2,920 results match your criteria: "Tampere University Hospital and Tampere University Medical School; Tampere-Finland. ari.mennander@hotmail.com.[Affiliation]"
The 2024 report of the Lancet Countdown on health and climate change: facing record-breaking threats from delayed action.
Lancet
November 2024
Institute for Global Health, University College London, London, UK.
Article Synopsis
- The world is nearing the critical threshold of 1.5°C warming, with 2023 recording an average temperature rise of 1.45°C since pre-industrial times, leading to severe climate-related impacts.
- The Countdown collaboration, formed to assess the health impacts of climate change post-Paris Agreement, involves over 300 experts analyzing data and trends annually.
- The 2024 report highlights troubling increases in climate-related health risks, such as a staggering 167% rise in heat-related deaths among seniors, indicating worsening conditions affecting wellbeing globally.
One-year employment outcome prediction after traumatic brain injury: A CENTER-TBI study.
Disabil Health J
October 2024
Department of Public Health, Vrije Universiteit Brussel, Belgium.
Article Synopsis
- - This study explores how machine learning can predict whether individuals with traumatic brain injury (TBI) will return to work one year after their injury, using data collected from 586 hospitalized patients across Europe.
- - By analyzing hospital stay and follow-up data, the researchers found that including follow-up information significantly improved prediction accuracy, going from around 81% to 88%.
- - The final model, which included five key predictors, achieved 90% accuracy and can help clinicians set realistic goals and tailor interventions for TBI patients, enhancing their chances of returning to work.
Disease Burden and Access to Biologic Therapy in Patients with Severe Asthma, 2017-2022: An Analysis of the International Severe Asthma Registry.
J Asthma Allergy
October 2024
BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA.
Introduction: Patients with severe asthma may be prescribed biologic therapies to improve disease control. The EVEREST study aimed to characterize the global disease burden of patients with severe asthma without access to biologics and those who have access but do not receive biologics, as well as the remaining unmet need despite use of these therapies.
Methods: This was a historical cohort study of patients with severe asthma (aged ≥18 years) in the International Severe Asthma Registry receiving Global Initiative for Asthma (GINA) 2018 step 5 treatment, or with uncontrolled disease at GINA step 4.
Perinatal and neonatal outcomes in gestational diabetes: The importance of the number of abnormal values in an oral glucose tolerance test.
Acta Obstet Gynecol Scand
January 2025
Research Unit of Clinical Medicine, Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Article Synopsis
- Gestational diabetes mellitus (GDM) is identified through abnormal results in an oral glucose tolerance test (OGTT), with a lack of clear understanding about how the number of abnormal values relates to negative birth outcomes.
- A study involving 4869 pregnant women in Finland analyzed the connection between the quantity of abnormal OGTT values and adverse perinatal and neonatal results, taking into account various health and social factors.
- Results indicated that women with two or more abnormal OGTT values had significantly higher rates of negative perinatal (35.0% vs. 27.5%) and neonatal outcomes (31.1% vs. 18.9%) compared to those with fewer or no abnormal values.
Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures.
Sci Rep
October 2024
Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early pathogenesis of celiac disease. Interactions between season of birth, genetics, and early-life environmental factors on the risk of celiac autoimmunity were investigated in the multicenter TEDDY birth cohort study.
View Article and Find Full Text PDFEffectiveness and Safety of Dupuytren Contracture Treatments: A Systematic Review and Meta-Analysis Using the GRADE Approach.
Plast Reconstr Surg
October 2024
Professor of Surgery, Section of Plastic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI.
Background: There is currently no consensus on the optimal treatment for Dupuytren contracture. Prior meta-analyses have been limited by suboptimal data synthesis methodologies. We conducted an updated evidence review comparing the effectiveness and safety of percutaneous needle fasciotomy (PNF), collagenase clostridium histolyticum (CCH), and limited fasciectomy (LF) using the GRADE approach.
View Article and Find Full Text PDFDosimetric consequences of adapting the craniocaudal isocenter distance to daily patient position in craniospinal irradiation using volumetric modulated arc therapy.
