to detail, humility, and self-awareness are vital for surgical precision and effective teamwork.
- The study advocates for integrated training that includes simulations and mentorship to enhance NTSs, while also stressing the need for research aimed at improving educational methods, especially in regions with unequal access to neurosurgical care.
Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis.
JAMA Cardiol
November 2024
St John's Institute of Dermatology, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Article Synopsis
- The study investigates the complex relationship between immune-mediated diseases (IMIDs), like psoriasis, and cardiovascular diseases (CVDs), such as coronary artery disease (CAD) and stroke, focusing on genetic factors.
- It employs Mendelian randomization to analyze data from large genome-wide association studies (GWAS) to establish potential causative links between psoriasis and these cardiovascular conditions.
- The analysis encompasses nearly 3.4 million individuals, providing insights into how genetic predictors of CAD and stroke may influence the risk of developing psoriasis and nine other IMIDs.
Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children.
Pediatr Allergy Immunol
September 2024
Faculty of Social Sciences, Health Sciences Unit, Tampere University, Tampere, Finland.
Background: Association of early pregnancy body mass index (BMI) and maternal gestational weight gain (GWG), and asthma and allergic disease in children is unclear.
Methods: We analyzed data from 3176 mother-child pairs in a prospective birth cohort study. Maternal anthropometric measurements in the first and last antenatal clinic visits were obtained through post-delivery questionnaires to calculate early pregnancy BMI and maternal GWG.
The European Health Data Space can be a boost for research beyond borders.
Nat Med
November 2024
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Body mass index and risk of over 100 cancer forms and subtypes in 4.1 million individuals in Sweden: the Obesity and Disease Development Sweden (ODDS) pooled cohort study.
Lancet Reg Health Eur
October 2024
Department of Translational Medicine, Lund University, Malmö, Sweden.
Background: Obesity, assessed by body mass index (BMI), is an established risk factor for 13 cancers. We aimed to identify further potential obesity-related cancers and to quantify their association with BMI relative to that of established obesity-related cancers.
Methods: Using Cox regression models on 4,142,349 individuals in Sweden (mean age 27.
Romantic and sexual relationships of young adults born very preterm: An individual participant data meta-analysis.
Acta Paediatr
December 2024
Department of Psychology, University of Warwick, Coventry, UK.
Aim: To compare romantic and sexual relationships between adults born very preterm (VP; <32 weeks of gestation) or with very low birth weight (VLBW; <1500 g) and at term, and to evaluate potential biological and environmental explanatory factors among VP/VLBW participants.
Methods: This individual participant data (IPD) meta-analysis included longitudinal studies assessing romantic and sexual relationships in adults (mean sample age ≥ 18 years) born VP/VLBW compared with term-born controls. Following PRISMA-IPD guidelines, 11 of the 13 identified cohorts provided IPD from 1606 VP/VLBW adults and 1659 term-born controls.
Life-period associations of body mass index with adult carotid intima-media thickness: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study.
Prev Med
December 2024
Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Baker Heart and Diabetes Institute, Melbourne, Australia. Electronic address:
Article Synopsis
- The study investigates how body mass index (BMI) during different life stages (childhood, adolescence, and young adulthood) affects the thickness of carotid arteries (cIMT) in adulthood.
- Using data from two large studies, researchers found that higher BMI levels over a lifetime are linked to increased cIMT in adults.
- The most significant impact on cIMT came from BMI during young adulthood for most participants, while for a specific group, childhood BMI was more influential, highlighting the importance of managing BMI at various life stages for cardiovascular health.
Clinical features and response to immune combinations in patients with renal cell carcinoma and sarcomatoid de-differentiation (ARON-1 study).
Int J Cancer
December 2024
Oncology Unit, Macerata Hospital, Macerata, Italy.
Article Synopsis
- - Metastatic renal cell carcinoma (mRCC) with sarcomatoid features (sRCC) is aggressive and has a poor prognosis; this study aimed to investigate its clinical features and outcomes compared to non-sarcomatoid patients.
- - The study analyzed data from 1362 mRCC patients, finding that the median overall survival for sRCC patients was 26.8 months, significantly lower than the 35.3 months for non-sRCC patients.
- - Both first-line treatment strategies, immunotherapy combined with immunotherapy (IO + IO) and immunotherapy with a tyrosine kinase inhibitor (IO + TKI), showed similar survival outcomes, confirming that
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.
Nature
October 2024
Department of Medicine, Section of CardioRespiratory Medicine, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
Article Synopsis
- * Early intermittent feeding of mice on a high-cholesterol diet speeds up atherosclerosis by altering arterial macrophage behavior and gene expression associated with ASCVD.
- * The Young Finns Study links early cholesterol exposure to increased carotid atherosclerotic plaque in adulthood, emphasizing the need for better hyperlipidaemia management early in life to prevent ASCVD.
