2 results match your criteria: "Tamilnadu Dr. J. Jayalalitha Fisheries University[Affiliation]"

Unraveling bioactive metabolites of mangroves as putative inhibitors of SARS-CoV-2 Mpro and RBD proteins: molecular dynamics and ADMET analysis.

J Biomol Struct Dyn

December 2024

Marine Biotechnology Research Laboratory, Department of Basic Sciences, Institute of Fisheries and Post Graduate Studies, Tamilnadu Dr. J. Jayalalitha Fisheries University, OMR Campus, Vaniyanchavadi, Chennai, Tamil Nadu, India.

COVID-19 is a deadly pandemic caused by Corona virus leading to millions of deaths worldwide. Till today no medicine was available to cure this disease. This study selected 262 potential bioactive natural products derived from mangroves to inhibit the main protease (Mpro) and receptor-binding domain (RBD) protein of the COVID-19 virus.

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The present study was undertaken to biosynthesize zinc oxide nanoparticles (ZnONPs) using a mangrove-associated actinobacterium Streptomyces olivaceus (MSU3) under in vitro conditions. The synthesized ZnONPs were structurally characterized through UV, FT-IR, TG-DTA, XRD, SEM and EDX analysis. Analysis of biosynthesized ZnONPs in UV-Vis spectroscopy showed presence of functional groups between the wavelengths 325 and 380 nm.

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