J Appl Clin Med Phys
January 2025
Department of Medical Physics, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland.
Purpose: In craniospinal irradiation, two or three isocenter groups along the craniocaudal axis are required to cover the long treatment target. Adapting the isocenter distance according to daily deviations in patient position is challenging because dosimetric hot or cold spots may occur in the field junction. The aim of this study was to quantify the effect of adapting the isocenter distance to patient position on the dose distribution of the field overlap region in craniospinal irradiation using partial-arc volumetric modulated arc therapy.
View Article and Find Full Text PDFRisk Factors of Hepatitis Associated With Time to Adopting a New Cancer Screening Model Under Diffusion of Innovation Theory-A 10-Year Cohort Study in Taiwan.
Public Health Nurs
January 2025
Division of Biostatistics, College of Public Health, National Taiwan University, Taipei, Taiwan.
Article Synopsis
- Hepatitis is a significant global health concern, prompting early screening recommendations, especially for those without symptoms.* -
- A study with nearly 58,000 participants in Taiwan investigated how lifestyle and liver function biomarkers influenced the adoption of a new cancer screening program, finding a connection to faster acceptance among healthier individuals.* -
- Understanding these factors can help healthcare providers enhance screening strategies for individuals at risk of hepatitis and liver cancer, potentially lowering mortality rates.*
In Reply to the Letter to the Editor Regarding "Positive Correlation Between Thoracic Aortic Diameter and Intracranial Aneurysm Size-An Observational Cohort Study".
World Neurosurg
October 2024
Clinical Neurosciences, University of Turku, Turku, Finland; Department of Neurosurgery, Neurocenter, Turku University Hospital, Turku, Finland.
Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation.
Epigenetics
December 2024
Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Article Synopsis
- Low maternal vitamin D levels during pregnancy have been linked to various health issues in offspring and may affect DNA methylation, a process that influences gene expression.
- The study examined the relationship between maternal vitamin D insufficiency (defined as less than 75 nmol/L) and DNA methylation patterns in the cord blood of newborns using data from 3738 mother-child pairs across seven cohorts.
- Despite a significant prevalence of vitamin D insufficiency among the mothers (ranging from 44.3% to 78.5%), the research found no significant association between maternal vitamin D levels and DNA methylation at the analyzed sites after adjusting for various factors.
Importance: The combination of ifosfamide and etoposide (IE) is commonly used to treat relapsed or refractory osteosarcoma; however, second-line treatment recommendations vary across guidelines.
Objective: To evaluate whether the addition of lenvatinib to IE (LEN-IE) improves outcomes in children and young adults with relapsed or refractory osteosarcoma.
Design, Setting, And Participants: The OLIE phase II, open-label, randomized clinical trial was conducted globally across Europe, Asia and the Pacific, and North America.
Predictors in Youth of Adult Cardiovascular Events.
Pediatrics
November 2024
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Background And Objectives: Childhood risk factors are associated with cardiovascular events in adulthood. We compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a model that additionally included lipids to predict cardiovascular events in adulthood.
Methods: The study comprised 11 550 participants from 7 longitudinal cohort studies in the United States, Australia, and Finland with risk factor measurements in adolescence and followed into adulthood.
Brain metabolic response to repetitive transcranial magnetic stimulation to lesion network in cervical dystonia.
Brain Stimul
December 2024
Turku Brain and Mind Center, Clinical Neurosciences, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland; Turku PET Centre, Turku University Hospital, Turku, Finland; Department of Clinical Neurophysiology, University of Turku, Finland.
Article Synopsis
- A previous study found a specific brain network linked to cervical dystonia (CD), pointing out its potential for treatment, especially with non-invasive techniques like repetitive transcranial magnetic stimulation (rTMS).
- The study aimed to evaluate how stimulating the somatosensory cortex (S1) affects brain metabolism in CD patients versus healthy controls, using methods like [F]FDG-PET to measure changes.
- Results showed that cTBS significantly increased metabolism in the S1 and brainstem of CD patients, suggesting abnormal sensory function in CD and supporting future therapeutic trials using this stimulation method.
