16 results match your criteria: "Tampa General Hospital Cancer Institute[Affiliation]"

Article Synopsis
  • Myelodysplastic Syndromes (MDS) during pregnancy is uncommon, leading to a lack of specific treatment guidelines for affected patients.
  • The paper discusses two clinical cases to illustrate potential management strategies for pregnant patients with MDS, drawing on expert opinions and existing research.
  • It highlights important considerations and necessary evaluations to assist healthcare providers in effectively navigating the challenges of managing pregnancy in patients with this condition.
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Background Chimeric antigen receptor T-cell (CAR-T) therapy offers a promising treatment for certain malignancies but can be associated with complications. Malnutrition and cachexia are common in cancer patients and may worsen outcomes. This study investigated the impact of malnutrition on the length of hospital stay (LOS) in patients with hematologic malignancies undergoing CAR-T therapy.

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Article Synopsis
  • Evidence-based treatment for advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) requires personalized decisions that take into account individual patient and cancer characteristics. !* -
  • A multidisciplinary panel reviewed 131 publications to develop a guidance document with 24 recommendations and 5 good clinical practice statements focusing on diagnostic features and biomarkers for managing unresectable or metastatic GEP-NENs. !* -
  • The document emphasizes treatment strategies based on tumor characteristics and specific biomarkers, and it received endorsements from major neuroendocrine tumor organizations. !*
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Article Synopsis
  • Traditional bolus materials in radiotherapy help optimize dose delivery to superficial targets, but they fall short for specialized cases like cavity filling, prompting the exploration of 3D printing as a solution.
  • The study aims to implement a comprehensive 3D printed bolus solution using failure modes and effects analysis (FMEA) to enhance workflow and quality assurance in a clinical setting.
  • The results showed a detailed workflow with numerous steps and potential failure modes, emphasizing the importance of early collaboration between physics and dosimetry to ensure safe and effective use of the new silicone bolus designs.
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A 67-year-old female came to Tampa General Hospital with Philadelphia chromosome-positive (Ph+) acute myeloid leukemia (AML) featuring an intriguing combination of mutations, including and mutations. Novel combination therapy with azacitidine, venetoclax and ponatinib allowed her to successfully achieve a complete response (CR) and undergo an allogeneic hematopoietic stem cell transplant (HSCT). This case report provides an overview of her clinical course, emphasizing the significance of integrated therapy and the challenges associated with balancing treatment for AML.

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A Qualitative Study Exploring Barriers to Colorectal Cancer Screening Among Firefighters.

J Occup Environ Med

June 2024

From the College of Nursing, University of South Florida, Tampa, Florida (J.K., B.P., M.E., U.M.); College of Public Health, University of South Florida, Tampa, Florida (A.G.); Morsani College of Medicine, University of South Florida, Tampa, Florida (L.S., N.A.); National Institute for Public Safety Health, Ascension Public Safety Medical, Indianapolis, Indiana (S.M.M., C.M.M.); University of Arizona Comprehensive Cancer Center, Tucson, Arizona (D.C.); and Tampa General Hospital Cancer Institute, Tampa, Florida (J.K., N.A., U.M.).

Objective: Firefighters are at increased risk of colorectal cancer (CRC), yet rates of CRC screening are low among this occupational group. This study examines perceived risks, barriers, and facilitators to CRC screening.

Methods: Three semistructured focus group discussions were conducted by investigators in Tucson, AZ.

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Management of venous thromboembolism (VTE) in patients with primary and metastatic brain tumors (BT) is challenging because of the risk of intracranial hemorrhage (ICH). There are no prospective clinical trials evaluating safety and efficacy of direct oral anticoagulants (DOACs), specifically in patients with BT, but they are widely used for VTE in this population. A group of neuro-oncology experts convened to provide practical clinical guidance for the off-label use of DOACs in treating VTE in patients with BT.

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Immunotherapy is now an integral aspect of cancer therapy. Strategies employing adoptive cell therapy (ACT) have seen the establishment of chimeric antigen receptor (CAR)-T cells using peripheral blood lymphocytes as well as tumor infiltrating lymphocytes (TILs) with significant clinical results. Despite these successes, the limitations of the current strategies are also emerging and novel approaches are needed.

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Proteogenomic insights suggest druggable pathways in endometrial carcinoma.

Cancer Cell

September 2023

Institute for Systems Genetics, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address:

We characterized a prospective endometrial carcinoma (EC) cohort containing 138 tumors and 20 enriched normal tissues using 10 different omics platforms. Targeted quantitation of two peptides can predict antigen processing and presentation machinery activity, and may inform patient selection for immunotherapy. Association analysis between MYC activity and metformin treatment in both patients and cell lines suggests a potential role for metformin treatment in non-diabetic patients with elevated MYC activity.

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Background: The Hispanic population is heterogeneous with differences in health behaviors across subgroups by nativity and preferred language. We evaluated cervical cancer screening adherence among English- and Spanish-speaking Hispanic patients receiving care at a safety net health system.

Methods: Electronic health records were used to identify 46,094 women aged 30-65.

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Background: Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signaling. However, the promise of targeted therapeutic inhibitors, has been tempered by disappointing clinical activity, likely due to complex resistance mechanisms that are not well understood. This study aims to investigate MEK inhibitor-associated resistance signaling and identify subpopulation(s) of CRC patients who may be sensitive to biomarker-driven drug combination(s).

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Coordinated Pembrolizumab and High Dose IL-2 (5-in-a-Row Schedule) for Therapy of Metastatic Clear Cell Renal Cancer.

Clin Genitourin Cancer

June 2022

University of South Florida Morsani College of Medicine, Department of Internal Medicine, Tampa, FL; Tampa General Hospital Cancer Institute, Genitourinary Oncology, Tampa, FL. Electronic address:

Introduction: The ligation of the interleukin-2 (IL-2) receptor and immune checkpoint blockade may each alter lymphocytes, thereby inducing regression in various cancers. Single agent objective response rates of 14% to 25% have been reported for usual schedule 14-dose-in-a-row IL-2 therapy of metastatic clear cell renal cancer (ccRCC), with a notable subset of responses being durable. Pembrolizumab yielded a 33% response rate in patients with metastatic ccRCC.

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