Patient-derived Organoid Pharmacotyping As A Predictive Tool for Therapeutic Selection in Pancreatic Ductal Adenocarcinoma.
Ann Surg
September 2024
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.
Article Synopsis
- Researchers developed a new method for matching chemotherapy regimens to pancreatic cancer patients based on chemosensitivity data from patient-derived organoids (PDOs).
- In a study involving PDOs from 95 patients, the method successfully matched 91% of the organoids to standard chemotherapeutics and showed that well-matched patients had significantly better clinical outcomes, such as reduced tumor markers and improved survival rates.
- The findings suggest that using PDO pharmacotyping to customize chemotherapy could lead to better treatment strategies and outcomes for patients with pancreatic ductal adenocarcinoma.
Thyroid hormones for euthyroid patients with simple goiter growing over time: a survey of European thyroid specialists.
Endocrine
January 2025
Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Article Synopsis
- An online survey of European thyroid specialists revealed that 28% believe thyroid hormone (TH) treatment may be appropriate for euthyroid patients with growing simple goiters, despite guidelines against this practice.
- There were significant regional differences in support for TH treatment, with only 7% in The Netherlands compared to 78% in the Czech Republic.
- Factors influencing the likelihood of recommending TH included the specialist's age and the historical iodine insufficiency of their region, while gender, country, and economic factors showed weak associations.
Myosin ATPase inhibition fails to rescue the metabolically dysregulated proteome of nebulin-deficient muscle.
J Physiol
October 2024
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nemaline myopathy (NM) is a genetic muscle disease, primarily caused by mutations in the NEB gene (NEB-NM) and with muscle myosin dysfunction as a major molecular pathogenic mechanism. Recently, we have observed that the myosin biochemical super-relaxed state was significantly impaired in NEB-NM, inducing an aberrant increase in ATP consumption and remodelling of the energy proteome in diseased muscle fibres. Because the small-molecule Mavacamten is known to promote the myosin super-relaxed state and reduce the ATP demand, we tested its potency in the context of NEB-NM.
View Article and Find Full Text PDFDeterminants of cough-related quality of life in interstitial lung diseases.
BMC Pulm Med
August 2024
Division of Respiratory Medicine, Institute of Clinical Medicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, POB 1627, Kuopio, 70211, Finland.
Background: Interstitial lung diseases (ILD) include a wide range of diseases impacting lung parenchyma and leading to fibrosis and architectural distortion. Chronic cough and dyspnea are common symptoms which affect the quality of life (QoL) in ILD patients. The mechanisms of cough in ILD patients are still unknown.
View Article and Find Full Text PDFKetamine Analgo-sedation for Mechanically Ventilated Critically Ill Adults: A Rapid Practice Guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine.
Anesth Analg
August 2024
Guidelines in Intensive Care Medicine, Development and Evaluation (GUIDE) Group, The Research Institute of St. Joe's, Hamilton, Canada.
Article Synopsis
- The Rapid Practice Guideline (RPG) was created to evaluate the effectiveness of ketamine for sedation in ICU patients on mechanical ventilation compared to other sedatives or usual care, while also highlighting areas for further research.
- A panel of 23 experts, including a patient representative, conducted a systematic review and meta-analysis to gather data, using a structured approach to assess the reliability and implications of the evidence collected.
- The findings indicated considerable uncertainty regarding the effects of ketamine, with low certainty about its benefits on reducing opioid use or mechanical ventilation duration; adjunct ketamine therapy did not significantly affect mortality within 28 days.
Inferring disease course from differential exon usage in the wide titinopathy spectrum.
Ann Clin Transl Neurol
October 2024
Folkhälsan Research Center, Helsinki, Uusimaa, Finland.
Objective: Biallelic titin truncating variants (TTNtv) have been associated with a wide phenotypic spectrum, ranging from complex prenatal muscle diseases with dysmorphic features to adult-onset limb-girdle muscular dystrophy, with or without cardiac involvement. Given the size and complexity of TTN, reaching an unequivocal molecular diagnosis and precise disease prognosis remains challenging.
Methods: In this case series, 12 unpublished cases and one already published case with biallelic TTNtv were collected from multiple international medical centers between November 2022 and September 2023.
Ketamine analgo-sedation for mechanically ventilated critically ill adults: A rapid practice guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine.
Acta Anaesthesiol Scand
October 2024
Guidelines in Intensive Care Medicine, Development and Evaluation (GUIDE) Group, The Research Institute of St. Joe's, Hamilton, Canada.
Background: This Rapid Practice Guideline (RPG) aimed to provide evidence-based recommendations for ketamine analgo-sedation (monotherapy and adjunct) versus non-ketamine sedatives or usual care in adult intensive care unit (ICU) patients on invasive mechanical ventilation (iMV) and to identify knowledge gaps for future research.