Constant Dizziness Versus Episodic Vertigo in Ménière's Disease: Health-Related Quality of Life, Cognitive Dissonance, and Postural Problems.
J Int Adv Otol
September 2024
Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Article Synopsis
- - The study focused on examining dizziness and vertigo in patients with Ménière's disease (MD) through a retrospective survey involving 539 participants and a detailed online questionnaire assessing symptoms and quality of life.
- - Findings revealed that a significant portion of patients experience varying levels of dizziness: 46% had episodic vertigo, 6% had constant dizziness, and 31% experienced no dizziness or vertigo in the past two years, highlighting the varied impacts on their health-related quality of life (HRQoL).
- - Constant dizziness was linked to several challenges including cognitive problems, fatigue, and severe balance issues, with the study suggesting that different types of dizziness may require tailored treatment approaches to manage symptoms effectively, although optimal
Characteristics and outcomes of children 2-23 months of age with prolonged diarrhoea: A secondary analysis of data from the 'Antibiotics for Children with Diarrhea' trial.
J Glob Health
October 2024
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Article Synopsis
- About 12% of diarrhoeal cases last 7-13 days, termed prolonged diarrhoea, which is linked to the majority of diarrhoeal deaths in young children.
- The study evaluated young children (2-23 months) with acute (<7 days) and prolonged (≥7-13 days) diarrhoea using data from a large trial conducted across seven countries in Asia and sub-Saharan Africa between 2017 and 2019.
- Findings showed that prolonged diarrhoea was associated with factors like younger age, larger family size, maternal illiteracy, moderate underweight, and the presence of certain pathogens, with significant implications for children's health outcomes at a 90-day follow-up.
Patterns and Determinants of Micronutrient Dietary Biomarkers and Their Associations with Dietary Intakes in Young Children.
J Nutr
December 2024
Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.
Article Synopsis
- - This study examined how various factors, including diet and other influences like genetics and medical history, affect the levels of vitamins A, C, D, and E in children aged 6 months to 4 years, using data from nearly 1,500 participants.
- - Researchers found that most vitamins studied were associated with nutrient intake, but childhood infections had a negative impact on the levels of certain vitamins, particularly β-carotene and retinol.
- - The results indicate that factors outside of diet, such as infections and genetic traits, significantly influence how the body processes and utilizes these essential vitamins.
Effect of alternative oxidase (AOX) expression on mouse cerebral mitochondria bioenergetics.
Redox Biol
November 2024
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, USA. Electronic address:
Alternative oxidase (AOX) is an enzyme that transfers electrons from reduced quinone directly to oxygen without proton translocation. When AOX from Ciona intestinalis is xenotopically expressed in mice, it can substitute the combined electron-transferring activity of mitochondrial complexes III/IV. Here, we used brain mitochondria from AOX-expressing mice with such a chimeric respiratory chain to study respiratory control bioenergetic mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
Interleukin-5 as a pleiotropic cytokine orchestrating airway type 2 inflammation: Effects on and beyond eosinophils.
Allergy
October 2024
Global Medical Affairs, Respiratory Specialty Care, GSK, London, UK.
Article Synopsis
- Interleukin-5 (IL-5) plays a crucial role in eosinophil behavior, which impacts various airway diseases through processes like maturation, activation, and survival of these cells.
- Anti-IL-5 therapies were developed due to the cytokine's significant role in diseases associated with eosinophils, but recent findings show that the therapeutic effects may extend beyond just eosinophil depletion.
- Emerging evidence indicates IL-5 influences a wider spectrum of immune cells—such as mast cells and T regulatory cells—suggesting that its role in type 2 inflammation and disease pathogenesis is more complex than previously understood.
Is fat mass a better predictor of 6-month survival than muscle mass among African children aged 6-59 months with severe pneumonia?
BMC Nutr
September 2024
KEMRI Wellcome Trust Research Programme, P. O. Box 230, Kilifi, Kenya.
Article Synopsis
- Pneumonia is a major cause of death in children under 5, particularly among those with poor nutrition, making it important to identify body composition measures that can predict survival rates in these patients.* -
- This study analyzed 369 children aged 6-59 months with severe pneumonia in Uganda and Kenya, comparing indices of fat and muscle mass to see which was a better predictor of 6-month survival.* -
- Results showed that while Arm-Fat-Area had a comparable predictive ability for survival as Arm-Muscle-Area and Arm-Muscle-Circumference, none of these were significantly better than the measurement of Mid-Upper Arm Circumference (MUAC).*
Safety of dostarlimab in combination with chemotherapy in patients with primary advanced or recurrent endometrial cancer in a phase III, randomized, placebo-controlled trial (ENGOT-EN6-NSGO/GOG-3031/RUBY).
Ther Adv Med Oncol
September 2024
Division of Gynecologic Oncology, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Background: In Part 1 of the phase III RUBY trial (NCT03981796) in patients with primary advanced or recurrent endometrial cancer (EC), dostarlimab plus carboplatin-paclitaxel (CP) significantly improved progression-free survival and overall survival compared with CP alone. Limited safety data have been reported for the combination of immunotherapies plus chemotherapy in this setting.
Objectives: The objective of this analysis was to identify the occurrence of treatment-related adverse events (TRAEs) and immune-related adverse events (irAEs) and to describe irAE management in Part 1 of the RUBY trial.
Dietary total antioxidant capacity and odds of lung cancer: a large case-control study.
BMC Cancer
September 2024
Cancer Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Islamic Republic of Iran.
Article Synopsis
- The study investigates the link between dietary total antioxidant capacity (dTAC) and the risk of lung cancer (LC) in an Iranian population.
- Researchers conducted interviews and dietary assessments with over 600 lung cancer patients and 3,400 healthy controls across 10 provinces in Iran.
- Results show that higher dTAC, measured by FRAP and TRAP scores, correlates with a lower risk of lung cancer, with consistent findings across different demographic and lifestyle groups.
AO Spine-DGOU Osteoporotic Fracture Classification System: Internal Validation by the AO Spine Knowledge Forum Trauma.
Global Spine J
September 2024
Center for Spinal and Scoliosis Surgery, Malteser Waldkrankenhaus St. Marien Erlangen, Erlangen, Germany.
Article Synopsis
- The study evaluated the reliability of the AO Spine-DGOU Osteoporotic Fracture classification system using a cross-sectional survey with 23 trauma experts rating 33 cases at two different times.
- The calculated kappa statistics indicated moderate inter-rater agreement and substantial intra-rater reproducibility, suggesting that while raters differed slightly, individual consistency was high.
- The findings highlight the importance of training in improving the reliability of the classification system for identifying fracture patterns and guiding treatment.
Valuation of the EORTC Quality of Life Utility Core 10 Dimensions (QLU-C10D) in a Multi-ethnic Asian Setting: How Does Having Cancer Matter?
Pharmacoeconomics
December 2024
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Objectives: The aim of the study was to develop and compare utility value sets for the EORTC QLU-C10D, a cancer-specific utility instrument based on the EORTC QLQ-C30, using the preferences of the general public and cancer patients in Singapore, and to assess their measurement properties.
Methods: A total of 600 individuals from the general public were recruited using a multi-stage random sampling, along with 626 cancer patients with clinically confirmed diagnoses from outpatient clinics of the largest tertiary cancer hospital. Each participant valued 16 pairs of EORTC QLU-C10D health states using a discrete choice experiment (DCE).
Excess of severe autoimmune diseases in women with premature ovarian insufficiency: a population-based study.
Hum Reprod
November 2024
Department of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Pohde, Oulu, Finland.
Article Synopsis
- Research shows that women with premature ovarian insufficiency (POI) are significantly more likely to have a history of severe autoimmune diseases, occurring 2.6 times more often than those without POI.
- The study analyzed data from nearly 4,000 women diagnosed with spontaneous POI, comparing their health outcomes to over 15,000 matched controls, which included tracking autoimmune diagnoses from childhood through 2017.
- Findings indicate that women with POI not only had a higher prevalence of autoimmune disorders prior to their diagnosis but also faced a 2 to 3 times increased risk for these diseases for several years afterward.