Methods: The RPG panel comprised 23 multinational multidisciplinary panelists, including a patient representative. An up-to-date systematic review and meta-analysis constituted the evidence base.
Supervised machine learning to predict smoking lapses from Ecological Momentary Assessments and sensor data: Implications for just-in-time adaptive intervention development.
PLOS Digit Health
August 2024
Department of Behavioural Science and Health, University College London, United Kingdom.
Specific moments of lapse among smokers attempting to quit often lead to full relapse, which highlights a need for interventions that target lapses before they might occur, such as just-in-time adaptive interventions (JITAIs). To inform the decision points and tailoring variables of a lapse prevention JITAI, we trained and tested supervised machine learning algorithms that use Ecological Momentary Assessments (EMAs) and wearable sensor data of potential lapse triggers and lapse incidence. We aimed to identify a best-performing and feasible algorithm to take forwards in a JITAI.
View Article and Find Full Text PDF"OpenWHO" SEARO NCD PEN-HEARTS Courses: Training 10000 Health Care Providers in 100 Countries in 100 Days.
WHO South East Asia J Public Health
January 2024
Director, NCD Department, WHO, Geneva, Switzerland.
Article Synopsis
- Enhancing primary care capacity is essential for quality care of noncommunicable diseases (NCDs), addressing issues like inadequate training resources and standards.
- The WHO South-East Asia Region utilized the OpenWHO platform to create four online courses tailored for low- or middle-income countries, focusing on NCD service planning, interventions, diabetic foot care, and palliative care for primary health-care managers.
- Launched on October 26, 2023, these courses gained significant interest, with 18,250 enrollments in 100 days, primarily from young health professionals, leading to over 7,000 certificates awarded through assessments.
Bidirectional associations between IgE-mediated food allergy and atopic dermatitis.
Pediatr Allergy Immunol
August 2024
Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.
Risk Variants Associated With Normal Pressure Hydrocephalus: Genome-Wide Association Study in the FinnGen Cohort.
Neurology
September 2024
From the Department of Neurosurgery (J. Räsänen, K.M., V.E.K., M.O., J.E.J., V.L.), Kuopio University Hospital and Institute of Clinical Medicine-Neurosurgery, and Institute of Biomedicine (S. Heikkinen, K.M., A.L., T.K., M.H.), University of Eastern Finland, Kuopio; Institute for Molecular Medicine Finland (FIMM) (J.M., A.P.), Helsinki Institute of Life Science (HiLIFE), University of Helsinki; Department of Neurology (A.J.), Clinical Neurosciences, Helsinki University Hospital and University of Helsinki, Finland; Univ. Lille (B.G.-B., C.B., J.-C.L.), Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, France; Department of Neurosurgery (M.O., K.L., J.S.), University of Helsinki and Helsinki University Hospital; Clinical Neurosciences (C.A., J.F., A.K., J. Rinne), Department of Neurosurgery, University of Turku and Turku University Hospital; Department of Neurosurgery (A.R.), Tampere University Hospital; Unit of Clinical Neuroscience (M.K., M.v.u.z.F.), Neurosurgery, University of Oulu and Medical Research Center, Oulu University Hospital; Finnish Institute for Health and Welfare (THL) (M.P.); University of Helsinki (M.P.); Department of Neurosciences (A.M.K., A.M.P.), University of Helsinki; Department of Geriatrics (A.M.K.), Helsinki University Hospital; NeuroCenter (A.M.K.), Kuopio University Hospital; Institute of Clinical Medicine-Neurology (V.J., H.S.), University of Eastern Finland; School of Medicine (A.M.), Institute of Clinical Medicine, Pathology and Forensic Medicine, and Translational Cancer Research Area, University of Eastern Finland; Department of Clinical Pathology (A.M.), Kuopio University Hospital; Unit of Clinical Medicine (S. Helisalmi), University of Eastern Finland, Kuopio, Finland; Department of Neurosurgery (P.K.E.), Oslo University Hospital-Rikshospitalet; Institute of Clinical Medicine (P.K.E.), Faculty of Medicine, and KG Jebsen Centre for Brain Fluid Research (P.K.E.), University of Oslo, Norway; Analytical and Translational Genetics Unit (A.P., M.I.K.), Department of Medicine, Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (A.P., M.I.K.), and Stanley Center for Psychiatric Research (A.P., M.I.K.), Broad Institute for Harvard and MIT, Cambridge, MA.
Background And Objectives: Large-scale genome-wide studies of chronic hydrocephalus have been lacking. We conducted a genome-wide association study (GWAS) in normal pressure hydrocephalus (NPH).
Methods: We used a case-control study design implementing FinnGen data containing 473,691 Finns with genotypes and nationwide health records.